{"id":"https://openalex.org/W2170348681","doi":"https://doi.org/10.1165/rcmb.2009-0165oc","title":"Epithelial Ablation of Bcl-XL Increases Sensitivity to Oxygen without Disrupting Lung Development","display_name":"Epithelial Ablation of Bcl-XL Increases Sensitivity to Oxygen without Disrupting Lung Development","publication_year":2009,"publication_date":"2009-10-30","ids":{"openalex":"https://openalex.org/W2170348681","doi":"https://doi.org/10.1165/rcmb.2009-0165oc","mag":"2170348681","pmid":"https://pubmed.ncbi.nlm.nih.gov/19880821","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2933553"},"language":"en","primary_location":{"id":"doi:10.1165/rcmb.2009-0165oc","doi":"https://doi.org/10.1165/rcmb.2009-0165oc","is_oa":false,"landing_page_url":"https://doi.org/10.1165/rcmb.2009-0165oc","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2933553","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042446775","display_name":"Rhonda J. Staversky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rhonda J. Staversky","raw_affiliation_strings":["Department of Pediatrics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045111286","display_name":"Peter F. Vitiello","orcid":"https://orcid.org/0000-0001-5344-9192","observed_orcids":["https://orcid.org/0000-0001-5344-9192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter F. Vitiello","raw_affiliation_strings":["Department of Pediatrics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026859426","display_name":"Min Yee","orcid":"https://orcid.org/0000-0002-5260-854X","observed_orcids":["https://orcid.org/0000-0002-5260-854X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Yee","raw_affiliation_strings":["Department of Pediatrics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076565130","display_name":"Linda M. Callahan","orcid":"https://orcid.org/0000-0002-7497-8074","observed_orcids":["https://orcid.org/0000-0002-7497-8074"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda M. Callahan","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017939101","display_name":"David A. Dean","orcid":"https://orcid.org/0000-0001-7748-8073","observed_orcids":["https://orcid.org/0000-0001-7748-8073"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Dean","raw_affiliation_strings":["Department of Pediatrics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055508411","display_name":"Michael A. O\u2019Reilly","orcid":"https://orcid.org/0000-0001-5094-696X","observed_orcids":["https://orcid.org/0000-0001-5094-696X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael A. O'Reilly","raw_affiliation_strings":["Department of Pediatrics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055508411"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.375,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.58830423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"43","issue":"3","first_page":"376","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.16089999675750732,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9980000257492065},{"id":"https://openalex.org/keywords/respiratory-epithelium","display_name":"respiratory epithelium","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.8709999918937683},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7170000076293945},{"id":"https://openalex.org/keywords/lung-development","display_name":"lung development","score":0.796999990940094},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.8209999799728394},{"id":"https://openalex.org/keywords/bak","display_name":"Bak","score":0.9940000176429749},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/8-oxoguanine","display_name":"8-oxoguanine","score":0.949999988079071},{"id":"https://openalex.org/keywords/perinatal-lethality","display_name":"perinatal lethality","score":0.8529999852180481},{"id":"https://openalex.org/keywords/surfactant-protein-c","display_name":"surfactant protein C","score":0.7160000205039978},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.8848165273666382},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.7158299684524536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6491371393203735},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.605947732925415},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5219930410385132},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5159916877746582},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4881518483161926},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46781134605407715},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.46526244282722473},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.45729362964630127},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.43289950489997864},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3424280881881714},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26271623373031616},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2371445596218109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1382119357585907},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0939195454120636},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07938262820243835}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018496","descriptor_name":"Hyperoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1165/rcmb.2009-0165oc","doi":"https://doi.org/10.1165/rcmb.2009-0165oc","is_oa":false,"landing_page_url":"https://doi.org/10.1165/rcmb.2009-0165oc","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2170201","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2933553","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2933553","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2933553","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Respir Cell Mol Biol","raw_type":"Text"},{"id":"pmid:19880821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19880821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2170201","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2933553","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1919931761","display_name":"Electroporation-mediated Pulmonary Gene Transfer for Acute Lung Injury","funder_award_id":"5r21hl092801-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G208308110","display_name":null,"funder_award_id":"HL091968","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2189277278","display_name":null,"funder_award_id":"ES-01247","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2289186176","display_name":null,"funder_award_id":"6-FY08-264","funder_id":"https://openalex.org/F4320306182","funder_display_name":"March of Dimes Foundation"},{"id":"https://openalex.org/G306999276","display_name":"Cytoplasmic trafficking of non-viral gene therapy vectors","funder_award_id":"R01EB009903","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G3155948302","display_name":"Cell survival and death in oxidant lung injury","funder_award_id":"R01HL067392","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3405300570","display_name":null,"funder_award_id":"HL67392","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3806731320","display_name":null,"funder_award_id":"HL81148","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4669862682","display_name":null,"funder_award_id":"R21 HL-092801","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6046150","display_name":"Alveolar Epithelial Cell-Specific Gene Therapy Plasmids","funder_award_id":"R01HL081148","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6125590448","display_name":"Vascular smooth muscle specific gene therapy vectors","funder_award_id":"R01HL059956","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6227783766","display_name":"Effect of Neonatal Hyperoxia on Alveolar Development and Infection","funder_award_id":"R01HL091968","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G682100620","display_name":null,"funder_award_id":"HL 59956","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8185607770","display_name":null,"funder_award_id":"6-FY08-264","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000020184","display_name":null,"funder_award_id":"ES01247","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000888856","display_name":"Environmental Agents as Modulators of Disease Processes","funder_award_id":"P30ES001247","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306182","display_name":"March of Dimes Foundation","ror":"https://ror.org/04bd5p711"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W348002317","https://openalex.org/W1564202134","https://openalex.org/W1607777232","https://openalex.org/W1938846285","https://openalex.org/W1965566566","https://openalex.org/W1976226379","https://openalex.org/W1979399988","https://openalex.org/W1981850977","https://openalex.org/W1989327230","https://openalex.org/W1993219930","https://openalex.org/W1994650375","https://openalex.org/W1996401569","https://openalex.org/W2000894919","https://openalex.org/W2003150155","https://openalex.org/W2008376982","https://openalex.org/W2008715871","https://openalex.org/W2008841394","https://openalex.org/W2019980431","https://openalex.org/W2021994448","https://openalex.org/W2025609880","https://openalex.org/W2027862098","https://openalex.org/W2028307977","https://openalex.org/W2029847215","https://openalex.org/W2043787490","https://openalex.org/W2049232422","https://openalex.org/W2052913152","https://openalex.org/W2054161575","https://openalex.org/W2056318894","https://openalex.org/W2059929805","https://openalex.org/W2063176993","https://openalex.org/W2066602623","https://openalex.org/W2067410074","https://openalex.org/W2087770023","https://openalex.org/W2089993659","https://openalex.org/W2098046341","https://openalex.org/W2103143496","https://openalex.org/W2103430146","https://openalex.org/W2104010513","https://openalex.org/W2104166019","https://openalex.org/W2112968535","https://openalex.org/W2118516780","https://openalex.org/W2123714940","https://openalex.org/W2131727825","https://openalex.org/W2133330925","https://openalex.org/W2149719174","https://openalex.org/W2157754987","https://openalex.org/W2165234158","https://openalex.org/W2186849894","https://openalex.org/W2244293347","https://openalex.org/W2414458067","https://openalex.org/W2435751324","https://openalex.org/W4300617423","https://openalex.org/W7095701206"],"related_works":["https://openalex.org/W2021994448","https://openalex.org/W2056810868","https://openalex.org/W2329642306","https://openalex.org/W2389455564","https://openalex.org/W2390051951","https://openalex.org/W1516851780","https://openalex.org/W2087770023","https://openalex.org/W2387973921","https://openalex.org/W2905702894","https://openalex.org/W1967567029"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"indicate":[2],"that":[3,207],"the":[4,13,46,51,54,72,84,94,99,113,121,135,147,169,208,235],"antiapoptotic":[5,158],"Bcl-X(L),":[6],"one":[7],"of":[8,19,63,83,93,101,112,128,137,168,211],"five":[9],"isoforms":[10],"expressed":[11,49],"by":[12,75,154],"Bcl-X":[14,85],"gene,":[15],"protects":[16],"a":[17,79,150,155,192],"variety":[18],"cell":[20],"lines":[21],"exposed":[22],"to":[23,172,187,222,239],"hyperoxia.":[24,173],"However,":[25,116,144],"its":[26],"role":[27],"in":[28,36,50,58,103,109,157,162,197],"lung":[29,142,148,218],"development":[30],"and":[31,53,165,234],"protection":[32],"against":[33,227],"oxidative":[34],"stress":[35],"vivo":[37],"is":[38,45,65,213],"not":[39,131,214],"known.":[40],"Here,":[41],"we":[42],"show":[43],"Bcl-X(L)":[44,64,68,102,129,201,212],"predominant":[47],"isoform":[48,56],"lung,":[52],"only":[55],"detected":[57],"respiratory":[59,73,104,170,224],"epithelium.":[60],"Because":[61],"loss":[62,100],"embryonically":[66],"lethal,":[67],"was":[69,106,202],"ablated":[70],"throughout":[71],"epithelium":[74,105,171],"mating":[76],"mice":[77,88,119,199],"with":[78,87],"floxed":[80],"exon":[81],"II":[82],"gene":[86,122],"expressing":[89],"Cre":[90],"under":[91],"control":[92],"surfactant":[95],"protein-C":[96],"promoter.":[97],"Interestingly,":[98],"perinatally":[107],"lethal":[108],"approximately":[110],"50%":[111],"expected":[114],"offspring.":[115],"some":[117,198],"adult":[118],"lacking":[120,200],"were":[123,181],"obtained.":[124],"The":[125],"epithelial-specific":[126,209],"ablation":[127],"did":[130],"disrupt":[132],"pulmonary":[133],"function,":[134],"expression":[136,210],"epithelial":[138,225],"cell-specific":[139],"markers,":[140],"or":[141],"development.":[143],"it":[145],"shifted":[146],"toward":[149],"proapoptotic":[151,163],"state,":[152],"defined":[153],"reduction":[156],"Mcl-1,":[159],"an":[160],"increase":[161],"Bak,":[164],"increased":[166,175],"sensitivity":[167],"Intriguingly,":[174],"8-oxoguanine":[176],"lesions":[177],"seen":[178],"during":[179,232],"hyperoxia":[180,233],"also":[182],"evident":[183],"as":[184,231],"lungs":[185],"transitioned":[186],"room":[188],"air":[189],"at":[190],"birth,":[191],"time":[193],"when":[194],"perinatal":[195],"lethality":[196],"observed.":[203],"These":[204],"findings":[205],"reveal":[206],"required":[215],"for":[216],"proper":[217],"development,":[219],"but":[220],"functions":[221],"protect":[223],"cells":[226],"oxygen-induced":[228],"toxicity,":[229],"such":[230],"lung's":[236],"first":[237],"exposure":[238],"ambient":[240],"air.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
