{"id":"https://openalex.org/W2169969738","doi":"https://doi.org/10.1530/eje.0.1470143","title":"Effect of the GH secretagogue L-163,255 and restricted feeding time on GH pulsatility in the rat","display_name":"Effect of the GH secretagogue L-163,255 and restricted feeding time on GH pulsatility in the rat","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2169969738","doi":"https://doi.org/10.1530/eje.0.1470143","mag":"2169969738","pmid":"https://pubmed.ncbi.nlm.nih.gov/12088931"},"language":"en","primary_location":{"id":"doi:10.1530/eje.0.1470143","doi":"https://doi.org/10.1530/eje.0.1470143","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1470143","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081783984","display_name":"Anargyros N. Moulas","orcid":"https://orcid.org/0000-0002-4681-6174","observed_orcids":["https://orcid.org/0000-0002-4681-6174"]},"institutions":[{"id":"https://openalex.org/I51955386","display_name":"Technological Educational Institute of Thessaly","ror":"https://ror.org/04056ja87","country_code":"GR","type":"education","lineage":["https://openalex.org/I51955386"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"AN Moulas","raw_affiliation_strings":["Department of Animal Production, Technological Education Institute (T.E.I.) of Larissa, GR 41110 Larissa, Greece. moulas@teilar.gr","Department of Animal Production, Technological Education Institute (T.E.I.) of Larissa, GR 41110 Larissa, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Production, Technological Education Institute (T.E.I.) of Larissa, GR 41110 Larissa, Greece. moulas@teilar.gr","institution_ids":["https://openalex.org/I51955386"]},{"raw_affiliation_string":"Department of Animal Production, Technological Education Institute (T.E.I.) of Larissa, GR 41110 Larissa, Greece","institution_ids":["https://openalex.org/I51955386"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Krieg RJ","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krieg RJ","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113664308","display_name":"J. D. Veldhuis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JD Veldhuis","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","Department of Biochemistry and Molecular Biophysics, Virginia Commonwealth University's Medical College of Virginia Campus, Richmond, Virginia 23298-0498, USA","Department of Pediatrics, Virginia Commonwealth University's Medical College of Virginia Campus, Richmond, Virginia 23298-0498, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Virginia Commonwealth University's Medical College of Virginia Campus, Richmond, Virginia 23298-0498, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]},{"raw_affiliation_string":"Department of Pediatrics, Virginia Commonwealth University's Medical College of Virginia Campus, Richmond, Virginia 23298-0498, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"last","author":{"id":null,"display_name":"JC Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JC Chan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Virginia Commonwealth University's Medical College of Virginia Campus, Richmond, Virginia 23298-0498, USA","Department of Pediatrics, Virginia Commonwealth University's Medical College of Virginia Campus, Richmond, Virginia 23298-0498, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Virginia Commonwealth University's Medical College of Virginia Campus, Richmond, Virginia 23298-0498, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]},{"raw_affiliation_string":"Department of Pediatrics, Virginia Commonwealth University's Medical College of Virginia Campus, Richmond, Virginia 23298-0498, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081783984"],"corresponding_institution_ids":["https://openalex.org/I51955386"],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":null,"fwci":0.1902,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.63392687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"147","issue":"1","first_page":"143","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-secretagogues","display_name":"growth hormone secretagogues","score":0.8379999995231628},{"id":"https://openalex.org/keywords/growth-hormone-pulsatility","display_name":"growth hormone pulsatility","score":0.9200000166893005},{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.6330000162124634},{"id":"https://openalex.org/keywords/meal-feeding","display_name":"meal feeding","score":0.6039999723434448},{"id":"https://openalex.org/keywords/meal-timing","display_name":"meal timing","score":0.7639999985694885},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.5460000038146973},{"id":"https://openalex.org/keywords/repeated-treatment","display_name":"repeated treatment","score":0.3720000088214874},{"id":"https://openalex.org/keywords/deconvolution","display_name":"deconvolution","score":0.7039999961853027},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7381739020347595},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7288455367088318},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.6423205137252808},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.5394248962402344},{"id":"https://openalex.org/C2780161494","wikidata":"https://www.wikidata.org/wiki/Q3510429","display_name":"Secretagogue","level":3,"score":0.5313278436660767},{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.4811652600765228},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4367740750312805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40973228216171265},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.34319770336151123},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08956137299537659}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011673","descriptor_name":"Pulsatile Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1530/eje.0.1470143","doi":"https://doi.org/10.1530/eje.0.1470143","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1470143","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:12088931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12088931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2183353118","display_name":null,"funder_award_id":"DK 07761","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G344580827","display_name":null,"funder_award_id":"AG-14799","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G36552548","display_name":"PEDIATRIC NEPHROLOGY TRAINING GRANT","funder_award_id":"T32DK007761","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G532277115","display_name":"VITAMIN E MODULATION OF PROGRESSIVE RENAL DISEASE","funder_award_id":"5r01dk050419-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6586361075","display_name":null,"funder_award_id":"DK50419","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G867037207","display_name":"THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN","funder_award_id":"R01AG014799","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W300311425","https://openalex.org/W1505863887","https://openalex.org/W1977182289","https://openalex.org/W1978904783","https://openalex.org/W1992301522","https://openalex.org/W1995734405","https://openalex.org/W2001208846","https://openalex.org/W2002748611","https://openalex.org/W2019931436","https://openalex.org/W2025246610","https://openalex.org/W2042134024","https://openalex.org/W2061776382","https://openalex.org/W2073256316","https://openalex.org/W2074457843","https://openalex.org/W2094719820","https://openalex.org/W2107364127","https://openalex.org/W2158534725","https://openalex.org/W2163865122","https://openalex.org/W2221176331","https://openalex.org/W2594231304"],"related_works":["https://openalex.org/W7098664927","https://openalex.org/W2001208846","https://openalex.org/W2074692039","https://openalex.org/W1992301522","https://openalex.org/W2319338389","https://openalex.org/W2134127282","https://openalex.org/W2197368411","https://openalex.org/W2005150551","https://openalex.org/W1988132413","https://openalex.org/W2002223604"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"the":[3,9,16,92,95,116,136,169,174],"effect":[4],"of":[5,19,34,94,118,135,158],"repeated":[6,197],"treatments":[7],"with":[8],"growth":[10],"hormone":[11],"secretagogue":[12],"(GHS)":[13],"L-163,255":[14,189],"on":[15],"pulsatile":[17],"release":[18,195],"GH":[20,108,119,194],"when":[21,144,206],"administered":[22,147,209],"in":[23,138,168,173,192,200,215],"meal-fed":[24,216],"rats":[25,35],"before":[26,122,148,210],"and":[27,51,65,81,107],"after":[28,91,152,196,213],"feeding.":[29,155],"DESIGN:":[30],"The":[31,43,132,156,202],"first":[32],"group":[33,114,171,176],"(AL,":[36],"n=6)":[37,54],"had":[38],"food":[39],"available":[40],"ad":[41],"libitum.":[42],"second":[44],"(restricted,":[45],"R,":[46,115],"n=6),":[47,50],"third":[48],"(GHSB,":[49],"fourth":[52],"(GHSA,":[53],"groups":[55],"were":[56,67,99,110,120,142],"fed":[57],"from":[58],"1100":[59],"to":[60,140],"1400":[61],"h.":[62],"Groups":[63],"GHSB":[64,170],"GHSA":[66,175],"given":[68],"GHS":[69,141,145,207],"by":[70,162],"gavage,":[71],"3.0":[72],"mg/kg":[73],"L-163,255,":[74],"at":[75,82,101],"1000":[76],"h":[77,84],"(before":[78],"feeding,":[79,86],"B)":[80],"1500":[83],"(after":[85],"A)":[87],"respectively.":[88],"Three":[89],"weeks":[90],"initiation":[93],"treatment,":[96],"blood":[97],"samples":[98],"collected":[100],"10-min":[102],"intervals":[103],"over":[104],"6":[105],"h,":[106],"levels":[109],"determined.":[111],"RESULTS:":[112],"In":[113],"concentrations":[117,134],"higher":[121,143,167],"feeding":[123,128,214],"(17.6+/-2.4":[124],"ng/ml)":[125,150,154],"than":[126,151,172,212],"during":[127],"(11.2+/-1.2":[129],"ng/ml),":[130],"P<0.05.":[131],"average":[133],"peak":[137],"response":[139],"was":[146,165],"(121.70+/-33.68":[149],"(49.67+/-17.87":[153],"mass":[157],"GH,":[159],"as":[160],"calculated":[161],"deconvolution":[163],"analysis":[164],"also":[166],"(251.6+/-64.1":[177],"ng/ml":[178,183],"per":[179,184],"min":[180,185],"vs":[181],"85.3+/-22.9":[182],"respectively,":[186],"P<0.05).":[187],"CONCLUSION:":[188],"is":[190,204,208],"effective":[191],"inducing":[193],"oral":[198],"administration":[199],"rats.":[201],"effectiveness":[203],"greater":[205],"rather":[211],"animals.":[217]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
