{"id":"https://openalex.org/W2170092490","doi":"https://doi.org/10.1681/asn.2005010052","title":"Fibroblast Growth Factor-23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease","display_name":"Fibroblast Growth Factor-23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease","publication_year":2005,"publication_date":"2005-05-25","ids":{"openalex":"https://openalex.org/W2170092490","doi":"https://doi.org/10.1681/asn.2005010052","mag":"2170092490","pmid":"https://pubmed.ncbi.nlm.nih.gov/15917335"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2005010052","doi":"https://doi.org/10.1681/asn.2005010052","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2005010052","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041495874","display_name":"Orlando M. Guti\u00e9rrez","orcid":"https://orcid.org/0000-0001-6593-3571","observed_orcids":["https://orcid.org/0000-0001-6593-3571","https://orcid.org/0009-0001-3737-3041"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Orlando Gutierrez","raw_affiliation_strings":["Department of Medicine Internal Medicine Residency Training Program, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA","Department of Medicine Internal Medicine Residency Training Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Internal Medicine Residency Training Program, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine Internal Medicine Residency Training Program","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003850042","display_name":"Tamara Isakova","orcid":"https://orcid.org/0000-0002-9763-2367","observed_orcids":["https://orcid.org/0000-0002-9763-2367"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tamara Isakova","raw_affiliation_strings":["Department of Medicine Internal Medicine Residency Training Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Internal Medicine Residency Training Program","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025948477","display_name":"Eugene P. Rhee","orcid":"https://orcid.org/0000-0002-4804-7583","observed_orcids":["https://orcid.org/0000-0002-4804-7583"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eugene Rhee","raw_affiliation_strings":["Department of Medicine Internal Medicine Residency Training Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Internal Medicine Residency Training Program","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006632874","display_name":"Anand Shah","orcid":"https://orcid.org/0000-0001-9861-5369","observed_orcids":["https://orcid.org/0000-0001-9861-5369"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anand Shah","raw_affiliation_strings":["Renal Unit and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046692200","display_name":"Julie Holmes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Holmes","raw_affiliation_strings":["Renal Unit and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059947277","display_name":"Gina Collerone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gina Collerone","raw_affiliation_strings":["Renal Unit and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Harald Ju[Combining Diaeresis]ppner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harald Ju[Combining Diaeresis]ppner","raw_affiliation_strings":["Endocrine and Pediatric Nephrology Units, Departments of Medicine and Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine and Pediatric Nephrology Units, Departments of Medicine and Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008906136","display_name":"Myles Selig Wolf","orcid":"https://orcid.org/0000-0002-1127-1442","observed_orcids":["https://orcid.org/0000-0002-1127-1442"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Myles Wolf","raw_affiliation_strings":["Department of Medicine Internal Medicine Residency Training Program","Dr. Myles Wolf, Bartlett 911, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114. Phone: 617-726-7595; Fax: 617-726-7491; E-mail: [email\u00a0protected]","Renal Unit and","Dr. Myles Wolf, Bartlett 911, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114. Phone: 617-726-7595","E-mail: [email\u00a0protected]","Fax: 617-726-7491"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Internal Medicine Residency Training Program","institution_ids":[]},{"raw_affiliation_string":"Dr. Myles Wolf, Bartlett 911, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114. Phone: 617-726-7595; Fax: 617-726-7491; E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Renal Unit and","institution_ids":[]},{"raw_affiliation_string":"Dr. Myles Wolf, Bartlett 911, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114. Phone: 617-726-7595","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"Fax: 617-726-7491","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003850042","https://openalex.org/A5008906136","https://openalex.org/A5025948477","https://openalex.org/A5041495874"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":17.0085,"has_fulltext":false,"cited_by_count":919,"citation_normalized_percentile":{"value":0.99427951,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"16","issue":"7","first_page":"2205","last_page":"2215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hyperphosphatemia","display_name":"hyperphosphatemia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/calcitriol-deficiency","display_name":"calcitriol deficiency","score":0.9940000176429749},{"id":"https://openalex.org/keywords/secondary-hyperparathyroidism","display_name":"secondary hyperparathyroidism","score":0.9449999928474426},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phosphaturia","display_name":"phosphaturia","score":0.8349999785423279},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9229999780654907},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.8730000257492065},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hypocalcemia","display_name":"hypocalcemia","score":0.699999988079071},{"id":"https://openalex.org/keywords/phosphate-homeostasis","display_name":"phosphate homeostasis","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2776036575","wikidata":"https://www.wikidata.org/wiki/Q1641062","display_name":"Hyperphosphatemia","level":3,"score":0.9731722474098206},{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.9027271866798401},{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.8438563942909241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8209409713745117},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.79653000831604},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6548908352851868},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6172913908958435},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5859354734420776},{"id":"https://openalex.org/C2778838027","wikidata":"https://www.wikidata.org/wiki/Q3622611","display_name":"Secondary hyperparathyroidism","level":4,"score":0.5002086162567139},{"id":"https://openalex.org/C2775945674","wikidata":"https://www.wikidata.org/wiki/Q1344835","display_name":"Hyperparathyroidism","level":2,"score":0.4403282403945923},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.41884130239486694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40114060044288635},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.17147687077522278}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010760","descriptor_name":"Phosphorus Metabolism Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1681/asn.2005010052","doi":"https://doi.org/10.1681/asn.2005010052","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2005010052","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmid:15917335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15917335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology : JASN","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3493866547","display_name":"General Clinical Research Center","funder_award_id":"M01RR001066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G789034101","display_name":"Cardiovascular Disease Following Hypertensive Pregnancy","funder_award_id":"K23RR017376","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1563425273","https://openalex.org/W1964403552","https://openalex.org/W1967604492","https://openalex.org/W1968779137","https://openalex.org/W1979425916","https://openalex.org/W1979542010","https://openalex.org/W1986604740","https://openalex.org/W1989792612","https://openalex.org/W1998100845","https://openalex.org/W2000241549","https://openalex.org/W2002494594","https://openalex.org/W2003490678","https://openalex.org/W2012468269","https://openalex.org/W2021852822","https://openalex.org/W2037498463","https://openalex.org/W2037575725","https://openalex.org/W2038786617","https://openalex.org/W2042639382","https://openalex.org/W2053425137","https://openalex.org/W2055864845","https://openalex.org/W2083116747","https://openalex.org/W2083288593","https://openalex.org/W2094262605","https://openalex.org/W2107207648","https://openalex.org/W2113356410","https://openalex.org/W2114372930","https://openalex.org/W2121814218","https://openalex.org/W2127560186","https://openalex.org/W2128059069","https://openalex.org/W2132817664","https://openalex.org/W2141482249","https://openalex.org/W2142452319","https://openalex.org/W2143568351","https://openalex.org/W2144414222","https://openalex.org/W2145632027","https://openalex.org/W2146992350","https://openalex.org/W2164952534","https://openalex.org/W2170351820","https://openalex.org/W2172200321","https://openalex.org/W2325704874","https://openalex.org/W2548549197","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2003490678","https://openalex.org/W7098286492","https://openalex.org/W2009712608","https://openalex.org/W2384504895","https://openalex.org/W2034451046","https://openalex.org/W7095077573","https://openalex.org/W2164142357","https://openalex.org/W7098077804","https://openalex.org/W2055048876","https://openalex.org/W1674343883"],"abstract_inverted_index":{"Hyperphosphatemia,":[0],"calcitriol":[1,73,123,183,224,245],"deficiency,":[2],"and":[3,30,68,80,90,113,131,138,156,160,170,189,215,223,247],"secondary":[4],"hyperparathyroidism":[5],"(SHPT)":[6],"are":[7,216],"common":[8],"complications":[9],"of":[10,38,64,76,94,140,144,176,185,211,239,258],"chronic":[11],"kidney":[12],"disease":[13],"(CKD).":[14],"Fibroblast":[15],"growth":[16],"factor-23":[17],"(FGF-23)":[18],"is":[19,51,58,69,199],"a":[20,251],"novel":[21],"phosphaturic":[22],"hormone":[23,66],"that":[24,44,201],"also":[25],"inhibits":[26],"renal":[27,48,77,186],"1alpha-hydroxylase":[28],"activity":[29],"thus":[31,248],"may":[32,228,243,249],"be":[33,250],"involved":[34],"in":[35,99,135,206,236,254],"the":[36,110,180,209,237,255],"pathogenesis":[37,257],"SHPT.":[39,259],"Several":[40],"hypotheses":[41],"were":[42,97,115,125,133,162,173,191],"tested:":[43],"FGF-23":[45,112,159,169,202,227],"increases":[46],"as":[47],"function":[49,187],"declines;":[50],"linearly":[52,126],"associated":[53,59,70,117,127,152,164,218],"with":[54,60,71,118,128,153,165,219],"serum":[55,212,220,233],"phosphate":[56,95,234],"levels;":[57],"increased":[61,158,166],"phosphaturia":[62],"independent":[63,75,174],"parathyroid":[65],"(PTH);":[67],"decreased":[72,154,171,177],"levels":[74,124,184,203,235],"function,":[78],"hyperphosphatemia,":[79],"vitamin":[81],"D":[82],"stores.":[83],"FGF-23,":[84],"PTH,":[85],"25(OH)D3,":[86],"calcitriol,":[87,178],"calcium,":[88],"phosphate,":[89,221],"urinary":[91],"fractional":[92],"excretion":[93],"(Fe(PO4))":[96],"measured":[98],"80":[100],"CKD":[101,207,241],"patients.":[102],"Multiple":[103],"linear":[104],"regression":[105],"was":[106,147,151],"used":[107],"to":[108,230],"test":[109],"hypotheses.":[111],"PTH":[114,161],"inversely":[116],"estimated":[119],"GFR":[120],"(eGFR),":[121],"whereas":[122],"eGFR.":[129],"Hyperphosphatemia":[130],"hypocalcemia":[132],"present":[134],"only":[136],"12":[137],"6%":[139],"patients,":[141],"respectively,":[142],"all":[143],"whose":[145],"eGFR":[146],"<30.":[148],"Increased":[149,168,226],"Fe(PO4)":[150],"eGFR,":[155],"both":[157],"independently":[163,217],"Fe(PO4).":[167],"25(OH)D3":[172],"predictors":[175],"but":[179,242],"effects":[181],"on":[182],"itself":[188],"hyperphosphatemia":[190],"completely":[192],"extinguished":[193],"by":[194],"adjusting":[195],"for":[196],"FGF-23.":[197],"It":[198],"concluded":[200],"increase":[204],"early":[205,256],"before":[208],"development":[210],"mineral":[213],"abnormalities":[214],"Fe(PO4),":[222],"deficiency.":[225],"contribute":[229],"maintaining":[231],"normal":[232],"face":[238],"advancing":[240],"worsen":[244],"deficiency":[246],"central":[252],"factor":[253]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":31},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":45},{"year":2020,"cited_by_count":40},{"year":2019,"cited_by_count":43},{"year":2018,"cited_by_count":54},{"year":2017,"cited_by_count":42},{"year":2016,"cited_by_count":37},{"year":2015,"cited_by_count":54},{"year":2014,"cited_by_count":53},{"year":2013,"cited_by_count":68},{"year":2012,"cited_by_count":88}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
