{"id":"https://openalex.org/W2170276146","doi":"https://doi.org/10.1111/j.1365-2796.2006.01746.x","title":"Active sugar transport in health and disease","display_name":"Active sugar transport in health and disease","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2170276146","doi":"https://doi.org/10.1111/j.1365-2796.2006.01746.x","mag":"2170276146","pmid":"https://pubmed.ncbi.nlm.nih.gov/17222166"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2796.2006.01746.x","doi":"https://doi.org/10.1111/j.1365-2796.2006.01746.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2796.2006.01746.x","pdf_url":null,"source":{"id":"https://openalex.org/S29157290","display_name":"Journal of Internal Medicine","issn_l":"0954-6820","issn":["0954-6820","1365-2796"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002353458","display_name":"Ernest Marshall Wright","orcid":"https://orcid.org/0000-0002-1023-4391","observed_orcids":["https://orcid.org/0000-0002-1023-4391"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E. M. Wright","raw_affiliation_strings":["Department of Physiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1751, USA. ewright@mednet.ucla.edu","Department of Physiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1751, USA. ewright@mednet.ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Physiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110402796","display_name":"Bruce A. Hirayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B. A. Hirayama","raw_affiliation_strings":["Department of Physiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108356467","display_name":"Donald D. F. Loo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. F. Loo","raw_affiliation_strings":["Department of Physiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002353458","https://openalex.org/A5110402796"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.6424,"has_fulltext":false,"cited_by_count":640,"citation_normalized_percentile":{"value":0.93516655,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"261","issue":"1","first_page":"32","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6039999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6039999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.2093999981880188,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sglt1","display_name":"SGLT1","score":0.8059999942779541},{"id":"https://openalex.org/keywords/sglt2","display_name":"SGLT2","score":1.0},{"id":"https://openalex.org/keywords/intestinal-glucose-uptake","display_name":"intestinal glucose absorption","score":0.9909999966621399},{"id":"https://openalex.org/keywords/renal-glucose-reabsorption","display_name":"renal glucose reabsorption","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glucose-galactose-malabsorption","display_name":"glucose-galactose malabsorption","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oral-rehydration-therapy","display_name":"oral rehydration therapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/secretory-diarrhea","display_name":"secretory diarrhea","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8517136573791504},{"id":"https://openalex.org/C90466245","wikidata":"https://www.wikidata.org/wiki/Q7312490","display_name":"Renal glucose reabsorption","level":4,"score":0.7733854055404663},{"id":"https://openalex.org/C2780439177","wikidata":"https://www.wikidata.org/wiki/Q1442923","display_name":"Malabsorption","level":2,"score":0.7122902274131775},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.5841671824455261},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5665148496627808},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4508591890335083},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.43686485290527344},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.4334614872932434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40992164611816406},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3852030038833618},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.2964455783367157},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.17596882581710815},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.17541980743408203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16355052590370178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08140191435813904}],"mesh":[{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008286","descriptor_name":"Malabsorption Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020895","descriptor_name":"Enterocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051247","descriptor_name":"Sodium-Glucose Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051247","descriptor_name":"Sodium-Glucose Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051247","descriptor_name":"Sodium-Glucose Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2796.2006.01746.x","doi":"https://doi.org/10.1111/j.1365-2796.2006.01746.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2796.2006.01746.x","pdf_url":null,"source":{"id":"https://openalex.org/S29157290","display_name":"Journal of Internal Medicine","issn_l":"0954-6820","issn":["0954-6820","1365-2796"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:17222166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17222166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W46752602","https://openalex.org/W1525861304","https://openalex.org/W1963826832","https://openalex.org/W1966154936","https://openalex.org/W1967096577","https://openalex.org/W1967709045","https://openalex.org/W1969979801","https://openalex.org/W1972942184","https://openalex.org/W1983055281","https://openalex.org/W1983199457","https://openalex.org/W1984487874","https://openalex.org/W1984579875","https://openalex.org/W1985205653","https://openalex.org/W1985657228","https://openalex.org/W2003060007","https://openalex.org/W2008613493","https://openalex.org/W2010617054","https://openalex.org/W2011041371","https://openalex.org/W2013672012","https://openalex.org/W2013930024","https://openalex.org/W2019530219","https://openalex.org/W2020817480","https://openalex.org/W2024534908","https://openalex.org/W2028056694","https://openalex.org/W2037926721","https://openalex.org/W2041968714","https://openalex.org/W2047060201","https://openalex.org/W2047614216","https://openalex.org/W2051728893","https://openalex.org/W2063986131","https://openalex.org/W2064039245","https://openalex.org/W2064823404","https://openalex.org/W2066928947","https://openalex.org/W2070457843","https://openalex.org/W2071277783","https://openalex.org/W2086812198","https://openalex.org/W2099384461","https://openalex.org/W2100090810","https://openalex.org/W2103196856","https://openalex.org/W2111321455","https://openalex.org/W2114376908","https://openalex.org/W2115879800","https://openalex.org/W2117052585","https://openalex.org/W2118707645","https://openalex.org/W2120242787","https://openalex.org/W2120825807","https://openalex.org/W2130274258","https://openalex.org/W2132610012","https://openalex.org/W2156037374","https://openalex.org/W2157078226","https://openalex.org/W2166211977","https://openalex.org/W2237447778","https://openalex.org/W2287439552","https://openalex.org/W3020063286","https://openalex.org/W3193212679","https://openalex.org/W4237424488","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3134871522","https://openalex.org/W2100547515","https://openalex.org/W121649067","https://openalex.org/W2348857287","https://openalex.org/W2129621420","https://openalex.org/W2792438660","https://openalex.org/W2036085963","https://openalex.org/W2883581800","https://openalex.org/W3081351755","https://openalex.org/W2946621217"],"abstract_inverted_index":{"Secondary":[0],"active":[1],"glucose":[2,34,38],"transport":[3],"occurs":[4],"by":[5],"at":[6],"least":[7],"four":[8],"members":[9],"of":[10,22,42,83],"the":[11,18,81],"SLC5":[12],"gene":[13],"family.":[14],"This":[15],"review":[16],"considers":[17],"structure":[19],"and":[20,27,29,36,47],"function":[21],"two":[23],"premier":[24],"members,":[25],"SGLT1":[26,51],"SGLT2,":[28],"their":[30],"role":[31,55],"in":[32,56],"intestinal":[33],"absorption":[35],"renal":[37],"reabsorption.":[39],"Genetics":[40],"disorders":[41],"SGLTs":[43,76],"include":[44],"Glucose-Galactose":[45],"Malabsorption,":[46],"Familial":[48],"Renal":[49],"Glucosuria.":[50],"plays":[52],"a":[53],"central":[54],"Oral":[57],"Rehydration":[58],"Therapy":[59],"used":[60],"so":[61],"effectively":[62],"to":[63],"treat":[64],"secretory":[65],"diarrhoea":[66],"such":[67],"as":[68,77],"cholera.":[69],"Increasing":[70],"attention":[71],"is":[72],"being":[73],"focused":[74],"on":[75],"drug":[78],"targets":[79],"for":[80],"therapy":[82],"diabetes.":[84]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":37},{"year":2018,"cited_by_count":30},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":49},{"year":2015,"cited_by_count":37},{"year":2014,"cited_by_count":54},{"year":2013,"cited_by_count":34},{"year":2012,"cited_by_count":45}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
