{"id":"https://openalex.org/W2170283846","doi":"https://doi.org/10.1093/rheumatology/kev090.004","title":"239. IL-1\u03b2 Regulates The Dectin-1 Induced Cytokine Profile in Human Dendritic Cells","display_name":"239. IL-1\u03b2 Regulates The Dectin-1 Induced Cytokine Profile in Human Dendritic Cells","publication_year":2015,"publication_date":"2015-04-20","ids":{"openalex":"https://openalex.org/W2170283846","doi":"https://doi.org/10.1093/rheumatology/kev090.004","mag":"2170283846"},"language":"en","primary_location":{"id":"doi:10.1093/rheumatology/kev090.004","doi":"https://doi.org/10.1093/rheumatology/kev090.004","is_oa":false,"landing_page_url":"https://doi.org/10.1093/rheumatology/kev090.004","pdf_url":null,"source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083380214","display_name":"Matthew J. Elder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Matthew J. Elder","raw_affiliation_strings":["Medicine, University of Cambridge, Cambridge, UK and 2 Surgery and Center for Inflammation, East Tennessee State University, Johnson City, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Cambridge, Cambridge, UK and 2 Surgery and Center for Inflammation, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070852592","display_name":"Steven J. Webster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Steven J. Webster","raw_affiliation_strings":["Medicine, University of Cambridge, Cambridge, UK and 2 Surgery and Center for Inflammation, East Tennessee State University, Johnson City, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Cambridge, Cambridge, UK and 2 Surgery and Center for Inflammation, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033677559","display_name":"David L. Williams","orcid":"https://orcid.org/0000-0002-4586-9290","observed_orcids":["https://orcid.org/0000-0002-4586-9290"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"David L. Williams","raw_affiliation_strings":["Medicine, University of Cambridge, Cambridge, UK and 2 Surgery and Center for Inflammation, East Tennessee State University, Johnson City, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Cambridge, Cambridge, UK and 2 Surgery and Center for Inflammation, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075168290","display_name":"Hill Gaston","orcid":"https://orcid.org/0000-0002-5789-5111","observed_orcids":["https://orcid.org/0000-0002-5789-5111"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"John Stanley Hill Gaston","raw_affiliation_strings":["Medicine, University of Cambridge, Cambridge, UK and 2 Surgery and Center for Inflammation, East Tennessee State University, Johnson City, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Cambridge, Cambridge, UK and 2 Surgery and Center for Inflammation, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389","https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005619823","display_name":"JANE C. GOODALL","orcid":"https://orcid.org/0000-0002-3761-161X","observed_orcids":["https://orcid.org/0000-0002-3761-161X"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Jane C. Goodall","raw_affiliation_strings":["Medicine, University of Cambridge, Cambridge, UK and 2 Surgery and Center for Inflammation, East Tennessee State University, Johnson City, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Cambridge, Cambridge, UK and 2 Surgery and Center for Inflammation, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389","https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3486,"currency":"GBP","value_usd":4597},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08069722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.07100000232458115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.07020000368356705,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8980000019073486},{"id":"https://openalex.org/keywords/dectin-1","display_name":"Dectin-1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9369999766349792},{"id":"https://openalex.org/keywords/beta-glucan","display_name":"\u03b2-glucan","score":0.9539999961853027},{"id":"https://openalex.org/keywords/curdlan","display_name":"curdlan","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.5770000219345093},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.7979999780654907},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thymic-stromal-lymphopoietin","display_name":"thymic stromal lymphopoietin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ccl22","display_name":"CCL22","score":0.9959999918937683},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.8960000276565552},{"id":"https://openalex.org/keywords/c-type-lectin-receptors","display_name":"C-type lectin receptors","score":0.7770000100135803},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.5389999747276306},{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8279500603675842},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6563038229942322},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5709787607192993},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5514065027236938},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45241424441337585},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.41630321741104126},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.22557002305984497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0853903591632843}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/rheumatology/kev090.004","doi":"https://doi.org/10.1093/rheumatology/kev090.004","is_oa":false,"landing_page_url":"https://doi.org/10.1093/rheumatology/kev090.004","pdf_url":null,"source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2729863621","https://openalex.org/W81837943","https://openalex.org/W2059180713","https://openalex.org/W4313380721","https://openalex.org/W2463363721","https://openalex.org/W2147497666","https://openalex.org/W982791403","https://openalex.org/W1967785414","https://openalex.org/W2314767964","https://openalex.org/W2024599485"],"abstract_inverted_index":{"Background:":[0],"C-type":[1],"lectin":[2],"receptors":[3,9],"including":[4,62],"dectin-1":[5,135,225],"are":[6,88,247],"pattern":[7],"recognition":[8],"that":[10,147,223,240],"recognize":[11],"\u03b2-glucans":[12,24,87,150,172],"on":[13],"the":[14,108,134,152,155,185,228],"surface":[15,230],"of":[16,33,44,53,94,101,110,154,177,184,208],"fungi,":[17],"yeasts":[18],"and":[19,38,64,84,107,124,128,164,188,217,245],"bacteria.":[20],"Immune":[21],"responses":[22,103],"to":[23,46,74,79,90,202],"have":[25,41],"been":[26],"implicated":[27],"both":[28],"in":[29,104,112],"a":[30,51],"murine":[31],"model":[32],"SpA":[34],"(the":[35],"SKG":[36],"mouse)":[37],"AS":[39],"patients":[40],"increased":[42],"levels":[43],"antibodies":[45],"yeast.":[47],"Dectin-1":[48],"stimulation":[49,213],"initiates":[50],"plethora":[52],"immunological":[54],"effector":[55],"mechanisms":[56],"from":[57,120,166,220,227],"human":[58,167],"dendritic":[59],"cells":[60],"(DCs),":[61],"phagocytosis":[63,209],"inflammatory":[65,82,156],"cytokine":[66,186],"secretion,":[67],"required":[68,232],"for":[69,233],"protective":[70],"immunity.":[71,96],"\u03b2-glucan":[72,99,197,212,241],"presentation":[73],"DCs":[75,106,117,130],"determines":[76],"their":[77,113,234],"capacity":[78],"generate":[80],"dectin-1-mediated":[81],"cytokines,":[83,179],"small":[85,211],"particulate":[86,149],"thought":[89],"be":[91],"poor":[92],"activators":[93],"innate":[95],"We":[97,145],"investigated":[98],"induction":[100],"immune":[102],"humans":[105],"role":[109],"IL-1\u03b2":[111,250],"regulation.":[114],"Methods:":[115],"Human":[116],"were":[118,131],"isolated":[119],"peripheral":[121],"blood":[122],"monocytes":[123],"differentiated":[125],"with":[126,133],"IL-4":[127],"GM-CSF.":[129],"stimulated":[132],"agonists,":[136],"curdlan":[137],"(CUR)":[138],"or":[139],"\u03b2-1,3":[140],"glucan":[141],"microparticles":[142],"(MPs).":[143],"Results:":[144],"show":[146,239],"large":[148],"stimulate":[151,174],"secretion":[153,219],"T":[157],"helper":[158],"17":[159],"(Th17)-priming":[160],"cytokines":[161],"IL-1\u03b2,":[162,215],"IL-6":[163,216],"IL-23":[165,218,244],"DCs.":[168],"In":[169,236],"comparison,":[170],"smaller":[171],"only":[173],"negligible":[175],"quantities":[176],"these":[178],"while":[180],"stimulating":[181],"equivalent":[182],"amounts":[183],"TSLP":[187,246],"chemokine":[189],"CCL22.":[190],"Surprisingly,":[191],"pro-IL-1\u03b2":[192,204],"upregulation":[193],"is":[194,205,231],"unaffected":[195],"by":[196,249],"size,":[198],"suggesting":[199,222],"inflammasome":[200],"activation":[201],"process":[203],"missing.":[206],"Inhibition":[207],"during":[210],"induces":[214],"DCs,":[221],"prolonged":[224],"signalling":[226],"cell":[229],"production.":[235,251],"addition,":[237],"we":[238],"induced":[242],"IL-6,":[243],"regulated":[248]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}