{"id":"https://openalex.org/W2169528009","doi":"https://doi.org/10.1164/rccm.201210-1829oc","title":"Nonlinear Exercise Training in Advanced Chronic Obstructive Pulmonary Disease Is Superior to Traditional Exercise Training. A Randomized Trial","display_name":"Nonlinear Exercise Training in Advanced Chronic Obstructive Pulmonary Disease Is Superior to Traditional Exercise Training. A Randomized Trial","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W2169528009","doi":"https://doi.org/10.1164/rccm.201210-1829oc","mag":"2169528009","pmid":"https://pubmed.ncbi.nlm.nih.gov/23449691"},"language":"en","primary_location":{"id":"doi:10.1164/rccm.201210-1829oc","doi":"https://doi.org/10.1164/rccm.201210-1829oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.201210-1829oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037999759","display_name":"Peter H.C. Klijn","orcid":"https://orcid.org/0000-0002-4665-4398","observed_orcids":["https://orcid.org/0000-0002-4665-4398"]},"institutions":[{"id":"https://openalex.org/I4210127153","display_name":"Merem","ror":"https://ror.org/03en95y37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127153"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Peter Klijn","raw_affiliation_strings":["Department of Pulmonology, Merem Asthma Center Heideheuvel, Hilversum, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology, Merem Asthma Center Heideheuvel, Hilversum, The Netherlands","institution_ids":["https://openalex.org/I4210127153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011387520","display_name":"Anton R.J. van Keimpema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210127153","display_name":"Merem","ror":"https://ror.org/03en95y37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127153"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anton van Keimpema","raw_affiliation_strings":["Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands","Department of Pulmonology, Merem Asthma Center Heideheuvel, Hilversum, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Department of Pulmonology, Merem Asthma Center Heideheuvel, Hilversum, The Netherlands","institution_ids":["https://openalex.org/I4210127153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012204995","display_name":"Monique Legemaat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127153","display_name":"Merem","ror":"https://ror.org/03en95y37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127153"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Monique Legemaat","raw_affiliation_strings":["Department of Pulmonology, Merem Asthma Center Heideheuvel, Hilversum, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology, Merem Asthma Center Heideheuvel, Hilversum, The Netherlands","institution_ids":["https://openalex.org/I4210127153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063371449","display_name":"Rik Gosselink","orcid":"https://orcid.org/0000-0003-0444-8606","observed_orcids":["https://orcid.org/0000-0003-0444-8606"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rik Gosselink","raw_affiliation_strings":["Kinesiology and Rehabilitation Sciences, Department of Rehabilitation Sciences, University of Leuven, Leuven, Belgium; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kinesiology and Rehabilitation Sciences, Department of Rehabilitation Sciences, University of Leuven, Leuven, Belgium; and","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061890525","display_name":"Henk F. van Stel","orcid":"https://orcid.org/0000-0002-3475-9846","observed_orcids":["https://orcid.org/0000-0002-3475-9846"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Henk van Stel","raw_affiliation_strings":["Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5037999759"],"corresponding_institution_ids":["https://openalex.org/I4210127153"],"apc_list":null,"apc_paid":null,"fwci":6.2105,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.96832085,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"188","issue":"2","first_page":"193","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/endurance-training","display_name":"endurance training","score":0.5509999990463257},{"id":"https://openalex.org/keywords/progressive-resistance-training","display_name":"progressive resistance training","score":0.9129999876022339},{"id":"https://openalex.org/keywords/exercise-training-intensity","display_name":"exercise training intensity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cycling-endurance","display_name":"cycling endurance","score":0.9269999861717224},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.8550000190734863},{"id":"https://openalex.org/keywords/chronic-respiratory-questionnaire","display_name":"Chronic Respiratory Questionnaire","score":0.7829999923706055},{"id":"https://openalex.org/keywords/severe-copd","display_name":"severe COPD","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9222015142440796},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7558952569961548},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.6722394227981567},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6349746584892273},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5977814793586731},{"id":"https://openalex.org/C2777973682","wikidata":"https://www.wikidata.org/wiki/Q1558681","display_name":"Interval training","level":2,"score":0.5099526643753052},{"id":"https://openalex.org/C2780779891","wikidata":"https://www.wikidata.org/wiki/Q3455927","display_name":"Pulmonary rehabilitation","level":3,"score":0.5043295621871948},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40167155861854553},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010807","descriptor_name":"Physical Endurance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D053580","descriptor_name":"Muscle Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1164/rccm.201210-1829oc","doi":"https://doi.org/10.1164/rccm.201210-1829oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.201210-1829oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:23449691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23449691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Comparative Study"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/b524007c-cc22-421f-b707-04b69e2f4424","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/nonlinear-exercise-training-in-advanced-chronic-obstructive-pulmonary-disease-is-superior-to-traditional-exercise-training-a-randomized-trial(b524007c-cc22-421f-b707-04b69e2f4424).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American journal of respiratory and critical care medicine, 188(2), 193 - 200. American Thoracic Society","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/438397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23449691","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine, vol. 188 (2), Art.No. 10.1164/rccm.201210-1829OC, (193-200)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W207386868","https://openalex.org/W604254747","https://openalex.org/W1210021383","https://openalex.org/W1240635074","https://openalex.org/W1576935744","https://openalex.org/W1583848026","https://openalex.org/W1585155217","https://openalex.org/W1687567765","https://openalex.org/W1895131631","https://openalex.org/W1938582593","https://openalex.org/W1967569804","https://openalex.org/W2027000781","https://openalex.org/W2040488181","https://openalex.org/W2047735169","https://openalex.org/W2052898302","https://openalex.org/W2066306225","https://openalex.org/W2078010422","https://openalex.org/W2082810688","https://openalex.org/W2083513935","https://openalex.org/W2096554557","https://openalex.org/W2101435837","https://openalex.org/W2105524929","https://openalex.org/W2112637186","https://openalex.org/W2116865489","https://openalex.org/W2121453719","https://openalex.org/W2127951128","https://openalex.org/W2132155488","https://openalex.org/W2134950977","https://openalex.org/W2138305742","https://openalex.org/W2138890460","https://openalex.org/W2141458607","https://openalex.org/W2149296107","https://openalex.org/W2149324635","https://openalex.org/W2160436389","https://openalex.org/W2161107429","https://openalex.org/W2162772535","https://openalex.org/W2197553214","https://openalex.org/W2471647485","https://openalex.org/W2994597783","https://openalex.org/W4211263216","https://openalex.org/W6639651532"],"related_works":["https://openalex.org/W2471647485","https://openalex.org/W4404105083","https://openalex.org/W2161107429","https://openalex.org/W2088802642","https://openalex.org/W2097807686","https://openalex.org/W2921402175","https://openalex.org/W4394999893","https://openalex.org/W1971091318","https://openalex.org/W2972873817","https://openalex.org/W2573829024"],"abstract_inverted_index":{"RATIONALE:":[0],"The":[1,78,95,126],"optimal":[2],"exercise":[3,10,30],"training":[4,11,32,43,68,201],"intensity":[5],"and":[6,39,85,101,189],"strategy":[7],"for":[8,75,168,178],"individualized":[9],"in":[12,34,44,97,115,119,128,146,150,183,186,194],"chronic":[13],"obstructive":[14],"pulmonary":[15],"disease":[16],"(COPD)":[17],"is":[18],"not":[19],"clear.":[20],"OBJECTIVES:":[21],"This":[22],"study":[23],"compares":[24],"the":[25,91,154,169],"effects":[26],"of":[27,52,88,153,192],"nonlinear":[28],"periodized":[29],"(NLPE)":[31],"used":[33],"athletes":[35],"to":[36,63,172],"traditional":[37,200],"endurance":[38,83,121,188],"progressive":[40],"resistance":[41],"(EPR)":[42],"patients":[45,54,195],"with":[46,55,124,159,196,206],"severe":[47,56,197],"COPD.":[48],"METHODS:":[49],"A":[50],"total":[51],"110":[53],"COPD":[57,198],"(FEV1":[58],"32%":[59],"predicted)":[60],"were":[61,81],"randomized":[62],"EPR":[64,100],"or":[65],"NLPE.":[66],"Exercise":[67],"was":[69,103,130],"performed":[70],"three":[71],"times":[72],"per":[73],"week":[74],"10":[76],"weeks.":[77],"primary":[79],"outcomes":[80],"cycling":[82,120],"time":[84,122],"health-related":[86,190],"quality":[87,191],"life":[89,193],"using":[90,105],"Chronic":[92,155],"Respiratory":[93,156],"Questionnaire.":[94],"difference":[96,127],"change":[98,129],"between":[99],"NLPE":[102,113,143,181],"assessed":[104],"linear":[106],"mixed-effects":[107],"modeling.":[108],"MEASUREMENTS":[109],"AND":[110],"MAIN":[111],"RESULTS:":[112],"resulted":[114,145],"significantly":[116,147],"greater":[117,148,184],"improvements":[118,149,185],"compared":[123,158],"EPR.":[125],"+300.6":[131],"seconds":[132],"(95%":[133,164,174],"confidence":[134],"interval":[135],"[CI]":[136],"=":[137,166,176],"197.2-404.2":[138],"s;":[139],"P":[140],"<":[141],"0.001).":[142],"also":[144],"all":[151],"domains":[152],"Questionnaire":[157],"EPR,":[160],"ranging":[161],"from":[162],"+0.48":[163],"CI":[165,175],"0.19-0.78)":[167],"domain,":[170],"emotions,":[171],"+0.96":[173],"0.57-1.35)":[177],"dyspnea.":[179],"CONCLUSIONS:":[180],"results":[182],"cycle":[187],"than":[199],"methods.":[202],"Clinical":[203],"trial":[204],"registered":[205],"www.trialregister.nl":[207],"(The":[208],"Netherlands":[209],"Trial":[210],"Register;":[211],"NTR":[212],"1045).":[213]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}