{"id":"https://openalex.org/W2169816347","doi":"https://doi.org/10.1172/jci36131","title":"Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells","display_name":"Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells","publication_year":2009,"publication_date":"2009-06-08","ids":{"openalex":"https://openalex.org/W2169816347","doi":"https://doi.org/10.1172/jci36131","mag":"2169816347","pmid":"https://pubmed.ncbi.nlm.nih.gov/19509467","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2701858"},"language":"en","primary_location":{"id":"doi:10.1172/jci36131","doi":"https://doi.org/10.1172/jci36131","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci36131","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2701858","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005436502","display_name":"Wendy K. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy K. Roberts","raw_affiliation_strings":["Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA","Howard Hughes Medical Institute and","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090480401","display_name":"Ilana J. DeLuca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilana J. Deluca","raw_affiliation_strings":["Howard Hughes Medical Institute and","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045614588","display_name":"Ashby Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashby Thomas","raw_affiliation_strings":["Howard Hughes Medical Institute and","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074594448","display_name":"John J. Fak","orcid":"https://orcid.org/0000-0002-7237-4699","observed_orcids":["https://orcid.org/0000-0002-7237-4699"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Fak","raw_affiliation_strings":["Howard Hughes Medical Institute and","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061558169","display_name":"Travis L. Williams","orcid":"https://orcid.org/0000-0002-0208-3431","observed_orcids":["https://orcid.org/0000-0002-0208-3431"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis Williams","raw_affiliation_strings":["Howard Hughes Medical Institute and","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051648778","display_name":"Noreen Buckley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noreen Buckley","raw_affiliation_strings":["Howard Hughes Medical Institute and","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085622245","display_name":"Athanasios Dousmanis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Athanasios G. Dousmanis","raw_affiliation_strings":["Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111371793","display_name":"Jerome B. Posner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome B. Posner","raw_affiliation_strings":["Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035034609","display_name":"Robert B. Darnell","orcid":"https://orcid.org/0000-0002-5134-8088","observed_orcids":["https://orcid.org/0000-0002-5134-8088"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert B. Darnell","raw_affiliation_strings":["Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","Howard Hughes Medical Institute and","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035034609"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1344073410","https://openalex.org/I83399316"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":3.2563,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.92430065,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"119","issue":"7","first_page":"2042","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5727999806404114,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5727999806404114,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.3402999937534332,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/type-2-cytokines","display_name":"type 2 cytokines","score":0.8640000224113464},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9649999737739563},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tumor-antigen-specific-t-cells","display_name":"tumor antigen-specific T cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/paraneoplastic-cerebellar-degeneration","display_name":"paraneoplastic cerebellar degeneration","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.639225959777832},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.631593644618988},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6089933514595032},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5800010561943054},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.562673807144165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48535481095314026},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.47543787956237793},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46830928325653076},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4449107348918915},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4161111116409302},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37819576263427734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.373250275850296},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3626347780227661},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10627931356430054},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09824866056442261},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067779","descriptor_name":"ELAV-Like Protein 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020362","descriptor_name":"Paraneoplastic Cerebellar Degeneration","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051959","descriptor_name":"ELAV Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci36131","doi":"https://doi.org/10.1172/jci36131","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci36131","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2701858","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2701858","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:19509467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19509467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2701858","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2701858","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G390224135","display_name":"Transforming Translational Science and Education to Benefit Human Health","funder_award_id":"UL1RR024143","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6777264179","display_name":null,"funder_award_id":"10021","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7054974147","display_name":"Tolerance versus tumor immunity in PND","funder_award_id":"R01CA085784","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000187834","display_name":null,"funder_award_id":"RR024143","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W187047728","https://openalex.org/W1533836571","https://openalex.org/W1571495508","https://openalex.org/W1579770523","https://openalex.org/W1817153273","https://openalex.org/W1964435516","https://openalex.org/W1966333025","https://openalex.org/W1967016761","https://openalex.org/W1972922050","https://openalex.org/W1973474949","https://openalex.org/W1979657237","https://openalex.org/W1991893050","https://openalex.org/W1992515367","https://openalex.org/W1992996825","https://openalex.org/W1993599565","https://openalex.org/W1995449744","https://openalex.org/W2012403244","https://openalex.org/W2014266239","https://openalex.org/W2016196890","https://openalex.org/W2019214729","https://openalex.org/W2035869111","https://openalex.org/W2041555606","https://openalex.org/W2042932408","https://openalex.org/W2043318055","https://openalex.org/W2046553158","https://openalex.org/W2060708740","https://openalex.org/W2061040031","https://openalex.org/W2062889582","https://openalex.org/W2063550875","https://openalex.org/W2067396413","https://openalex.org/W2082615180","https://openalex.org/W2085106063","https://openalex.org/W2090009109","https://openalex.org/W2093730193","https://openalex.org/W2097413644","https://openalex.org/W2113170330","https://openalex.org/W2114280442","https://openalex.org/W2133916339","https://openalex.org/W2147391813","https://openalex.org/W2170375626","https://openalex.org/W4253422011","https://openalex.org/W4293081664"],"related_works":["https://openalex.org/W2246493554","https://openalex.org/W1967016761","https://openalex.org/W7100167400","https://openalex.org/W2078533888","https://openalex.org/W2118588377","https://openalex.org/W94588973","https://openalex.org/W2031263853","https://openalex.org/W1982718806","https://openalex.org/W2076087427","https://openalex.org/W2085968407"],"abstract_inverted_index":{"Paraneoplastic":[0],"neurologic":[1,49],"disorders":[2],"(PNDs)":[3],"offer":[4],"an":[5,92,169],"uncommon":[6],"opportunity":[7],"to":[8,29,31,54,56,156,197],"study":[9],"human":[10],"tumor":[11,36,141,188,193],"immunity":[12],"and":[13,90,129,131,147,182],"autoimmunity.":[14],"In":[15],"small":[16],"cell":[17,174],"lung":[18],"cancer":[19],"(SCLC),":[20],"expression":[21],"of":[22,35,42,45,106,109,168],"the":[23,46,158,166,178],"HuD":[24],"neuronal":[25],"antigen":[26],"is":[27],"thought":[28],"lead":[30],"immune":[32,189],"recognition,":[33],"suppression":[34],"growth,":[37],"and,":[38],"in":[39,64,77,87,175],"a":[40],"subset":[41],"patients,":[43],"triggering":[44],"Hu":[47,78,88,102,179],"paraneoplastic":[48,65,180],"syndrome.":[50],"Antigen-specific":[51],"CTLs":[52,116],"believed":[53],"contribute":[55],"disease":[57],"pathophysiology":[58],"were":[59],"described":[60],"10":[61],"years":[62],"ago":[63],"cerebellar":[66],"degeneration.":[67],"Despite":[68],"parallel":[69],"efforts,":[70],"similar":[71],"cells":[72,86,120,142,155,196],"have":[73,82],"not":[74],"been":[75,99],"defined":[76],"patients.":[79],"Here,":[80],"we":[81,136],"identified":[83],"HuD-specific":[84,110],"T":[85,112,119,154,173,195],"patients":[89,103,176],"provided":[91],"explanation":[93],"for":[94],"why":[95],"their":[96],"detection":[97],"has":[98],"elusive.":[100],"Different":[101],"harbored":[104],"1":[105],"2":[107,124,145,161],"kinds":[108],"CD8+":[111,153,172],"cells:":[113],"classical":[114],"IFN-gamma-producing":[115],"or":[117],"unusual":[118,170,199],"that":[121,139,148,184],"produced":[122,143],"type":[123,144,160],"cytokines,":[125],"most":[126],"prominently":[127],"IL-13":[128],"IL-5,":[130],"lacked":[132],"cytolytic":[133],"activity.":[134],"Further,":[135],"found":[137],"evidence":[138],"SCLC":[140,185],"cytokines":[146,150],"these":[149],"trigger":[151],"naive":[152],"adopt":[157],"atypical":[159],"phenotype.":[162,201],"These":[163],"observations":[164],"demonstrate":[165],"presence":[167],"noncytotoxic":[171],"with":[177],"syndrome":[181],"suggest":[183],"may":[186],"evade":[187],"surveillance":[190],"by":[191],"skewing":[192],"antigen-specific":[194],"this":[198],"noncytolytic":[200]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
