{"id":"https://openalex.org/W2170303471","doi":"https://doi.org/10.1242/dev.081083","title":"Gde2 regulates cortical neuronal identity by controlling the timing of cortical progenitor differentiation","display_name":"Gde2 regulates cortical neuronal identity by controlling the timing of cortical progenitor differentiation","publication_year":2012,"publication_date":"2012-09-06","ids":{"openalex":"https://openalex.org/W2170303471","doi":"https://doi.org/10.1242/dev.081083","mag":"2170303471","pmid":"https://pubmed.ncbi.nlm.nih.gov/22951639"},"language":"en","primary_location":{"id":"doi:10.1242/dev.081083","doi":"https://doi.org/10.1242/dev.081083","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.081083","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042242033","display_name":"Marianeli Rodriguez","orcid":"https://orcid.org/0000-0001-5814-7900","observed_orcids":["https://orcid.org/0000-0001-5814-7900"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marianeli Rodriguez","raw_affiliation_strings":["The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, PCTB1004, 725 N Wolfe Street, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, PCTB1004, 725 N Wolfe Street, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103125577","display_name":"Jeonghoon Choi","orcid":"https://orcid.org/0000-0002-4022-9470","observed_orcids":["https://orcid.org/0000-0002-4022-9470"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeonghoon Choi","raw_affiliation_strings":["The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, PCTB1004, 725 N Wolfe Street, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, PCTB1004, 725 N Wolfe Street, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323608","display_name":"Sung Jin Park","orcid":"https://orcid.org/0000-0001-5801-5537","observed_orcids":["https://orcid.org/0000-0001-5801-5537","https://orcid.org/0000-0003-4754-5799"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sungjin Park","raw_affiliation_strings":["The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, PCTB1004, 725 N Wolfe Street, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, PCTB1004, 725 N Wolfe Street, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013652397","display_name":"Shanthini Sockanathan","orcid":"https://orcid.org/0000-0003-4147-4782","observed_orcids":["https://orcid.org/0000-0003-4147-4782"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shanthini Sockanathan","raw_affiliation_strings":["The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, PCTB1004, 725 N Wolfe Street, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, PCTB1004, 725 N Wolfe Street, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013652397"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":null,"apc_paid":null,"fwci":0.7759,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.64663563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"139","issue":"20","first_page":"3870","last_page":"3879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortical-lamination","display_name":"cortical lamination","score":0.6330000162124634},{"id":"https://openalex.org/keywords/neuronal-birthdate","display_name":"neuronal birthdate","score":0.8519999980926514},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/deep-layer-neurons","display_name":"deep-layer neurons","score":0.6610000133514404},{"id":"https://openalex.org/keywords/cortical-development","display_name":"cortical development","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.884270429611206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8139127492904663},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6866587996482849},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6392948031425476},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.5120766758918762},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.5044828653335571},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.46930626034736633},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.465257465839386},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.4603736996650696},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37756869196891785},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32099923491477966},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2884362041950226},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2128390371799469},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1242/dev.081083","doi":"https://doi.org/10.1242/dev.081083","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.081083","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:22951639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22951639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320311557","display_name":"Brain Science Institute, Johns Hopkins University","ror":"https://ror.org/00za53h95"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1508615665","https://openalex.org/W1538926863","https://openalex.org/W1964445267","https://openalex.org/W1966562637","https://openalex.org/W1967533792","https://openalex.org/W1973303770","https://openalex.org/W1976824219","https://openalex.org/W1981521584","https://openalex.org/W1998601032","https://openalex.org/W2003935374","https://openalex.org/W2003938266","https://openalex.org/W2015964634","https://openalex.org/W2022274052","https://openalex.org/W2029911383","https://openalex.org/W2042727933","https://openalex.org/W2051409024","https://openalex.org/W2051655214","https://openalex.org/W2058734213","https://openalex.org/W2060246740","https://openalex.org/W2060902761","https://openalex.org/W2071060745","https://openalex.org/W2083131697","https://openalex.org/W2083289939","https://openalex.org/W2096870699","https://openalex.org/W2097546542","https://openalex.org/W2100007797","https://openalex.org/W2103457712","https://openalex.org/W2107315373","https://openalex.org/W2107478514","https://openalex.org/W2110387447","https://openalex.org/W2118159405","https://openalex.org/W2120120735","https://openalex.org/W2129582161","https://openalex.org/W2134413846","https://openalex.org/W2134711325","https://openalex.org/W2146180544","https://openalex.org/W2156511976","https://openalex.org/W2159884201","https://openalex.org/W2161396457","https://openalex.org/W2161428910","https://openalex.org/W2165132176","https://openalex.org/W2169062325","https://openalex.org/W2188474087","https://openalex.org/W2188539251","https://openalex.org/W2414063588"],"related_works":["https://openalex.org/W1994943548","https://openalex.org/W2125715661","https://openalex.org/W2100007797","https://openalex.org/W7100270376","https://openalex.org/W2010852678","https://openalex.org/W4313460915","https://openalex.org/W2890693517","https://openalex.org/W1966562637","https://openalex.org/W3139911415","https://openalex.org/W2579599311"],"abstract_inverted_index":{"The":[0],"mammalian":[1],"cortex":[2,95],"is":[3,53,74,90,190],"a":[4,27,82,175,202],"multilaminar":[5],"structure":[6],"consisting":[7],"of":[8,64,71,102,127,157,195,216,222,237],"specialized":[9],"layer-specific":[10],"neurons":[11,23,37,45],"that":[12,35,80,85,168,178,220,227],"form":[13],"complex":[14],"circuits":[15],"throughout":[16,96],"the":[17,62,68,93,100,109,119,125,128,193,214,235,238],"brain":[18],"and":[19,117,139,145,218],"spinal":[20,87],"cord.":[21],"These":[22,131,199],"are":[24],"generated":[25],"in":[26,39,67,92,134,141,148,174,187,207],"defined":[28],"sequence":[29],"dictated":[30],"by":[31,56,212],"their":[32],"birthdate":[33,52],"such":[34],"early-born":[36],"settle":[38],"deep":[40],"cortical":[41,97,104,209],"layers":[42],"whereas":[43],"late-born":[44],"populate":[46],"more":[47],"superficial":[48,149,182],"layers.":[49],"Cortical":[50],"neuronal":[51,88,143,150,210,230],"partly":[54],"controlled":[55],"an":[57],"intrinsic":[58],"clock-type":[59],"mechanism;":[60],"however,":[61],"role":[63,204],"extrinsic":[65],"factors":[66],"temporal":[69],"control":[70],"cell-cycle":[72,135,197],"exit":[73,108,118],"less":[75],"clear.":[76],"Here,":[77],"we":[78],"show":[79,154,219],"Gde2,":[81,103],"six-transmembrane":[83],"protein":[84],"induces":[86],"differentiation,":[89],"expressed":[91],"developing":[94],"neurogenesis.":[98],"In":[99],"absence":[101],"progenitors":[105,163,231],"fail":[106,164],"to":[107,165,181,232],"cell":[110,120],"cycle":[111,121],"on":[112],"time,":[113],"remain":[114],"cycling,":[115],"accumulate":[116],"en":[122],"masse":[123],"towards":[124],"end":[126,236],"neurogenic":[129,239],"period.":[130,240],"dynamic":[132],"changes":[133],"progression":[136],"cause":[137],"deficits":[138],"delays":[140],"deep-layer":[142],"differentiation":[144],"robust":[146],"increases":[147],"numbers.":[151],"Gde2(-/-)":[152],"cortices":[153],"elevated":[155],"levels":[156],"Notch":[158,170,188],"signaling":[159,189],"coincident":[160],"with":[161],"when":[162],"differentiate,":[166],"suggesting":[167],"abnormal":[169],"activation":[171],"retains":[172],"cells":[173],"proliferative":[176],"phase":[177],"biases":[179],"them":[180],"fates.":[183],"However,":[184],"no":[185],"change":[186],"observed":[191],"at":[192,234],"time":[194],"increased":[196],"exit.":[198],"observations":[200],"define":[201],"key":[203],"for":[205],"Gde2":[206,223],"controlling":[208],"fates":[211],"regulating":[213],"timing":[215],"neurogenesis,":[217],"loss":[221],"uncovers":[224],"additional":[225],"mechanisms":[226],"trigger":[228],"remaining":[229],"differentiate":[233]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
