{"id":"https://openalex.org/W2169935510","doi":null,"title":"Impairment of survival factor function potentiates chemotherapy-induced apoptosis in tumor cells.","display_name":"Impairment of survival factor function potentiates chemotherapy-induced apoptosis in tumor cells.","publication_year":1998,"publication_date":"1998-02-15","ids":{"openalex":"https://openalex.org/W2169935510","mag":"2169935510","pmid":"https://pubmed.ncbi.nlm.nih.gov/9485038"},"language":"en","primary_location":{"id":"pmid:9485038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9485038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041665063","display_name":"G\u00e1bor M. Lamm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195525897","display_name":"Research Institute of Molecular Pathology","ror":"https://ror.org/02c5jsm26","country_code":"AT","type":"facility","lineage":["https://openalex.org/I195525897"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G M Lamm","raw_affiliation_strings":["Research Institute of Molecular Pathology, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Molecular Pathology, Vienna, Austria","institution_ids":["https://openalex.org/I195525897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072271891","display_name":"Gerhard Christofori","orcid":"https://orcid.org/0000-0002-8696-9896","observed_orcids":["https://orcid.org/0000-0002-8696-9896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Christofori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5451,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.9370442,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"58","issue":"4","first_page":"801","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.03610000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.9779999852180481},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tumor-cell-survival","display_name":"tumor cell survival","score":0.6079999804496765},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/beta-cell-tumors","display_name":"beta cell tumors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9399999976158142},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":0.9570000171661377},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dominant-negative-receptor","display_name":"dominant negative receptor","score":0.6309999823570251},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6083943843841553},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5938089489936829},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49409201741218567},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.4299580156803131},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.42868250608444214},{"id":"https://openalex.org/C130287650","wikidata":"https://www.wikidata.org/wiki/Q17091190","display_name":"Growth factor receptor inhibitor","level":4,"score":0.4223373532295227},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3928678631782532},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.3764200806617737},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35592225193977356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3257324695587158},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.30827444791793823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3026263117790222},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007340","descriptor_name":"Insulinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007340","descriptor_name":"Insulinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9485038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9485038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2169935510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9485038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W7405620","https://openalex.org/W71615215","https://openalex.org/W139481359","https://openalex.org/W1484020898","https://openalex.org/W1520783088","https://openalex.org/W1541378865","https://openalex.org/W1542569743","https://openalex.org/W1543443055","https://openalex.org/W1562838305","https://openalex.org/W1591166893","https://openalex.org/W1591360311","https://openalex.org/W1601158247","https://openalex.org/W1621124914","https://openalex.org/W1760666683","https://openalex.org/W1827870815","https://openalex.org/W1863695472","https://openalex.org/W1877069809","https://openalex.org/W1926825532","https://openalex.org/W1965131913","https://openalex.org/W1965757356","https://openalex.org/W1969692213","https://openalex.org/W1969804540","https://openalex.org/W1982784171","https://openalex.org/W1985528986","https://openalex.org/W1997748522","https://openalex.org/W1999012962","https://openalex.org/W2000141884","https://openalex.org/W2003594755","https://openalex.org/W2007055603","https://openalex.org/W2012940389","https://openalex.org/W2025944087","https://openalex.org/W2026692684","https://openalex.org/W2028625808","https://openalex.org/W2032361307","https://openalex.org/W2036188996","https://openalex.org/W2038862314","https://openalex.org/W2038901680","https://openalex.org/W2043395027","https://openalex.org/W2048121649","https://openalex.org/W2052624241","https://openalex.org/W2059928759","https://openalex.org/W2060203869","https://openalex.org/W2079327471","https://openalex.org/W2082015778","https://openalex.org/W2089723533","https://openalex.org/W2106410559","https://openalex.org/W2111209219","https://openalex.org/W2127526484","https://openalex.org/W2138302361","https://openalex.org/W2140884727","https://openalex.org/W2150710841","https://openalex.org/W2152776758","https://openalex.org/W2164109910","https://openalex.org/W2164545422","https://openalex.org/W2166585583","https://openalex.org/W2172072395","https://openalex.org/W2314351677","https://openalex.org/W3121869049"],"related_works":["https://openalex.org/W2112206631","https://openalex.org/W1973299005","https://openalex.org/W7097672041","https://openalex.org/W1988668248","https://openalex.org/W1998961381","https://openalex.org/W1522008678","https://openalex.org/W1966872309","https://openalex.org/W2018623078","https://openalex.org/W225914980","https://openalex.org/W2118980160"],"abstract_inverted_index":{"The":[0],"balance":[1],"between":[2],"tumor":[3,14,37,54,71,159],"cell":[4,23,38,55,72],"proliferation":[5],"and":[6,103,105],"apoptosis":[7,84],"is":[8,31],"a":[9,17,49,63,80,139,149],"critical":[10],"determinant":[11],"of":[12,21,36,41,52,83,118,126,142,158,166],"malignant":[13],"outgrowth.":[15],"In":[16,89],"transgenic":[18,46],"mouse":[19],"model":[20],"beta":[22,53,70],"tumorigenesis":[24],"(Rip1Tag2),":[25],"insulin-like":[26],"growth":[27],"factor":[28,121,176],"II":[29],"(IGF-II)":[30],"up-regulated":[32],"during":[33],"the":[34,116,119,143,156,164],"onset":[35],"proliferation.":[39],"Disruption":[40],"IGF-II":[42,60,122],"expression":[43],"in":[44,155],"these":[45],"mice":[47,78],"causes":[48],"dramatic":[50],"increase":[51],"(betaTC)":[56],"apoptosis,":[57],"indicating":[58],"that":[59,69],"acts":[61],"as":[62,100,110],"survival":[64,120,157,175],"factor.":[65],"Here":[66],"we":[67],"report":[68],"lines":[73],"derived":[74],"from":[75],"IGF-II-deficient":[76,91],"Rip1Tag2":[77],"show":[79],"higher":[81],"incidence":[82],"than":[85],"their":[86],"wild-type":[87],"counterparts.":[88],"particular,":[90],"betaTCs":[92,130],"are":[93],"more":[94],"sensitive":[95],"to":[96,106,134],"apoptotic":[97],"stimuli,":[98],"such":[99,109],"serum":[101],"deprivation":[102],"staurosporine,":[104],"chemotherapeutic":[107,124],"agents,":[108],"daunomycin,":[111],"etoposide,":[112],"or":[113],"vincristine.":[114],"Thus,":[115],"lack":[117],"potentiates":[123],"treatment":[125],"betaTCs.":[127],"Furthermore,":[128],"normal":[129],"can":[131],"be":[132],"sensitized":[133],"chemotherapy":[135],"when":[136],"transfected":[137],"with":[138,174],"dominant-negative":[140],"mutant":[141],"IGF-I":[144],"receptor.":[145],"These":[146],"results":[147],"demonstrate":[148],"pivotal":[150],"role":[151],"for":[152],"IGF-mediated":[153],"signaling":[154],"cells":[160],"and,":[161],"thus,":[162],"raise":[163],"possibility":[165],"novel":[167],"approaches":[168],"toward":[169],"cancer":[170],"therapy":[171],"by":[172],"interfering":[173],"function.":[177]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}