{"id":"https://openalex.org/W2170086069","doi":"https://doi.org/10.1016/s0140-6736(11)60355-3","title":"Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)","display_name":"Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W2170086069","doi":"https://doi.org/10.1016/s0140-6736(11)60355-3","mag":"2170086069","pmid":"https://pubmed.ncbi.nlm.nih.gov/21571150","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133619"},"language":"en","primary_location":{"id":"doi:10.1016/s0140-6736(11)60355-3","doi":"https://doi.org/10.1016/s0140-6736(11)60355-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(11)60355-3","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133619","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068017197","display_name":"Winfred C. Wang","orcid":"https://orcid.org/0000-0001-6774-9698","observed_orcids":["https://orcid.org/0000-0001-6774-9698"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Winfred C Wang","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN 38105, USA. winfred.wang@stjude.org","From St Jude Children's Research Hospital, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN 38105, USA. winfred.wang@stjude.org","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"From St Jude Children's Research Hospital, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040752648","display_name":"Russell E. Ware","orcid":"https://orcid.org/0000-0001-9582-0594","observed_orcids":["https://orcid.org/0000-0001-9582-0594"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell E Ware","raw_affiliation_strings":["From St Jude Children's Research Hospital, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From St Jude Children's Research Hospital, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108727049","display_name":"Scott T. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott T Miller","raw_affiliation_strings":["SUNY Downstate Medical Center, Brooklyn, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Downstate Medical Center, Brooklyn, NY, USA","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037966196","display_name":"Rathi V. Iyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rathi V Iyer","raw_affiliation_strings":["University of Mississippi Medical Center, Jackson, MS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mississippi Medical Center, Jackson, MS, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020958437","display_name":"James F. Casella","orcid":"https://orcid.org/0000-0002-2846-9420","observed_orcids":["https://orcid.org/0000-0002-2846-9420"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James F Casella","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016200313","display_name":"Caterina P. Minniti","orcid":"https://orcid.org/0000-0002-7059-2959","observed_orcids":["https://orcid.org/0000-0002-7059-2959"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caterina P Minniti","raw_affiliation_strings":["Children's National Medical Center, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's National Medical Center, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074819957","display_name":"SOHAIL R. RANA","orcid":"https://orcid.org/0000-0001-6745-7900","observed_orcids":["https://orcid.org/0000-0001-6745-7900"]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sohail Rana","raw_affiliation_strings":["Howard University College of Medicine, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University College of Medicine, Washington, DC, USA","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033166660","display_name":"Courtney D. Thornburg","orcid":"https://orcid.org/0000-0002-5665-8958","observed_orcids":["https://orcid.org/0000-0002-5665-8958"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney D Thornburg","raw_affiliation_strings":["Duke University Medical Center, Raleigh, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Raleigh, NC, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048634068","display_name":"Zora R. Rogers","orcid":"https://orcid.org/0000-0003-1478-2368","observed_orcids":["https://orcid.org/0000-0003-1478-2368"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zora R Rogers","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087767536","display_name":"Ram V. Kalpatthi","orcid":"https://orcid.org/0000-0002-2135-2801","observed_orcids":["https://orcid.org/0000-0002-2135-2801"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ram V Kalpatthi","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010703149","display_name":"Julio C. Barredo","orcid":"https://orcid.org/0000-0003-4654-4145","observed_orcids":["https://orcid.org/0000-0003-4654-4145"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio C Barredo","raw_affiliation_strings":["University of Miami, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051820244","display_name":"Clark Brown","orcid":"https://orcid.org/0000-0003-0674-0213","observed_orcids":["https://orcid.org/0000-0003-0674-0213"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Clark Brown","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035252702","display_name":"Sharada A. Sarnaik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130818","display_name":"Children's Hospital of Michigan","ror":"https://ror.org/0429x9p85","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800326109","https://openalex.org/I4210130818"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharada A Sarnaik","raw_affiliation_strings":["Children's Hospital of Michigan, Detroit, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Michigan, Detroit, MI, USA","institution_ids":["https://openalex.org/I4210130818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113416219","display_name":"Thomas H. Howard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas H Howard","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052759849","display_name":"Lynn Witte Wynn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]},{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn W Wynn","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital (WCW, REW, LWW), SUNY Downstate Medical Center (STM), University of Mississippi Medical Center (RVI), Johns Hopkins University School of Medicine (JFC), Children\u2019s National Medical Center (CPM), Howard University College of Medicine (SR), Duke University Medical Center (CDT), University of Texas Southwestern Medical Center, Dallas (ZRR), Medical University of South Carolina (RVK), University of Miami (JCB, FDA), Emory University School of Medicine (RCB, BAF), Children\u2019s Hospital of Michigan (SAS), University of Alabama at Birmingham (THH), Medical College of Georgia (AK), the National Heart, Lung and Blood Institute (JCG*, MAW*), and the Clinical Trials & Surveys Corporation (XH, BWT)","From St Jude Children's Research Hospital, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital (WCW, REW, LWW), SUNY Downstate Medical Center (STM), University of Mississippi Medical Center (RVI), Johns Hopkins University School of Medicine (JFC), Children\u2019s National Medical Center (CPM), Howard University College of Medicine (SR), Duke University Medical Center (CDT), University of Texas Southwestern Medical Center, Dallas (ZRR), Medical University of South Carolina (RVK), University of Miami (JCB, FDA), Emory University School of Medicine (RCB, BAF), Children\u2019s Hospital of Michigan (SAS), University of Alabama at Birmingham (THH), Medical College of Georgia (AK), the National Heart, Lung and Blood Institute (JCG*, MAW*), and the Clinical Trials & Surveys Corporation (XH, BWT)","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I137853757","https://openalex.org/I145311948","https://openalex.org/I181697535","https://openalex.org/I29606459","https://openalex.org/I32389192","https://openalex.org/I4210126298","https://openalex.org/I867280407"]},{"raw_affiliation_string":"From St Jude Children's Research Hospital, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059999119","display_name":"Abdullah Kutlar","orcid":"https://orcid.org/0000-0002-5482-8087","observed_orcids":["https://orcid.org/0000-0002-5482-8087"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdullah Kutlar","raw_affiliation_strings":["Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059510530","display_name":"Floyd Daniel Armstrong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Daniel Armstrong","raw_affiliation_strings":["University of Miami, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113618181","display_name":"Beatrice A. Files","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beatrice A Files","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064976025","display_name":"Jonathan C. Goldsmith","orcid":"https://orcid.org/0000-0002-9907-9526","observed_orcids":["https://orcid.org/0000-0002-9907-9526"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan C Goldsmith","raw_affiliation_strings":["National Heart, Lung and Blood Institute, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111879281","display_name":"Myron A. Waclawiw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myron A Waclawiw","raw_affiliation_strings":["National Heart, Lung and Blood Institute, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112799412","display_name":"Xiangke Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126415","display_name":"Clinical Trials and Surveys Corporation","ror":"https://ror.org/02yp59539","country_code":"US","type":"other","lineage":["https://openalex.org/I4210126415"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangke Huang","raw_affiliation_strings":["Clinical Trials and Surveys Corporation, Owings Mills, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials and Surveys Corporation, Owings Mills, MD, USA","institution_ids":["https://openalex.org/I4210126415"]}]},{"author_position":"last","author":{"id":null,"display_name":"Bruce W Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126415","display_name":"Clinical Trials and Surveys Corporation","ror":"https://ror.org/02yp59539","country_code":"US","type":"other","lineage":["https://openalex.org/I4210126415"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce W Thompson","raw_affiliation_strings":["Clinical Trials and Surveys Corporation, Owings Mills, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials and Surveys Corporation, Owings Mills, MD, USA","institution_ids":["https://openalex.org/I4210126415"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5068017197"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":23.0484,"has_fulltext":false,"cited_by_count":798,"citation_normalized_percentile":{"value":0.9976773,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"377","issue":"9778","first_page":"1663","last_page":"1672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.9620000123977661},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.5040000081062317},{"id":"https://openalex.org/keywords/splenic-function","display_name":"spleen function","score":0.6859999895095825},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.8769999742507935},{"id":"https://openalex.org/keywords/acute-chest-syndrome","display_name":"acute chest syndrome","score":0.7639999985694885},{"id":"https://openalex.org/keywords/pain-episodes","display_name":"pain episodes","score":0.47200000286102295},{"id":"https://openalex.org/keywords/fetal-hemoglobin","display_name":"fetal hemoglobin","score":0.8169999718666077},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.4970000088214874},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.640999972820282},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.621999979019165},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":0.7860000133514404},{"id":"https://openalex.org/keywords/organ-dysfunction","display_name":"organ dysfunction","score":0.49399998784065247},{"id":"https://openalex.org/keywords/growth","display_name":"growth","score":0.3149999976158142},{"id":"https://openalex.org/keywords/transcranial-doppler","display_name":"transcranial Doppler","score":0.7149999737739563},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.7310000061988831},{"id":"https://openalex.org/keywords/urine-osmolality","display_name":"urine osmolality","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2779316324","wikidata":"https://www.wikidata.org/wiki/Q212272","display_name":"Hydroxycarbamide","level":3,"score":0.9621356725692749},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9116177558898926},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7190517783164978},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.49723175168037415},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.4560922682285309},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4427284896373749},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.41016873717308044},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37662985920906067},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.37298816442489624},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.16626647114753723},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000986","descriptor_name":"Antisickling Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000986","descriptor_name":"Antisickling Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002657","descriptor_name":"Child Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014556","descriptor_name":"Urine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016284","descriptor_name":"Technetium Tc 99m Pentetate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017585","descriptor_name":"Ultrasonography, Doppler, Transcranial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056586","descriptor_name":"Acute Chest Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D056586","descriptor_name":"Acute Chest Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0140-6736(11)60355-3","doi":"https://doi.org/10.1016/s0140-6736(11)60355-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(11)60355-3","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:21571150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21571150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2216089","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133619","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3133619","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133619","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Lancet","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2216089","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133619","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1072246852","display_name":"Pediatric Hydroxyurea Phase III Clinical Trial","funder_award_id":"n01hb07156-19-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1125831847","display_name":null,"funder_award_id":"N01-HB-07154","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1172335439","display_name":null,"funder_award_id":"N01-HB-07157","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1319551310","display_name":null,"funder_award_id":"N01-HB-07160","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1599327000","display_name":null,"funder_award_id":"N01 HB007155","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1880043266","display_name":"Pediatric Hydroxyurea Phase III Clinical Trial","funder_award_id":"n01hb07159-25-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3231757479","display_name":null,"funder_award_id":"N01-HB07155","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3363026091","display_name":"Pediatric Hydroxyurea Phase III Clinical Trial","funder_award_id":"n01hb07153-18-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3639968965","display_name":null,"funder_award_id":"N01-HB-07152","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3883564511","display_name":"PEDRIATRIC HYDROXYUREA PHASE III CLINICAL TRIAL CLINICAL","funder_award_id":"n01hb07155-16-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4260930042","display_name":"PEDIATRIC HYDROXYUREA PHASE III CLINICAL TRIAL","funder_award_id":"n01hb07158-17-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4270972704","display_name":"PEDIATRIC HYDROXYUREA PHASE III CLINICAL TRIAL","funder_award_id":"n01hb07157-15-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4966991233","display_name":null,"funder_award_id":"N01-HB-07153","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5117245682","display_name":null,"funder_award_id":"N01 HB007150","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5688329730","display_name":"PEDIATRIC HYDROXYUREA PHASE III CLINICAL TRIAL","funder_award_id":"n01hb07152-18-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5969790455","display_name":null,"funder_award_id":"N01-HB-07151","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6282633620","display_name":"PEDIATRIC HYDROXYUREA PHASE III CLINICAL TRIAL","funder_award_id":"n01hb07151-17-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6455780639","display_name":"Pediatric Hydroxyurea Phase III Clinical Trial","funder_award_id":"n01hb07150-20-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6554995438","display_name":null,"funder_award_id":"N01-HB-07158","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6983254085","display_name":"Pediatric Hydroxyurea Phase III Clinical Trial","funder_award_id":"n01hb07160-38-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G704583645","display_name":null,"funder_award_id":"N01-HB-07150","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7247049072","display_name":null,"funder_award_id":"N01 HB007160","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7737788201","display_name":null,"funder_award_id":"N01-HB-07159","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7964539973","display_name":null,"funder_award_id":"N01-HB-07156","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G848077634","display_name":"PEDIATRIC HYDROXYUREA PHASE III CLINICAL TRIAL","funder_award_id":"n01hb07154-21-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W83314201","https://openalex.org/W1566270415","https://openalex.org/W1719867626","https://openalex.org/W1963802507","https://openalex.org/W1964620166","https://openalex.org/W1974160108","https://openalex.org/W1980933059","https://openalex.org/W1982989569","https://openalex.org/W1986705681","https://openalex.org/W1987371443","https://openalex.org/W1994489695","https://openalex.org/W1995325755","https://openalex.org/W2022246541","https://openalex.org/W2025172439","https://openalex.org/W2025723371","https://openalex.org/W2027887215","https://openalex.org/W2033040678","https://openalex.org/W2039423483","https://openalex.org/W2059228501","https://openalex.org/W2063696061","https://openalex.org/W2074858698","https://openalex.org/W2089165596","https://openalex.org/W2107617324","https://openalex.org/W2140272338","https://openalex.org/W2143865657","https://openalex.org/W2143927179","https://openalex.org/W2157799454","https://openalex.org/W2160308620","https://openalex.org/W2183703703","https://openalex.org/W2313541759","https://openalex.org/W2322074970","https://openalex.org/W2334263927","https://openalex.org/W2462295051","https://openalex.org/W4247230067","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2004585486","https://openalex.org/W2121595879","https://openalex.org/W1983850386","https://openalex.org/W4229505373","https://openalex.org/W2907965864","https://openalex.org/W4292120962","https://openalex.org/W3036176677","https://openalex.org/W2914959822","https://openalex.org/W2951128124","https://openalex.org/W3204749493"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":39},{"year":2025,"cited_by_count":41},{"year":2024,"cited_by_count":58},{"year":2023,"cited_by_count":49},{"year":2022,"cited_by_count":58},{"year":2021,"cited_by_count":54},{"year":2020,"cited_by_count":58},{"year":2019,"cited_by_count":67},{"year":2018,"cited_by_count":50},{"year":2017,"cited_by_count":64},{"year":2016,"cited_by_count":52},{"year":2015,"cited_by_count":61},{"year":2014,"cited_by_count":51},{"year":2013,"cited_by_count":45},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}