{"id":"https://openalex.org/W2170385940","doi":"https://doi.org/10.1001/archotol.1993.01880240033005","title":"Detection and Typing of Human Papillomavirus in Verrucous Carcinoma of the Oral Cavity Using the Polymerase Chain Reaction","display_name":"Detection and Typing of Human Papillomavirus in Verrucous Carcinoma of the Oral Cavity Using the Polymerase Chain Reaction","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W2170385940","doi":"https://doi.org/10.1001/archotol.1993.01880240033005","mag":"2170385940","pmid":"https://pubmed.ncbi.nlm.nih.gov/17431983"},"language":"en","primary_location":{"id":"doi:10.1001/archotol.1993.01880240033005","doi":"https://doi.org/10.1001/archotol.1993.01880240033005","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archotol.1993.01880240033005","pdf_url":null,"source":{"id":"https://openalex.org/S101791497","display_name":"Archives of Otolaryngology - Head and Neck Surgery","issn_l":"0886-4470","issn":["0886-4470","1538-361X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Otolaryngology - Head and Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019429785","display_name":"S E Noble-Topham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S. E. Noble-Topham","raw_affiliation_strings":["Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1291836623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075221444","display_name":"Dan Marian Fliss","orcid":"https://orcid.org/0000-0001-6883-4982","observed_orcids":["https://orcid.org/0000-0001-6883-4982","https://orcid.org/0000-0002-6500-0728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. M. Fliss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045323090","display_name":"R. Warren J. Hartwick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. W. J. Hartwick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013048325","display_name":"Catherine Meg McLachlin","orcid":"https://orcid.org/0000-0002-3518-7376","observed_orcids":["https://orcid.org/0000-0002-3518-7376"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. M. McLachlin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056695807","display_name":"Jeremy L. Freeman","orcid":"https://orcid.org/0000-0002-4184-3683","observed_orcids":["https://orcid.org/0000-0002-4184-3683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. L. Freeman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112173975","display_name":"A M Noyek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. M. Noyek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051193305","display_name":"Irene Louise Andrulis","orcid":"https://orcid.org/0000-0002-4226-6435","observed_orcids":["https://orcid.org/0000-0002-4226-6435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. L. Andrulis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.14,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.91459823,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"119","issue":"12","first_page":"1299","last_page":"1304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hpv-18","display_name":"HPV 18","score":0.8169999718666077},{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.9079999923706055},{"id":"https://openalex.org/keywords/oral-verrucous-carcinoma","display_name":"oral verrucous carcinoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.6600000262260437},{"id":"https://openalex.org/keywords/hpv-testing","display_name":"HPV testing","score":0.6190000176429749},{"id":"https://openalex.org/keywords/hpv-typing","display_name":"HPV typing","score":0.5950000286102295},{"id":"https://openalex.org/keywords/hpv-prevalence","display_name":"HPV prevalence","score":0.5509999990463257},{"id":"https://openalex.org/keywords/cancer-etiology","display_name":"cancer etiology","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2776034340","wikidata":"https://www.wikidata.org/wiki/Q7922592","display_name":"Verrucous carcinoma","level":3,"score":0.8207536935806274},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.7564165592193604},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.7280721664428711},{"id":"https://openalex.org/C2781209916","wikidata":"https://www.wikidata.org/wiki/Q3215756","display_name":"Typing","level":2,"score":0.6232304573059082},{"id":"https://openalex.org/C2986629439","wikidata":"https://www.wikidata.org/wiki/Q9635","display_name":"Oral cavity","level":2,"score":0.5164873600006104},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.41286370158195496},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4046735465526581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33786460757255554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32167014479637146},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2841050326824188},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.20675045251846313},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12195548415184021},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11914414167404175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10584509372711182},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.07218471169471741}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018289","descriptor_name":"Carcinoma, Verrucous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018289","descriptor_name":"Carcinoma, Verrucous","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D052685","descriptor_name":"Alphapapillomavirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1001/archotol.1993.01880240033005","doi":"https://doi.org/10.1001/archotol.1993.01880240033005","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archotol.1993.01880240033005","pdf_url":null,"source":{"id":"https://openalex.org/S101791497","display_name":"Archives of Otolaryngology - Head and Neck Surgery","issn_l":"0886-4470","issn":["0886-4470","1538-361X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Otolaryngology - Head and Neck Surgery","raw_type":"journal-article"},{"id":"pmid:17431983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17431983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of otolaryngology--head & neck surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W6688127","https://openalex.org/W1510691971","https://openalex.org/W1510715774","https://openalex.org/W1536539595","https://openalex.org/W1879840035","https://openalex.org/W1958258106","https://openalex.org/W1964327711","https://openalex.org/W1971150511","https://openalex.org/W1971917499","https://openalex.org/W1987731273","https://openalex.org/W1988773835","https://openalex.org/W1992635463","https://openalex.org/W1994130188","https://openalex.org/W1996017378","https://openalex.org/W1997525190","https://openalex.org/W1998943545","https://openalex.org/W1999053674","https://openalex.org/W2000756006","https://openalex.org/W2004098973","https://openalex.org/W2004204418","https://openalex.org/W2005486605","https://openalex.org/W2005793669","https://openalex.org/W2009057801","https://openalex.org/W2010879720","https://openalex.org/W2013283747","https://openalex.org/W2013538737","https://openalex.org/W2015587833","https://openalex.org/W2020370093","https://openalex.org/W2020968809","https://openalex.org/W2021755730","https://openalex.org/W2023614043","https://openalex.org/W2036225741","https://openalex.org/W2037367872","https://openalex.org/W2038500217","https://openalex.org/W2039955640","https://openalex.org/W2043612261","https://openalex.org/W2047375105","https://openalex.org/W2054127757","https://openalex.org/W2056554221","https://openalex.org/W2060786724","https://openalex.org/W2065532219","https://openalex.org/W2069844469","https://openalex.org/W2079437959","https://openalex.org/W2087063127","https://openalex.org/W2090452582","https://openalex.org/W2097435298","https://openalex.org/W2103340588","https://openalex.org/W2137006881","https://openalex.org/W2146863392","https://openalex.org/W2163180100","https://openalex.org/W2228363200","https://openalex.org/W2314907759","https://openalex.org/W2407851486","https://openalex.org/W2416143770","https://openalex.org/W2464764930","https://openalex.org/W2468078318","https://openalex.org/W4240636172"],"related_works":["https://openalex.org/W2470706475","https://openalex.org/W1967773428","https://openalex.org/W2329334732","https://openalex.org/W2088965948","https://openalex.org/W2108664304","https://openalex.org/W2080448247","https://openalex.org/W1970156370","https://openalex.org/W2005486605","https://openalex.org/W2257573158","https://openalex.org/W2057684181"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1,19,62],"study":[2,63],"examined":[3,31,64],"the":[4,33,109,174],"prevalence":[5,98],"and":[6,46,82,103,134,151,180,188,201],"types":[7,43],"of":[8,21,51,74,91,99,121,159,165,176,191],"human":[9],"papillomavirus":[10],"(HPV)":[11],"DNA":[12,38,105,115,137,162,179],"in":[13,58,71,118,144,163],"oral":[14,66,166,182,195],"cavity":[15,67,167,183,196],"verrucous":[16,68,92,168,184,197],"carcinoma.":[17,93],"DESIGN:":[18],"was":[20,106,116],"a":[22,72],"retrospective":[23],"screening":[24],"study.":[25,205],"Formalin-fixed,":[26],"paraffin-embedded":[27],"tissue":[28],"samples":[29],"were":[30,53,142],"by":[32,108],"polymerase":[34],"chain":[35],"reaction":[36],"using":[37],"primers":[39],"specific":[40],"for":[41,194],"HPV":[42,100,114,125,128,131,135,139,160,177,192],"6b/11,":[44,101],"16,":[45,102],"18.":[47],"SETTING:":[48],"The":[49,97,113,124,157,186],"majority":[50],"patients":[52,76],"seen":[54],"at":[55],"referral":[56],"centers":[57],"Ontario,":[59],"Canada.":[60],"PATIENTS:":[61],"29":[65],"carcinomas":[69,169],"occurring":[70],"sample":[73],"25":[75,122],"from":[77],"four":[78],"institutions":[79],"between":[80,173],"1966":[81],"1992.":[83],"All":[84],"tumors":[85],"met":[86],"standardized":[87],"histologic":[88],"diagnostic":[89],"criteria":[90],"MAIN":[94],"OUTCOME":[95],"MEASURE:":[96],"18":[104,132,140,161,178,193],"determined":[107],"PCR":[110],"technique.":[111],"RESULTS:":[112],"detected":[117,143],"12":[119],"(48%)":[120],"patients.":[123],"6b/11":[126],"DNA,":[127,130,133,141],"16":[129,136],"plus":[138],"one":[145,147,152],"(4%),":[146,148],"nine":[149],"(36%),":[150],"(4%)":[153],"cases,":[154],"respectively.":[155],"CONCLUSIONS:":[156],"detection":[158],"40%":[164],"suggests":[170],"an":[171],"association":[172],"presence":[175],"some":[181],"carcinomas.":[185],"etiologic":[187],"prognostic":[189],"significance":[190],"carcinoma":[198],"remains":[199],"unanswered":[200],"will":[202],"require":[203],"further":[204]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
