{"id":"https://openalex.org/W217009674","doi":null,"title":"Conservation of cytokine-mediated responses in innate immunity: a flow cytometric study investigating the effects of human proinflammatory cytokines on phagocytosis in the earthworm Eisenia hortensis","display_name":"Conservation of cytokine-mediated responses in innate immunity: a flow cytometric study investigating the effects of human proinflammatory cytokines on phagocytosis in the earthworm Eisenia hortensis","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W217009674","mag":"217009674"},"language":"en","primary_location":{"id":"pmh:oai:isj.unimo.it:article/166","doi":null,"is_oa":true,"landing_page_url":"https://isj.unimore.it/index.php/ISJ/article/view/166","pdf_url":"https://isj.unimore.it/index.php/ISJ/article/download/166/82","source":{"id":"https://openalex.org/S2481433337","display_name":"Invertebrate survival journal","issn_l":"1824-307X","issn":["1824-307X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317690","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/P4310317690"],"host_organization_lineage_names":["University of Modena and Reggio Emilia"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1824-307X","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://isj.unimore.it/index.php/ISJ/article/download/166/82","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"K Grant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204085392","display_name":"Cabrini University","ror":"https://ror.org/057a9pj22","country_code":"US","type":"education","lineage":["https://openalex.org/I204085392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Grant","raw_affiliation_strings":["Science Department, Cabrini College, Radnor, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science Department, Cabrini College, Radnor, Pennsylvania, USA","institution_ids":["https://openalex.org/I204085392"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Hill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204085392","display_name":"Cabrini University","ror":"https://ror.org/057a9pj22","country_code":"US","type":"education","lineage":["https://openalex.org/I204085392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Hill","raw_affiliation_strings":["Science Department, Cabrini College, Radnor, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science Department, Cabrini College, Radnor, Pennsylvania, USA","institution_ids":["https://openalex.org/I204085392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038076216","display_name":"Laura L. Goodfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204085392","display_name":"Cabrini University","ror":"https://ror.org/057a9pj22","country_code":"US","type":"education","lineage":["https://openalex.org/I204085392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Goodfield","raw_affiliation_strings":["Science Department, Cabrini College, Radnor, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science Department, Cabrini College, Radnor, Pennsylvania, USA","institution_ids":["https://openalex.org/I204085392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110602557","display_name":"Sheryl L. Fuller-Espie","orcid":"https://orcid.org/0000-0002-3321-3278","observed_orcids":["https://orcid.org/0000-0002-3321-3278"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SL Fuller-Espie","raw_affiliation_strings":["College of Graduate Studies, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Graduate Studies, Thomas Jefferson University, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061513873","display_name":"Nicole DeRogatis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N DeRogatis","raw_affiliation_strings":["The Children\u2019s Hospital of Philadelphia, Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children\u2019s Hospital of Philadelphia, Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6694,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.66702789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.902999997138977},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/coelomocytes","display_name":"coelomocytes","score":0.984000027179718},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9179999828338623},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9200000166893005},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/invertebrate-evolution","display_name":"invertebrate evolution","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.828323483467102},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7315677404403687},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.7309739589691162},{"id":"https://openalex.org/C2776332788","wikidata":"https://www.wikidata.org/wiki/Q124378","display_name":"Earthworm","level":2,"score":0.6451026201248169},{"id":"https://openalex.org/C2781144357","wikidata":"https://www.wikidata.org/wiki/Q1501422","display_name":"Eisenia fetida","level":3,"score":0.5685706734657288},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5348146557807922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5129799246788025},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4602815508842468},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39445948600769043},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.27649974822998047},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1977190375328064},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16859504580497742}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:isj.unimo.it:article/166","doi":null,"is_oa":true,"landing_page_url":"https://isj.unimore.it/index.php/ISJ/article/view/166","pdf_url":"https://isj.unimore.it/index.php/ISJ/article/download/166/82","source":{"id":"https://openalex.org/S2481433337","display_name":"Invertebrate survival journal","issn_l":"1824-307X","issn":["1824-307X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317690","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/P4310317690"],"host_organization_lineage_names":["University of Modena and Reggio Emilia"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1824-307X","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:493ff44fc788404cb0e36856b526879e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/493ff44fc788404cb0e36856b526879e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Invertebrate Survival Journal, Vol 5, Iss 2, Pp 124-134 (2008)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7d8cabb5dbce490eb535f7254fa76311","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7d8cabb5dbce490eb535f7254fa76311","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Invertebrate Survival Journal, Vol 5, Iss 2 (2008)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:isj.unimo.it:article/166","doi":null,"is_oa":true,"landing_page_url":"https://isj.unimore.it/index.php/ISJ/article/view/166","pdf_url":"https://isj.unimore.it/index.php/ISJ/article/download/166/82","source":{"id":"https://openalex.org/S2481433337","display_name":"Invertebrate survival journal","issn_l":"1824-307X","issn":["1824-307X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317690","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/P4310317690"],"host_organization_lineage_names":["University of Modena and Reggio Emilia"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1824-307X","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W217009674.pdf","grobid_xml":"https://content.openalex.org/works/W217009674.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W80371281","https://openalex.org/W623821109","https://openalex.org/W860714929","https://openalex.org/W1568036408","https://openalex.org/W1643969150","https://openalex.org/W1896252221","https://openalex.org/W1934712179","https://openalex.org/W1971449037","https://openalex.org/W1980744142","https://openalex.org/W1997146688","https://openalex.org/W1997201440","https://openalex.org/W1998148517","https://openalex.org/W2009915884","https://openalex.org/W2011633007","https://openalex.org/W2023327548","https://openalex.org/W2029816800","https://openalex.org/W2031258840","https://openalex.org/W2045471143","https://openalex.org/W2053685560","https://openalex.org/W2054411996","https://openalex.org/W2057123987","https://openalex.org/W2057714768","https://openalex.org/W2058849388","https://openalex.org/W2068083081","https://openalex.org/W2070793039","https://openalex.org/W2079438686","https://openalex.org/W2093093495","https://openalex.org/W2094355629","https://openalex.org/W2098419854","https://openalex.org/W2118299957","https://openalex.org/W2118308508","https://openalex.org/W2124249714","https://openalex.org/W2129204027","https://openalex.org/W2134224958","https://openalex.org/W2145532819","https://openalex.org/W2150226695","https://openalex.org/W2166466663","https://openalex.org/W2169238760","https://openalex.org/W2169482482","https://openalex.org/W2183326125","https://openalex.org/W2946291706","https://openalex.org/W4256523371"],"related_works":["https://openalex.org/W2011926986","https://openalex.org/W2087333737","https://openalex.org/W3197618054","https://openalex.org/W1984715104","https://openalex.org/W1989656223","https://openalex.org/W2029942476","https://openalex.org/W2977805916","https://openalex.org/W2161514950","https://openalex.org/W2022940391","https://openalex.org/W7134961699"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,48,84,109],"aimed":[3],"at":[4],"determining":[5],"the":[6,16,69,90,100,152,159],"influence":[7],"of":[8,21,61,72,92,104,131],"human":[9,54],"proinflammatory":[10,55,107,115],"cytokines":[11,56,108,116],"on":[12,77,151],"innateimmune":[13],"responses":[14],"in":[15,64,99,127],"earthworm":[17,22],"Eisenia":[18],"hortensis.":[19,74],"Preincubation":[20],"coelomocytes":[23,81],"invitro":[24],"with":[25,106],"either":[26],"interleukin-1":[27],"beta":[28],"(IL-1":[29],"beta),":[30],"granulocyte-macrophage":[31],"colony":[32],"stimulating":[33],"factor":[34],"(GMCSF),":[35],"interleukin-2":[36],"(IL-2),":[37],"or":[38,102],"tumor":[39],"necrosis":[40],"factor-alpha":[41],"(TNF-alpha)":[42],"followed":[43],"by":[44,79],"subsequent":[45],"bacterial":[46],"challenge":[47],"carried":[49],"out":[50],"to":[51,119],"investigate":[52],"whether":[53],"would":[57],"induce":[58],"a":[59,120],"state":[60],"enhanced":[62,117],"responsiveness":[63],"phagocytic":[65],"cells":[66],"derived":[67],"from":[68],"coelomic":[70],"cavity":[71],"E.":[73],"The":[75],"effect":[76],"phagocytosis":[78,118],"large":[80],"(hyaline":[82],"amebocytes)":[83],"evaluated":[85],"using":[86],"flow":[87],"cytometry":[88],"where":[89],"uptake":[91],"Escherichia":[93],"coli":[94],"expressing":[95],"green":[96],"fluorescence":[97],"protein":[98],"presence":[101],"absence":[103],"pretreatment":[105],"measured.":[110],"Our":[111,156],"results":[112,157],"show":[113],"that":[114,161],"statistically":[121],"significant":[122],"(p":[123],"\u2264":[124],"0.05)":[125],"degree":[126],"10-":[128],"18":[129],"%":[130,138,142,147],"earthworms":[132],"tested":[133],"for":[134,139,143,148],"IL-1":[135],"beta,":[136],"20":[137],"GM-CSF,":[140],"20-27":[141],"IL-2,":[144],"and":[145,171],"27-30":[146],"TNFalpha,":[149],"depending":[150],"cytokine":[153],"concentration":[154],"used.":[155],"favor":[158],"suggestion":[160],"receptorcoding":[162],"genes":[163],"have":[164],"been":[165],"conserved":[166],"through":[167],"evolution":[168],"between":[169],"vertebrates":[170],"invertebrates.":[172]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
