{"id":"https://openalex.org/W2169944161","doi":null,"title":"Cathepsins B, H, and L and their inhibitors stefin A and cystatin C in sera of melanoma patients.","display_name":"Cathepsins B, H, and L and their inhibitors stefin A and cystatin C in sera of melanoma patients.","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W2169944161","mag":"2169944161","pmid":"https://pubmed.ncbi.nlm.nih.gov/9815568"},"language":"en","primary_location":{"id":"pmid:9815568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059675124","display_name":"Janko Kos","orcid":"https://orcid.org/0000-0002-4228-3518","observed_orcids":["https://orcid.org/0000-0002-4228-3518"]},"institutions":[{"id":"https://openalex.org/I3006985408","display_name":"Jo\u017eef Stefan Institute","ror":"https://ror.org/05060sz93","country_code":"SI","type":"facility","lineage":["https://openalex.org/I3006985408"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"J Kos","raw_affiliation_strings":["Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, 1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, 1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064116320","display_name":"Borut \u0160tabuc","orcid":"https://orcid.org/0000-0002-5281-4802","observed_orcids":["https://orcid.org/0000-0002-5281-4802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Stabuc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002216987","display_name":"Ana Schweiger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Schweiger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049295690","display_name":"Marta Kra\u0161ovec","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Krasovec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018020613","display_name":"Nina Gunde Cimerman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Cimerman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056184136","display_name":"Nata\u0161a Kopitar\u2010Jerala","orcid":"https://orcid.org/0000-0003-1381-070X","observed_orcids":["https://orcid.org/0000-0003-1381-070X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Kopitar-Jerala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038818700","display_name":"Ivan Vrhovec","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Vrhovec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4061,"has_fulltext":false,"cited_by_count":180,"citation_normalized_percentile":{"value":0.90393936,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"10","first_page":"1815","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cathepsin-h","display_name":"cathepsin H","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cathepsin-l","display_name":"cathepsin L","score":1.0},{"id":"https://openalex.org/keywords/stefin-a","display_name":"stefin A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":1.0},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.8050000071525574},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8209999799728394},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9750000238418579},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9179999828338623},{"id":"https://openalex.org/keywords/chemoimmunotherapy-response","display_name":"chemoimmunotherapy response","score":0.9509999752044678},{"id":"https://openalex.org/keywords/advanced-melanoma","display_name":"advanced melanoma","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.75031578540802},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7041356563568115},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.6555315256118774},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6503102779388428},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5449265241622925},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.5123113393783569},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.45741671323776245},{"id":"https://openalex.org/C2780412452","wikidata":"https://www.wikidata.org/wiki/Q4505907","display_name":"Cystatin","level":4,"score":0.4316263198852539},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25514405965805054},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.11724087595939636},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.07860866189002991}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002401","descriptor_name":"Cathepsin B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002401","descriptor_name":"Cathepsin B","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015891","descriptor_name":"Cystatins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015993","descriptor_name":"Life Tables","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055312","descriptor_name":"Cystatin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055316","descriptor_name":"Cystatin C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056655","descriptor_name":"Cathepsin H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056668","descriptor_name":"Cathepsin L","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9815568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Comparative Study"},{"id":"mag:2169944161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W33785876","https://openalex.org/W99799268","https://openalex.org/W143588586","https://openalex.org/W1528494395","https://openalex.org/W1531559622","https://openalex.org/W1917686103","https://openalex.org/W1964189685","https://openalex.org/W1968319976","https://openalex.org/W1975136716","https://openalex.org/W1977560544","https://openalex.org/W1979300931","https://openalex.org/W1979501070","https://openalex.org/W1979873958","https://openalex.org/W1988784463","https://openalex.org/W2006235551","https://openalex.org/W2007431327","https://openalex.org/W2008614592","https://openalex.org/W2009017819","https://openalex.org/W2017491563","https://openalex.org/W2017709423","https://openalex.org/W2023289223","https://openalex.org/W2030777180","https://openalex.org/W2042272211","https://openalex.org/W2045373355","https://openalex.org/W2059596763","https://openalex.org/W2069787721","https://openalex.org/W2070866151","https://openalex.org/W2081733578","https://openalex.org/W2110680001","https://openalex.org/W2325453239","https://openalex.org/W2331848977","https://openalex.org/W2402088829","https://openalex.org/W2410154757","https://openalex.org/W2411931888","https://openalex.org/W2419449550","https://openalex.org/W2427676947","https://openalex.org/W2461211657","https://openalex.org/W2503602991","https://openalex.org/W2521749502","https://openalex.org/W2995133996","https://openalex.org/W3003233883"],"related_works":["https://openalex.org/W2086792167","https://openalex.org/W242056882","https://openalex.org/W1903026513","https://openalex.org/W2441270751","https://openalex.org/W2401910779","https://openalex.org/W2470997542","https://openalex.org/W2155593291","https://openalex.org/W2119609078","https://openalex.org/W2119474556","https://openalex.org/W1993304834"],"abstract_inverted_index":{"The":[0,50,75,157,231],"levels":[1,51,204,280],"of":[2,22,38,52,66,121,130,160,187,205,240,281],"cathepsins":[3],"(Cats)":[4],"B,":[5],"H,":[6],"and":[7,9,14,41,55,57,99,148,190,213,222,246,253,271,284],"L":[8,141],"their":[10],"inhibitors":[11],"stefin":[12,267],"A":[13],"cystatin":[15,58,102,149,269],"C":[16,59,103,150],"were":[17,60],"determined":[18],"in":[19,28,42,166,179,262],"the":[20,64,72,87,100,119,172,177,200,278],"sera":[21],"43":[23],"patients":[24,30,69,123,167,183,201,241,292],"with":[25,31,35,71,124,127,139,184,202,293],"metastatic":[26,39,67],"melanoma,":[27],"54":[29],"treated":[32],"cutaneous":[33],"melanoma":[34,68,122,182],"no":[36,125,169,249,260],"evidence":[37],"disease,":[40],"30":[43],"healthy":[44,73],"blood":[45],"donors,":[46],"using":[47,226],"quantitative":[48],"ELISAs.":[49],"Cats":[53,282],"B":[54,78,134,189,283],"H":[56,90,113,162,192,285],"significantly":[61,116,164,194],"higher":[62],"within":[63,118],"group":[65,120,239],"compared":[70,175],"controls.":[74],"median":[76,88,101,129],"Cat":[77,89,112,133,140,161,188,191,217,272],"was":[79,91,104,114,135,163,264],"4.8":[80],"versus":[81,93,106],"3.6":[82],"ng/ml":[83,95,108],"(P":[84,96,109],"<":[85,97,110,146,155,211,220],"0.013),":[86],"13.7":[92],"4.9":[94],"0.0001),":[98],"470":[105],"320":[107],"0.02).":[111],"also":[115],"increased":[117,165],"metastasis,":[126],"a":[128],"9.6":[131],"ng/ml.":[132],"found":[136,265],"to":[137,171,176],"correlate":[138],"(r":[142,151],"=":[143,152],"0.36;":[144],"P":[145,154,210,219],"0.02)":[147],"0.41;":[153],"0.008).":[156],"serum":[158,279],"level":[159,178],"showing":[168],"response":[170],"chemoimmunotherapy":[173],"as":[174,228,288],"responders.":[180],"Metastatic":[181],"high":[185],"contents":[186],"experienced":[193],"shorter":[195],"overall":[196],"survival":[197,263],"rates":[198],"than":[199],"low":[203],"each":[206],"enzyme":[207],"(Cat":[208],"B:":[209],"0.003":[212],"relative":[214,223],"risk,":[215,224],"2.5;":[216],"H:":[218],"0.006":[221],"2.4,":[225],"medians":[227],"cutoff":[229],"values).":[230],"other":[232],"potential":[233],"factors":[234,290],"for":[235,237,266,291],"prognosis":[236],"this":[238],"revealed":[242],"moderate":[243],"(histological":[244],"type":[245],"age)":[247],"or":[248],"(tumor":[250],"thickness,":[251],"sex,":[252],"lymph":[254],"node":[255],"metastasis)":[256],"prognostic":[257,289],"significance.":[258],"Similarly,":[259],"difference":[261],"A,":[268],"C,":[270],"L.":[273],"These":[274],"results":[275],"suggest":[276],"that":[277],"could":[286],"serve":[287],"advanced":[294],"melanoma.":[295]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}