{"id":"https://openalex.org/W2169155656","doi":"https://doi.org/10.1136/heart.89.8.871","title":"Increased urinary 15-F2t-isoprostane concentrations in patients with non-ischaemic congestive heart failure: a marker of oxidative stress","display_name":"Increased urinary 15-F2t-isoprostane concentrations in patients with non-ischaemic congestive heart failure: a marker of oxidative stress","publication_year":2003,"publication_date":"2003-07-14","ids":{"openalex":"https://openalex.org/W2169155656","doi":"https://doi.org/10.1136/heart.89.8.871","mag":"2169155656","pmid":"https://pubmed.ncbi.nlm.nih.gov/12860861","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1767773"},"language":"en","primary_location":{"id":"doi:10.1136/heart.89.8.871","doi":"https://doi.org/10.1136/heart.89.8.871","is_oa":true,"landing_page_url":"https://doi.org/10.1136/heart.89.8.871","pdf_url":"https://heart.bmj.com/content/heartjnl/89/8/871.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://heart.bmj.com/content/heartjnl/89/8/871.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076630786","display_name":"Mutsuko Nonaka\u2010Sarukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Nonaka-Sarukawa","raw_affiliation_strings":["Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329-0498, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329-0498, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"K Yamamoto","raw_affiliation_strings":["Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329\u20130498, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329\u20130498, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Aoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Aoki","raw_affiliation_strings":["Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329\u20130498, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329\u20130498, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Takano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136772","display_name":"BML (Japan)","ror":"https://ror.org/04vr3cf25","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210136772"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Takano","raw_affiliation_strings":["BML, Inc, Kawagoe, Saitama 350\u20131101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BML, Inc, Kawagoe, Saitama 350\u20131101, Japan","institution_ids":["https://openalex.org/I4210136772"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T Katsuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Katsuki","raw_affiliation_strings":["Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329\u20130498, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329\u20130498, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":null,"display_name":"U Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"U Ikeda","raw_affiliation_strings":["Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329\u20130498, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329\u20130498, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"last","author":{"id":null,"display_name":"K Shimada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Shimada","raw_affiliation_strings":["Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329\u20130498, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Jichi Medical School, Minamikawachi-Machi, Tochigi 329\u20130498, Japan","institution_ids":["https://openalex.org/I146500386"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I146500386"],"apc_list":null,"apc_paid":null,"fwci":4.7687,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.95602355,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"89","issue":"8","first_page":"871","last_page":"874"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.6675000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.6675000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.08129999786615372,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/8-isoprostane","display_name":"8-isoprostane","score":0.9340000152587891},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.7360000014305115},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8299999833106995},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9160000085830688},{"id":"https://openalex.org/keywords/non-ischemic-heart-failure","display_name":"non-ischemic heart failure","score":0.9559999704360962},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.8659999966621399},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8999999761581421},{"id":"https://openalex.org/keywords/thrombomodulin","display_name":"thrombomodulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.8889999985694885},{"id":"https://openalex.org/keywords/heart-failure-severity","display_name":"heart failure severity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/acute-heart-failure-exacerbation","display_name":"acute heart failure exacerbation","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8396316766738892},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6832279562950134},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6443383097648621},{"id":"https://openalex.org/C2780340399","wikidata":"https://www.wikidata.org/wiki/Q4198767","display_name":"Isoprostane","level":4,"score":0.6431185007095337},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5984581708908081},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5931090116500854},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.5469706654548645},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3802127242088318},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37970808148384094},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.1524975597858429}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018180","descriptor_name":"Thrombomodulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D028441","descriptor_name":"F2-Isoprostanes","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/heart.89.8.871","doi":"https://doi.org/10.1136/heart.89.8.871","is_oa":true,"landing_page_url":"https://doi.org/10.1136/heart.89.8.871","pdf_url":"https://heart.bmj.com/content/heartjnl/89/8/871.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1767773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1767773","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"Text"},{"id":"pmid:12860861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12860861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart (British Cardiac Society)","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.860.5801","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.860.5801","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://heart.bmj.com/content/89/8/871.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1136/heart.89.8.871","doi":"https://doi.org/10.1136/heart.89.8.871","is_oa":true,"landing_page_url":"https://doi.org/10.1136/heart.89.8.871","pdf_url":"https://heart.bmj.com/content/heartjnl/89/8/871.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2169155656.pdf","grobid_xml":"https://content.openalex.org/works/W2169155656.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1483108854","https://openalex.org/W1964507366","https://openalex.org/W1970598712","https://openalex.org/W1972153352","https://openalex.org/W1972253696","https://openalex.org/W1980468558","https://openalex.org/W1987003312","https://openalex.org/W1989348728","https://openalex.org/W1989447605","https://openalex.org/W1996726425","https://openalex.org/W1998318767","https://openalex.org/W2000287422","https://openalex.org/W2000545849","https://openalex.org/W2009986585","https://openalex.org/W2015090490","https://openalex.org/W2023200717","https://openalex.org/W2027712499","https://openalex.org/W2028816863","https://openalex.org/W2040151193","https://openalex.org/W2061679479","https://openalex.org/W2090881549","https://openalex.org/W2095014707","https://openalex.org/W2097744068","https://openalex.org/W2110379629","https://openalex.org/W2113865982","https://openalex.org/W4233370122","https://openalex.org/W7074142570"],"related_works":["https://openalex.org/W7097956237","https://openalex.org/W972441319","https://openalex.org/W2004289384","https://openalex.org/W1981017040","https://openalex.org/W3007057152","https://openalex.org/W2085411120","https://openalex.org/W4231107285","https://openalex.org/W2027295036","https://openalex.org/W3115018039","https://openalex.org/W2003653014"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"a":[3,105,196],"novel":[4],"marker":[5,106,197],"of":[6,38,102,107,142,176,198],"oxidative":[7,203],"stress":[8,204],"in":[9,81,91,95,130,137,171,178,205],"patients":[10,18,23,55,82,96,114,131,206],"with":[11,19,24,27,56,83,97,115,132,152,162,207],"congestive":[12],"heart":[13],"failure":[14],"(CHF).":[15],"PATIENTS:":[16],"15":[17,22,31],"mild":[20,98],"CHF,":[21,58],"severe":[25,57,84,133],"CHF":[26,85,116,134,143,177],"acute":[28],"exacerbation,":[29],"and":[30,50,64,67,77,117,126,156],"control":[32,92,118],"subjects.":[33,119],"MAIN":[34],"OUTCOME":[35],"MEASURES:":[36],"Measurement":[37],"urinary":[39,122,147,192],"15-F2t-isoprostane,":[40,74,123],"plasma":[41,75,124,153],"brain":[42],"natriuretic":[43],"peptide":[44],"(BNP),":[45],"serum":[46,51,78,103,127,157,163],"interleukin":[47],"6":[48],"(IL-6),":[49],"thrombomodulin":[52,164],"concentrations.":[53,165],"In":[54,120],"samples":[59],"were":[60,86,110],"taken":[61],"at":[62],"admission":[63],"4,":[65],"7,":[66],"14":[68],"days":[69],"after":[70],"admission.":[71],"RESULTS:":[72],"Urinary":[73,167],"BNP,":[76,125],"IL-6":[79,128,158],"concentrations":[80,101,129,149,155,169],"significantly":[87,150],"higher":[88],"than":[89],"those":[90],"subjects":[93],"or":[94],"CHF.":[99,208],"However,":[100],"thrombomodulin,":[104],"endothelial":[108],"damage,":[109],"not":[111,161],"different":[112],"between":[113],"addition,":[121],"gradually":[135],"decreased":[136],"proportion":[138,172],"to":[139,173],"the":[140,174],"severity":[141,175],"during":[144],"hospitalisation.":[145],"Interestingly,":[146],"15-F2t-isoprostane":[148,168,186,193],"correlated":[151],"BNP":[154],"concentrations,":[159],"but":[160],"CONCLUSIONS:":[166],"increased":[170,185],"patients.":[179],"This":[180],"may":[181,194],"be":[182,195],"caused":[183],"by":[184],"production.":[187],"These":[188],"findings":[189],"suggest":[190],"that":[191],"morbidity":[199],"as":[200,202],"well":[201]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}