{"id":"https://openalex.org/W2170142229","doi":"https://doi.org/10.1172/jci3113","title":"Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus.","display_name":"Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus.","publication_year":1998,"publication_date":"1998-08-15","ids":{"openalex":"https://openalex.org/W2170142229","doi":"https://doi.org/10.1172/jci3113","mag":"2170142229","pmid":"https://pubmed.ncbi.nlm.nih.gov/9710436","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/508930"},"language":"en","primary_location":{"id":"doi:10.1172/jci3113","doi":"https://doi.org/10.1172/jci3113","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci3113","pdf_url":"http://www.jci.org/articles/view/3113/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/3113/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086942556","display_name":"Thomas D\u00f6rner","orcid":"https://orcid.org/0000-0002-6478-7725","observed_orcids":["https://orcid.org/0000-0002-6478-7725"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T D\u00f6rner","raw_affiliation_strings":["Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA","Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002387330","display_name":"Sandra J. Foster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S J Foster","raw_affiliation_strings":["Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110404147","display_name":"Nancy L. Farner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N L Farner","raw_affiliation_strings":["Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043874873","display_name":"Peter E. Lipsky","orcid":"https://orcid.org/0000-0002-9287-1676","observed_orcids":["https://orcid.org/0000-0002-9287-1676"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P E Lipsky","raw_affiliation_strings":["Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":5.2589,"has_fulltext":true,"cited_by_count":110,"citation_normalized_percentile":{"value":0.95949691,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"102","issue":"4","first_page":"688","last_page":"694"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/receptor-editing","display_name":"receptor editing","score":0.7710000276565552},{"id":"https://openalex.org/keywords/immunoglobulin-kappa-chain","display_name":"immunoglobulin kappa chain","score":0.8320000171661377},{"id":"https://openalex.org/keywords/b-cell-receptor-gene-rearrangement","display_name":"B-cell receptor gene rearrangement","score":0.5230000019073486},{"id":"https://openalex.org/keywords/cd19-b-cells","display_name":"CD19+ B cells","score":0.800000011920929},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.8131487369537354},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7044429779052734},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.5838094353675842},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5721614360809326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.506105363368988},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4821764826774597},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.48030585050582886},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.47809717059135437},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.4346684515476227},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.42863601446151733},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40422284603118896},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007133","descriptor_name":"Immunoglobulin Joining Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007145","descriptor_name":"Immunoglobulin kappa-Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015322","descriptor_name":"Gene Rearrangement, B-Lymphocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci3113","doi":"https://doi.org/10.1172/jci3113","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci3113","pdf_url":"http://www.jci.org/articles/view/3113/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:508930","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/508930","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:9710436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9710436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1172/jci3113","doi":"https://doi.org/10.1172/jci3113","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci3113","pdf_url":"http://www.jci.org/articles/view/3113/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1460087149","display_name":null,"funder_award_id":"AI3 1229","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2352898231","display_name":"MOLECULAR ANALYSIS OF AUTOANTIBODY FORMATION","funder_award_id":"P01AI031229","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170142229.pdf","grobid_xml":"https://content.openalex.org/works/W2170142229.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1481408709","https://openalex.org/W1525531086","https://openalex.org/W1552738427","https://openalex.org/W1692714928","https://openalex.org/W1833972154","https://openalex.org/W1915715813","https://openalex.org/W1919334117","https://openalex.org/W1957020580","https://openalex.org/W1974596630","https://openalex.org/W1989560823","https://openalex.org/W2000231159","https://openalex.org/W2000469953","https://openalex.org/W2003956281","https://openalex.org/W2005098855","https://openalex.org/W2022486030","https://openalex.org/W2033134260","https://openalex.org/W2036930370","https://openalex.org/W2046800939","https://openalex.org/W2049570304","https://openalex.org/W2059417353","https://openalex.org/W2064438534","https://openalex.org/W2067185719","https://openalex.org/W2067618246","https://openalex.org/W2070189648","https://openalex.org/W2070814047","https://openalex.org/W2077679863","https://openalex.org/W2079725260","https://openalex.org/W2087880569","https://openalex.org/W2088183174","https://openalex.org/W2095180364","https://openalex.org/W2097314888","https://openalex.org/W2098497060","https://openalex.org/W2120852180","https://openalex.org/W2127199904","https://openalex.org/W2134544592","https://openalex.org/W2135843106","https://openalex.org/W2146203649","https://openalex.org/W2152581958","https://openalex.org/W2160930032","https://openalex.org/W2162320902","https://openalex.org/W2419613087","https://openalex.org/W2578150941","https://openalex.org/W4246441622","https://openalex.org/W4298360230","https://openalex.org/W6724437293"],"related_works":["https://openalex.org/W2007412943","https://openalex.org/W800272375","https://openalex.org/W7095835704","https://openalex.org/W2145700736","https://openalex.org/W4313347827","https://openalex.org/W1567780580","https://openalex.org/W2108579454","https://openalex.org/W1957020580","https://openalex.org/W2067618246","https://openalex.org/W7096444893"],"abstract_inverted_index":{"To":[0],"determine":[1],"whether":[2],"receptor":[3,137],"editing":[4,138],"of":[5,13,20,55,65,75,82,101,139,164,171],"Vkappa":[6,21,45,98,107,124,140],"genes":[7,66,94,125],"was":[8,39],"involved":[9],"in":[10,43,50,68,110,145,150,157],"the":[11,18,44,51,63,83,89,96,102,111,115,134,162],"pathogenesis":[12],"systemic":[14],"lupus":[15],"erythematosus":[16],"(SLE),":[17],"usage":[19,49,74],"and":[22,46,78,85,92,152],"Jkappa":[23,47],"gene":[24,48,53,99,108],"elements":[25],"from":[26,33],"individual":[27],"peripheral":[28],"CD19(+)":[29],"B":[30],"cells":[31],"obtained":[32],"a":[34,79,155],"patient":[35,58,148],"with":[36,62,123,127,133],"untreated":[37],"SLE":[38,57,103,147],"examined.":[40],"No":[41],"differences":[42],"nonproductive":[52,116],"repertoire":[54,100,117],"this":[56,146,158],"were":[59],"noted":[60],"compared":[61,122],"distribution":[64],"found":[67],"normal":[69],"adults.":[70],"However,":[71],"an":[72,168],"increased":[73],"Jkappa5":[76],"segments,":[77],"significant":[80],"overrepresentation":[81],"Vkappa1":[84],"Vkappa4":[86],"families,":[87],"especially":[88],"L15,":[90],"O14/O4,":[91],"B3":[93],"characterized":[95],"productive":[97,112],"patient.":[104],"Furthermore,":[105],"Jkappa5-containing":[106],"rearrangements":[109],"but":[113],"not":[114,167],"manifested":[118],"significantly":[119],"fewer":[120],"mutations":[121],"recombined":[126],"Jkappa1-4.":[128],"These":[129],"data":[130],"are":[131],"consistent":[132],"conclusion":[135],"that":[136,154],"is":[141,166],"much":[142],"more":[143],"apparent":[144],"than":[149],"normals":[151],"suggest":[153],"deficiency":[156],"means":[159],"to":[160],"counteract":[161],"emergence":[163],"autoimmunity":[165],"essential":[169],"feature":[170],"SLE.":[172]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}