{"id":"https://openalex.org/W2170232513","doi":"https://doi.org/10.2337/diabetes.51.3.652","title":"Dipeptidyl Peptidase IV-Resistant [ d -Ala2]Glucose-Dependent Insulinotropic Polypeptide (GIP) Improves Glucose Tolerance in Normal and Obese Diabetic Rats","display_name":"Dipeptidyl Peptidase IV-Resistant [ d -Ala2]Glucose-Dependent Insulinotropic Polypeptide (GIP) Improves Glucose Tolerance in Normal and Obese Diabetic Rats","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2170232513","doi":"https://doi.org/10.2337/diabetes.51.3.652","mag":"2170232513","pmid":"https://pubmed.ncbi.nlm.nih.gov/11872663"},"language":"en","primary_location":{"id":"doi:10.2337/diabetes.51.3.652","doi":"https://doi.org/10.2337/diabetes.51.3.652","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.51.3.652","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054346791","display_name":"Simon A. Hinke","orcid":"https://orcid.org/0000-0003-4464-1929","observed_orcids":["https://orcid.org/0000-0003-4464-1929"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Simon A. Hinke","raw_affiliation_strings":["Department of Physiology, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014392022","display_name":"Richard W. Gelling","orcid":"https://orcid.org/0000-0001-7832-4951","observed_orcids":["https://orcid.org/0000-0001-7832-4951"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Richard W. Gelling","raw_affiliation_strings":["Department of Physiology, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113765887","display_name":"Raymond A. Pederson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Raymond A. Pederson","raw_affiliation_strings":["Department of Physiology, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040786000","display_name":"Susanne Manhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne Manhart","raw_affiliation_strings":["Probiodrug Research, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug Research, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111892959","display_name":"Cuilan Nian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Cuilan Nian","raw_affiliation_strings":["Department of Physiology, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001127178","display_name":"Hans\u2010Ulrich Demuth","orcid":"https://orcid.org/0000-0002-5276-0007","observed_orcids":["https://orcid.org/0000-0002-5276-0007"]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Ulrich Demuth","raw_affiliation_strings":["Probiodrug Research, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug Research, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111557732","display_name":"Christopher H.S. McIntosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christopher H.S. McIntosh","raw_affiliation_strings":["Department of Physiology, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6966,"has_fulltext":false,"cited_by_count":133,"citation_normalized_percentile":{"value":0.96075716,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"51","issue":"3","first_page":"652","last_page":"661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.06129999831318855,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-dependent-insulinotropic-polypeptide","display_name":"glucose-dependent insulinotropic polypeptide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/peptide-stability","display_name":"peptide stability","score":0.5929999947547913},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7099999785423279},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.9509999752044678},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7910000085830688},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.49000000953674316},{"id":"https://openalex.org/keywords/obese-zucker-rats","display_name":"Zucker fatty rats","score":0.5170000195503235},{"id":"https://openalex.org/keywords/gip-receptor","display_name":"GIP receptor","score":0.5799999833106995},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7401232123374939},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7150177955627441},{"id":"https://openalex.org/C2781469919","wikidata":"https://www.wikidata.org/wiki/Q5279728","display_name":"Dipeptidyl peptidase","level":3,"score":0.6463775634765625},{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.553696870803833},{"id":"https://openalex.org/C2778881409","wikidata":"https://www.wikidata.org/wiki/Q1420402","display_name":"Incretin","level":4,"score":0.4994692802429199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4518161118030548},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.42902445793151855},{"id":"https://openalex.org/C2776129832","wikidata":"https://www.wikidata.org/wiki/Q22677256","display_name":"Gastric inhibitory polypeptide","level":4,"score":0.41681843996047974},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3139920234680176},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.23254835605621338},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.22986209392547607},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.206222265958786},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13409677147865295},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.06731307506561279}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005749","descriptor_name":"Gastric Inhibitory Polypeptide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005749","descriptor_name":"Gastric Inhibitory Polypeptide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005749","descriptor_name":"Gastric Inhibitory Polypeptide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011964","descriptor_name":"Receptors, Gastrointestinal Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011964","descriptor_name":"Receptors, Gastrointestinal Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018819","descriptor_name":"Dipeptidyl Peptidase 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diabetes.51.3.652","doi":"https://doi.org/10.2337/diabetes.51.3.652","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.51.3.652","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:11872663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11872663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.615.5968","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.615.5968","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/51/3/652.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1604448406","https://openalex.org/W1969932276","https://openalex.org/W1972481662","https://openalex.org/W1977680116","https://openalex.org/W1978953702","https://openalex.org/W1978959127","https://openalex.org/W1979916078","https://openalex.org/W1983441757","https://openalex.org/W1984199148","https://openalex.org/W1985206613","https://openalex.org/W1986522335","https://openalex.org/W1992452630","https://openalex.org/W1993026259","https://openalex.org/W1993351024","https://openalex.org/W1999041565","https://openalex.org/W2001998235","https://openalex.org/W2005260032","https://openalex.org/W2019431672","https://openalex.org/W2023201121","https://openalex.org/W2024454400","https://openalex.org/W2025551701","https://openalex.org/W2027434254","https://openalex.org/W2031468509","https://openalex.org/W2036147787","https://openalex.org/W2037839438","https://openalex.org/W2038868574","https://openalex.org/W2043790508","https://openalex.org/W2047906394","https://openalex.org/W2050133162","https://openalex.org/W2050856569","https://openalex.org/W2051839278","https://openalex.org/W2054590142","https://openalex.org/W2054764073","https://openalex.org/W2056594490","https://openalex.org/W2057802735","https://openalex.org/W2061202826","https://openalex.org/W2068361325","https://openalex.org/W2068876308","https://openalex.org/W2070027753","https://openalex.org/W2071157269","https://openalex.org/W2076880341","https://openalex.org/W2087707716","https://openalex.org/W2097018460","https://openalex.org/W2103040459","https://openalex.org/W2104723919","https://openalex.org/W2104763836","https://openalex.org/W2128979121","https://openalex.org/W2137856216","https://openalex.org/W2145140318","https://openalex.org/W2148182710","https://openalex.org/W2152960998","https://openalex.org/W2157068658","https://openalex.org/W2158665637","https://openalex.org/W2297124431","https://openalex.org/W2409561014","https://openalex.org/W2418019735","https://openalex.org/W3020972883","https://openalex.org/W4234825176","https://openalex.org/W4236513507","https://openalex.org/W4285719527","https://openalex.org/W4290995475"],"related_works":["https://openalex.org/W7099154289","https://openalex.org/W1996796636","https://openalex.org/W2105096600","https://openalex.org/W1999609515","https://openalex.org/W1985921802","https://openalex.org/W1988234896","https://openalex.org/W2103040459","https://openalex.org/W2028479574","https://openalex.org/W2097018460","https://openalex.org/W60888570"],"abstract_inverted_index":{"The":[0,130],"therapeutic":[1],"potential":[2],"of":[3,18,127,140,179],"glucose-dependent":[4],"insulinotropic":[5],"polypeptide":[6],"(GIP)":[7],"for":[8,30,47,79],"improving":[9],"glycemic":[10,116],"control":[11],"has":[12],"largely":[13],"gone":[14],"unstudied.":[15],"A":[16],"series":[17],"synthetic":[19],"GIP":[20,51,111,155],"peptides":[21],"modified":[22],"at":[23,72,152],"the":[24,48,60,73,83,177],"NH(2)-terminus":[25],"were":[26],"screened":[27],"in":[28,82,89,98,135,149,168,176],"vitro":[29,54],"resistance":[31,62,141],"to":[32,41,63,142],"dipeptidyl":[33],"peptidase":[34],"IV":[35],"(DP":[36],"IV)":[37],"degradation":[38],"and":[39,45,87,92,112,156,171],"potency":[40],"stimulate":[42],"cyclic":[43],"AMP":[44],"affinity":[46],"transfected":[49],"rat":[50,85],"receptor.":[52,74],"In":[53],"experiments":[55],"indicated":[56],"that":[57],"[D-Ala(2)]GIP":[58,113],"possessed":[59],"greatest":[61],"enzymatic":[64,143],"degradation,":[65],"combined":[66],"with":[67,158],"minimal":[68],"effects":[69],"on":[70],"efficacy":[71],"Thus,":[75],"[D-Ala(2)]GIP(1--42)":[76],"was":[77],"selected":[78],"further":[80],"testing":[81],"perfused":[84],"pancreas":[86],"bioassay":[88],"conscious":[90],"Wistar":[91],"Zucker":[93,108],"rats.":[94],"When":[95],"injected":[96],"subcutaneously":[97],"normal":[99],"Wistar,":[100],"Fa/?,":[101],"or":[102],"fa/fa":[103],"Vancouver":[104],"Diabetic":[105],"Fatty":[106],"(VDF)":[107],"rats,":[109],"both":[110],"significantly":[114],"reduced":[115,147],"excursions":[117],"during":[118],"a":[119],"concurrent":[120],"oral":[121],"glucose":[122,164],"tolerance":[123,165],"test":[124],"via":[125],"stimulation":[126],"insulin":[128],"release.":[129],"latter":[131],"peptide":[132],"displayed":[133],"greater":[134],"vivo":[136],"effectiveness,":[137],"likely":[138],"because":[139],"degradation.":[144],"Hence,":[145],"despite":[146],"bioactivity":[148],"diabetic":[150,180],"models":[151],"physiological":[153],"concentrations,":[154],"analogs":[157],"improved":[159],"plasma":[160],"stability":[161],"still":[162],"improve":[163],"when":[166],"given":[167],"supraphysiological":[169],"doses,":[170],"thus":[172],"may":[173],"prove":[174],"useful":[175],"treatment":[178],"states.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}