{"id":"https://openalex.org/W2169387542","doi":"https://doi.org/10.1056/nejmoa0706482","title":"Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes","display_name":"Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes","publication_year":2007,"publication_date":"2007-11-04","ids":{"openalex":"https://openalex.org/W2169387542","doi":"https://doi.org/10.1056/nejmoa0706482","mag":"2169387542","pmid":"https://pubmed.ncbi.nlm.nih.gov/17982182"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa0706482","doi":"https://doi.org/10.1056/nejmoa0706482","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa0706482","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa0706482?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa0706482?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107928205","display_name":"Stephen D. Wiviott","orcid":"https://orcid.org/0000-0002-4922-9880","observed_orcids":["https://orcid.org/0000-0002-4922-9880"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen D. Wiviott","raw_affiliation_strings":["Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA","Brigham and Women's Hospital and Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022267024","display_name":"Eugene Braunwald M. D","orcid":"https://orcid.org/0000-0002-3472-626X","observed_orcids":["https://orcid.org/0000-0002-3472-626X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene Braunwald","raw_affiliation_strings":["Brigham and Women's Hospital and Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104358605","display_name":"Carolyn H. McCabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn H. McCabe","raw_affiliation_strings":["Brigham and Women's Hospital and Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027244910","display_name":"Gilles Montalescot","orcid":"https://orcid.org/0000-0003-0824-6809","observed_orcids":["https://orcid.org/0000-0003-0824-6809"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gilles Montalescot","raw_affiliation_strings":["Institut de Cardiologie and INSERM Unit 856, Piti\u00e9\u2013Salp\u00eatri\u00e8re University Hospital, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Cardiologie and INSERM Unit 856, Piti\u00e9\u2013Salp\u00eatri\u00e8re University Hospital, Paris","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033136642","display_name":"Witold Ru\u017cy\u0142\u0142o","orcid":"https://orcid.org/0000-0003-4191-8988","observed_orcids":["https://orcid.org/0000-0003-4191-8988"]},"institutions":[{"id":"https://openalex.org/I4210136231","display_name":"Institute of Cardiology","ror":"https://ror.org/03h2xy876","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210136231"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Witold Ruzyllo","raw_affiliation_strings":["Instytut Kardiologii, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instytut Kardiologii, Warsaw, Poland","institution_ids":["https://openalex.org/I4210136231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042044513","display_name":"Shmuel Gottlieb","orcid":"https://orcid.org/0000-0001-9147-4524","observed_orcids":["https://orcid.org/0000-0001-9147-4524"]},"institutions":[{"id":"https://openalex.org/I2802879425","display_name":"Bikur Cholim Hospital","ror":"https://ror.org/03zpnb459","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2802879425"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shmuel Gottlieb","raw_affiliation_strings":["Bikur Cholim Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bikur Cholim Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2802879425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108537084","display_name":"F.-J. Neumann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133302","display_name":"Universit\u00e4ts-Herzzentrum Freiburg-Bad Krozingen","ror":"https://ror.org/02w6m7e50","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073","https://openalex.org/I4210133302"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franz-Joseph Neumann","raw_affiliation_strings":["Herz-Zentrum Bad Krozingen, Bad Krozingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Herz-Zentrum Bad Krozingen, Bad Krozingen, Germany","institution_ids":["https://openalex.org/I4210133302"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037745068","display_name":"Diego Ardissino","orcid":"https://orcid.org/0000-0003-0410-3528","observed_orcids":["https://orcid.org/0000-0003-0410-3528"]},"institutions":[{"id":"https://openalex.org/I4210135416","display_name":"Ospedale di Parma","ror":"https://ror.org/03jg24239","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210135416"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diego Ardissino","raw_affiliation_strings":["Azienda Ospedaliero\u2013Universitaria di Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Ospedaliero\u2013Universitaria di Parma, Parma, Italy","institution_ids":["https://openalex.org/I4210135416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042435666","display_name":"Stefano De Servi","orcid":"https://orcid.org/0000-0002-9588-2995","observed_orcids":["https://orcid.org/0000-0002-9588-2995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefano De Servi","raw_affiliation_strings":["Azienda Ospedaliera Civile di Legano, Legano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Ospedaliera Civile di Legano, Legano, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085897222","display_name":"Sabina A. Murphy","orcid":"https://orcid.org/0000-0002-8231-3611","observed_orcids":["https://orcid.org/0000-0002-8231-3611"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabina A. Murphy","raw_affiliation_strings":["Brigham and Women's Hospital and Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108126290","display_name":"Jeffrey Riesmeyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Riesmeyer","raw_affiliation_strings":["Eli Lilly Research Laboratories, Indianapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly Research Laboratories, Indianapolis","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079645471","display_name":"Govinda J. Weerakkody","orcid":"https://orcid.org/0000-0003-0595-5554","observed_orcids":["https://orcid.org/0000-0003-0595-5554"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Govinda Weerakkody","raw_affiliation_strings":["Eli Lilly Research Laboratories, Indianapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly Research Laboratories, Indianapolis","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007026783","display_name":"Charles Michael Gibson","orcid":"https://orcid.org/0000-0002-4857-9125","observed_orcids":["https://orcid.org/0000-0002-4857-9125"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Michael Gibson","raw_affiliation_strings":["Brigham and Women's Hospital and Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019612250","display_name":"Elliott Marshall Antman","orcid":"https://orcid.org/0000-0002-0808-9199","observed_orcids":["https://orcid.org/0000-0002-0808-9199"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliott M. Antman","raw_affiliation_strings":["Brigham and Women's Hospital and Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":219.4237,"has_fulltext":false,"cited_by_count":6808,"citation_normalized_percentile":{"value":0.99995379,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"357","issue":"20","first_page":"2001","last_page":"2015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prasugrel","display_name":"prasugrel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":1.0},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.9599999785423279},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.9120000004768372},{"id":"https://openalex.org/keywords/dual-antiplatelet-therapy","display_name":"dual antiplatelet therapy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/thienopyridines","display_name":"thienopyridines","score":0.9049999713897705},{"id":"https://openalex.org/keywords/major-bleeding","display_name":"major bleeding","score":0.7770000100135803},{"id":"https://openalex.org/keywords/stent-thrombosis","display_name":"stent thrombosis","score":0.902999997138977},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9739999771118164},{"id":"https://openalex.org/keywords/target-vessel-revascularization","display_name":"target vessel revascularization","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.6330000162124634},{"id":"https://openalex.org/keywords/bleeding-risk-stratification","display_name":"bleeding risk stratification","score":0.6610000133514404},{"id":"https://openalex.org/keywords/bleeding-risk-score","display_name":"bleeding risk score","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C2777028646","wikidata":"https://www.wikidata.org/wiki/Q416232","display_name":"Prasugrel","level":4,"score":0.9754582047462463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.965368390083313},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.9285752773284912},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.5602808594703674},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5396885871887207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4945065677165985},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.2994688153266907},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.19175106287002563}],"mesh":[{"descriptor_ui":"D000068799","descriptor_name":"Prasugrel Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068799","descriptor_name":"Prasugrel Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068799","descriptor_name":"Prasugrel Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015906","descriptor_name":"Angioplasty, Balloon, Coronary","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015906","descriptor_name":"Angioplasty, Balloon, Coronary","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015906","descriptor_name":"Angioplasty, Balloon, Coronary","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D058919","descriptor_name":"Purinergic P2 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058919","descriptor_name":"Purinergic P2 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058919","descriptor_name":"Purinergic P2 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejmoa0706482","doi":"https://doi.org/10.1056/nejmoa0706482","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa0706482","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa0706482?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:17982182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17982182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial, Phase III"}],"best_oa_location":{"id":"doi:10.1056/nejmoa0706482","doi":"https://doi.org/10.1056/nejmoa0706482","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa0706482","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa0706482?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2169387542.pdf"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W141287021","https://openalex.org/W200979310","https://openalex.org/W1553345686","https://openalex.org/W1985835171","https://openalex.org/W1991655882","https://openalex.org/W2001688139","https://openalex.org/W2003593234","https://openalex.org/W2005726649","https://openalex.org/W2024352468","https://openalex.org/W2034690624","https://openalex.org/W2041936661","https://openalex.org/W2048562616","https://openalex.org/W2049120615","https://openalex.org/W2053379248","https://openalex.org/W2054371088","https://openalex.org/W2056384040","https://openalex.org/W2060063218","https://openalex.org/W2066239730","https://openalex.org/W2074466057","https://openalex.org/W2081246578","https://openalex.org/W2107797912","https://openalex.org/W2113513640","https://openalex.org/W2116457054","https://openalex.org/W2119951798","https://openalex.org/W2125966324","https://openalex.org/W2130350603","https://openalex.org/W2134124835","https://openalex.org/W2152442470","https://openalex.org/W2152823642","https://openalex.org/W2156266070","https://openalex.org/W2156506897","https://openalex.org/W2162245427","https://openalex.org/W2166728273","https://openalex.org/W2230838014","https://openalex.org/W2232858378","https://openalex.org/W2411971210","https://openalex.org/W2615692617","https://openalex.org/W4213078423","https://openalex.org/W4237892021","https://openalex.org/W4256202725"],"related_works":["https://openalex.org/W2066953453","https://openalex.org/W2412620152","https://openalex.org/W2231277951","https://openalex.org/W2398373652","https://openalex.org/W2154214456","https://openalex.org/W2618010215","https://openalex.org/W2004017808","https://openalex.org/W2585688399","https://openalex.org/W3093781987","https://openalex.org/W3134665543"],"abstract_inverted_index":{"BACKGROUND:":[0],"Dual-antiplatelet":[1],"therapy":[2,246],"with":[3,32,39,44,236,240,249,260],"aspirin":[4],"and":[5,21,56,68,116,167,184,226],"a":[6,9,29,57,69],"thienopyridine":[7],"is":[8],"cornerstone":[10],"of":[11,17,112,118,149,180,187,209,253,264],"treatment":[12,277],"to":[13,49,76,134,197],"prevent":[14],"thrombotic":[15],"complications":[16],"acute":[18,41,237],"coronary":[19,23,42,47,238,243],"syndromes":[20,43,239],"percutaneous":[22,46,242],"intervention.":[24],"METHODS:":[25],"To":[26],"compare":[27],"prasugrel,":[28],"new":[30],"thienopyridine,":[31],"clopidogrel,":[33,127],"we":[34],"randomly":[35],"assigned":[36],"13,608":[37],"patients":[38,113,119,181,188,235],"moderate-to-high-risk":[40],"scheduled":[45,241],"intervention":[48],"receive":[50],"prasugrel":[51,121,125,144,183,204,245],"(a":[52,64],"60-mg":[53],"loading":[54,66],"dose":[55,67],"10-mg":[58],"daily":[59,71],"maintenance":[60,72],"dose)":[61],"or":[62,92],"clopidogrel":[63,115,154,190],"300-mg":[65],"75-mg":[70],"dose),":[73],"for":[74,124,153,157],"6":[75],"15":[77],"months.":[78],"The":[79,95,104],"primary":[80,105],"efficacy":[81,106],"end":[82,98,107],"point":[83,99,108],"was":[84,100,176,206,247],"death":[85],"from":[86],"cardiovascular":[87],"causes,":[88],"nonfatal":[89,93,217],"myocardial":[90,150],"infarction,":[91],"stroke.":[94],"key":[96],"safety":[97],"major":[101,265],"bleeding.":[102,269],"RESULTS:":[103],"occurred":[109],"in":[110,142,146,178,185,202],"12.1%":[111],"receiving":[114,120,182,189],"9.9%":[117],"(hazard":[122,191],"ratio":[123],"vs.":[126,155,164,171,213,220,230],"0.81;":[128],"95%":[129,194],"confidence":[130],"interval":[131],"[CI],":[132],"0.73":[133],"0.90;":[135],"P<0.001).":[136,173],"We":[137],"also":[138],"found":[139],"significant":[140],"reductions":[141],"the":[143,147,203,207],"group":[145,205],"rates":[148,252],"infarction":[151],"(9.7%":[152],"7.4%":[156],"prasugrel;":[158],"P<0.001),":[159,166],"urgent":[160],"target-vessel":[161],"revascularization":[162],"(3.7%":[163],"2.5%;":[165],"stent":[168,257],"thrombosis":[169],"(2.4%":[170],"1.1%;":[172],"Major":[174],"bleeding":[175,211,218,228],"observed":[177],"2.4%":[179],"1.8%":[186],"ratio,":[192,223],"1.32;":[193],"CI,":[195],"1.03":[196],"1.68;":[198],"P=0.03).":[199],"Also":[200],"greater":[201],"rate":[208],"life-threatening":[210],"(1.4%":[212],"0.9%;":[214,221],"P=0.01),":[215],"including":[216,256,267],"(1.1%":[219],"hazard":[222],"1.25;":[224],"P=0.23)":[225],"fatal":[227,268],"(0.4%":[229],"0.1%;":[231],"P=0.002).":[232],"CONCLUSIONS:":[233],"In":[234],"intervention,":[244],"associated":[248],"significantly":[250,275],"reduced":[251],"ischemic":[254],"events,":[255],"thrombosis,":[258],"but":[259],"an":[261],"increased":[262],"risk":[263],"bleeding,":[266],"Overall":[270],"mortality":[271],"did":[272],"not":[273],"differ":[274],"between":[276],"groups.":[278],"(ClinicalTrials.gov":[279],"number,":[280],"NCT00097591":[281],"[ClinicalTrials.gov].)":[282]},"counts_by_year":[{"year":2026,"cited_by_count":153},{"year":2025,"cited_by_count":202},{"year":2024,"cited_by_count":187},{"year":2023,"cited_by_count":265},{"year":2022,"cited_by_count":310},{"year":2021,"cited_by_count":325},{"year":2020,"cited_by_count":338},{"year":2019,"cited_by_count":360},{"year":2018,"cited_by_count":389},{"year":2017,"cited_by_count":418},{"year":2016,"cited_by_count":417},{"year":2015,"cited_by_count":464},{"year":2014,"cited_by_count":450},{"year":2013,"cited_by_count":499},{"year":2012,"cited_by_count":508}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
