{"id":"https://openalex.org/W2170149792","doi":"https://doi.org/10.4049/jimmunol.181.9.6664","title":"Crucial Role of Aspartic Acid at Position 265 in the CH2 Domain for Murine IgG2a and IgG2b Fc-Associated Effector Functions","display_name":"Crucial Role of Aspartic Acid at Position 265 in the CH2 Domain for Murine IgG2a and IgG2b Fc-Associated Effector Functions","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W2170149792","doi":"https://doi.org/10.4049/jimmunol.181.9.6664","mag":"2170149792","pmid":"https://pubmed.ncbi.nlm.nih.gov/18941257"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.181.9.6664","doi":"https://doi.org/10.4049/jimmunol.181.9.6664","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.181.9.6664","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://archive-ouverte.unige.ch/unige:1395","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091696212","display_name":"Lucie Baudino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Lucie Baudino","raw_affiliation_strings":["Department of Pathology and Immunology, University of Geneva , Geneva,","*Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, University of Geneva , Geneva,","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"*Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland;","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015129391","display_name":"Yasuro Shinohara","orcid":"https://orcid.org/0000-0001-6681-6764","observed_orcids":["https://orcid.org/0000-0001-6681-6764"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuro Shinohara","raw_affiliation_strings":["Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University , Sapporo,","\u2020Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University, Sapporo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University , Sapporo,","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"\u2020Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University, Sapporo, Japan;","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086501578","display_name":"Falk Nimmerjahn","orcid":"https://orcid.org/0000-0002-5418-316X","observed_orcids":["https://orcid.org/0000-0002-5418-316X"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Falk Nimmerjahn","raw_affiliation_strings":["Laboratory for Experimental Immunology and Immunotherapy, Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg , Erlangen,","\u2021Laboratory for Experimental Immunology and Immunotherapy, Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Erlangen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Experimental Immunology and Immunotherapy, Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg , Erlangen,","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"\u2021Laboratory for Experimental Immunology and Immunotherapy, Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Erlangen, Germany;","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103270610","display_name":"Jun\u2010ichi Furukawa","orcid":"https://orcid.org/0000-0002-7284-2261","observed_orcids":["https://orcid.org/0000-0002-7284-2261"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-Ichi Furukawa","raw_affiliation_strings":["Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University , Sapporo,","\u2020Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University, Sapporo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University , Sapporo,","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"\u2020Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University, Sapporo, Japan;","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112065290","display_name":"Munehiro Nakata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Munehiro Nakata","raw_affiliation_strings":["Department of Applied Biochemistry, Tokai University , Hiratsuka, Kanagawa,","\u00a7Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biochemistry, Tokai University , Hiratsuka, Kanagawa,","institution_ids":["https://openalex.org/I1314466530"]},{"raw_affiliation_string":"\u00a7Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa, Japan;","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049465996","display_name":"Eduardo Mart\u00ednez-Soria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Eduardo Mart\u00ednez-Soria","raw_affiliation_strings":["Department of Pathology and Immunology, University of Geneva , Geneva,","*Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, University of Geneva , Geneva,","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"*Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland;","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037338916","display_name":"Franz Petry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franz Petry","raw_affiliation_strings":["Institute of Medical Microbiology and Hygiene, Johannes Gutenberg-University , Mainz,","\u00b6Institute of Medical Microbiology and Hygiene, Johannes Gutenberg-University, Mainz, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, Johannes Gutenberg-University , Mainz,","institution_ids":["https://openalex.org/I197323543"]},{"raw_affiliation_string":"\u00b6Institute of Medical Microbiology and Hygiene, Johannes Gutenberg-University, Mainz, Germany; and","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109240733","display_name":"Jeffery V. Ravetch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery V. Ravetch","raw_affiliation_strings":["\u2225The Rockefeller University, New York, NY 10065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2225The Rockefeller University, New York, NY 10065","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074428939","display_name":"Shin\u2010Ichiro Nishimura","orcid":"https://orcid.org/0000-0002-6608-8418","observed_orcids":["https://orcid.org/0000-0002-6608-8418"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-Ichiro Nishimura","raw_affiliation_strings":["Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University , Sapporo,","\u2020Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University, Sapporo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University , Sapporo,","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"\u2020Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Hokkaido University, Sapporo, Japan;","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006692678","display_name":"Shozo Izui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Shozo Izui","raw_affiliation_strings":["Department of Pathology and Immunology, University of Geneva , Geneva,","*Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, University of Geneva , Geneva,","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"*Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland;","institution_ids":["https://openalex.org/I114457229"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5006692678","https://openalex.org/A5091696212"],"corresponding_institution_ids":["https://openalex.org/I114457229"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.7276,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.74659942,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"181","issue":"9","first_page":"6664","last_page":"6669"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igg2a","display_name":"IgG2a","score":0.8539999723434448},{"id":"https://openalex.org/keywords/igg2b","display_name":"IgG2b","score":1.0},{"id":"https://openalex.org/keywords/igg1","display_name":"IgG1","score":0.6439999938011169},{"id":"https://openalex.org/keywords/fc-region","display_name":"Fc fragment","score":0.6909999847412109},{"id":"https://openalex.org/keywords/fc-gamma-receptor","display_name":"Fc gamma receptor","score":0.7870000004768372},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.875},{"id":"https://openalex.org/keywords/effector-function","display_name":"effector function","score":0.6650000214576721},{"id":"https://openalex.org/keywords/sialic-acid","display_name":"sialic acid","score":0.7279999852180481},{"id":"https://openalex.org/keywords/oligosaccharide-side-chains","display_name":"oligosaccharide side chains","score":0.8489999771118164},{"id":"https://openalex.org/keywords/anti-red-blood-cell-antibodies","display_name":"anti-red blood cell antibodies","score":0.7419999837875366},{"id":"https://openalex.org/keywords/antibody-pathogenicity","display_name":"antibody pathogenicity","score":0.6290000081062317},{"id":"https://openalex.org/keywords/class-switch-recombination","display_name":"class switch recombination","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.77646803855896},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.683935284614563},{"id":"https://openalex.org/C125823703","wikidata":"https://www.wikidata.org/wiki/Q1616930","display_name":"Fragment crystallizable region","level":3,"score":0.6723195314407349},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.6622971296310425},{"id":"https://openalex.org/C2780115458","wikidata":"https://www.wikidata.org/wiki/Q419311","display_name":"Sialic acid","level":2,"score":0.6501363515853882},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.6294416785240173},{"id":"https://openalex.org/C2781208047","wikidata":"https://www.wikidata.org/wiki/Q178450","display_name":"Aspartic acid","level":3,"score":0.5748728513717651},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.560136079788208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.499769926071167},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4722418487071991},{"id":"https://openalex.org/C2779931124","wikidata":"https://www.wikidata.org/wiki/Q417823","display_name":"Fc receptor","level":3,"score":0.45279183983802795},{"id":"https://openalex.org/C2909900342","wikidata":"https://www.wikidata.org/wiki/Q1616930","display_name":"Immunoglobulin Fc Fragments","level":4,"score":0.4508960247039795},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44563132524490356},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.44530433416366577},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43966230750083923},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.4209129214286804},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39651286602020264},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.3964996337890625},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.39481765031814575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3764265775680542},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23943686485290527},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.1733427345752716},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13024333119392395}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000744","descriptor_name":"Anemia, Hemolytic, Autoimmune","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000744","descriptor_name":"Anemia, Hemolytic, Autoimmune","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012794","descriptor_name":"Sialic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.181.9.6664","doi":"https://doi.org/10.4049/jimmunol.181.9.6664","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.181.9.6664","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:18941257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18941257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:aou:unige:1395","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:1395","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 0022-1767","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:unige:1395","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:1395","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0022-1767","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:unige.ch:unige:1395","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:1395","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0022-1767","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1518973800","https://openalex.org/W1539242187","https://openalex.org/W1565711480","https://openalex.org/W1762176245","https://openalex.org/W1964180982","https://openalex.org/W1965399166","https://openalex.org/W1969482494","https://openalex.org/W1976394313","https://openalex.org/W1989084578","https://openalex.org/W2003590292","https://openalex.org/W2012177306","https://openalex.org/W2016708646","https://openalex.org/W2027747719","https://openalex.org/W2035433348","https://openalex.org/W2051666192","https://openalex.org/W2067367025","https://openalex.org/W2086542713","https://openalex.org/W2094417597","https://openalex.org/W2096758869","https://openalex.org/W2128402413","https://openalex.org/W2134341587","https://openalex.org/W2142381258","https://openalex.org/W2148238498","https://openalex.org/W2151335597","https://openalex.org/W2152621712","https://openalex.org/W2155074186","https://openalex.org/W2155840908","https://openalex.org/W2158006372","https://openalex.org/W2158885292","https://openalex.org/W2159287844"],"related_works":["https://openalex.org/W2147952606","https://openalex.org/W3102332556","https://openalex.org/W2057936669","https://openalex.org/W1574841349","https://openalex.org/W2042589581","https://openalex.org/W1984148884","https://openalex.org/W2144699392","https://openalex.org/W1539242187","https://openalex.org/W2607033547","https://openalex.org/W1977631644"],"abstract_inverted_index":{"Replacement":[0],"of":[1,18,65,96,103,112,121,127,139,148,153,158,173,183,209,218],"aspartic":[2,193],"acid":[3,194],"by":[4,212],"alanine":[5],"at":[6,195],"position":[7,196],"265":[8,197],"(D265A)":[9],"in":[10,14,89,203],"mouse":[11],"IgG1":[12],"results":[13,190],"a":[15,199,214],"complete":[16],"loss":[17],"interaction":[19,50],"between":[20],"this":[21,69],"isotype":[22],"and":[23,30,58,61,74,84,88,115,124],"low-affinity":[24],"IgG":[25],"Fc":[26,31,54,59,122,186,220],"receptors":[27],"(Fc":[28,56],"gammaRIIB":[29],"gammaRIII).":[32],"However,":[33],"it":[34],"has":[35],"not":[36],"yet":[37],"been":[38],"defined":[39],"whether":[40],"the":[41,49,63,79,97,104,110,125,156,165,174,184,205,219],"D265A":[42,80,105,161,175],"substitution":[43],"could":[44],"exhibit":[45],"similar":[46],"effects":[47],"on":[48,62],"with":[51,94],"two":[52],"other":[53],"gammaR":[55,123],"gammaRI":[57],"gammaRIV)":[60],"activation":[64,126],"complement.":[66,128],"To":[67],"address":[68],"question,":[70],"34-3C":[71,113],"anti-RBC":[72],"IgG2a":[73,114],"IgG2b":[75,116],"switch":[76],"variants":[77,162],"bearing":[78],"mutation":[81,106],"were":[82,92,132,142,177],"generated,":[83],"their":[85],"effector":[86,171,207],"functions":[87,172,208],"vivo":[90],"pathogenicity":[91],"compared":[93],"those":[95,152],"respective":[98],"wild-type":[99,154],"Abs.":[100],"The":[101],"introduction":[102],"almost":[107],"completely":[108],"abolished":[109],"binding":[111],"to":[117,144,179],"all":[118],"four":[119],"classes":[120],"Consequently,":[129],"these":[130,140],"mutants":[131,141,176],"hardly":[133],"pathogenic.":[134],"Although":[135],"oligosaccharide":[136],"side":[137],"chains":[138],"found":[143],"contain":[145],"higher":[146],"levels":[147],"sialic":[149],"acids":[150],"than":[151],"Abs,":[155],"analysis":[157],"enzymatically":[159],"desialylated":[160],"ruled":[163],"out":[164],"possibility":[166],"that":[167,192],"very":[168],"poor":[169],"Fc-associated":[170,206],"due":[178],"an":[180],"increased":[181],"level":[182],"mutant":[185],"sialylation.":[187],"Thus,":[188],"our":[189],"demonstrate":[191],"is":[198],"residue":[200],"critically":[201],"implicated":[202],"triggering":[204],"IgG,":[210],"probably":[211],"defining":[213],"crucial":[215],"three-dimensional":[216],"structure":[217],"region.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
