{"id":"https://openalex.org/W2169703537","doi":"https://doi.org/10.1158/1541-7786.mcr-14-0337","title":"Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma","display_name":"Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma","publication_year":2015,"publication_date":"2015-01-07","ids":{"openalex":"https://openalex.org/W2169703537","doi":"https://doi.org/10.1158/1541-7786.mcr-14-0337","mag":"2169703537","pmid":"https://pubmed.ncbi.nlm.nih.gov/25563294"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.mcr-14-0337","doi":"https://doi.org/10.1158/1541-7786.mcr-14-0337","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-14-0337","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034991786","display_name":"Erika A. Newman","orcid":"https://orcid.org/0000-0003-3999-0323","observed_orcids":["https://orcid.org/0000-0003-3999-0323"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210097513","display_name":"Women's Hospital","ror":"https://ror.org/00raa0r66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210097513","https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210151884","display_name":"C. S. Mott Children's Hospital","ror":"https://ror.org/05h0f1d70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika A. Newman","raw_affiliation_strings":["1Department of Surgery, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210097513","https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029878554","display_name":"Fujia Lu","orcid":"https://orcid.org/0009-0005-9583-5856","observed_orcids":["https://orcid.org/0009-0005-9583-5856"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210097513","display_name":"Women's Hospital","ror":"https://ror.org/00raa0r66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210097513","https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210151884","display_name":"C. S. Mott Children's Hospital","ror":"https://ror.org/05h0f1d70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fujia Lu","raw_affiliation_strings":["1Department of Surgery, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210097513","https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057528183","display_name":"Daniela Bashllari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210097513","display_name":"Women's Hospital","ror":"https://ror.org/00raa0r66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210097513","https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210151884","display_name":"C. S. Mott Children's Hospital","ror":"https://ror.org/05h0f1d70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Bashllari","raw_affiliation_strings":["1Department of Surgery, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210097513","https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336119","display_name":"Li Wang","orcid":"https://orcid.org/0000-0002-8686-6627","observed_orcids":["https://orcid.org/0000-0002-8686-6627"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210097513","display_name":"Women's Hospital","ror":"https://ror.org/00raa0r66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210097513","https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210151884","display_name":"C. S. Mott Children's Hospital","ror":"https://ror.org/05h0f1d70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Wang","raw_affiliation_strings":["2Department of Pediatrics, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pediatrics, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210097513","https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006804543","display_name":"Anthony W. Opipari","orcid":"https://orcid.org/0000-0002-4093-302X","observed_orcids":["https://orcid.org/0000-0002-4093-302X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210097513","display_name":"Women's Hospital","ror":"https://ror.org/00raa0r66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210097513","https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210151884","display_name":"C. S. Mott Children's Hospital","ror":"https://ror.org/05h0f1d70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony W. Opipari","raw_affiliation_strings":["3Department of Obstetrics and Gynecology, C.S. Mott Children and Women's Hospital, The University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Obstetrics and Gynecology, C.S. Mott Children and Women's Hospital, The University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210097513","https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108449145","display_name":"Valerie P. Castle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210097513","display_name":"Women's Hospital","ror":"https://ror.org/00raa0r66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210097513","https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210151884","display_name":"C. S. Mott Children's Hospital","ror":"https://ror.org/05h0f1d70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerie P. Castle","raw_affiliation_strings":["2Department of Pediatrics, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pediatrics, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210097513","https://openalex.org/I4210114445","https://openalex.org/I4210151884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.6692,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.96314775,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"13","issue":"3","first_page":"470","last_page":"482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.2768999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/alternative-nhej","display_name":"alternative NHEJ","score":0.8450000286102295},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.8970000147819519},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.984000027179718},{"id":"https://openalex.org/keywords/error-prone-dna-repair","display_name":"error-prone DNA repair","score":0.8109999895095825},{"id":"https://openalex.org/keywords/dna-ligase-i","display_name":"DNA ligase I","score":0.9879999756813049},{"id":"https://openalex.org/keywords/parp1-inhibition","display_name":"PARP1 inhibition","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mycn-amplification","display_name":"MYCN amplification","score":0.7609999775886536},{"id":"https://openalex.org/keywords/17q-gain","display_name":"17q gain","score":0.9089999794960022},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6159999966621399},{"id":"https://openalex.org/keywords/dna-repair-fidelity","display_name":"DNA repair fidelity","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.8127977848052979},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.7263942956924438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6947738528251648},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6667364835739136},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5791254639625549},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.46863532066345215},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4499474763870239},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27370160818099976},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2526441812515259},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.227007657289505},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.1376264989376068},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059766","descriptor_name":"DNA End-Joining Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059766","descriptor_name":"DNA End-Joining Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059766","descriptor_name":"DNA End-Joining Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1158/1541-7786.mcr-14-0337","doi":"https://doi.org/10.1158/1541-7786.mcr-14-0337","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-14-0337","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:25563294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25563294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306139","display_name":"Robert Wood Johnson Foundation","ror":"https://ror.org/02ymmdj85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1482231686","https://openalex.org/W1527833446","https://openalex.org/W1648266957","https://openalex.org/W1661391341","https://openalex.org/W1902445142","https://openalex.org/W1970810396","https://openalex.org/W1975445093","https://openalex.org/W1987369963","https://openalex.org/W1989924028","https://openalex.org/W1999103183","https://openalex.org/W2003581594","https://openalex.org/W2024280594","https://openalex.org/W2024531852","https://openalex.org/W2027379868","https://openalex.org/W2027574826","https://openalex.org/W2041381844","https://openalex.org/W2046916766","https://openalex.org/W2049942970","https://openalex.org/W2050164541","https://openalex.org/W2055890925","https://openalex.org/W2061020520","https://openalex.org/W2069921265","https://openalex.org/W2080152855","https://openalex.org/W2088107605","https://openalex.org/W2090365348","https://openalex.org/W2102003117","https://openalex.org/W2102618729","https://openalex.org/W2102734723","https://openalex.org/W2106845421","https://openalex.org/W2111746502","https://openalex.org/W2114322342","https://openalex.org/W2117094974","https://openalex.org/W2118071133","https://openalex.org/W2118077034","https://openalex.org/W2127193805","https://openalex.org/W2128916321","https://openalex.org/W2131776400","https://openalex.org/W2140289804","https://openalex.org/W2149034978","https://openalex.org/W2150823346","https://openalex.org/W2155952235","https://openalex.org/W2164900838","https://openalex.org/W2165491538","https://openalex.org/W2168518606","https://openalex.org/W2185096561","https://openalex.org/W2330923897","https://openalex.org/W2507105849","https://openalex.org/W4211031423","https://openalex.org/W6639827826","https://openalex.org/W6676865234","https://openalex.org/W6686379722"],"related_works":["https://openalex.org/W2588147230","https://openalex.org/W3163592337","https://openalex.org/W4235838281","https://openalex.org/W1994926061","https://openalex.org/W4303672090","https://openalex.org/W2097345307","https://openalex.org/W3169532181","https://openalex.org/W2169703537","https://openalex.org/W2118211359","https://openalex.org/W2897434296"],"abstract_inverted_index":{"UNLABELLED:":[0],"In":[1,209],"neuroblastoma,":[2],"MYCN":[3],"genomic":[4,53],"amplification":[5],"and":[6,24,36,148,173,181,187,239],"segmental":[7],"chromosomal":[8,46],"alterations":[9,29],"including":[10],"1p":[11],"or":[12],"11q":[13],"loss":[14],"of":[15,34,45,51,64,88,152,179,212,218,242],"heterozygocity":[16],"and/or":[17],"17q":[18],"gain":[19],"are":[20,30],"associated":[21,223],"with":[22,110,135,224],"progression":[23],"poor":[25,225],"clinical":[26],"outcome.":[27],"Segmental":[28],"the":[31,82,243],"strongest":[32],"predictor":[33],"relapse":[35],"result":[37],"from":[38,123],"unbalanced":[39],"translocations":[40],"attributable":[41],"to":[42,117,184,192,201],"erroneous":[43],"repair":[44,100,111,130,235],"breaks.":[47],"Although":[48],"sequence":[49],"analysis":[50],"affected":[52],"regions":[54],"suggests":[55],"that":[56,84,113,205],"these":[57],"errors":[58],"arise":[59],"by":[60],"nonhomologous":[61],"end-joining":[62],"(NHEJ)":[63],"DNA":[65,129,144,165,169,234],"double-strand":[66],"breaks":[67],"(DSB),":[68],"abnormalities":[69],"in":[70,76,106,143,195,237],"NHEJ":[71,89,104,162],"have":[72],"not":[73],"been":[74],"implicated":[75],"neuroblastoma":[77,93,108,139,214,238],"pathogenesis.":[78],"On":[79],"this":[80],"basis,":[81],"hypothesis":[83],"an":[85,159,231],"error-prone":[86,115,160],"mechanism":[87],"is":[90],"critical":[91],"for":[92,158],"cell":[94,188,193],"survival":[95,194],"was":[96],"tested.":[97],"Plasmid-based":[98],"DSB":[99,185],"assays":[101],"demonstrated":[102,199],"efficient":[103],"activity":[105],"human":[107,213],"cells":[109,121,140,198],"products":[112],"were":[114,141,176],"relative":[116],"nontransformed":[118],"cells.":[119,137],"Neuroblastoma":[120,197],"derived":[122],"tumorigenic":[124],"neuroblastic":[125],"phenotypes":[126],"had":[127],"differential":[128],"protein":[131,175],"expression":[132],"patterns":[133],"compared":[134],"nontumorigenic":[136],"Tumorigenic":[138],"deficient":[142],"ligase":[145],"IV":[146],"(Lig4)":[147],"Artemis":[149],"(DCLRE1C),":[150],"mediators":[151],"canonical":[153],"NHEJ.":[154],"Conversely,":[155],"enzymes":[156],"required":[157],"alternative":[161],"pathway":[163,245],"(alt-NHEJ),":[164],"Ligase":[166,170],"III\u03b1":[167],"(Lig3),":[168],"I":[171],"(Lig1),":[172],"PARP1":[174,202,207],"upregulated.":[177],"Inhibition":[178],"Lig3":[180],"Lig1":[182],"led":[183],"accumulation":[186],"death,":[189],"linking":[190],"alt-NHEJ":[191,221,244],"neuroblastoma.":[196],"sensitivity":[200],"inhibition":[203],"(PARPi)":[204],"paralleled":[206],"expression.":[208],"a":[210],"dataset":[211],"patient":[215],"tumors,":[216],"overexpression":[217],"genes":[219],"encoding":[220],"proteins":[222],"survival.":[226],"IMPLICATIONS:":[227],"These":[228],"findings":[229],"provide":[230],"insight":[232],"into":[233],"fidelity":[236],"identify":[240],"components":[241],"as":[246],"promising":[247],"therapeutic":[248],"targets.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}