{"id":"https://openalex.org/W2170066005","doi":"https://doi.org/10.1091/mbc.e12-06-0445","title":"Endosomal acidification by Na+/H+exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling","display_name":"Endosomal acidification by Na+/H+exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling","publication_year":2013,"publication_date":"2013-09-05","ids":{"openalex":"https://openalex.org/W2170066005","doi":"https://doi.org/10.1091/mbc.e12-06-0445","mag":"2170066005","pmid":"https://pubmed.ncbi.nlm.nih.gov/24006492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3814139"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.e12-06-0445","doi":"https://doi.org/10.1091/mbc.e12-06-0445","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e12-06-0445","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3814139/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081849997","display_name":"Graham H. Diering","orcid":"https://orcid.org/0000-0001-6113-6946","observed_orcids":["https://orcid.org/0000-0001-6113-6946"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Graham H. Diering","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109260366","display_name":"Yuka Numata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yuka Numata","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055624396","display_name":"Steven H.Y. Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Steven Fan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Church","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John Church","raw_affiliation_strings":["Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111805857","display_name":"Masayuki Numata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Masayuki Numata","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111805857"],"corresponding_institution_ids":["https://openalex.org/I141945490"],"apc_list":null,"apc_paid":null,"fwci":1.236,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.73223875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"21","first_page":"3435","last_page":"3448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/na-h-exchanger","display_name":"Na+/H+ exchanger","score":0.9449999928474426},{"id":"https://openalex.org/keywords/endosomal-acidification","display_name":"endosomal acidification","score":0.9860000014305115},{"id":"https://openalex.org/keywords/recycling-endosomes","display_name":"recycling endosomes","score":0.8349999785423279},{"id":"https://openalex.org/keywords/trka","display_name":"TrkA","score":0.8730000257492065},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.8899999856948853},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8629999756813049},{"id":"https://openalex.org/keywords/receptor-trafficking","display_name":"receptor trafficking","score":0.6399999856948853},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.8370000123977661},{"id":"https://openalex.org/keywords/endosomal-ph","display_name":"endosomal pH","score":0.7730000019073486},{"id":"https://openalex.org/keywords/neurotrophin-signaling","display_name":"neurotrophin signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.6639999747276306},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.8875824809074402},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7428576946258545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7266544699668884},{"id":"https://openalex.org/C134139212","wikidata":"https://www.wikidata.org/wiki/Q24719927","display_name":"Trk receptor","level":4,"score":0.6698878407478333},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.6113053560256958},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6063623428344727},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.5423811674118042},{"id":"https://openalex.org/C171034665","wikidata":"https://www.wikidata.org/wiki/Q14897694","display_name":"Tropomyosin receptor kinase A","level":4,"score":0.5170732140541077},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4896000027656555},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4649682343006134},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.4236401319503784},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4106743335723877},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2066325545310974},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.17345958948135376},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12378007173538208},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000143","descriptor_name":"Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020917","descriptor_name":"Receptor, trkA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1091/mbc.e12-06-0445","doi":"https://doi.org/10.1091/mbc.e12-06-0445","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e12-06-0445","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3814139","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3814139/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3814139/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2877514","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3814139","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:24006492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24006492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.790.6017","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.790.6017","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/6e/45/3435.PMC3814139.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3814139","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3814139/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3814139/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320319965","display_name":"Michael Smith Health Research BC","ror":"https://ror.org/020x39229"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170066005.pdf","grobid_xml":"https://content.openalex.org/works/W2170066005.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W63424200","https://openalex.org/W1504699909","https://openalex.org/W1506914739","https://openalex.org/W1508964919","https://openalex.org/W1541488575","https://openalex.org/W1544613382","https://openalex.org/W1600856176","https://openalex.org/W1797204943","https://openalex.org/W1827340218","https://openalex.org/W1966311581","https://openalex.org/W1967737783","https://openalex.org/W1969117282","https://openalex.org/W1970338125","https://openalex.org/W1970587959","https://openalex.org/W1971345886","https://openalex.org/W1972032978","https://openalex.org/W1973918504","https://openalex.org/W1978129579","https://openalex.org/W1981728824","https://openalex.org/W1987065177","https://openalex.org/W1990790897","https://openalex.org/W1991555625","https://openalex.org/W1991738499","https://openalex.org/W1995490147","https://openalex.org/W1995804648","https://openalex.org/W2000785948","https://openalex.org/W2002096723","https://openalex.org/W2005496979","https://openalex.org/W2005983739","https://openalex.org/W2007970732","https://openalex.org/W2008393425","https://openalex.org/W2012423618","https://openalex.org/W2017214527","https://openalex.org/W2018258118","https://openalex.org/W2025339136","https://openalex.org/W2027785297","https://openalex.org/W2029473695","https://openalex.org/W2032189193","https://openalex.org/W2032466814","https://openalex.org/W2034224320","https://openalex.org/W2037253867","https://openalex.org/W2037367816","https://openalex.org/W2037972941","https://openalex.org/W2040951085","https://openalex.org/W2044788777","https://openalex.org/W2045508653","https://openalex.org/W2046133662","https://openalex.org/W2046615366","https://openalex.org/W2051338141","https://openalex.org/W2054883747","https://openalex.org/W2056442594","https://openalex.org/W2057031051","https://openalex.org/W2057370954","https://openalex.org/W2061369703","https://openalex.org/W2062562477","https://openalex.org/W2064265756","https://openalex.org/W2066994840","https://openalex.org/W2072307289","https://openalex.org/W2073935838","https://openalex.org/W2074325696","https://openalex.org/W2079577857","https://openalex.org/W2079889598","https://openalex.org/W2082024168","https://openalex.org/W2086454484","https://openalex.org/W2087277008","https://openalex.org/W2087661112","https://openalex.org/W2087784543","https://openalex.org/W2092211446","https://openalex.org/W2093507482","https://openalex.org/W2100909138","https://openalex.org/W2100963961","https://openalex.org/W2101045457","https://openalex.org/W2105306454","https://openalex.org/W2106538910","https://openalex.org/W2109493256","https://openalex.org/W2109955944","https://openalex.org/W2110568819","https://openalex.org/W2110654250","https://openalex.org/W2110795584","https://openalex.org/W2111607026","https://openalex.org/W2113471132","https://openalex.org/W2115732451","https://openalex.org/W2118660831","https://openalex.org/W2123105928","https://openalex.org/W2123832957","https://openalex.org/W2124009392","https://openalex.org/W2124804313","https://openalex.org/W2124825357","https://openalex.org/W2129890352","https://openalex.org/W2131545168","https://openalex.org/W2135012473","https://openalex.org/W2139565721","https://openalex.org/W2142458084","https://openalex.org/W2142672347","https://openalex.org/W2151687527","https://openalex.org/W2154730918","https://openalex.org/W2160025503","https://openalex.org/W2167897285","https://openalex.org/W2170242857","https://openalex.org/W2171146188","https://openalex.org/W2174160083","https://openalex.org/W2312836697","https://openalex.org/W4211214945"],"related_works":["https://openalex.org/W7096133214","https://openalex.org/W2264952008","https://openalex.org/W2008393425","https://openalex.org/W2041238197","https://openalex.org/W2573285293","https://openalex.org/W1797204943","https://openalex.org/W2012839323","https://openalex.org/W4230785238","https://openalex.org/W2124804313","https://openalex.org/W1976161959"],"abstract_inverted_index":{"To":[0],"facilitate":[1],"polarized":[2],"vesicular":[3],"trafficking":[4,85,169],"and":[5,26,32,108,110,128,177],"signal":[6],"transduction,":[7],"neuronal":[8,179],"endosomes":[9,45,90],"have":[10],"evolved":[11],"sophisticated":[12],"mechanisms":[13],"for":[14],"pH":[15,167],"homeostasis.":[16],"NHE5":[17,41,49,100,102,148],"is":[18,27,94],"a":[19],"member":[20],"of":[21,61,78,86,106,170],"the":[22,72,95],"Na(+)/H(+)":[23],"exchanger":[24],"family":[25],"abundantly":[28],"expressed":[29],"in":[30,46,114,150,154],"neurons":[31,153],"associates":[33],"with":[34,71],"recycling":[35,44,89],"endosomes.":[36],"Here":[37],"we":[38],"show":[39],"that":[40,67,83,165],"potently":[42],"acidifies":[43],"PC12":[47],"cells.":[48],"depletion":[50,149],"by":[51,99,133,143],"plasmid-based":[52],"short":[53],"hairpin":[54],"RNA":[55],"significantly":[56],"reduces":[57,104],"cell":[58],"surface":[59],"abundance":[60],"TrkA,":[62],"an":[63],"effect":[64],"similar":[65],"to":[66,91,116,138],"observed":[68],"after":[69],"treatment":[70],"V-ATPase":[73],"inhibitor":[74],"bafilomycin.":[75],"A":[76],"series":[77],"cell-surface":[79],"biotinylation":[80],"experiments":[81],"suggests":[82],"anterograde":[84],"TrkA":[87],"from":[88],"plasma":[92],"membrane":[93],"likeliest":[96],"target":[97],"affected":[98,142],"depletion.":[101],"knockdown":[103],"phosphorylation":[105],"Akt":[107],"Erk1/2":[109],"impairs":[111],"neurite":[112,159],"outgrowth":[113],"response":[115],"nerve":[117],"growth":[118],"factor":[119],"(NGF)":[120],"treatment.":[121],"Of":[122],"interest,":[123],"although":[124],"both":[125],"phosphoinositide":[126],"3-kinase-Akt":[127],"Erk":[129],"signaling":[130],"are":[131],"activated":[132],"NGF-TrkA,":[134],"NGF-induced":[135],"Akt-phosphorylation":[136],"appears":[137],"be":[139],"more":[140],"sensitively":[141],"perturbed":[144],"endosomal":[145,166],"pH.":[146],"Furthermore,":[147],"rat":[151],"cortical":[152],"primary":[155],"culture":[156],"also":[157],"inhibits":[158],"formation.":[160],"These":[161],"results":[162],"collectively":[163],"suggest":[164],"modulates":[168],"Trk-family":[171],"receptor":[172],"tyrosine":[173],"kinases,":[174],"neurotrophin":[175],"signaling,":[176],"possibly":[178],"differentiation.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
