{"id":"https://openalex.org/W2169923455","doi":"https://doi.org/10.1073/pnas.95.2.657","title":"Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes","display_name":"Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes","publication_year":1998,"publication_date":"1998-01-20","ids":{"openalex":"https://openalex.org/W2169923455","doi":"https://doi.org/10.1073/pnas.95.2.657","mag":"2169923455","pmid":"https://pubmed.ncbi.nlm.nih.gov/9435248","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/18476"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.95.2.657","doi":"https://doi.org/10.1073/pnas.95.2.657","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.95.2.657","pdf_url":"https://www.pnas.org/content/pnas/95/2/657.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/95/2/657.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Christopher A. Klug","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A. Klug","raw_affiliation_strings":["Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I161318765","https://openalex.org/I4210117453","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079548260","display_name":"Sean J. Morrison","orcid":"https://orcid.org/0000-0003-1587-8329","observed_orcids":["https://orcid.org/0000-0003-1587-8329"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean J. Morrison","raw_affiliation_strings":["Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I161318765","https://openalex.org/I4210117453","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marilyn Masek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilyn Masek","raw_affiliation_strings":["Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I161318765","https://openalex.org/I4210117453","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109192025","display_name":"Kyungmin Hahm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyungmin Hahm","raw_affiliation_strings":["Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I161318765","https://openalex.org/I4210117453","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055489898","display_name":"Stephen T. Smale","orcid":"https://orcid.org/0000-0002-9835-6907","observed_orcids":["https://orcid.org/0000-0002-9835-6907"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen T. Smale","raw_affiliation_strings":["Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I161318765","https://openalex.org/I4210117453","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082894731","display_name":"Irving L. Weissman","orcid":"https://orcid.org/0000-0002-9077-7467","observed_orcids":["https://orcid.org/0000-0002-9077-7467"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irving L. Weissman","raw_affiliation_strings":["Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5428; Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125; Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024-1662","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I161318765","https://openalex.org/I4210117453","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.5021,"has_fulltext":true,"cited_by_count":168,"citation_normalized_percentile":{"value":0.98391275,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"95","issue":"2","first_page":"657","last_page":"662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7797999978065491,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7797999978065491,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.1753000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ikaros","display_name":"Ikaros","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ikzf1","display_name":"IKZF1","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/lymphoid-progenitors","display_name":"lymphoid progenitors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8019999861717224},{"id":"https://openalex.org/keywords/zinc-finger-transcription-factor","display_name":"zinc finger transcription factor","score":0.8050000071525574},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pre-b-cells","display_name":"pre-B cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/lymphoid-development","display_name":"lymphoid development","score":0.8759999871253967},{"id":"https://openalex.org/keywords/multipotent-progenitors","display_name":"multipotent progenitors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7885068655014038},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6693601608276367},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6476550102233887},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5952115654945374},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5114044547080994},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.49020296335220337},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.48362815380096436},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.3977266550064087},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2228211760520935},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1043718159198761}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006570","descriptor_name":"Heterochromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006570","descriptor_name":"Heterochromatin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051740","descriptor_name":"Ikaros Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.95.2.657","doi":"https://doi.org/10.1073/pnas.95.2.657","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.95.2.657","pdf_url":"https://www.pnas.org/content/pnas/95/2/657.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1235172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/18476","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:18476","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/18476","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9435248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9435248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:authors.library.caltech.edu:52269","doi":null,"is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20141202-112044031","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.95.2.657","doi":"https://doi.org/10.1073/pnas.95.2.657","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.95.2.657","pdf_url":"https://www.pnas.org/content/pnas/95/2/657.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7177514046","display_name":"NORMAL AND NEOPLASTIC LYMPHOCYTE MATURATION","funder_award_id":"R35CA042551","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2169923455.pdf","grobid_xml":"https://content.openalex.org/works/W2169923455.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W19721907","https://openalex.org/W81453212","https://openalex.org/W1588840730","https://openalex.org/W1883290480","https://openalex.org/W1968115774","https://openalex.org/W1969676330","https://openalex.org/W1982295124","https://openalex.org/W1989645452","https://openalex.org/W1995286997","https://openalex.org/W1998566378","https://openalex.org/W2001488949","https://openalex.org/W2019338546","https://openalex.org/W2021312689","https://openalex.org/W2027509917","https://openalex.org/W2047724514","https://openalex.org/W2048365283","https://openalex.org/W2059696301","https://openalex.org/W2069501059","https://openalex.org/W2071023317","https://openalex.org/W2087181226","https://openalex.org/W2091253809","https://openalex.org/W2106960031","https://openalex.org/W2120141012","https://openalex.org/W2123791127","https://openalex.org/W2143041969","https://openalex.org/W2146924580","https://openalex.org/W2149939821","https://openalex.org/W2152414109","https://openalex.org/W2156692094","https://openalex.org/W2160000876","https://openalex.org/W2169846226","https://openalex.org/W2175016040"],"related_works":["https://openalex.org/W2048365283","https://openalex.org/W2143041969","https://openalex.org/W2017165266","https://openalex.org/W2053126869","https://openalex.org/W167122770","https://openalex.org/W3114780995","https://openalex.org/W6948095308","https://openalex.org/W1529336396","https://openalex.org/W2004862158","https://openalex.org/W1973054937"],"abstract_inverted_index":{"The":[0],"generation":[1],"of":[2,11,45,68,81,88,102],"lymphoid":[3,155],"cells":[4,70,113,119],"in":[5,38,65,85,97,137,154],"mice":[6,35],"depends":[7],"on":[8],"the":[9,12,43,47,78,86,89,98],"function":[10],"Ikaros":[13,15,33,63,82,103,133,153],"protein.":[14],"has":[16],"been":[17],"characterized":[18],"as":[19,109,122],"a":[20,149],"lymphoid-restricted,":[21],"zinc-finger":[22],"transcription":[23],"factor":[24],"that":[25,77],"is":[26],"derived":[27],"from":[28],"an":[29],"alternatively":[30],"spliced":[31],"message.":[32],"knockout":[34],"have":[36],"defects":[37],"multiple":[39,50],"cell":[40,94],"lineages,":[41],"raising":[42],"question":[44],"whether":[46],"protein":[48],"regulates":[49],"committed":[51,73],"progenitors":[52,125],"and/or":[53],"multipotent":[54,69,124],"stem":[55,93,112,118],"cells.":[56],"To":[57],"address":[58],"this":[59],"issue,":[60],"we":[61,131],"examined":[62],"expression":[64],"purified":[66],"populations":[67],"and":[71,120],"more":[72],"progenitors.":[74,129],"We":[75],"found":[76,132],"DNA-binding":[79],"isoforms":[80],"were":[83],"localized":[84,134],"nucleus":[87],"most":[90],"primitive":[91],"hematopoietic":[92],"subset.":[95],"Changes":[96],"RNA":[99],"splicing":[100],"pattern":[101],"occurred":[104],"at":[105],"two":[106],"stages:":[107],"(i)":[108],"long-term":[110],"self-renewing":[111,117],"differentiated":[114,126],"into":[115,127],"short-term":[116],"(ii)":[121],"non-self-renewing":[123],"lymphoid-committed":[128],"Unexpectedly,":[130],"to":[135],"heterochromatin":[136],"Abelson-transformed":[138],"pre-B":[139],"lymphocytes":[140],"by":[141],"using":[142],"immunogold":[143],"electron":[144],"microscopy.":[145],"These":[146],"observations":[147],"suggest":[148],"complex":[150],"role":[151],"for":[152],"development.":[156]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
