{"id":"https://openalex.org/W2169775201","doi":null,"title":"Macrophage-mediated induction of drug-resistant variants in a mouse mammary tumor cell line.","display_name":"Macrophage-mediated induction of drug-resistant variants in a mouse mammary tumor cell line.","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W2169775201","mag":"2169775201","pmid":"https://pubmed.ncbi.nlm.nih.gov/3084067"},"language":"en","primary_location":{"id":"pmid:3084067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3084067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005482537","display_name":"Kenji Yamashina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Yamashina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108226172","display_name":"Bonnie E. Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B E Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111404599","display_name":"Gloria H. Heppner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G H Heppner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3454,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.89647981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"46","issue":"5","first_page":"2396","last_page":"401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9269999861717224},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9290000200271606},{"id":"https://openalex.org/keywords/thioguanine-resistance","display_name":"thioguanine resistance","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hypoxanthine-guanine-phosphoribosyltransferase","display_name":"hypoxanthine-guanine phosphoribosyltransferase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/oxygen-free-radicals","display_name":"oxygen free radicals","score":0.4779999852180481},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tumor-cell-variants","display_name":"tumor cell variants","score":0.4230000078678131},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.7084493637084961},{"id":"https://openalex.org/C78179603","wikidata":"https://www.wikidata.org/wiki/Q14864606","display_name":"Hypoxanthine-guanine phosphoribosyltransferase","level":4,"score":0.6205670237541199},{"id":"https://openalex.org/C2781116151","wikidata":"https://www.wikidata.org/wiki/Q410305","display_name":"Hypoxanthine","level":3,"score":0.5890255570411682},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.579871654510498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5167700052261353},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.4852902591228485},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4716702401638031},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4356297552585602},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42646366357803345},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.42394891381263733},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3260647654533386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32351452112197876},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22724521160125732},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19542500376701355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1408282220363617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12170252203941345},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11438620090484619},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11182153224945068},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.06046208739280701},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007041","descriptor_name":"Hypoxanthine Phosphoribosyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008353","descriptor_name":"Mannitol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013866","descriptor_name":"Thioguanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3084067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3084067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2169775201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3084067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W14760913","https://openalex.org/W144631464","https://openalex.org/W1481238256","https://openalex.org/W1491249237","https://openalex.org/W1497880181","https://openalex.org/W1530164382","https://openalex.org/W1530595785","https://openalex.org/W1530803476","https://openalex.org/W1558416642","https://openalex.org/W1967304777","https://openalex.org/W1969021695","https://openalex.org/W1969572403","https://openalex.org/W1987974154","https://openalex.org/W1991811105","https://openalex.org/W2001127059","https://openalex.org/W2002330857","https://openalex.org/W2016040499","https://openalex.org/W2017772699","https://openalex.org/W2023122744","https://openalex.org/W2034323095","https://openalex.org/W2041002260","https://openalex.org/W2045411834","https://openalex.org/W2052401206","https://openalex.org/W2060774868","https://openalex.org/W2069071175","https://openalex.org/W2069728752","https://openalex.org/W2069860437","https://openalex.org/W2081608638","https://openalex.org/W2097383933","https://openalex.org/W2098621632","https://openalex.org/W2112621503","https://openalex.org/W2119525287","https://openalex.org/W2120912312","https://openalex.org/W2120969858","https://openalex.org/W2124798043","https://openalex.org/W2129923788","https://openalex.org/W2136530652","https://openalex.org/W2137282767","https://openalex.org/W2138961046","https://openalex.org/W2150942684","https://openalex.org/W2153009861","https://openalex.org/W2168504041","https://openalex.org/W2186379414","https://openalex.org/W2254389335","https://openalex.org/W2314324465","https://openalex.org/W2340714428","https://openalex.org/W2614442853","https://openalex.org/W4313314124"],"related_works":["https://openalex.org/W1898496624","https://openalex.org/W4382344526","https://openalex.org/W1493122264","https://openalex.org/W6992631482","https://openalex.org/W1965111824","https://openalex.org/W7074227982","https://openalex.org/W2606610150","https://openalex.org/W2919567071","https://openalex.org/W2046646046","https://openalex.org/W4320709078"],"abstract_inverted_index":{"The":[0,91,102,114,169],"ability":[1],"of":[2,32,43,54,74,77,93,104,119,126,132,153,164,189,211],"macrophages":[3,95],"to":[4,28,40,62,67,123,148,187],"induce":[5],"drug-resistant":[6,105],"variants":[7,56,78,106,128,157,182],"was":[8,96,160,183],"studied":[9],"in":[10,12,51,179,215],"an":[11,49],"vitro":[13],"macrophage-tumor":[14],"cell":[15,83],"coculture":[16,61],"system":[17],"utilizing":[18],"the":[19,52,70,81,94,117,137,154,174],"hypoxanthine-guanine":[20,165,175],"phosphoribosyl":[21,166,176],"transferase":[22,167,177],"locus":[23,178],"as":[24,46,203,205],"measured":[25],"by":[26,48,110],"resistance":[27,45,159,214],"6-thioguanine.":[29],"Tumor":[30],"cells":[31,121,135,144],"mouse":[33],"mammary":[34,201],"tumor":[35],"line":[36,216],"66":[37,217],"were":[38,145,209],"sensitive":[39,147],"macrophage":[41,60],"induction":[42,103,125],"thioguanine":[44,213],"shown":[47],"increase":[50],"frequency":[53,172],"thioguanine-resistant":[55,120,194],"which":[57],"arose":[58],"following":[59],"levels":[63],"at":[64,173],"least":[65],"5-":[66],"10-fold":[68],"above":[69],"spontaneous":[71],"frequency.":[72],"Detection":[73],"increased":[75],"numbers":[76],"depended":[79],"upon":[80,98],"macrophage:tumor":[82],"ratio,":[84],"with":[85,162],"50:1":[86],"or":[87],"greater":[88],"being":[89],"necessary.":[90],"activity":[92],"dependent":[97],"their":[99],"activation":[100],"stage.":[101],"could":[107],"be":[108,124],"inhibited":[109],"oxygen":[111],"radical":[112],"scavengers.":[113],"basis":[115],"for":[116],"emergence":[118],"appeared":[122],"new":[127],"rather":[129],"than":[130],"selection":[131],"preexisting":[133],"resistant":[134],"from":[136,199],"parental":[138],"population,":[139],"since":[140],"thioguanine-sensitive":[141],"and":[142,185],"-resistant":[143],"equally":[146],"macrophage-mediated":[149],"toxicity.":[150],"In":[151],"six":[152,155],"macrophage-induced":[156,181],"tested,":[158],"associated":[161],"loss":[163],"activity.":[168],"reverse":[170],"variation":[171],"five":[180],"low":[184],"similar":[186],"that":[188],"a":[190],"stable":[191],"ethyl":[192],"methanesulfonate-induced,":[193],"line.":[195],"Macrophages":[196],"isolated":[197],"directly":[198],"growing":[200],"tumors,":[202],"well":[204],"activated":[206],"peritoneal":[207],"macrophages,":[208],"capable":[210],"inducing":[212],"cells.":[218]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
