{"id":"https://openalex.org/W2169102863","doi":"https://doi.org/10.1084/jem.137.4.1060","title":"BLOCKING AND REDISTRIBUTION (\"CAPPING\") OF ANTIGEN RECEPTORS ON T AND B LYMPHOCYTES BY ANTI-IMMUNOGLOBULIN ANTIBODY","display_name":"BLOCKING AND REDISTRIBUTION (\"CAPPING\") OF ANTIGEN RECEPTORS ON T AND B LYMPHOCYTES BY ANTI-IMMUNOGLOBULIN ANTIBODY","publication_year":1973,"publication_date":"1973-04-01","ids":{"openalex":"https://openalex.org/W2169102863","doi":"https://doi.org/10.1084/jem.137.4.1060","mag":"2169102863","pmid":"https://pubmed.ncbi.nlm.nih.gov/4571327","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2139224"},"language":"en","primary_location":{"id":"doi:10.1084/jem.137.4.1060","doi":"https://doi.org/10.1084/jem.137.4.1060","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.137.4.1060","pdf_url":"https://rupress.org/jem/article-pdf/137/4/1060/1085321/1060.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/137/4/1060/1085321/1060.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108486612","display_name":"Georges E. Roelants","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georges Roelants","raw_affiliation_strings":["From the Basel Institute for Immunology, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Basel Institute for Immunology, Basel, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003741167","display_name":"Luciana Forni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luciana Forni","raw_affiliation_strings":["From the Basel Institute for Immunology, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Basel Institute for Immunology, Basel, Switzerland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111990600","display_name":"Benvenuto Pernis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benvenuto Pernis","raw_affiliation_strings":["From the Basel Institute for Immunology, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Basel Institute for Immunology, Basel, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.4879,"has_fulltext":true,"cited_by_count":93,"citation_normalized_percentile":{"value":0.99137234,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"137","issue":"4","first_page":"1060","last_page":"1077"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-immunoglobulin-antibodies","display_name":"anti-immunoglobulin antibodies","score":0.9240000247955322},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antigen-binding","display_name":"antigen binding","score":0.5740000009536743},{"id":"https://openalex.org/keywords/igm-receptor","display_name":"IgM receptor","score":0.5600000023841858},{"id":"https://openalex.org/keywords/receptor-density","display_name":"receptor density","score":0.42899999022483826},{"id":"https://openalex.org/keywords/antigen-specific-receptors","display_name":"antigen-specific receptors","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6010327339172363},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5185557007789612},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4735794961452484},{"id":"https://openalex.org/C45121317","wikidata":"https://www.wikidata.org/wiki/Q4927287","display_name":"Blocking antibody","level":3,"score":0.47218480706214905},{"id":"https://openalex.org/C2911212856","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Surface Immunoglobulin","level":4,"score":0.44610846042633057},{"id":"https://openalex.org/C74080474","wikidata":"https://www.wikidata.org/wiki/Q7305975","display_name":"Redistribution (election)","level":3,"score":0.4299629330635071},{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.41862866282463074},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.41135865449905396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37650561332702637},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3658236861228943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34720635414123535},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3331793546676636},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.28542059659957886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15467488765716553},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13310599327087402},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.11640411615371704},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000888","descriptor_name":"Antibodies, Anti-Idiotypic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000961","descriptor_name":"Antilymphocyte Serum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006433","descriptor_name":"Hemocyanins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007456","descriptor_name":"Iodine Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008806","descriptor_name":"Mice, Inbred AKR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009194","descriptor_name":"Myeloma Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1084/jem.137.4.1060","doi":"https://doi.org/10.1084/jem.137.4.1060","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.137.4.1060","pdf_url":"https://rupress.org/jem/article-pdf/137/4/1060/1085321/1060.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2139224","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2139224","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:4571327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4571327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.273.2194","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.2194","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2e/c9/J_Exp_Med_1973_Mar_31_137(4)_1060-1077.tar.gz","raw_type":"text"},{"id":"pmh:oai:mouseion.jax.org:ssbb1973-2016","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1973/1017","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1973","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1084/jem.137.4.1060","doi":"https://doi.org/10.1084/jem.137.4.1060","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.137.4.1060","pdf_url":"https://rupress.org/jem/article-pdf/137/4/1060/1085321/1060.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2169102863.pdf","grobid_xml":"https://content.openalex.org/works/W2169102863.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W65419923","https://openalex.org/W128621551","https://openalex.org/W158400344","https://openalex.org/W188019936","https://openalex.org/W1513523027","https://openalex.org/W1518493381","https://openalex.org/W1563050911","https://openalex.org/W1563519230","https://openalex.org/W1597299973","https://openalex.org/W1604517016","https://openalex.org/W1758803187","https://openalex.org/W1968373623","https://openalex.org/W1968614812","https://openalex.org/W1977602326","https://openalex.org/W1986355182","https://openalex.org/W1995252281","https://openalex.org/W2005475362","https://openalex.org/W2013295182","https://openalex.org/W2016955490","https://openalex.org/W2021427629","https://openalex.org/W2028127354","https://openalex.org/W2035336520","https://openalex.org/W2057969721","https://openalex.org/W2065611281","https://openalex.org/W2067499651","https://openalex.org/W2078777959","https://openalex.org/W2079757266","https://openalex.org/W2082476632","https://openalex.org/W2087327848","https://openalex.org/W2089911739","https://openalex.org/W2124967626","https://openalex.org/W2126760519","https://openalex.org/W2161574642","https://openalex.org/W2162666693","https://openalex.org/W2413045917","https://openalex.org/W4313310073","https://openalex.org/W4313377000"],"related_works":["https://openalex.org/W38352386","https://openalex.org/W4313309260","https://openalex.org/W1797548493","https://openalex.org/W1998790889","https://openalex.org/W2079477641","https://openalex.org/W2004417655","https://openalex.org/W1534849710","https://openalex.org/W2062776627","https://openalex.org/W1544790717","https://openalex.org/W1656467347"],"abstract_inverted_index":{"Antigen-binding":[0],"T":[1,44,71,83,94,107,189,205,234,238],"and":[2,10,82,93,152,233,247],"B":[3,36,81,92,115,137,192,203,232],"lymphocytes":[4,14,235],"were":[5,21,38,70,166],"studied":[6],"by":[7,80,98,141,212],"combined":[8],"autoradiography":[9],"immunofluorescence;":[11],"mouse":[12,217],"spleen":[13],"binding":[15],"the":[16,67,134,153,162,172,185,249,258],"antigens,":[17],"[(125)I]MSH":[18],"or":[19,27,42,48,102,123,204,211],"[(125)I]TIGAL,":[20],"incubated":[22],"with":[23,28,207,216],"rhodamine-labeled":[24,30],"anti-Ig":[25,145,213],"reagents":[26,214],"a":[29],"IgG":[31],"fraction":[32],"of":[33,66,76,89,136,144,188,196,222,225,230,244,251,260],"anti-theta":[34,124],"serum.":[35],"cells":[37,45,69,84,95,108,138,154,190,206,239],"identified":[39],"as":[40,46,191],"Ig+":[41],"theta-,":[43],"Ig-":[47],"theta+.":[49],"It":[50],"was":[51,85,96,109,139,180,199],"found":[52,181],"that:":[53],"(a)":[54],"20%":[55],"(1-2":[56],"mo":[57,63],"after":[58,64],"priming)":[59,65],"to":[60,91,106,114,147,157,255],"30%":[61],"(3.5-4":[62],"antigen-binding":[68,231],"cells.":[72,116,193],"(b)":[73],"The":[74,219],"range":[75,256],"antigen":[77,90,128,179,197],"molecules":[78],"bound":[79],"similar.":[86],"(c)":[87],"Binding":[88,105],"inhibited":[97,112],"polyvalent":[99],"anti-Ig,":[100],"anti-micro,":[101],"anti-L":[103],"reagents.":[104],"more":[110],"readily":[111],"than":[113],"Normal":[117],"rabbit":[118,209],"serum,":[119,122],"antimouse":[120],"lymphocyte":[121],"did":[125],"not":[126,200],"inhibit":[127],"binding.":[129],"(d)":[130],"When":[131],"Ig":[132,173],"at":[133],"surface":[135],"induced,":[140],"noninhibiting":[142],"concentrations":[143],"reagents,":[146],"redistribute":[148],"into":[149],"polar":[150],"caps":[151,169],"subsequently":[155],"exposed":[156],"[(125)I)antigen":[158],"under":[159],"noncapping":[160],"conditions,":[161],"[(125)I]antigen":[163],"silver":[164],"grains":[165],"distributed":[167],"in":[168,182,184,202,257],"superimposed":[170],"on":[171],"fluorescent":[174],"cap.":[175],"Of":[176],"crucial":[177],"importance,":[178],"cap":[183],"same":[186],"proportion":[187],"Significant":[194],"capping":[195],"receptors":[198,253],"induced":[201],"normal":[208],"serum":[210],"absorbed":[215],"Ig.":[218],"main":[220],"conclusions":[221],"this":[223],"series":[224],"experiments":[226],"using":[227],"direct":[228],"visualization":[229],"is":[236],"that":[237,248],"have":[240],"antigen-specific":[241],"receptors,":[242],"probably":[243],"IgM":[245],"nature,":[246],"number":[250],"these":[252],"appears":[254],"order":[259],"thousands.":[261]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}