{"id":"https://openalex.org/W2170307472","doi":"https://doi.org/10.1093/brain/awq017","title":"Increased sensorimotor network activity in DYT1 dystonia: a functional imaging study","display_name":"Increased sensorimotor network activity in DYT1 dystonia: a functional imaging study","publication_year":2010,"publication_date":"2010-03-01","ids":{"openalex":"https://openalex.org/W2170307472","doi":"https://doi.org/10.1093/brain/awq017","mag":"2170307472","pmid":"https://pubmed.ncbi.nlm.nih.gov/20207699","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2842516"},"language":"en","primary_location":{"id":"doi:10.1093/brain/awq017","doi":"https://doi.org/10.1093/brain/awq017","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awq017","pdf_url":"https://academic.oup.com/brain/article-pdf/133/3/690/17343856/awq017.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/brain/article-pdf/133/3/690/17343856/awq017.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060915126","display_name":"Maren Carbon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]},{"id":"https://openalex.org/I2800496781","display_name":"North Shore University Hospital","ror":"https://ror.org/05m8d2x46","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I2800496781"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maren Carbon","raw_affiliation_strings":["Centre for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA. mcarbon@nshs.edu","Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA","Departments of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA. mcarbon@nshs.edu","institution_ids":["https://openalex.org/I1327576362"]},{"raw_affiliation_string":"Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]},{"raw_affiliation_string":"Departments of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I2800496781","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038719354","display_name":"Mikl\u00f3s \u00c1rgyel\u00e1n","orcid":"https://orcid.org/0000-0002-7254-1776","observed_orcids":["https://orcid.org/0000-0002-7254-1776"]},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miklos Argyelan","raw_affiliation_strings":["Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049228057","display_name":"Christian Georg Habeck","orcid":"https://orcid.org/0000-0001-9961-7446","observed_orcids":["https://orcid.org/0000-0001-9961-7446"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Habeck","raw_affiliation_strings":["Cognitive Neuroscience Division, Taub Institute, Columbia University Medical Centre, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cognitive Neuroscience Division, Taub Institute, Columbia University Medical Centre, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050919667","display_name":"M. F. Ghilardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Felice Ghilardi","raw_affiliation_strings":["Department of Pharmacology and Physiology, CUNY Medical School at City College of New York, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Physiology, CUNY Medical School at City College of New York, New York, NY, USA","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057532842","display_name":"Toni Fitzpatrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toni Fitzpatrick","raw_affiliation_strings":["Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074164462","display_name":"VIJAY M. DHAWAN","orcid":"https://orcid.org/0000-0002-2418-5674","observed_orcids":["https://orcid.org/0000-0002-2418-5674"]},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]},{"id":"https://openalex.org/I2800496781","display_name":"North Shore University Hospital","ror":"https://ror.org/05m8d2x46","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I2800496781"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay Dhawan","raw_affiliation_strings":["Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA","Departments of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]},{"raw_affiliation_string":"Departments of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I2800496781","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109353404","display_name":"Michael Pourfar","orcid":"https://orcid.org/0009-0001-5097-6998","observed_orcids":["https://orcid.org/0009-0001-5097-6998"]},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]},{"id":"https://openalex.org/I2800496781","display_name":"North Shore University Hospital","ror":"https://ror.org/05m8d2x46","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I2800496781"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Pourfar","raw_affiliation_strings":["Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA","Departments of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]},{"raw_affiliation_string":"Departments of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I2800496781","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015080716","display_name":"Susan Bressman","orcid":"https://orcid.org/0000-0002-3513-8048","observed_orcids":["https://orcid.org/0000-0002-3513-8048"]},"institutions":[{"id":"https://openalex.org/I1287643137","display_name":"Mount Sinai Beth Israel","ror":"https://ror.org/01742jq13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287643137","https://openalex.org/I1320796813"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan B. Bressman","raw_affiliation_strings":["Mirken Department of Neurology, Beth Israel Medical Centre, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirken Department of Neurology, Beth Israel Medical Centre, New York, NY, USA","institution_ids":["https://openalex.org/I1287643137"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041539272","display_name":"David Eidelberg","orcid":"https://orcid.org/0000-0002-0854-864X","observed_orcids":["https://orcid.org/0000-0002-0854-864X"]},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]},{"id":"https://openalex.org/I2800496781","display_name":"North Shore University Hospital","ror":"https://ror.org/05m8d2x46","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I2800496781"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Eidelberg","raw_affiliation_strings":["Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA","Departments of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]},{"raw_affiliation_string":"Departments of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I2800496781","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4224,"currency":"GBP","value_usd":5570},"apc_paid":null,"fwci":7.3469,"has_fulltext":true,"cited_by_count":101,"citation_normalized_percentile":{"value":0.97620091,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"133","issue":"3","first_page":"690","last_page":"700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13966","display_name":"Neurological and metabolic disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dyt1-dystonia","display_name":"DYT1 dystonia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/sensorimotor-network","display_name":"sensorimotor network","score":0.7009999752044678},{"id":"https://openalex.org/keywords/primary-dystonia","display_name":"primary dystonia","score":0.5839999914169312},{"id":"https://openalex.org/keywords/dorsal-premotor-cortex","display_name":"dorsal premotor cortex","score":0.8949999809265137},{"id":"https://openalex.org/keywords/supplementary-motor-area","display_name":"supplementary motor area","score":1.0},{"id":"https://openalex.org/keywords/inferior-parietal-cortex","display_name":"inferior parietal cortex","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.8970000147819519},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.30300000309944153},{"id":"https://openalex.org/keywords/15o-water-pet","display_name":"15O-water PET","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2779534489","wikidata":"https://www.wikidata.org/wiki/Q2998090","display_name":"Premotor cortex","level":3,"score":0.7732239961624146},{"id":"https://openalex.org/C2781300654","wikidata":"https://www.wikidata.org/wiki/Q2467403","display_name":"Supplementary motor area","level":3,"score":0.7123750448226929},{"id":"https://openalex.org/C39313694","wikidata":"https://www.wikidata.org/wiki/Q2940624","display_name":"Statistical parametric mapping","level":3,"score":0.6933150291442871},{"id":"https://openalex.org/C2780307956","wikidata":"https://www.wikidata.org/wiki/Q18707","display_name":"Primary motor cortex","level":4,"score":0.6915618181228638},{"id":"https://openalex.org/C2778373776","wikidata":"https://www.wikidata.org/wiki/Q18696","display_name":"Motor cortex","level":3,"score":0.6609282493591309},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6426352858543396},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5677700042724609},{"id":"https://openalex.org/C2778559928","wikidata":"https://www.wikidata.org/wiki/Q906492","display_name":"Dystonia","level":2,"score":0.44048359990119934},{"id":"https://openalex.org/C137813230","wikidata":"https://www.wikidata.org/wiki/Q2996165","display_name":"Motor control","level":2,"score":0.4258258044719696},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.41649672389030457},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.4149632155895233},{"id":"https://openalex.org/C6757342","wikidata":"https://www.wikidata.org/wiki/Q3486606","display_name":"Posterior parietal cortex","level":2,"score":0.4139823615550995},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.4100882411003113},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3311011493206024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3002907335758209},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.21651408076286316},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.12255176901817322},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.1159084141254425},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004421","descriptor_name":"Dystonia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004421","descriptor_name":"Dystonia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004421","descriptor_name":"Dystonia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010104","descriptor_name":"Oxygen Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/brain/awq017","doi":"https://doi.org/10.1093/brain/awq017","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awq017","pdf_url":"https://academic.oup.com/brain/article-pdf/133/3/690/17343856/awq017.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2842516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2842516","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"Text"},{"id":"pmid:20207699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20207699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain : a journal of neurology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/brain/awq017","doi":"https://doi.org/10.1093/brain/awq017","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awq017","pdf_url":"https://academic.oup.com/brain/article-pdf/133/3/690/17343856/awq017.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2250816904","display_name":"Multivariate approaches to neuroimaging analysis","funder_award_id":"R01EB006204","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4700852728","display_name":null,"funder_award_id":"R01 NS","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5580380648","display_name":"General Clinical Research Center","funder_award_id":"M01RR018535","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6152195246","display_name":"Brain and Behavior in Dystonia: A Multicenter Study","funder_award_id":"R01NS047668","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170307472.pdf","grobid_xml":"https://content.openalex.org/works/W2170307472.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1563137494","https://openalex.org/W1780831758","https://openalex.org/W1965762009","https://openalex.org/W1966560502","https://openalex.org/W1983669648","https://openalex.org/W1994483469","https://openalex.org/W1995945562","https://openalex.org/W1998995153","https://openalex.org/W2002804846","https://openalex.org/W2005293968","https://openalex.org/W2007660683","https://openalex.org/W2008123743","https://openalex.org/W2016079316","https://openalex.org/W2022658952","https://openalex.org/W2025082517","https://openalex.org/W2037475508","https://openalex.org/W2040372154","https://openalex.org/W2041529043","https://openalex.org/W2044897765","https://openalex.org/W2047000182","https://openalex.org/W2048473451","https://openalex.org/W2053632199","https://openalex.org/W2055454548","https://openalex.org/W2059837034","https://openalex.org/W2062488246","https://openalex.org/W2063352489","https://openalex.org/W2065556410","https://openalex.org/W2065739318","https://openalex.org/W2067450921","https://openalex.org/W2070490154","https://openalex.org/W2071396208","https://openalex.org/W2074461496","https://openalex.org/W2079386795","https://openalex.org/W2082444101","https://openalex.org/W2086641492","https://openalex.org/W2088037244","https://openalex.org/W2094517189","https://openalex.org/W2100093562","https://openalex.org/W2101833134","https://openalex.org/W2112643024","https://openalex.org/W2114825563","https://openalex.org/W2117451014","https://openalex.org/W2118225192","https://openalex.org/W2118283826","https://openalex.org/W2128542490","https://openalex.org/W2130065503","https://openalex.org/W2133639311","https://openalex.org/W2136179920","https://openalex.org/W2142145583","https://openalex.org/W2145206337","https://openalex.org/W2151119018","https://openalex.org/W2159159912","https://openalex.org/W2159873817","https://openalex.org/W2163274894","https://openalex.org/W2175474691","https://openalex.org/W2186388293","https://openalex.org/W2412318627","https://openalex.org/W2797563284"],"related_works":["https://openalex.org/W2156136240","https://openalex.org/W3116822928","https://openalex.org/W2266085241","https://openalex.org/W2041529043","https://openalex.org/W2325853427","https://openalex.org/W2158456601","https://openalex.org/W2091734452","https://openalex.org/W4376133614","https://openalex.org/W2397815153","https://openalex.org/W2094517189"],"abstract_inverted_index":{"Neurophysiological":[0],"studies":[1,17],"have":[2,398],"provided":[3],"evidence":[4],"of":[5,37,110,121,128,143,165,205,284,317,344,352,356,371,383,388,404,409],"primary":[6,11],"motor":[7,74,112,136,173,196,234],"cortex":[8],"hyperexcitability":[9],"in":[10,35,43,80,107,117,134,141,176,226,253,263,269,276,281,298,304,309,323,363,394,407],"dystonia,":[12],"but":[13,261,306],"several":[14],"functional":[15],"imaging":[16],"suggest":[18],"otherwise.":[19],"To":[20],"address":[21],"this":[22,129,291,384],"issue,":[23],"we":[24,99],"measured":[25,247],"sensorimotor":[26,190,228,346,375],"activation":[27,105,174,215,244,295,320,360,391],"at":[28],"both":[29,282],"the":[30,38,135,144,152,177,189,199,206,227,239,254,270,313,324,345,364],"regional":[31],"and":[32,42,50,64,87,113,137,147,159,168,198,236,414],"network":[33,97,277,376],"levels":[34],"carriers":[36,63,146,167,257,286,300],"DYT1":[39,58,62,166],"dystonia":[40,330,413],"mutation":[41],"control":[44,84,138,272],"subjects.":[45,125],"We":[46],"used":[47],"(15)Oxygen-labelled":[48],"water":[49],"positron":[51],"emission":[52],"tomography":[53],"to":[54,188],"scan":[55],"nine":[56],"manifesting":[57,255],"carriers,":[59],"10":[60],"non-manifesting":[61,265,299],"12":[65],"age-matched":[66],"controls":[67,169],"while":[68],"they":[69,76],"performed":[70],"a":[71,81,102,108,211,349],"kinematically":[72],"controlled":[73],"task;":[75],"were":[77,90,155,279],"also":[78],"scanned":[79],"non-motor":[82,271,365],"audio-visual":[83,114,325,372],"condition.":[85],"Within-":[86],"between-group":[88],"contrasts":[89],"analysed":[91],"with":[92,157,328,374],"statistical":[93,184],"parametric":[94,185],"mapping.":[95],"For":[96],"analysis,":[98],"first":[100],"identified":[101],"normal":[103,213,242,293,318,358,389],"motor-related":[104,214,243,294,319,359,390],"pattern":[106,130,216,245,296,321,361,392],"set":[109],"39":[111],"scans":[115,139],"acquired":[116,140],"an":[118,379,401],"independent":[119,329],"cohort":[120,209],"18":[122],"healthy":[123],"volunteer":[124],"The":[126,354],"expression":[127,246,297,322,362,393],"was":[131,250,301],"prospectively":[132],"quantified":[133],"each":[142],"gene":[145,256,285],"controls.":[148],"Network":[149,203],"values":[150],"for":[151,412],"three":[153],"groups":[154,283],"compared":[156],"ANOVA":[158],"post":[160],"hoc":[161],"contrasts.":[162],"Voxel-wise":[163],"comparison":[164],"revealed":[170,210],"abnormally":[171,251],"increased":[172],"responses":[175],"former":[178],"group":[179],"(P":[180,218,258,287],"<":[181,219,259,288],"0.05,":[182],"corrected;":[183],"mapping),":[186],"localized":[187],"cortex,":[191,194,229,232],"dorsal":[192,230],"premotor":[193,231],"supplementary":[195,233],"area":[197,235],"inferior":[200],"parietal":[201],"cortex.":[202],"analysis":[204],"normative":[207],"derivation":[208],"significant":[212],"topography":[217],"0.0001)":[220],"characterized":[221],"by":[222],"covarying":[223],"neural":[224],"activity":[225,278,377],"cerebellum.":[237],"In":[238,267,290,312],"study":[240],"cohort,":[241],"during":[248],"movement":[249],"elevated":[252,357],"0.001)":[260],"not":[262],"their":[264],"counterparts.":[266],"contrast,":[268],"condition,":[273,292],"abnormal":[274,369],"increases":[275],"present":[280],"0.001).":[289],"greater":[302],"than":[303,308],"controls,":[305],"lower":[307],"affected":[310],"carriers.":[311],"latter":[314],"group,":[315],"measures":[316],"condition":[326,366],"correlated":[327],"clinical":[331],"ratings":[332],"(r":[333],"=":[334,337],"0.70,":[335],"P":[336],"0.04).":[338],"These":[339],"findings":[340],"confirm":[341],"that":[342,368],"overexcitability":[343],"system":[347],"is":[348,378],"robust":[350],"feature":[351,382],"dystonia.":[353],"presence":[355],"suggests":[367],"integration":[370],"input":[373],"important":[380],"trait":[381],"disorder.":[385],"Lastly,":[386],"quantification":[387],"individual":[395],"cases":[396],"may":[397],"utility":[399],"as":[400],"objective":[402],"descriptor":[403],"therapeutic":[405],"response":[406],"trials":[408],"new":[410],"treatments":[411],"related":[415],"disorders.":[416]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}