{"id":"https://openalex.org/W2169908075","doi":"https://doi.org/10.1084/jem.183.6.2635","title":"HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis.","display_name":"HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis.","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W2169908075","doi":"https://doi.org/10.1084/jem.183.6.2635","mag":"2169908075","pmid":"https://pubmed.ncbi.nlm.nih.gov/8676084","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2192625"},"language":"en","primary_location":{"id":"doi:10.1084/jem.183.6.2635","doi":"https://doi.org/10.1084/jem.183.6.2635","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.183.6.2635","pdf_url":"https://rupress.org/jem/article-pdf/183/6/2635/1678546/2635.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/183/6/2635/1678546/2635.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071677758","display_name":"Kouichi Ito","orcid":"https://orcid.org/0000-0002-0424-2125","observed_orcids":["https://orcid.org/0000-0002-0424-2125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ito","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079108200","display_name":"Hongjin Bian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Bian","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042685010","display_name":"M. Rosana S. Molina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Molina","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025365221","display_name":"Jaeseok Han","orcid":"https://orcid.org/0000-0001-6402-9740","observed_orcids":["https://orcid.org/0000-0001-6402-9740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Han","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032929917","display_name":"Jeanne Magram","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Magram","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"E Saar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Saar","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075548751","display_name":"Charles J. Belunis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Belunis","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"D R Bolin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R Bolin","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"R Arceo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Arceo","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081805141","display_name":"Robert M. Campbell","orcid":"https://orcid.org/0000-0003-0345-6516","observed_orcids":["https://orcid.org/0000-0003-0345-6516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Campbell","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090159756","display_name":"Fiorenza Falcioni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Falcioni","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081047915","display_name":"Damir Vidovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Vidovi\u0107","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033293194","display_name":"J\u00fcrgen Hammer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Hammer","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042486585","display_name":"Zolt\u00e1n \u00c1. Nagy","orcid":"https://orcid.org/0000-0002-8947-6448","observed_orcids":["https://orcid.org/0000-0002-8947-6448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z A Nagy","raw_affiliation_strings":["Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.6881,"has_fulltext":true,"cited_by_count":193,"citation_normalized_percentile":{"value":0.97470164,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"183","issue":"6","first_page":"2635","last_page":"2644"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-dr4","display_name":"HLA-DR4","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hla-drb1-04-01","display_name":"HLA-DRB1*0401","score":0.8659999966621399},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/autoimmune-disease-susceptibility","display_name":"autoimmune disease susceptibility","score":0.7269999980926514},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/myelin-basic-protein","display_name":"myelin basic protein","score":0.6669999957084656},{"id":"https://openalex.org/keywords/proteolipid-protein","display_name":"proteolipid protein","score":0.9909999966621399},{"id":"https://openalex.org/keywords/immunodominant-epitopes","display_name":"immunodominant epitopes","score":0.8870000243186951},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.6324504613876343},{"id":"https://openalex.org/C7821365","wikidata":"https://www.wikidata.org/wiki/Q14912011","display_name":"Proteolipid protein 1","level":5,"score":0.5928979516029358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5793622732162476},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5772868394851685},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5366997122764587},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.5355579257011414},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5245050191879272},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5071349143981934},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5016870498657227},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.49694064259529114},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.4731135070323944},{"id":"https://openalex.org/C21957315","wikidata":"https://www.wikidata.org/wiki/Q287896","display_name":"Beta-2 microglobulin","level":2,"score":0.4662695527076721},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4524102210998535},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43121108412742615},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.42472490668296814},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.23826605081558228},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14770793914794922},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07227450609207153},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0695393979549408},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.06846502423286438},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005802","descriptor_name":"Genes, MHC Class II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009185","descriptor_name":"Myelin Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015804","descriptor_name":"HLA-DR4 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059805","descriptor_name":"HLA-DR alpha-Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059811","descriptor_name":"HLA-DRB1 Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1084/jem.183.6.2635","doi":"https://doi.org/10.1084/jem.183.6.2635","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.183.6.2635","pdf_url":"https://rupress.org/jem/article-pdf/183/6/2635/1678546/2635.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2192625","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2192625","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:8676084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8676084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.284.1577","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.284.1577","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1b/4f/J_Exp_Med_1996_Jun_1_183(6)_2635-2644.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1084/jem.183.6.2635","doi":"https://doi.org/10.1084/jem.183.6.2635","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.183.6.2635","pdf_url":"https://rupress.org/jem/article-pdf/183/6/2635/1678546/2635.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309432","display_name":"F. Hoffmann-La Roche","ror":"https://ror.org/00by1q217"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2169908075.pdf","grobid_xml":"https://content.openalex.org/works/W2169908075.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1482318554","https://openalex.org/W1522399766","https://openalex.org/W1581073319","https://openalex.org/W1587724111","https://openalex.org/W1624101748","https://openalex.org/W1639391087","https://openalex.org/W1656620318","https://openalex.org/W1704042180","https://openalex.org/W1925667402","https://openalex.org/W1976257073","https://openalex.org/W1982021670","https://openalex.org/W1984288819","https://openalex.org/W1987105386","https://openalex.org/W1990640592","https://openalex.org/W2003769309","https://openalex.org/W2040838085","https://openalex.org/W2046202438","https://openalex.org/W2047150609","https://openalex.org/W2051527779","https://openalex.org/W2060095976","https://openalex.org/W2077924884","https://openalex.org/W2079833943","https://openalex.org/W2081395451","https://openalex.org/W2091616465","https://openalex.org/W2093143038","https://openalex.org/W2095408546","https://openalex.org/W2109180598","https://openalex.org/W2127880180","https://openalex.org/W2150501046","https://openalex.org/W2157744956","https://openalex.org/W2165500378","https://openalex.org/W2171397519"],"related_works":["https://openalex.org/W1993276441","https://openalex.org/W1972677079","https://openalex.org/W2004879939","https://openalex.org/W2027213907","https://openalex.org/W1992731679","https://openalex.org/W1570193556","https://openalex.org/W4313305882","https://openalex.org/W46018229","https://openalex.org/W2047150609","https://openalex.org/W2077915791"],"abstract_inverted_index":{"To":[0],"investigate":[1],"the":[2,34,38,47,88,138,214],"development":[3,89,139],"of":[4,25,81,90,112,140,198,213,218],"HLA-DR-associated":[5],"autoimmune":[6,91,270],"diseases,":[7],"we":[8],"generated":[9],"transgenic":[10],"(Tg)":[11],"mice":[12,65,76,167,239],"with":[13,117,170,224,241],"HLA-DRA-IE":[14,118,133],"alpha":[15,96,100,119],"and":[16,30,33,40,54,159,177,206,216,234],"HLA-DRB1*0401-IE":[17],"beta":[18,97,101,115,135,154,157,161],"chimeric":[19,44],"genes.":[20],"The":[21,43,63,132],"transgene-encoded":[22],"proteins":[23],"consisted":[24],"antigen-binding":[26,49],"domains":[27,36],"from":[28,37,203],"HLA-DRA":[29],"HLA-DRB1*0401":[31,52],"molecules":[32,45,102,136],"remaining":[35],"IE(d)-alpha":[39],"IE(d)-beta":[41],"chains.":[42],"showed":[46],"same":[48],"specificity":[50],"as":[51],"molecules,":[53],"were":[55,66,103,163,168],"functional":[56],"in":[57,106,123,144,189,210],"presenting":[58],"antigens":[59],"to":[60,68,77,185,265],"T":[61,142,150,201,231],"cells.":[62],"Tg":[64,107,125,166,204],"backcrossed":[67],"MHC":[69,83,145,256],"class":[70,84,146,257],"II-deficient":[71,147],"(IA":[72],"beta-,":[73],"IE":[74,99,114],"alpha-)":[75],"eliminate":[78],"any":[79],"effect":[80],"endogenous":[82,113],"II":[85,258],"genes":[86],"on":[87],"diseases.":[92],"As":[93],"expected,":[94],"IA":[95],"or":[98,244],"not":[104,121,247],"expressed":[105],"mice.":[108],"Moreover,":[109],"cell-surface":[110],"expression":[111],"associated":[116],"was":[120],"detectable":[122],"several":[124],"mouse":[126],"lines":[127],"by":[128],"flow":[129],"cytometric":[130],"analysis.":[131],"alpha/HLA-DRB1*0401-IE":[134],"rescued":[137],"CD4+":[141],"cells":[143,151,202],"mice,":[148,205],"but":[149],"expressing":[152],"V":[153,156,160],"5,":[155],"11,":[158],"12":[162],"specifically":[164],"deleted.":[165],"immunized":[169,240],"peptides,":[171],"myelin":[172],"basic":[173],"protein":[174,179],"(MBP)":[175],"87-106":[176],"proteolipid":[178],"(PLP)":[180],"175-192,":[181],"that":[182,253],"are":[183],"considered":[184],"be":[186],"immunodominant":[187],"epitopes":[188],"HLA-DR4":[190],"individuals.":[191],"PLP175-192":[192,243],"provoked":[193],"a":[194,227,254],"strong":[195],"proliferative":[196,230],"response":[197,233],"lymph":[199],"node":[200],"caused":[207,235],"inflammatory":[208],"lesions":[209],"white":[211],"matter":[212],"CNS":[215],"symptoms":[217],"experimental":[219],"allergic":[220],"encephalomyelitis":[221],"(EAE).":[222],"Immunization":[223],"MBP87-106":[225,245],"elicited":[226],"very":[228],"weak":[229],"cell":[232],"mild":[236],"EAE.":[237,249],"Non-Tg":[238],"either":[242],"did":[246],"develop":[248],"These":[250],"results":[251],"demonstrated":[252],"human":[255],"binding":[259],"site":[260],"alone":[261],"can":[262],"confer":[263],"susceptibility":[264],"an":[266],"experimentally":[267],"induced":[268],"murine":[269],"disease.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
