{"id":"https://openalex.org/W2169999050","doi":"https://doi.org/10.3892/or.2015.4405","title":"10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity","display_name":"10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity","publication_year":2015,"publication_date":"2015-11-09","ids":{"openalex":"https://openalex.org/W2169999050","doi":"https://doi.org/10.3892/or.2015.4405","mag":"2169999050","pmid":"https://pubmed.ncbi.nlm.nih.gov/26554741"},"language":"en","primary_location":{"id":"doi:10.3892/or.2015.4405","doi":"https://doi.org/10.3892/or.2015.4405","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2015.4405","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2015.4405/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/or.2015.4405/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056996598","display_name":"Ji\u2010Hye Joo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"JI-HYE JOO","raw_affiliation_strings":["Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030583130","display_name":"Seong Su Hong","orcid":"https://orcid.org/0000-0002-2498-7546","observed_orcids":["https://orcid.org/0000-0002-2498-7546"]},"institutions":[{"id":"https://openalex.org/I4405260488","display_name":"Gyeonggido Business and Science Accelerator","ror":"https://ror.org/03tpec229","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405260488"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"SEONG-SU HONG","raw_affiliation_strings":["Gyeonggi Biocenter, Gyeonggi Institute of Science and Technology Promotion, Suwon 16229, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gyeonggi Biocenter, Gyeonggi Institute of Science and Technology Promotion, Suwon 16229, Republic of Korea","institution_ids":["https://openalex.org/I4405260488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019489608","display_name":"Young\u2010Rak Cho","orcid":"https://orcid.org/0000-0002-1077-796X","observed_orcids":["https://orcid.org/0000-0002-1077-796X"]},"institutions":[{"id":"https://openalex.org/I4405260488","display_name":"Gyeonggido Business and Science Accelerator","ror":"https://ror.org/03tpec229","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405260488"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"YOUNG-RAK CHO","raw_affiliation_strings":["Gyeonggi Biocenter, Gyeonggi Institute of Science and Technology Promotion, Suwon 16229, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gyeonggi Biocenter, Gyeonggi Institute of Science and Technology Promotion, Suwon 16229, Republic of Korea","institution_ids":["https://openalex.org/I4405260488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044806903","display_name":"Dong Wan Seo","orcid":"https://orcid.org/0000-0003-4971-834X","observed_orcids":["https://orcid.org/0000-0003-4971-834X"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"DONG-WAN SEO","raw_affiliation_strings":["Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea","institution_ids":["https://openalex.org/I89015989"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8149,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.93640167,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"35","issue":"2","first_page":"779","last_page":"784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/10-gingerol","display_name":"10-gingerol","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.859000027179718},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.949999988079071},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9760000109672546},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9869999885559082},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cyclins","display_name":"cyclins","score":0.878000020980835},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ginger","display_name":"ginger","score":0.9129999876022339},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.7307862043380737},{"id":"https://openalex.org/C2776039994","wikidata":"https://www.wikidata.org/wiki/Q421081","display_name":"Gingerol","level":2,"score":0.6803097128868103},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6366558074951172},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6158272624015808},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6055794358253479},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6001700162887573},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.5133251547813416},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5119179487228394},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4967716336250305},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49300524592399597},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4608359932899475},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4431793689727783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43804439902305603},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43548721075057983},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4127448797225952},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3545784056186676},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.287910521030426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09741437435150146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005233","descriptor_name":"Fatty Alcohols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.2015.4405","doi":"https://doi.org/10.3892/or.2015.4405","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2015.4405","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2015.4405/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:26554741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26554741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/or.2015.4405","doi":"https://doi.org/10.3892/or.2015.4405","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2015.4405","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2015.4405/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321209","display_name":"Dankook University","ror":"https://ror.org/058pdbn81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2169999050.pdf","grobid_xml":"https://content.openalex.org/works/W2169999050.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1970961751","https://openalex.org/W1974331847","https://openalex.org/W1978548948","https://openalex.org/W1981448691","https://openalex.org/W1981714984","https://openalex.org/W1984130814","https://openalex.org/W1986627544","https://openalex.org/W1988055795","https://openalex.org/W1995014753","https://openalex.org/W2002286451","https://openalex.org/W2004738728","https://openalex.org/W2005334224","https://openalex.org/W2012431465","https://openalex.org/W2015375238","https://openalex.org/W2025092277","https://openalex.org/W2027329004","https://openalex.org/W2029286778","https://openalex.org/W2034991912","https://openalex.org/W2044883658","https://openalex.org/W2064600697","https://openalex.org/W2072271599","https://openalex.org/W2075404997","https://openalex.org/W2081223018","https://openalex.org/W2082124830","https://openalex.org/W2083297935","https://openalex.org/W2093841965","https://openalex.org/W2097579313","https://openalex.org/W2125899548","https://openalex.org/W2135421972","https://openalex.org/W2140056178","https://openalex.org/W2141546964","https://openalex.org/W2147915725","https://openalex.org/W2157546003","https://openalex.org/W2171010297","https://openalex.org/W2917837889"],"related_works":["https://openalex.org/W2125899548","https://openalex.org/W2596314029","https://openalex.org/W2002059497","https://openalex.org/W2400807077","https://openalex.org/W2046903227","https://openalex.org/W4387686698","https://openalex.org/W2885750996","https://openalex.org/W2761772094","https://openalex.org/W2762088851","https://openalex.org/W2586928666"],"abstract_inverted_index":{"In":[0,56],"the":[1,6,94,119],"present":[2],"study,":[3],"we":[4],"investigated":[5],"roles":[7,96],"and":[8,24,47,49,79,82,105,107,111,121],"molecular":[9],"mechanism":[10],"of":[11,26,38,52,71,77,84,97,123],"10-gingerol,":[12],"a":[13,114],"phenolic":[14],"compound":[15],"isolated":[16],"from":[17],"Zingiber":[18],"officinale,":[19],"in":[20,63,99],"regulating":[21,100],"cell":[22,34,39,61,103],"proliferation":[23,35],"invasion":[25,62],"MDA\u2011MB\u2011231":[27],"breast":[28,101,124],"cancer":[29,102],"cells.":[30],"10-gingerol":[31,98],"treatment":[32,59,122],"inhibited":[33],"through":[36,75],"downregulation":[37],"cycle":[40],"regulatory":[41],"proteins":[42],"such":[43],"as":[44,113],"cyclin-dependent":[45],"kinases":[46],"cyclins,":[48],"subsequent":[50],"induction":[51],"G1":[53],"phase":[54],"arrest.":[55],"addition,":[57],"10\u2011gingerol":[58,72],"blocked":[60],"response":[64],"to":[65],"mitogenic":[66],"stimulation.":[67],"These":[68],"antitumor":[69],"activities":[70],"were":[73],"mediated":[74],"inactivation":[76],"Akt":[78],"p38MAPK":[80],"activity,":[81],"suppression":[83],"epidermal":[85],"growth":[86,104],"factor":[87],"receptor":[88],"expression.":[89],"Collectively,":[90],"these":[91],"findings":[92],"demonstrate":[93],"pharmacological":[95],"progression,":[106],"suggest":[108],"further":[109],"evaluation":[110],"development":[112],"potential":[115],"therapeutic":[116],"agent":[117],"for":[118],"prevention":[120],"cancer.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
