{"id":"https://openalex.org/W2170176798","doi":null,"title":"The role of hypoxia-inducible factor-1 in hyperthermia-induced tumor reoxygenation and therapy resistance","display_name":"The role of hypoxia-inducible factor-1 in hyperthermia-induced tumor reoxygenation and therapy resistance","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2170176798","mag":"2170176798"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/3000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/3000","pdf_url":"http://hdl.handle.net/10161/3000","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10161/3000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068692519","display_name":"Eui Jung Moon","orcid":"https://orcid.org/0000-0001-7916-7978","observed_orcids":["https://orcid.org/0000-0001-7916-7978"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eui Jung Moon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7916-7978","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068692519"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1","display_name":"HIF-1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tumor-reoxygenation","display_name":"tumor reoxygenation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.984000027179718},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.6779999732971191},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.7570000290870667},{"id":"https://openalex.org/keywords/nox1","display_name":"NOX1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9729999899864197},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.6140000224113464},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hif-1alpha-stabilization","display_name":"HIF-1\u03b1 stabilization","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/tumor-vascularization","display_name":"tumor vascularization","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7690260410308838},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.7241116762161255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47130879759788513},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4542177617549896},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.42402249574661255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3424229323863983},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24740013480186462},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.18534165620803833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07705450057983398},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/3000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/3000","pdf_url":"http://hdl.handle.net/10161/3000","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:2170176798","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/bitstream/10161/3000/1/D_Moon_Eui_Jung_a_2010.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/3000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/3000","pdf_url":"http://hdl.handle.net/10161/3000","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170176798.pdf","grobid_xml":"https://content.openalex.org/works/W2170176798.grobid-xml"},"referenced_works_count":204,"referenced_works":["https://openalex.org/W52324175","https://openalex.org/W1480185538","https://openalex.org/W1488835155","https://openalex.org/W1492332150","https://openalex.org/W1502163633","https://openalex.org/W1511867239","https://openalex.org/W1524518602","https://openalex.org/W1524688066","https://openalex.org/W1530921593","https://openalex.org/W1534920898","https://openalex.org/W1537712767","https://openalex.org/W1547863599","https://openalex.org/W1552722442","https://openalex.org/W1554643012","https://openalex.org/W1578920942","https://openalex.org/W1586389918","https://openalex.org/W1591132661","https://openalex.org/W1595873372","https://openalex.org/W1664517074","https://openalex.org/W1749022239","https://openalex.org/W1799768544","https://openalex.org/W1844723954","https://openalex.org/W1898544988","https://openalex.org/W1934351474","https://openalex.org/W1965431285","https://openalex.org/W1967054089","https://openalex.org/W1969328947","https://openalex.org/W1971917580","https://openalex.org/W1972376030","https://openalex.org/W1973063176","https://openalex.org/W1973287769","https://openalex.org/W1973448020","https://openalex.org/W1975439501","https://openalex.org/W1975474535","https://openalex.org/W1975545468","https://openalex.org/W1976800838","https://openalex.org/W1977077904","https://openalex.org/W1979784399","https://openalex.org/W1980614613","https://openalex.org/W1981612052","https://openalex.org/W1982030800","https://openalex.org/W1982194648","https://openalex.org/W1983270572","https://openalex.org/W1984604224","https://openalex.org/W1984646045","https://openalex.org/W1985804036","https://openalex.org/W1986432005","https://openalex.org/W1986948325","https://openalex.org/W1988036361","https://openalex.org/W1988131776","https://openalex.org/W1989764515","https://openalex.org/W1991956961","https://openalex.org/W1995827857","https://openalex.org/W1998230962","https://openalex.org/W2000124620","https://openalex.org/W2000624133","https://openalex.org/W2001098966","https://openalex.org/W2002660236","https://openalex.org/W2004118426","https://openalex.org/W2005828644","https://openalex.org/W2006809455","https://openalex.org/W2008523969","https://openalex.org/W2009570698","https://openalex.org/W2009640428","https://openalex.org/W2009987256","https://openalex.org/W2010045309","https://openalex.org/W2010394923","https://openalex.org/W2010401911","https://openalex.org/W2011810742","https://openalex.org/W2012276721","https://openalex.org/W2012461405","https://openalex.org/W2014245338","https://openalex.org/W2015344488","https://openalex.org/W2016204586","https://openalex.org/W2016861891","https://openalex.org/W2017007251","https://openalex.org/W2017575850","https://openalex.org/W2021381932","https://openalex.org/W2022126917","https://openalex.org/W2022643257","https://openalex.org/W2024206845","https://openalex.org/W2030575063","https://openalex.org/W2030962744","https://openalex.org/W2031364590","https://openalex.org/W2031681500","https://openalex.org/W2032211726","https://openalex.org/W2032402605","https://openalex.org/W2032437813","https://openalex.org/W2033958147","https://openalex.org/W2033985429","https://openalex.org/W2037051111","https://openalex.org/W2037698415","https://openalex.org/W2039500562","https://openalex.org/W2042925882","https://openalex.org/W2046905314","https://openalex.org/W2046990824","https://openalex.org/W2047359489","https://openalex.org/W2047470479","https://openalex.org/W2047902687","https://openalex.org/W2049429077","https://openalex.org/W2050153313","https://openalex.org/W2051043829","https://openalex.org/W2052391094","https://openalex.org/W2052412821","https://openalex.org/W2053077212","https://openalex.org/W2053198775","https://openalex.org/W2054115441","https://openalex.org/W2054987125","https://openalex.org/W2055448212","https://openalex.org/W2061047112","https://openalex.org/W2062515127","https://openalex.org/W2063932838","https://openalex.org/W2065797823","https://openalex.org/W2066313697","https://openalex.org/W2066402214","https://openalex.org/W2067125783","https://openalex.org/W2067387756","https://openalex.org/W2067817921","https://openalex.org/W2069224399","https://openalex.org/W2069698188","https://openalex.org/W2070262526","https://openalex.org/W2070692392","https://openalex.org/W2070700876","https://openalex.org/W2072146315","https://openalex.org/W2072634616","https://openalex.org/W2073292880","https://openalex.org/W2077129920","https://openalex.org/W2078844125","https://openalex.org/W2079061893","https://openalex.org/W2080032941","https://openalex.org/W2080812076","https://openalex.org/W2081460564","https://openalex.org/W2083519058","https://openalex.org/W2084506573","https://openalex.org/W2085128107","https://openalex.org/W2085470258","https://openalex.org/W2085609942","https://openalex.org/W2086262311","https://openalex.org/W2089692551","https://openalex.org/W2090627731","https://openalex.org/W2091068407","https://openalex.org/W2091581243","https://openalex.org/W2093753955","https://openalex.org/W2093916414","https://openalex.org/W2094550005","https://openalex.org/W2094767524","https://openalex.org/W2096655588","https://openalex.org/W2097602835","https://openalex.org/W2098902167","https://openalex.org/W2098972920","https://openalex.org/W2100542389","https://openalex.org/W2100830025","https://openalex.org/W2101155247","https://openalex.org/W2102416115","https://openalex.org/W2108540588","https://openalex.org/W2109554229","https://openalex.org/W2109557452","https://openalex.org/W2109621782","https://openalex.org/W2111080918","https://openalex.org/W2111220039","https://openalex.org/W2111272053","https://openalex.org/W2114585931","https://openalex.org/W2115308669","https://openalex.org/W2116088571","https://openalex.org/W2116531861","https://openalex.org/W2116638751","https://openalex.org/W2119143835","https://openalex.org/W2119917332","https://openalex.org/W2120807407","https://openalex.org/W2121224008","https://openalex.org/W2127782902","https://openalex.org/W2127990020","https://openalex.org/W2128556368","https://openalex.org/W2128950429","https://openalex.org/W2131112712","https://openalex.org/W2132378346","https://openalex.org/W2133026487","https://openalex.org/W2136267489","https://openalex.org/W2139873374","https://openalex.org/W2141713397","https://openalex.org/W2142311051","https://openalex.org/W2142619483","https://openalex.org/W2142786915","https://openalex.org/W2144009262","https://openalex.org/W2148270074","https://openalex.org/W2148518922","https://openalex.org/W2148957818","https://openalex.org/W2149884878","https://openalex.org/W2152475006","https://openalex.org/W2153007740","https://openalex.org/W2155184914","https://openalex.org/W2161877652","https://openalex.org/W2162018845","https://openalex.org/W2165623186","https://openalex.org/W2167041673","https://openalex.org/W2168607632","https://openalex.org/W2170488093","https://openalex.org/W2171409673","https://openalex.org/W2268957067","https://openalex.org/W2319962899","https://openalex.org/W2416939230","https://openalex.org/W4291518211","https://openalex.org/W4301193832","https://openalex.org/W4322715279"],"related_works":["https://openalex.org/W1988163677","https://openalex.org/W4301018861","https://openalex.org/W2021506776","https://openalex.org/W2143643269","https://openalex.org/W2000233421","https://openalex.org/W7098738646","https://openalex.org/W2727336727","https://openalex.org/W3038113579","https://openalex.org/W3031546028","https://openalex.org/W2188158161"],"abstract_inverted_index":{"Imbalance":[0],"between":[1],"oxygen":[2,129,186],"consumption":[3,130],"and":[4,11,27,29,62,91,104,116,127,160,224,233,269,295,316,326,349,370,381],"supply":[5],"often":[6,334],"makes":[7],"tumors":[8],"hypoxic":[9],"(Bristow":[10],"Hill":[12],"2008).":[13],"Tumor":[14],"hypoxia":[15,49,136],"is":[16,38,137,153,200,333],"significantly":[17,321],"correlated":[18],"with":[19,113],"aggressive":[20],"tumor":[21,48,53,74,125,135,149,158,172,260,302,345],"growth,":[22],"ineffective":[23],"response":[24,367],"to":[25,43,147,244,368,373,383,406,414],"radiation":[26,398],"chemotherapy,":[28],"as":[30,392],"a":[31,39,133,154,168,336,363,411],"result,":[32,134],"poor":[33],"patient":[34],"prognosis.":[35],"Hyperthermia":[36],"(HT)":[37],"strong":[40],"adjuvant":[41],"treatment":[42,228],"overcome":[44],"these":[45,143],"challenges":[46],"of":[47,70,118,157,205,222,229,271,341,377],"because":[50,340],"it":[51],"causes":[52,280],"reoxygenation":[54,173],"at":[55,217],"temperatures":[56],"lower":[57],"than":[58],"43\u00baC":[59],"(Song,":[60],"Park,":[61],"Griffin":[63],"2001).":[64],"However,":[65,356],"the":[66,210,227,266],"detailed":[67],"molecular":[68],"mechanisms":[69],"how":[71],"HT":[72,86,122,140,223,369],"enhances":[73,124],"oxygenation":[75],"have":[76,394],"not":[77],"been":[78],"elucidated.":[79],"Here":[80],"we":[81,180,195,237,393],"determine":[82,196,310],"that":[83,142,165,182,197,249,265,289,311,360],"1":[84,108,273],"hour":[85],"activates":[87,252],"hypoxia-inducible":[88],"factor-1":[89],"(HIF-1)":[90],"its":[92,119,176,342,385],"downstream":[93,120,177],"targets,":[94],"vascular":[95],"endothelial":[96],"growth":[97],"factor":[98],"(VEGF),":[99],"lactate":[100],"dehydrogenase":[101,106],"A":[102,213],"(LDHA),":[103],"pyruvate":[105],"kinase":[107],"(PDK1)":[109],"in":[110,170,226,283,301,305,344,366,410],"tumors.":[111],"Consistent":[112],"HIF-1":[114,152,166,191,242,257,332,361,379,403],"activation":[115,380],"upregulation":[117],"genes,":[121],"also":[123,251,263,382],"perfusion/vascularization":[126],"decreases":[128],"rates.":[131],"As":[132],"reduced":[138],"after":[139,192],"suggesting":[141],"physiological":[144],"changes":[145],"contribute":[146],"HT-induced":[148,171,378],"reoxygenation.":[150],"Since":[151],"potent":[155],"regulator":[156],"vascularization":[159],"metabolism,":[161],"our":[162,357],"findings":[163,358],"suggest":[164,359],"plays":[167,362],"role":[169,343,365],"by":[174,202,389,397],"transactivating":[175],"targets.":[178],"Mechanistically,":[179],"demonstrate":[181],"NADPH":[183,206],"oxidase-mediated":[184],"reactive":[185],"species":[187],"(ROS)":[188],"production":[189,300,325],"upregulates":[190,292],"HT.":[193],"Further,":[194],"this":[198],"pathway":[199,279],"initiated":[201],"increased":[203],"transcription":[204,272],"oxidase-1":[207],"(NOX1)":[208],"through":[209],"ERK":[211],"pathway.":[212],"major":[214],"research":[215],"effort":[216],"Duke":[218],"focuses":[219],"on":[220],"combinations":[221],"doxorubicin":[225,245,250],"locally":[230],"advanced":[231],"breast":[232],"other":[234],"cancers.":[235],"Thus,":[236],"investigated":[238],"whether":[239],"there":[240],"are":[241],"responses":[243],"treatment.":[246],"We":[247,262,287,308],"reveal":[248,264],"HIF-1.":[253],"Unlike":[254],"HT,":[255],"doxorubicin-induced":[256,328],"promotes":[258,296],"persistent":[259],"angiogenesis.":[261],"signal":[267],"transducer":[268],"activator":[270],"(STAT1)/inducible":[274],"nitric":[275,297],"oxide":[276,298],"synthase":[277],"(iNOS)":[278],"HIF-1\u03b1":[281,306,330],"accumulation":[282],"an":[284],"oxygen-independent":[285],"manner.":[286],"show":[288],"activated":[290],"STAT1":[291,317],"iNOS":[293,313],"expression":[294],"(NO)":[299],"cells":[303],"resulting":[304],"stabilization.":[307],"further":[309],"both":[312],"inhibitor,":[314,318],"1400W":[315],"epigallocatechin-3-gallate":[319],"(EGCG)":[320],"decrease":[322],"intracellular":[323],"NO":[324],"suppress":[327,384],"normoxic":[329],"accumulation.":[331],"considered":[335],"promising":[337],"therapeutic":[338,417],"target":[339],"progression":[346],"(Semenza":[347],"2003)":[348],"therapy":[350],"resistance":[351],"(Moeller":[352,399],"et":[353,400],"al.":[354,401],"2004).":[355],"pleiotropic":[364],"chemotherapy.":[371],"Therefore,":[372],"preferentially":[374],"take":[375],"advantage":[376],"deleterious":[386],"effects":[387],"induced":[388],"chemotherapy":[390],"or":[391],"previously":[395],"reported,":[396],"2004),":[402],"inhibition":[404],"needs":[405],"be":[407],"carefully":[408],"regulated":[409],"time-sensitive":[412],"manner":[413],"achieve":[415],"optimal":[416],"effects.":[418]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}