{"id":"https://openalex.org/W2169727232","doi":"https://doi.org/10.1002/mc.22225","title":"Taxane\u2010induced hedgehog signaling is linked to expansion of breast cancer stem\u2010like populations after chemotherapy","display_name":"Taxane\u2010induced hedgehog signaling is linked to expansion of breast cancer stem\u2010like populations after chemotherapy","publication_year":2014,"publication_date":"2014-09-27","ids":{"openalex":"https://openalex.org/W2169727232","doi":"https://doi.org/10.1002/mc.22225","mag":"2169727232","pmid":"https://pubmed.ncbi.nlm.nih.gov/25263583"},"language":"en","primary_location":{"id":"doi:10.1002/mc.22225","doi":"https://doi.org/10.1002/mc.22225","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mc.22225","pdf_url":null,"source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070573234","display_name":"Jennifer Sims\u2010Mourtada","orcid":"https://orcid.org/0000-0003-1602-4560","observed_orcids":["https://orcid.org/0000-0003-1602-4560"]},"institutions":[{"id":"https://openalex.org/I1281704429","display_name":"Christiana Care Health System","ror":"https://ror.org/02h905004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281704429"]},{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer Sims\u2010Mourtada","raw_affiliation_strings":["Center for Translational Cancer Research Helen F. Graham Cancer Center Christiana Care Health Services, Inc. Newark Delaware","Department of Medical Laboratory Sciences University of Delaware Newark Delaware","Center for Translational Cancer Research, Helen F. Graham Cancer Center, Christiana Care Health Services, Inc., Newark, Delaware","Department of Medical Laboratory Sciences, University of Delaware, Newark, Delaware"],"raw_orcid":"https://orcid.org/0000-0003-1602-4560","affiliations":[{"raw_affiliation_string":"Center for Translational Cancer Research Helen F. Graham Cancer Center Christiana Care Health Services, Inc. Newark Delaware","institution_ids":["https://openalex.org/I1281704429"]},{"raw_affiliation_string":"Department of Medical Laboratory Sciences University of Delaware Newark Delaware","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Center for Translational Cancer Research, Helen F. Graham Cancer Center, Christiana Care Health Services, Inc., Newark, Delaware","institution_ids":["https://openalex.org/I1281704429"]},{"raw_affiliation_string":"Department of Medical Laboratory Sciences, University of Delaware, Newark, Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113806170","display_name":"Lynn M. Opdenaker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281704429","display_name":"Christiana Care Health System","ror":"https://ror.org/02h905004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281704429"]},{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn M. Opdenaker","raw_affiliation_strings":["Center for Translational Cancer Research Helen F. Graham Cancer Center Christiana Care Health Services, Inc. Newark Delaware","Department of Biological Sciences University of Delaware Newark Delaware","Center for Translational Cancer Research, Helen F. Graham Cancer Center, Christiana Care Health Services, Inc., Newark, Delaware","Department of Biological Sciences, University of Delaware, Newark, Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Cancer Research Helen F. Graham Cancer Center Christiana Care Health Services, Inc. Newark Delaware","institution_ids":["https://openalex.org/I1281704429"]},{"raw_affiliation_string":"Department of Biological Sciences University of Delaware Newark Delaware","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Center for Translational Cancer Research, Helen F. Graham Cancer Center, Christiana Care Health Services, Inc., Newark, Delaware","institution_ids":["https://openalex.org/I1281704429"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Delaware, Newark, Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013639503","display_name":"Joshua J. Davis","orcid":"https://orcid.org/0000-0002-6096-2856","observed_orcids":["https://orcid.org/0000-0002-6096-2856"]},"institutions":[{"id":"https://openalex.org/I1281704429","display_name":"Christiana Care Health System","ror":"https://ror.org/02h905004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281704429"]},{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Davis","raw_affiliation_strings":["Center for Translational Cancer Research Helen F. Graham Cancer Center Christiana Care Health Services, Inc. Newark Delaware","Department of Biological Sciences University of Delaware Newark Delaware","Center for Translational Cancer Research, Helen F. Graham Cancer Center, Christiana Care Health Services, Inc., Newark, Delaware","Department of Biological Sciences, University of Delaware, Newark, Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Cancer Research Helen F. Graham Cancer Center Christiana Care Health Services, Inc. Newark Delaware","institution_ids":["https://openalex.org/I1281704429"]},{"raw_affiliation_string":"Department of Biological Sciences University of Delaware Newark Delaware","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Center for Translational Cancer Research, Helen F. Graham Cancer Center, Christiana Care Health Services, Inc., Newark, Delaware","institution_ids":["https://openalex.org/I1281704429"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Delaware, Newark, Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kimberly M. Arnold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281704429","display_name":"Christiana Care Health System","ror":"https://ror.org/02h905004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281704429"]},{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly M. Arnold","raw_affiliation_strings":["Center for Translational Cancer Research Helen F. Graham Cancer Center Christiana Care Health Services, Inc. Newark Delaware","Department of Medical Laboratory Sciences University of Delaware Newark Delaware","Center for Translational Cancer Research, Helen F. Graham Cancer Center, Christiana Care Health Services, Inc., Newark, Delaware","Department of Medical Laboratory Sciences, University of Delaware, Newark, Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Cancer Research Helen F. Graham Cancer Center Christiana Care Health Services, Inc. Newark Delaware","institution_ids":["https://openalex.org/I1281704429"]},{"raw_affiliation_string":"Department of Medical Laboratory Sciences University of Delaware Newark Delaware","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Center for Translational Cancer Research, Helen F. Graham Cancer Center, Christiana Care Health Services, Inc., Newark, Delaware","institution_ids":["https://openalex.org/I1281704429"]},{"raw_affiliation_string":"Department of Medical Laboratory Sciences, University of Delaware, Newark, Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019873684","display_name":"Daniel C. Flynn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281704429","display_name":"Christiana Care Health System","ror":"https://ror.org/02h905004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281704429"]},{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Flynn","raw_affiliation_strings":["Center for Translational Cancer Research Helen F. Graham Cancer Center Christiana Care Health Services, Inc. Newark Delaware","Department of Medical Laboratory Sciences University of Delaware Newark Delaware","Center for Translational Cancer Research, Helen F. Graham Cancer Center, Christiana Care Health Services, Inc., Newark, Delaware","Department of Medical Laboratory Sciences, University of Delaware, Newark, Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Cancer Research Helen F. Graham Cancer Center Christiana Care Health Services, Inc. Newark Delaware","institution_ids":["https://openalex.org/I1281704429"]},{"raw_affiliation_string":"Department of Medical Laboratory Sciences University of Delaware Newark Delaware","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Center for Translational Cancer Research, Helen F. Graham Cancer Center, Christiana Care Health Services, Inc., Newark, Delaware","institution_ids":["https://openalex.org/I1281704429"]},{"raw_affiliation_string":"Department of Medical Laboratory Sciences, University of Delaware, Newark, Delaware","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070573234"],"corresponding_institution_ids":["https://openalex.org/I1281704429","https://openalex.org/I86501945"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":null,"fwci":1.8325,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.85640102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"54","issue":"11","first_page":"1480","last_page":"1493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.7919999957084656},{"id":"https://openalex.org/keywords/breast-cancer-stem-cells","display_name":"breast cancer stem cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9800000190734863},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7329999804496765},{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.9160000085830688},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.972000002861023},{"id":"https://openalex.org/keywords/mammosphere-formation","display_name":"mammosphere formation","score":0.765999972820282},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.6060000061988831},{"id":"https://openalex.org/keywords/stem-cell-markers","display_name":"stem cell markers","score":0.7139999866485596},{"id":"https://openalex.org/keywords/clonogenic-growth","display_name":"clonogenic growth","score":0.7300000190734863},{"id":"https://openalex.org/keywords/hedgehog-pathway-inhibitors","display_name":"Hedgehog pathway inhibitors","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7487929463386536},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.7193784713745117},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.667054295539856},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6653906106948853},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.5809402465820312},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5806866884231567},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5322399139404297},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.5307127237319946},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5301735401153564},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.526911199092865},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.46830666065216064},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4554540514945984},{"id":"https://openalex.org/C2780546549","wikidata":"https://www.wikidata.org/wiki/Q7508338","display_name":"Side population","level":4,"score":0.451114684343338},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36906898021698},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3531894087791443},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24887794256210327},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23856371641159058},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11004853248596191},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06958785653114319},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mc.22225","doi":"https://doi.org/10.1002/mc.22225","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mc.22225","pdf_url":null,"source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:25263583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25263583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000004866","display_name":null,"funder_award_id":"U54GM104941","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000228616","display_name":null,"funder_award_id":"8 P20 GM103446-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W86247143","https://openalex.org/W1540425699","https://openalex.org/W1591608420","https://openalex.org/W1880118344","https://openalex.org/W1965124339","https://openalex.org/W1966544332","https://openalex.org/W1974937388","https://openalex.org/W1979333273","https://openalex.org/W1992375116","https://openalex.org/W1997847812","https://openalex.org/W1997905438","https://openalex.org/W2009478313","https://openalex.org/W2012962381","https://openalex.org/W2015044035","https://openalex.org/W2028835259","https://openalex.org/W2030643315","https://openalex.org/W2031770999","https://openalex.org/W2033671499","https://openalex.org/W2055498399","https://openalex.org/W2057528904","https://openalex.org/W2065901589","https://openalex.org/W2067238392","https://openalex.org/W2070632651","https://openalex.org/W2080927137","https://openalex.org/W2096083635","https://openalex.org/W2100826888","https://openalex.org/W2104964892","https://openalex.org/W2108707301","https://openalex.org/W2110327197","https://openalex.org/W2114639059","https://openalex.org/W2117480880","https://openalex.org/W2125519401","https://openalex.org/W2125904252","https://openalex.org/W2127111173","https://openalex.org/W2128341240","https://openalex.org/W2129375080","https://openalex.org/W2133117291","https://openalex.org/W2133998111","https://openalex.org/W2140490644","https://openalex.org/W2141589190","https://openalex.org/W2151907359","https://openalex.org/W2154589460","https://openalex.org/W2164244124","https://openalex.org/W2165901843","https://openalex.org/W2170086508","https://openalex.org/W2171958606"],"related_works":["https://openalex.org/W2039762497","https://openalex.org/W2901604565","https://openalex.org/W2064272569","https://openalex.org/W2009400743","https://openalex.org/W2364879349","https://openalex.org/W2060505600","https://openalex.org/W3008016544","https://openalex.org/W2378829050","https://openalex.org/W2380748750","https://openalex.org/W1978833015"],"abstract_inverted_index":{"Recurrence":[0],"of":[1,38,55,67,79,86,98,117,124,144,180,187,229],"breast":[2,12,39,69,169,230],"cancer":[3,13,40,70,170,231],"after":[4,106,147,160,234],"chemotherapy":[5,51],"is":[6],"thought":[7],"to":[8,20,32,47,50,73,128,133,178],"arise":[9],"from":[10],"resistant":[11],"stem":[14,41,171,232],"cells":[15,233],"which":[16],"are":[17],"eventually":[18],"able":[19],"repopulate":[21],"the":[22,34,53,87,99,115,118,168,185,217],"tumor.":[23],"The":[24],"Hedgehog":[25,81],"(HH)":[26],"signaling":[27,126],"pathway":[28,89,137,204],"has":[29,44],"been":[30,45],"shown":[31,46],"regulate":[33],"proliferation":[35],"and":[36,43,58,84,95,190,227],"survival":[37,60,226],"cells,":[42],"promote":[48],"resistance":[49,57],"through":[52],"activation":[54,85,110,138,205],"multi-drug":[56],"pro":[59],"pathways.":[61],"Here":[62],"we":[63],"report":[64],"that":[65,179,202],"exposure":[66],"heterogenous":[68],"cell":[71,120,145,172,181],"lines":[72,146,182],"docetaxel":[74],"(DOC)":[75],"resulted":[76],"in":[77,131,150,167,184],"release":[78],"Sonic":[80],"ligand":[82],"(SHH)":[83],"HH":[88,125,136,197,203],"as":[90,122,153,155],"evidenced":[91],"by":[92,194,207],"increased":[93],"expression":[94],"nuclear":[96],"translocation":[97],"downstream":[100],"effector":[101],"Gli-1":[102],"at":[103],"4-24":[104],"h":[105],"DOC":[107,163,208],"treatment.":[108],"This":[109],"had":[111],"little":[112],"effect":[113,215],"on":[114,216],"bulk":[116],"tumor":[119,219],"population":[121],"inhibition":[123],"failed":[127],"increase":[129,166],"apoptosis":[130],"response":[132],"DOC.":[134,148],"However,":[135],"was":[139],"required":[140,224],"for":[141,225],"clonogenic":[142],"growth":[143],"Increases":[149],"stemness":[151],"markers":[152],"well":[154],"mammosphere":[156],"formation":[157],"were":[158,176],"observed":[159],"treatment":[161,209],"with":[162,196],"suggesting":[164],"an":[165],"populations.":[173],"These":[174,199],"increases":[175],"similar":[177],"cultured":[183],"presence":[186],"recombinant":[188],"SHH":[189],"could":[191],"be":[192,223],"eliminated":[193],"co-treatment":[195],"inhibitors.":[198],"results":[200],"suggest":[201],"induced":[206],"does":[210],"not":[211],"have":[212],"a":[213],"chemosensitizing":[214],"heterogeneous":[218],"population,":[220],"but":[221],"may":[222],"expansion":[228],"chemotherapy.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
