{"id":"https://openalex.org/W2169901259","doi":null,"title":"Electrochemotherapy in cancer patients: first clinical trial in Greece.","display_name":"Electrochemotherapy in cancer patients: first clinical trial in Greece.","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2169901259","mag":"2169901259","pmid":"https://pubmed.ncbi.nlm.nih.gov/21471545"},"language":"en","primary_location":{"id":"pmid:21471545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21471545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011394643","display_name":"Ioannis Skarlatos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121914","display_name":"St Savas Hospital","ror":"https://ror.org/036h9st94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210121914"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Skarlatos","raw_affiliation_strings":["First Department of Radiation Oncology, St. Savvas Anticancer Hospital of Athens, 171 Alexandras Ave., 11522, Athens, Greece. skarl@ath.forthnet.gr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Radiation Oncology, St. Savvas Anticancer Hospital of Athens, 171 Alexandras Ave., 11522, Athens, Greece. skarl@ath.forthnet.gr","institution_ids":["https://openalex.org/I4210121914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035112588","display_name":"George Kyrgias","orcid":"https://orcid.org/0000-0002-6122-7634","observed_orcids":["https://orcid.org/0000-0002-6122-7634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Kyrgias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071963164","display_name":"Eytyxia Mosa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eytyxia Mosa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041570147","display_name":"Xeni Provatopoulou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xeni Provatopoulou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Spyrou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Spyrou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103569403","display_name":"Kyriaki Theodorou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyriaki Theodorou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068554694","display_name":"Antonios Lepouras","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonios Lepouras","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049936783","display_name":"Antonia Gounaris","orcid":"https://orcid.org/0000-0001-9170-1651","observed_orcids":["https://orcid.org/0000-0001-9170-1651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonia Gounaris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026228151","display_name":"Michael Ioannis Koukourakis","orcid":"https://orcid.org/0000-0002-2324-699X","observed_orcids":["https://orcid.org/0000-0002-2324-699X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Koukourakis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0745,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.72098922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"2","first_page":"265","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrochemotherapy","display_name":"electrochemotherapy","score":1.0},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cutaneous-tumors","display_name":"cutaneous tumors","score":0.8199999928474426},{"id":"https://openalex.org/keywords/recurrent-tumor","display_name":"recurrent tumor","score":0.671999990940094},{"id":"https://openalex.org/keywords/local-tumor-control","display_name":"local tumor control","score":0.7979999780654907},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.7089999914169312},{"id":"https://openalex.org/keywords/brachytherapy","display_name":"brachytherapy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6100000143051147},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.75}],"concepts":[{"id":"https://openalex.org/C2777108052","wikidata":"https://www.wikidata.org/wiki/Q3137263","display_name":"Electrochemotherapy","level":4,"score":0.960078239440918},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.8023865222930908},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7832220792770386},{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.6740448474884033},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5260517597198486},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4793299436569214},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4279817044734955},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4261510968208313},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39657700061798096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23184734582901},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1568179428577423}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006115","descriptor_name":"Greece","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053672","descriptor_name":"Electrochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21471545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21471545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Clinical Trial"},{"id":"mag:2169901259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21471545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W85067608","https://openalex.org/W169771143","https://openalex.org/W1490324405","https://openalex.org/W1972913617","https://openalex.org/W1977625153","https://openalex.org/W1981579055","https://openalex.org/W1982549056","https://openalex.org/W1988230026","https://openalex.org/W1988403890","https://openalex.org/W1998980212","https://openalex.org/W2008522415","https://openalex.org/W2015729552","https://openalex.org/W2021312203","https://openalex.org/W2033516066","https://openalex.org/W2041472987","https://openalex.org/W2044686244","https://openalex.org/W2053525254","https://openalex.org/W2055851137","https://openalex.org/W2056104198","https://openalex.org/W2072230940","https://openalex.org/W2072783319","https://openalex.org/W2088523359","https://openalex.org/W2088924447","https://openalex.org/W2100820352","https://openalex.org/W2108153643","https://openalex.org/W2109250391","https://openalex.org/W2111409695","https://openalex.org/W2113381172","https://openalex.org/W2116679286","https://openalex.org/W2121420886","https://openalex.org/W2125990297","https://openalex.org/W2127480875","https://openalex.org/W2144688973","https://openalex.org/W2146362841","https://openalex.org/W2158229432","https://openalex.org/W2159995158","https://openalex.org/W2167670081","https://openalex.org/W2328143196","https://openalex.org/W2328333669","https://openalex.org/W2331285763","https://openalex.org/W2409788302"],"related_works":["https://openalex.org/W2013130076","https://openalex.org/W2162071711","https://openalex.org/W2644075232","https://openalex.org/W2085644112","https://openalex.org/W2014027326","https://openalex.org/W1993234213","https://openalex.org/W2168725163","https://openalex.org/W2603137958","https://openalex.org/W2515052152","https://openalex.org/W4410280735"],"abstract_inverted_index":{"Electrochemotherapy":[0],"is":[1,103],"currently":[2],"undergoing":[3],"intensive":[4],"investigation":[5],"in":[6,44,54,94],"the":[7,25,79,107],"field":[8],"of":[9,12,28,78,91,110,112],"local":[10,87],"control":[11,109],"cancer.":[13],"In":[14],"Greece,":[15],"five":[16],"medical":[17],"centers":[18],"have":[19],"co-operated":[20],"to":[21,61],"perform":[22],"ECT":[23,39,92],"for":[24,67],"efficient":[26],"management":[27],"growing,":[29],"recurrent":[30],"or":[31,43],"newly":[32],"emerging":[33],"cutaneous":[34],"and":[35,52,75,105,115],"subcutaneous":[36],"tumor":[37],"nodules.":[38,81],"was":[40,70],"applied":[41],"alone":[42],"combination":[45],"with":[46],"external":[47],"beam":[48],"radiation":[49],"therapy,":[50],"brachytherapy":[51],"surgery":[53],"52":[55],"cancer":[56],"patients,":[57],"using":[58],"bleomycin":[59],"according":[60],"standard":[62],"protocols.":[63],"The":[64,89],"treatment":[65,101],"response":[66],"various":[68,113],"tumors":[69,111],"63.83%":[71],"complete,":[72],"31.91%":[73],"partial,":[74],"95.74%":[76],"overall":[77],"treated":[80],"Patients":[82],"exerted":[83],"neither":[84],"systemic":[85],"nor":[86],"side-effects.":[88],"results":[90],"performance":[93],"Greece":[95],"provided":[96],"evidence":[97],"that":[98],"this":[99],"new":[100],"strategy":[102],"safe":[104],"permits":[106],"effective":[108],"origins":[114],"histological":[116],"types.":[117]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}