{"id":"https://openalex.org/W2170438345","doi":"https://doi.org/10.2337/diabetes.50.2.425","title":"Transgenic Complementation of Leptin-Receptor Deficiency","display_name":"Transgenic Complementation of Leptin-Receptor Deficiency","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W2170438345","doi":"https://doi.org/10.2337/diabetes.50.2.425","mag":"2170438345","pmid":"https://pubmed.ncbi.nlm.nih.gov/11272157"},"language":"en","primary_location":{"id":"doi:10.2337/diabetes.50.2.425","doi":"https://doi.org/10.2337/diabetes.50.2.425","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.50.2.425","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085983731","display_name":"Timothy J. Kowalski","orcid":"https://orcid.org/0000-0002-0659-9857","observed_orcids":["https://orcid.org/0000-0002-0659-9857"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J. Kowalski","raw_affiliation_strings":["From the Department of Pediatrics, Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110728595","display_name":"Shun-Mei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shun-Mei Liu","raw_affiliation_strings":["From the Department of Pediatrics, Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005825467","display_name":"Rudolph L. Leibel","orcid":"https://orcid.org/0000-0002-6062-7222","observed_orcids":["https://orcid.org/0000-0002-6062-7222"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rudolph L. Leibel","raw_affiliation_strings":["From the Department of Pediatrics, Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066893639","display_name":"Streamson C. Chua","orcid":"https://orcid.org/0000-0002-9437-9925","observed_orcids":["https://orcid.org/0000-0002-9437-9925"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Streamson C. Chua","raw_affiliation_strings":["From the Department of Pediatrics, Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1437,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.93380615,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"50","issue":"2","first_page":"425","last_page":"435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin-receptor","display_name":"leptin receptor","score":0.949999988079071},{"id":"https://openalex.org/keywords/leptin-receptor-isoforms","display_name":"leptin receptor isoforms","score":0.8130000233650208},{"id":"https://openalex.org/keywords/transgenic-complementation","display_name":"transgenic complementation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/neuron-specific-enolase-promoter","display_name":"neuron-specific enolase promoter","score":0.7879999876022339},{"id":"https://openalex.org/keywords/leptin-sensitivity","display_name":"leptin sensitivity","score":0.5849999785423279},{"id":"https://openalex.org/keywords/hypothalamic-neurons","display_name":"hypothalamic neurons","score":0.6510000228881836},{"id":"https://openalex.org/keywords/proopiomelanocortin-neurons","display_name":"proopiomelanocortin neurons","score":0.9290000200271606},{"id":"https://openalex.org/keywords/melanin-concentrating-hormone-neurons","display_name":"melanin-concentrating hormone neurons","score":0.9279999732971191},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5590000152587891},{"id":"https://openalex.org/keywords/hyperphagia","display_name":"hyperphagia","score":0.9710000157356262},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.796999990940094},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cold-sensitivity","display_name":"cold sensitivity","score":0.781000018119812},{"id":"https://openalex.org/keywords/fertility","display_name":"fertility","score":0.7710000276565552},{"id":"https://openalex.org/keywords/leptin-resistance","display_name":"leptin resistance","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7793992757797241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7784929275512695},{"id":"https://openalex.org/C2781309135","wikidata":"https://www.wikidata.org/wiki/Q418896","display_name":"Proopiomelanocortin","level":3,"score":0.7479945421218872},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.7079852819442749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7018044590950012},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6954461336135864},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.6670701503753662},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.6625416874885559},{"id":"https://openalex.org/C93984277","wikidata":"https://www.wikidata.org/wiki/Q24782073","display_name":"Neuropeptide Y receptor","level":4,"score":0.6265923976898193},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5339279174804688},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45780229568481445},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.45605677366256714},{"id":"https://openalex.org/C19519825","wikidata":"https://www.wikidata.org/wiki/Q417867","display_name":"Galanin","level":4,"score":0.43306902050971985},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.3890400230884552},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.38567808270454407},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2557362914085388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2298126220703125},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10156366229057312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09707286953926086},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006963","descriptor_name":"Hyperphagia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010751","descriptor_name":"Phosphopyruvate Hydratase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018149","descriptor_name":"Glucose Intolerance","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2337/diabetes.50.2.425","doi":"https://doi.org/10.2337/diabetes.50.2.425","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.50.2.425","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:11272157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11272157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1103572253","display_name":"FUNCTIONS OF LEPTIN RECEPTOR ISOFORMS IN THE BRAIN","funder_award_id":"F32NS010675","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3771701322","display_name":"The molecular genetic analysis of human obesity","funder_award_id":"R01DK052431","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000867824","display_name":"New York Obesity Research Center","funder_award_id":"P30DK026687","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1484163259","https://openalex.org/W1490643348","https://openalex.org/W1578775270","https://openalex.org/W1580569338","https://openalex.org/W1623365227","https://openalex.org/W1825634791","https://openalex.org/W1964815717","https://openalex.org/W1983241347","https://openalex.org/W1985528328","https://openalex.org/W1987290579","https://openalex.org/W1996713062","https://openalex.org/W1999887945","https://openalex.org/W2001530093","https://openalex.org/W2002646221","https://openalex.org/W2005109180","https://openalex.org/W2007867899","https://openalex.org/W2010142606","https://openalex.org/W2013583119","https://openalex.org/W2016979581","https://openalex.org/W2016994959","https://openalex.org/W2020270875","https://openalex.org/W2021895570","https://openalex.org/W2023433178","https://openalex.org/W2024385957","https://openalex.org/W2025846514","https://openalex.org/W2027360957","https://openalex.org/W2032326780","https://openalex.org/W2039351893","https://openalex.org/W2044153433","https://openalex.org/W2049943263","https://openalex.org/W2054704603","https://openalex.org/W2055956383","https://openalex.org/W2056159864","https://openalex.org/W2056383195","https://openalex.org/W2058106399","https://openalex.org/W2060109610","https://openalex.org/W2060682066","https://openalex.org/W2061240699","https://openalex.org/W2061340727","https://openalex.org/W2066932627","https://openalex.org/W2068462949","https://openalex.org/W2068555170","https://openalex.org/W2070319580","https://openalex.org/W2076776277","https://openalex.org/W2078249055","https://openalex.org/W2090122012","https://openalex.org/W2091087465","https://openalex.org/W2095308289","https://openalex.org/W2096299662","https://openalex.org/W2098099693","https://openalex.org/W2099520624","https://openalex.org/W2105470099","https://openalex.org/W2108933895","https://openalex.org/W2125312207","https://openalex.org/W2125510262","https://openalex.org/W2133553913","https://openalex.org/W2146868985","https://openalex.org/W2148844770","https://openalex.org/W2164578725","https://openalex.org/W2172019568","https://openalex.org/W2188054290","https://openalex.org/W2278847276","https://openalex.org/W2319488049"],"related_works":["https://openalex.org/W7096386638","https://openalex.org/W2170075414","https://openalex.org/W2144219438","https://openalex.org/W2067357463","https://openalex.org/W2739517163","https://openalex.org/W2146159869","https://openalex.org/W2941905771","https://openalex.org/W2103270369","https://openalex.org/W2183631403","https://openalex.org/W110583738"],"abstract_inverted_index":{"Mice":[0,29],"homozygous":[1,30],"for":[2,9,31],"the":[3,14,32,37,42,51,54,72,77,82,92,95,105,128,143,158,178,199,249,252,255,263],"Leprdb3J":[4],"(db3J)":[5],"mutation":[6,35],"are":[7,20,245],"null":[8],"all":[10],"known":[11],"isoforms":[12,56,164,181],"of":[13,53,75,80,87,94,110,152,161,172,193,206,215,229,234,251,254],"leptin":[15,207,216,232],"receptor":[16],"(LEPR).":[17],"These":[18],"animals":[19],"obese,":[21],"hyperphagic,":[22],"cold":[23,144],"intolerant,":[24],"insulin":[25],"resistant,":[26],"and":[27,62,85,115,133,141,226,242,266],"infertile.":[28],"Leprdb":[33],"(db)":[34],"(lacking":[36],"B":[38,73],"isoform":[39,74,78],"only)":[40],"have":[41],"same":[43],"phenotype":[44],"as":[45,248],"db3J":[46],"animals.":[47],"To":[48],"better":[49],"understand":[50],"function(s)":[52],"LEPR":[55,163,180],"in":[57,104,112,122,139,146,185,198,218],"vivo,":[58],"we":[59,202],"generated":[60],"db3J/db3J":[61,124,174],"db/db":[63,166],"mice":[64,125,155],"bearing":[65],"a":[66,227],"transgene":[67,101,120,257],"(neuron-specific":[68],"enolase":[69,97],"[NSE]-Rb)":[70],"expressing":[71],"LEPR,":[76],"capable":[79],"activating":[81],"signal":[83],"transducer":[84],"activator":[86],"transcription":[88],"(STAT)":[89],"pathway,":[90],"under":[91],"control":[93],"neuron-specific":[96],"enhancer/promoter.":[98],"The":[99,149],"NSE-Rb":[100,123,153,173,256],"was":[102],"expressed":[103],"brain,":[106],"with":[107],"low":[108],"levels":[109],"expression":[111,121,197],"adrenals,":[113],"testis,":[114],"white":[116],"adipose":[117],"tissue.":[118],"LEPR-B":[119],"partially":[126],"corrected":[127],"increased":[129],"fat":[130],"mass,":[131],"hyperphagia,":[132],"glucose":[134,267],"intolerance":[135,145],"while":[136],"restoring":[137],"fertility":[138],"males":[140],"rescuing":[142],"both":[147],"sexes.":[148],"body":[150,186],"weights":[151],"transgenic":[154,200],"that":[156,177],"possessed":[157],"full":[159,204],"complement":[160],"short":[162,179],"(NSE-Rb":[165],"mice)":[167],"were":[168],"similar":[169],"to":[170,209],"those":[171],"mice,":[175],"suggesting":[176],"play":[182],"little":[183],"role":[184],"weight":[187],"regulation.":[188],"Based":[189],"on":[190,231,258],"quantitative":[191],"analysis":[192],"hypothalamic":[194,240],"neuropeptide":[195],"gene":[196],"animals,":[201],"infer":[203],"restoration":[205],"sensitivity":[208,217,233],"proopiomelanocortin":[210],"(POMC)":[211],"neurons,":[212,225],"partial":[213],"correction":[214],"agouti":[219],"gene-related":[220],"protein":[221],"(AGRP)/neuropeptide":[222],"Y":[223],"(NPY)":[224],"lack":[228],"effect":[230],"melanin":[235],"concentrating":[236],"hormone":[237],"neurons.":[238],"Thus,":[239],"POMC":[241],"AGRP/NPY":[243],"neurons":[244],"primary":[246],"candidates":[247],"mediators":[250],"effects":[253],"energy":[259],"homeostasis,":[260],"ingestive":[261],"behavior,":[262],"neuroendocrine":[264],"system,":[265],"metabolism.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}