{"id":"https://openalex.org/W2170078699","doi":"https://doi.org/10.1248/cpb.53.435","title":"2'-Amino-.ALPHA.-chloroacetophenone as a Valuable Tool for the Synthesis of Conveniently-Substituted .ALPHA.,.BETA.-Epoxychalcone Derivatives","display_name":"2'-Amino-.ALPHA.-chloroacetophenone as a Valuable Tool for the Synthesis of Conveniently-Substituted .ALPHA.,.BETA.-Epoxychalcone Derivatives","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2170078699","doi":"https://doi.org/10.1248/cpb.53.435","mag":"2170078699","pmid":"https://pubmed.ncbi.nlm.nih.gov/15802847"},"language":"en","primary_location":{"id":"doi:10.1248/cpb.53.435","doi":"https://doi.org/10.1248/cpb.53.435","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.53.435","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/53/4/53_4_435/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/cpb/53/4/53_4_435/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111991953","display_name":"Madeleine Blanc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I4387154850","display_name":"D\u00e9partement de Pharmacochimie Mol\u00e9culaire","ror":"https://ror.org/04fhvpc68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387154850","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Madeleine Blanc","raw_affiliation_strings":["D\u00e9partement de Pharmacochimie Mol\u00e9culaire, UMR CNRS-UJF 5063. Facult\u00e9 de Pharmacie de Grenoble"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Pharmacochimie Mol\u00e9culaire, UMR CNRS-UJF 5063. Facult\u00e9 de Pharmacie de Grenoble","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I177483745","https://openalex.org/I4387154850"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maud Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I4387154850","display_name":"D\u00e9partement de Pharmacochimie Mol\u00e9culaire","ror":"https://ror.org/04fhvpc68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387154850","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maud Martin","raw_affiliation_strings":["D\u00e9partement de Pharmacochimie Mol\u00e9culaire, UMR CNRS-UJF 5063. Facult\u00e9 de Pharmacie de Grenoble"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Pharmacochimie Mol\u00e9culaire, UMR CNRS-UJF 5063. Facult\u00e9 de Pharmacie de Grenoble","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I177483745","https://openalex.org/I4387154850"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007564769","display_name":"Sabrina Okombi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I4387154850","display_name":"D\u00e9partement de Pharmacochimie Mol\u00e9culaire","ror":"https://ror.org/04fhvpc68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387154850","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sabrina Okombi","raw_affiliation_strings":["D\u00e9partement de Pharmacochimie Mol\u00e9culaire, UMR CNRS-UJF 5063. Facult\u00e9 de Pharmacie de Grenoble"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Pharmacochimie Mol\u00e9culaire, UMR CNRS-UJF 5063. Facult\u00e9 de Pharmacie de Grenoble","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I177483745","https://openalex.org/I4387154850"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058676221","display_name":"Ahc\u00e8ne Boumendjel","orcid":"https://orcid.org/0000-0002-1830-6409","observed_orcids":["https://orcid.org/0000-0002-1830-6409"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I4387154850","display_name":"D\u00e9partement de Pharmacochimie Mol\u00e9culaire","ror":"https://ror.org/04fhvpc68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387154850","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ahc\u00e8ne Boumendjel","raw_affiliation_strings":["D\u00e9partement de Pharmacochimie Mol\u00e9culaire, UMR CNRS-UJF 5063. Facult\u00e9 de Pharmacie de Grenoble"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Pharmacochimie Mol\u00e9culaire, UMR CNRS-UJF 5063. Facult\u00e9 de Pharmacie de Grenoble","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I177483745","https://openalex.org/I4387154850"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1906,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.50104878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"53","issue":"4","first_page":"435","last_page":"436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/darzens-condensation","display_name":"Darzens condensation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/benzaldehyde","display_name":"benzaldehyde","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cyclization","display_name":"cyclization","score":0.8790000081062317},{"id":"https://openalex.org/keywords/flavonoid-analogs","display_name":"flavonoid analogs","score":0.9789999723434448},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8948589563369751},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.8520207405090332},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.6354769468307495},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.451416015625},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3608558773994446},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.07925698161125183},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.050049036741256714},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000096","descriptor_name":"Acetone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098","descriptor_name":"Acetophenones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001547","descriptor_name":"Benzaldehydes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003500","descriptor_name":"Cyclization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1248/cpb.53.435","doi":"https://doi.org/10.1248/cpb.53.435","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.53.435","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/53/4/53_4_435/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:15802847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15802847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical & pharmaceutical bulletin","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00123112v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00123112","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chem. Pharm. Bull., 2005, 53, pp.435-436. ⟨10.1248/cpb.53.435⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-00385833v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00385833","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chem. Pharm. Bull., 2005, pp.435-436","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1248/cpb.53.435","doi":"https://doi.org/10.1248/cpb.53.435","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.53.435","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/53/4/53_4_435/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170078699.pdf","grobid_xml":"https://content.openalex.org/works/W2170078699.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1966398425","https://openalex.org/W1973645776","https://openalex.org/W1974793097","https://openalex.org/W2042257530","https://openalex.org/W2066749591","https://openalex.org/W2072823203","https://openalex.org/W2076934232","https://openalex.org/W2095059393","https://openalex.org/W2148378007","https://openalex.org/W2168427820","https://openalex.org/W2338280448","https://openalex.org/W2465854239","https://openalex.org/W2949498797"],"related_works":["https://openalex.org/W2951170503","https://openalex.org/W2952957357","https://openalex.org/W236918055","https://openalex.org/W2067946277","https://openalex.org/W2505920140","https://openalex.org/W2951949979","https://openalex.org/W2402610125","https://openalex.org/W6922659824","https://openalex.org/W2050487106","https://openalex.org/W4318814254"],"abstract_inverted_index":{"The":[0,18],"synthesis":[1],"of":[2,14,29],"conveniently":[3],"substituted":[4],"2'-amino-alpha,beta-epoxychalcones":[5],"is":[6],"described.":[7],"They":[8],"were":[9],"obtained":[10],"through":[11],"Darzens":[12],"condensation":[13],"2'-amino-3',5'-dimethoxy-alpha-chloroacetophenone":[15],"with":[16,32],"benzaldehydes.":[17],"latter":[19],"can":[20],"undergo":[21],"different":[22],"cyclization":[23],"possibilities":[24],"and":[25],"afford":[26],"a":[27],"variety":[28],"flavonoid":[30],"analogs":[31],"biological":[33],"potential.":[34]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}