{"id":"https://openalex.org/W2169979510","doi":"https://doi.org/10.4049/jimmunol.1101823","title":"Epitope-Specific Human Influenza Antibody Repertoires Diversify by B Cell Intraclonal Sequence Divergence and Interclonal Convergence","display_name":"Epitope-Specific Human Influenza Antibody Repertoires Diversify by B Cell Intraclonal Sequence Divergence and Interclonal Convergence","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W2169979510","doi":"https://doi.org/10.4049/jimmunol.1101823","mag":"2169979510","pmid":"https://pubmed.ncbi.nlm.nih.gov/21880983","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3178754"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1101823","doi":"https://doi.org/10.4049/jimmunol.1101823","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1101823","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3178754","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065488663","display_name":"Jens C. Krause","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jens C Krause","raw_affiliation_strings":["Department of Pediatrics, Vanderbilt University Medical Center , Nashville, TN 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center , Nashville, TN 37232","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005794867","display_name":"Tshidi Tsibane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tshidi Tsibane","raw_affiliation_strings":["Department of Microbiology, Mount Sinai School of Medicine , New York City, NY 10029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Mount Sinai School of Medicine , New York City, NY 10029","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083896657","display_name":"Terrence M. Tumpey","orcid":"https://orcid.org/0000-0001-6292-8240","observed_orcids":["https://orcid.org/0000-0001-6292-8240"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terrence M Tumpey","raw_affiliation_strings":["Influenza Division, Centers for Disease Control and Prevention , Atlanta, GA 30333"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, GA 30333","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028535500","display_name":"Chelsey J. Huffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelsey J Huffman","raw_affiliation_strings":["Department of Pediatrics, Vanderbilt University Medical Center , Nashville, TN 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center , Nashville, TN 37232","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067720514","display_name":"Bryan S. Briney","orcid":"https://orcid.org/0000-0001-9535-2866","observed_orcids":["https://orcid.org/0000-0001-9535-2866"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan S Briney","raw_affiliation_strings":["Department of Pediatrics, Vanderbilt University Medical Center , Nashville, TN 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center , Nashville, TN 37232","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034782903","display_name":"Scott Alan Smith","orcid":"https://orcid.org/0000-0002-5519-8662","observed_orcids":["https://orcid.org/0000-0002-5519-8662","https://orcid.org/0000-0001-5153-2726"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A Smith","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232","\u00a7Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"\u00a7Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232; and","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054163903","display_name":"Christopher F. Basler","orcid":"https://orcid.org/0000-0003-4195-425X","observed_orcids":["https://orcid.org/0000-0003-4195-425X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher F Basler","raw_affiliation_strings":["Department of Microbiology, Mount Sinai School of Medicine , New York City, NY 10029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Mount Sinai School of Medicine , New York City, NY 10029","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046971682","display_name":"James E. Crowe","orcid":"https://orcid.org/0000-0002-0049-1079","observed_orcids":["https://orcid.org/0000-0002-0049-1079"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James E Crowe","raw_affiliation_strings":["\u00b6Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232","Department of Pediatrics, Vanderbilt University Medical Center , Nashville, TN 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center , Nashville, TN 37232","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046971682"],"corresponding_institution_ids":["https://openalex.org/I901861585"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":7.2708,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.97675621,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"187","issue":"7","first_page":"3704","last_page":"3711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-hemagglutinin","display_name":"influenza hemagglutinin","score":0.8730000257492065},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8889999985694885},{"id":"https://openalex.org/keywords/b-cell-repertoire","display_name":"B cell receptor repertoire","score":0.5239999890327454},{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/antibody-glycosylation","display_name":"antibody glycosylation","score":0.4659999907016754},{"id":"https://openalex.org/keywords/epitope-escape","display_name":"epitope escape","score":0.7049999833106995},{"id":"https://openalex.org/keywords/h1n1-influenza","display_name":"H1N1 influenza","score":0.7860000133514404},{"id":"https://openalex.org/keywords/affinity-maturation","display_name":"affinity maturation","score":0.46299999952316284},{"id":"https://openalex.org/keywords/antigenic-drift","display_name":"antigenic drift","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8581042885780334},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.7451923489570618},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.6889658570289612},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6111499071121216},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5476547479629517},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5404243469238281},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49041008949279785},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.4892990291118622},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.46533337235450745},{"id":"https://openalex.org/C7842527","wikidata":"https://www.wikidata.org/wiki/Q575258","display_name":"Antigenic drift","level":4,"score":0.456705778837204},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.41019320487976074}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.1101823","doi":"https://doi.org/10.4049/jimmunol.1101823","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1101823","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:21880983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21880983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3178754","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3178754","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3178754","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3178754","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1002678292","display_name":null,"funder_award_id":"CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1764958080","display_name":null,"funder_award_id":"DK058404","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G275969444","display_name":"Mount Sinai Institutes for Clinical and Translational Sciences","funder_award_id":"UL1RR029887","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3088297989","display_name":"MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF PANDEMIC FLU","funder_award_id":"P01AI058113","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3479296141","display_name":null,"funder_award_id":"HHSN272200900047C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5828220805","display_name":"1918 Influenza Virus-Neutralizing Antibodies from Individuals Born 1960-1990","funder_award_id":"R21AI085306","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6365056742","display_name":null,"funder_award_id":"EY-008126","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000862353","display_name":"Molecular and Cellular Basis for Digestive Diseases","funder_award_id":"P30DK058404","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000906943","display_name":"Core Grant in Vision Research","funder_award_id":"P30EY008126","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W112705421","https://openalex.org/W1480478557","https://openalex.org/W1489752929","https://openalex.org/W1525438580","https://openalex.org/W1607133945","https://openalex.org/W1964287936","https://openalex.org/W1973645409","https://openalex.org/W1984248194","https://openalex.org/W1996626942","https://openalex.org/W1997311863","https://openalex.org/W1998170980","https://openalex.org/W2000489836","https://openalex.org/W2001089308","https://openalex.org/W2006667246","https://openalex.org/W2017177963","https://openalex.org/W2020094108","https://openalex.org/W2022824615","https://openalex.org/W2026195872","https://openalex.org/W2049631297","https://openalex.org/W2054214000","https://openalex.org/W2061138316","https://openalex.org/W2061221862","https://openalex.org/W2061410538","https://openalex.org/W2062740562","https://openalex.org/W2066346013","https://openalex.org/W2067284235","https://openalex.org/W2068310820","https://openalex.org/W2068592034","https://openalex.org/W2071461138","https://openalex.org/W2074899179","https://openalex.org/W2098349861","https://openalex.org/W2119483297","https://openalex.org/W2127852419","https://openalex.org/W2129973151","https://openalex.org/W2135858175","https://openalex.org/W2139249955","https://openalex.org/W2142081242","https://openalex.org/W2148495628","https://openalex.org/W2149850870","https://openalex.org/W2152617913","https://openalex.org/W2157116486","https://openalex.org/W2163431518","https://openalex.org/W2164807254","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2148855679","https://openalex.org/W1943796204","https://openalex.org/W7096769729","https://openalex.org/W2169156878","https://openalex.org/W3132799312","https://openalex.org/W988335204","https://openalex.org/W2104403880","https://openalex.org/W4403682121","https://openalex.org/W1537411000","https://openalex.org/W3012408738"],"abstract_inverted_index":{"We":[0,141],"generated":[1],"from":[2,191],"a":[3,28,80,134,148],"single":[4],"blood":[5],"sample":[6],"five":[7,35],"independent":[8,48,67,131],"human":[9,194],"mAbs":[10],"that":[11,63,75,143,165,184],"recognized":[12],"the":[13,18,38,66,105,110,123],"Sa":[14],"antigenic":[15],"site":[16],"on":[17],"head":[19],"of":[20,31,58,65,71,82,95,117,130,147,151,154,160],"influenza":[21,174],"hemagglutinin":[22],"and":[23,40],"exhibited":[24,127],"inhibitory":[25],"activity":[26],"against":[27],"broad":[29],"panel":[30],"H1N1":[32],"strains.":[33],"All":[34],"Abs":[36],"used":[37],"V(H)3-7":[39],"J(H)6":[41],"gene":[42],"segments,":[43],"but":[44],"at":[45],"least":[46],"four":[47],"clones":[49,68,156,180],"were":[50,69],"identified":[51],"by":[52,128],"junctional":[53],"analysis.":[54],"High-throughput":[55],"sequence":[56,120],"analysis":[57],"circulating":[59],"B":[60,89],"cells":[61,90],"revealed":[62],"each":[64],"members":[70,129],"complex":[72],"phylogenetic":[73],"lineages":[74,94],"had":[76],"diversified":[77],"widely":[78],"using":[79],"pattern":[81],"progressive":[83],"diversification":[84],"through":[85],"somatic":[86,152],"mutation.":[87],"Unexpectedly,":[88],"encoding":[91],"multiple":[92],"diverging":[93],"these":[96,178],"clones,":[97,132],"including":[98],"many":[99],"containing":[100],"very":[101],"few":[102],"mutations":[103],"in":[104,109,122,145,167],"Ab":[106,179],"genes,":[107],"persisted":[108],"circulation.":[111],"Conversely,":[112],"we":[113],"noted":[114],"frequent":[115],"instances":[116],"amino":[118],"acid":[119],"convergence":[121],"Ag":[124],"combining":[125],"sites":[126,188],"suggesting":[133],"strong":[135],"selection":[136],"for":[137],"optimal":[138],"binding":[139],"sites.":[140],"suggest":[142],"maintenance":[144],"circulation":[146],"wide":[149],"diversity":[150],"variants":[153],"dominant":[155],"may":[157],"facilitate":[158],"recognition":[159],"drift":[161],"variant":[162],"virus":[163,170],"epitopes":[164],"occur":[166],"rapidly":[168],"mutating":[169],"Ags,":[171],"such":[172],"as":[173],"hemagglutinin.":[175],"In":[176],"fact,":[177],"recognize":[181],"an":[182],"epitope":[183],"acquired":[185],"three":[186],"glycosylation":[187],"mediating":[189],"escape":[190],"previously":[192],"isolated":[193],"Abs.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}