{"id":"https://openalex.org/W2169608963","doi":"https://doi.org/10.3109/08916939608995324","title":"The Effect of Soluble Complement Receptor 1 (sCR1) and Human Thyroid Antibodies on the Course of Experimental Autoimmune Thyroiditis in Rats","display_name":"The Effect of Soluble Complement Receptor 1 (sCR1) and Human Thyroid Antibodies on the Course of Experimental Autoimmune Thyroiditis in Rats","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2169608963","doi":"https://doi.org/10.3109/08916939608995324","mag":"2169608963","pmid":"https://pubmed.ncbi.nlm.nih.gov/8871757"},"language":"en","primary_location":{"id":"doi:10.3109/08916939608995324","doi":"https://doi.org/10.3109/08916939608995324","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08916939608995324","pdf_url":null,"source":{"id":"https://openalex.org/S41163404","display_name":"Autoimmunity","issn_l":"0891-6934","issn":["0891-6934","1026-7859","1607-842X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autoimmunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111972115","display_name":"R. A. Metcalfe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801759359","display_name":"Northern General Hospital","ror":"https://ror.org/05r409z22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801759359","https://openalex.org/I4210102902"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. A. Metcalfe","raw_affiliation_strings":["Department of Medicine, University of Sheffield, Clinical Sciences Centre, Northern General Hospital, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Sheffield, Clinical Sciences Centre, Northern General Hospital, UK","institution_ids":["https://openalex.org/I2801759359","https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026664368","display_name":"Richard Stephen McIntosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801759359","display_name":"Northern General Hospital","ror":"https://ror.org/05r409z22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801759359","https://openalex.org/I4210102902"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. S. Mcintosh","raw_affiliation_strings":["Department of Medicine, University of Sheffield Clinical Sciences Centre, Northern General Hospital, Shefield, S5 7A U"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Sheffield Clinical Sciences Centre, Northern General Hospital, Shefield, S5 7A U","institution_ids":["https://openalex.org/I2801759359","https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090102833","display_name":"B. Paul Morgan","orcid":"https://orcid.org/0000-0003-4075-7676","observed_orcids":["https://orcid.org/0000-0003-4075-7676"]},"institutions":[{"id":"https://openalex.org/I97429440","display_name":"University of Wales","ror":"https://ror.org/01se4f844","country_code":"GB","type":"education","lineage":["https://openalex.org/I97429440"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. P. Morgan","raw_affiliation_strings":["Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, CF4 4XN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, CF4 4XN, USA","institution_ids":["https://openalex.org/I97429440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111612844","display_name":"J. L. Levin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. L. Levin","raw_affiliation_strings":["T Cell Sciences Inc., 115 Fourth Avenue, Needham, MA, 02194\u20132725, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"T Cell Sciences Inc., 115 Fourth Avenue, Needham, MA, 02194\u20132725, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030150193","display_name":"Anthony Peter Weetman","orcid":"https://orcid.org/0000-0002-5145-5385","observed_orcids":["https://orcid.org/0000-0002-5145-5385"]},"institutions":[{"id":"https://openalex.org/I2801759359","display_name":"Northern General Hospital","ror":"https://ror.org/05r409z22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801759359","https://openalex.org/I4210102902"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. P. Weetman","raw_affiliation_strings":["Department of Medicine, University of Sheffield Clinical Sciences Centre, Northern General Hospital, Shefield, S5 7A U"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Sheffield Clinical Sciences Centre, Northern General Hospital, Shefield, S5 7A U","institution_ids":["https://openalex.org/I2801759359","https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.19825368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"23","issue":"1","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.1306000053882599,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0357000008225441,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/experimental-autoimmune-thyroiditis","display_name":"experimental autoimmune thyroiditis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/soluble-complement-receptor-1","display_name":"soluble complement receptor 1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/complement-inhibition","display_name":"complement inhibition","score":0.9419999718666077},{"id":"https://openalex.org/keywords/anti-thyroid-peroxidase-antibodies","display_name":"thyroid peroxidase antibodies","score":0.9520000219345093},{"id":"https://openalex.org/keywords/thyroid-autoantibodies","display_name":"thyroid autoantibodies","score":0.8339999914169312},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/autoimmune-thyroid-disease","display_name":"autoimmune thyroid disease","score":0.8240000009536743},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.5120000243186951},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7334421277046204},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6915856599807739},{"id":"https://openalex.org/C2778696486","wikidata":"https://www.wikidata.org/wiki/Q11835644","display_name":"Thyroiditis","level":3,"score":0.6175042986869812},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5958566069602966},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5891026854515076},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5250465869903564},{"id":"https://openalex.org/C50181227","wikidata":"https://www.wikidata.org/wiki/Q1943709","display_name":"Anti-thyroid autoantibodies","level":4,"score":0.5028652548789978},{"id":"https://openalex.org/C180650514","wikidata":"https://www.wikidata.org/wiki/Q419502","display_name":"Thyroid peroxidase","level":3,"score":0.495853990316391},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.47828349471092224},{"id":"https://openalex.org/C175773311","wikidata":"https://www.wikidata.org/wiki/Q5156412","display_name":"Complement receptor","level":4,"score":0.4443340003490448},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4387974143028259},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.4179963171482086},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3976982831954956},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39299866557121277}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013967","descriptor_name":"Thyroiditis, Autoimmune","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017463","descriptor_name":"Receptors, Complement 3b","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017463","descriptor_name":"Receptors, Complement 3b","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/08916939608995324","doi":"https://doi.org/10.3109/08916939608995324","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08916939608995324","pdf_url":null,"source":{"id":"https://openalex.org/S41163404","display_name":"Autoimmunity","issn_l":"0891-6934","issn":["0891-6934","1026-7859","1607-842X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autoimmunity","raw_type":"journal-article"},{"id":"pmid:8871757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8871757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autoimmunity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W41729299","https://openalex.org/W45096280","https://openalex.org/W150766136","https://openalex.org/W162184855","https://openalex.org/W182792572","https://openalex.org/W283704935","https://openalex.org/W1483379419","https://openalex.org/W1515843903","https://openalex.org/W1531027674","https://openalex.org/W1547029341","https://openalex.org/W1976393897","https://openalex.org/W1976415677","https://openalex.org/W1982534428","https://openalex.org/W1991675791","https://openalex.org/W1997952082","https://openalex.org/W2005668178","https://openalex.org/W2015533040","https://openalex.org/W2037116263","https://openalex.org/W2071052998","https://openalex.org/W2071177681","https://openalex.org/W2073346397","https://openalex.org/W2078552760","https://openalex.org/W2082396797","https://openalex.org/W2085586749","https://openalex.org/W2091334519","https://openalex.org/W2128471317","https://openalex.org/W2134942803","https://openalex.org/W2163876117","https://openalex.org/W2166627164","https://openalex.org/W2339788578","https://openalex.org/W2410012417","https://openalex.org/W2415325024","https://openalex.org/W4313376459"],"related_works":["https://openalex.org/W1982534428","https://openalex.org/W2047095916","https://openalex.org/W2362679207","https://openalex.org/W45096280","https://openalex.org/W2075826272","https://openalex.org/W2166633672","https://openalex.org/W102466290","https://openalex.org/W3167632578","https://openalex.org/W7096136416","https://openalex.org/W2978106037"],"abstract_inverted_index":{"Experimental":[0],"autoimmune":[1,154,177],"thyroiditis":[2,54,100],"(EAT),":[3],"induced":[4],"by":[5,30],"immunisation":[6,59,95],"of":[7,26,41,48,53,64,84,94,99,120,139,152,172],"rats":[8,90],"with":[9],"thyroid":[10,65,85,178],"extract":[11],"and":[12,144],"complete":[13],"Freund's":[14],"adjuvant,":[15],"has":[16],"been":[17],"used":[18],"as":[19],"a":[20,132],"model":[21],"to":[22,89,106],"study":[23],"the":[24,38,42,51,62,72,92,121,136,150,157,169],"effects":[25],"complement":[27,32,128,145,164],"inhibition":[28,146],"mediated":[29],"soluble":[31],"receptor":[33],"1":[34],"(sCR1)":[35],"administration":[36],"during":[37,71,168],"initial":[39,137],"phase":[40,138,171],"disease.":[43,179],"There":[44],"was":[45,69],"no":[46,115],"effect":[47,116],"sCR1":[49,68,112],"on":[50,61],"severity":[52,101],"at":[55,91],"day":[56],"28":[57],"after":[58,77],"or":[60,74],"levels":[63,83],"antibodies,":[66],"whether":[67],"given":[70,88],"first":[73],"second":[75],"week":[76],"immunisation.":[78],"Human":[79],"IgG":[80],"containing":[81],"high":[82],"peroxidase":[86],"antibodies":[87],"time":[93],"caused":[96],"significant":[97],"worsening":[98],"(P":[102],"<":[103],"0.01":[104],"compared":[105],"animals":[107],"receiving":[108],"normal":[109],"IgG)":[110],"but":[111],"again":[113],"had":[114],"in":[117,135,142,175],"this":[118],"variant":[119],"EAT":[122,143],"model.":[123],"The":[124],"results":[125],"indicate":[126],"that":[127,163],"does":[129,147],"not":[130,148],"play":[131],"major":[133],"role":[134],"tissue":[140],"injury":[141],"impair":[149],"generation":[151],"an":[153],"response":[155],"against":[156],"thyroid,":[158],"although":[159],"it":[160],"remains":[161],"possible":[162],"activation":[165],"is":[166],"important":[167],"chronic":[170],"disease":[173],"maintenance":[174],"human":[176]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
