{"id":"https://openalex.org/W2169044136","doi":"https://doi.org/10.1590/s0004-27302013000600005","title":"New insights into steroidogenesis in normo- and hyperandrogenic polycystic ovary syndrome patients","display_name":"New insights into steroidogenesis in normo- and hyperandrogenic polycystic ovary syndrome patients","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2169044136","doi":"https://doi.org/10.1590/s0004-27302013000600005","mag":"2169044136","pmid":"https://pubmed.ncbi.nlm.nih.gov/24030183"},"language":"en","primary_location":{"id":"doi:10.1590/s0004-27302013000600005","doi":"https://doi.org/10.1590/s0004-27302013000600005","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302013000600005","pdf_url":"https://www.scielo.br/j/abem/a/85V9D46kPVGbv6rNMfXBVcL/?lang=en&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/abem/a/85V9D46kPVGbv6rNMfXBVcL/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102970385","display_name":"Sebasti\u00e3o Freitas de Medeiros","orcid":"https://orcid.org/0000-0003-1292-2515","observed_orcids":["https://orcid.org/0000-0003-1292-2515"]},"institutions":[{"id":"https://openalex.org/I32725510","display_name":"Universidade Federal de Mato Grosso","ror":"https://ror.org/01mqvjv41","country_code":"BR","type":"education","lineage":["https://openalex.org/I32725510"]},{"id":"https://openalex.org/I4210135201","display_name":"Instituto Tropical de Medicina Reprodutiva","ror":"https://ror.org/04rd2ca50","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210135201"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Sebasti\u00e3o Freitas de Medeiros","raw_affiliation_strings":["Universidade Federal de Mato Grosso, Brazil; Julio Muller University Hospital, Brazil; Tropical Institute of Reproductive Medicine and Menopause, Brazil","Cuiaba, Mato Grosso, Universidade Federal de Mato Grosso, Medical Science School, Department of Gynecology and Obstetrics, Brazil, Cuiaba, Mato Grosso, Universidade Federal de Mato Grosso, Brazil, Cuiaba, , Instituto Tropical de Medicina Reprodutiva e Menopausa, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Mato Grosso, Brazil; Julio Muller University Hospital, Brazil; Tropical Institute of Reproductive Medicine and Menopause, Brazil","institution_ids":["https://openalex.org/I32725510","https://openalex.org/I4210135201"]},{"raw_affiliation_string":"Cuiaba, Mato Grosso, Universidade Federal de Mato Grosso, Medical Science School, Department of Gynecology and Obstetrics, Brazil, Cuiaba, Mato Grosso, Universidade Federal de Mato Grosso, Brazil, Cuiaba, , Instituto Tropical de Medicina Reprodutiva e Menopausa, Brazil","institution_ids":["https://openalex.org/I32725510","https://openalex.org/I4210135201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024914699","display_name":"\u00c2ngelo Barrionuevo Gil-Junior","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32725510","display_name":"Universidade Federal de Mato Grosso","ror":"https://ror.org/01mqvjv41","country_code":"BR","type":"education","lineage":["https://openalex.org/I32725510"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"\u00c2ngelo Barrionuevo Gil-Junior","raw_affiliation_strings":["Julio Muller University Hospital, Brazil","Cuiaba, Mato Grosso, Universidade Federal de Mato Grosso, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Julio Muller University Hospital, Brazil","institution_ids":[]},{"raw_affiliation_string":"Cuiaba, Mato Grosso, Universidade Federal de Mato Grosso, Brazil","institution_ids":["https://openalex.org/I32725510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051818927","display_name":"Jacklyne Silva Barbosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135201","display_name":"Instituto Tropical de Medicina Reprodutiva","ror":"https://ror.org/04rd2ca50","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210135201"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jacklyne Silva Barbosa","raw_affiliation_strings":["Tropical Institute of Reproductive Medicine and Menopause, Brazil","Cuiaba, , Instituto Tropical de Medicina Reprodutiva e Menopausa, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tropical Institute of Reproductive Medicine and Menopause, Brazil","institution_ids":["https://openalex.org/I4210135201"]},{"raw_affiliation_string":"Cuiaba, , Instituto Tropical de Medicina Reprodutiva e Menopausa, Brazil","institution_ids":["https://openalex.org/I4210135201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027804278","display_name":"\u00c9rico Duarte Isa\u00edas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32725510","display_name":"Universidade Federal de Mato Grosso","ror":"https://ror.org/01mqvjv41","country_code":"BR","type":"education","lineage":["https://openalex.org/I32725510"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"\u00c9rico Duarte Isa\u00edas","raw_affiliation_strings":["Julio Muller University Hospital, Brazil","Cuiaba, Mato Grosso, Universidade Federal de Mato Grosso, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Julio Muller University Hospital, Brazil","institution_ids":[]},{"raw_affiliation_string":"Cuiaba, Mato Grosso, Universidade Federal de Mato Grosso, Brazil","institution_ids":["https://openalex.org/I32725510"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102714645","display_name":"M\u00e1rcia Marly Winck Yamamoto","orcid":"https://orcid.org/0000-0002-4845-4226","observed_orcids":["https://orcid.org/0000-0002-4845-4226"]},"institutions":[{"id":"https://openalex.org/I4210135201","display_name":"Instituto Tropical de Medicina Reprodutiva","ror":"https://ror.org/04rd2ca50","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210135201"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M\u00e1rcia Marly Winck Yamamoto","raw_affiliation_strings":["Tropical Institute of Reproductive Medicine and Menopause, Brazil","Cuiaba, , Instituto Tropical de Medicina Reprodutiva e Menopausa, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tropical Institute of Reproductive Medicine and Menopause, Brazil","institution_ids":["https://openalex.org/I4210135201"]},{"raw_affiliation_string":"Cuiaba, , Instituto Tropical de Medicina Reprodutiva e Menopausa, Brazil","institution_ids":["https://openalex.org/I4210135201"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102970385"],"corresponding_institution_ids":["https://openalex.org/I32725510","https://openalex.org/I4210135201"],"apc_list":null,"apc_paid":null,"fwci":2.0738,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.84123422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"57","issue":"6","first_page":"437","last_page":"444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.9049999713897705},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/17alpha-hydroxylase","display_name":"17\u03b1-hydroxylase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/17-20-lyase","display_name":"17,20-lyase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/21-hydroxylase","display_name":"21-hydroxylase","score":0.9649999737739563},{"id":"https://openalex.org/keywords/11beta-hydroxylase","display_name":"11\u03b2-hydroxylase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/adrenal-stimulation","display_name":"adrenal stimulation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/tetracosactrin","display_name":"tetracosactrin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.8140000104904175},{"id":"https://openalex.org/keywords/androstenedione","display_name":"androstenedione","score":0.902999997138977},{"id":"https://openalex.org/keywords/17-hydroxyprogesterone","display_name":"17-hydroxyprogesterone","score":0.8939999938011169},{"id":"https://openalex.org/keywords/17alpha-hydroxypregnenolone","display_name":"17-hydroxypregnenolone","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.9490769505500793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5220865607261658},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4263150691986084},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3789184093475342},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.07289749383926392},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.03683909773826599}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000312","descriptor_name":"Adrenal Hyperplasia, Congenital","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008190","descriptor_name":"Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013252","descriptor_name":"Steroid 11-beta-Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013254","descriptor_name":"Steroid 17-alpha-Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013255","descriptor_name":"Steroid 21-Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017588","descriptor_name":"Hyperandrogenism","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D019326","descriptor_name":"17-alpha-Hydroxyprogesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1590/s0004-27302013000600005","doi":"https://doi.org/10.1590/s0004-27302013000600005","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302013000600005","pdf_url":"https://www.scielo.br/j/abem/a/85V9D46kPVGbv6rNMfXBVcL/?lang=en&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},{"id":"pmid:24030183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24030183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos brasileiros de endocrinologia e metabologia","raw_type":"Comparative Study"},{"id":"pmh:oai:scielo:S0004-27302013000600005","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0004-27302013000600005","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp;amp; Metabologia v.57 n.6 2013","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2623503","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2623503","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp;amp; Metabologia v.57 n.6 2013","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1590/s0004-27302013000600005","doi":"https://doi.org/10.1590/s0004-27302013000600005","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302013000600005","pdf_url":"https://www.scielo.br/j/abem/a/85V9D46kPVGbv6rNMfXBVcL/?lang=en&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2169044136.pdf","grobid_xml":"https://content.openalex.org/works/W2169044136.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1968635151","https://openalex.org/W1969062482","https://openalex.org/W1978635385","https://openalex.org/W1982523050","https://openalex.org/W1984067141","https://openalex.org/W2001983775","https://openalex.org/W2005723451","https://openalex.org/W2010208043","https://openalex.org/W2018452033","https://openalex.org/W2021823436","https://openalex.org/W2040330692","https://openalex.org/W2049026413","https://openalex.org/W2050869495","https://openalex.org/W2051943519","https://openalex.org/W2053043637","https://openalex.org/W2064315460","https://openalex.org/W2091378375","https://openalex.org/W2095394983","https://openalex.org/W2095645359","https://openalex.org/W2096887626","https://openalex.org/W2108727975","https://openalex.org/W2115154529","https://openalex.org/W2124041132","https://openalex.org/W2126733133","https://openalex.org/W2126846194","https://openalex.org/W2141227160","https://openalex.org/W2143057061","https://openalex.org/W2159937286","https://openalex.org/W2170855066","https://openalex.org/W2186218348","https://openalex.org/W2235942812","https://openalex.org/W2316958484","https://openalex.org/W2407804907","https://openalex.org/W3126094907"],"related_works":["https://openalex.org/W2152379909","https://openalex.org/W4285494804","https://openalex.org/W1968635151","https://openalex.org/W2915991879","https://openalex.org/W157341527","https://openalex.org/W3000060430","https://openalex.org/W2038084757","https://openalex.org/W1995994721","https://openalex.org/W2545129117","https://openalex.org/W2095645359"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1,21],"study":[2,23],"sought":[3],"to":[4,42,94,182],"examine":[5],"corticosteroidogenic":[6],"enzyme":[7],"activities":[8,38,71,111,134],"in":[9,57,72,112,129,148,184,194],"normo-":[10],"and":[11,30,50,68,79,88,105,125,166,197,203],"hyperandrogenic":[12,63,185,198],"polycystic":[13],"ovary":[14],"syndrome":[15],"(PCOS)":[16],"patients.":[17,96],"SUBJECTS":[18],"AND":[19],"METHODS:":[20],"cohort":[22],"included":[24],"81":[25],"patients":[26,32,64,116,157,187,199],"with":[27,33,177],"biochemical":[28],"hyperandrogenism":[29],"41":[31],"normal":[34,178],"androgen":[35],"levels.":[36],"Enzyme":[37],"were":[39],"assessed":[40],"according":[41],"the":[43,58,98,103,142,149],"serum":[44],"steroid":[45],"product/precursor":[46],"ratios":[47],"at":[48,164],"baseline":[49,165],"after":[51,167],"adrenal":[52,168,195],"stimulation.":[53,169],"RESULTS:":[54],"At":[55],"baseline,":[56],"delta":[59,99],"4":[60],"(\u03944)":[61],"pathway,":[62,102],"showed":[65,109],"greater":[66],"17-hydroxylase":[67,104],"17,20":[69,106,143,160],"lyase":[70,107,144,161],"converting":[73],"progesterone":[74],"(P4)":[75],"into":[76,82,175],"17-hydroxyprogesterone":[77],"(17-OHP4)":[78],"17-hydroxypregnenolone":[80],"(17-OHPE)":[81],"androstenedione":[83],"(A)":[84],"(p":[85,122,135,152],"=":[86,90,123],"0.0005":[87],"p":[89],"0.047,":[91],"respectively)":[92],"compared":[93],"normoandrogenic":[95],"In":[97],"5":[100],"(\u03945)":[101],"enzymes":[108],"similar":[110],"both":[113,163],"groups.":[114],"Hyperandrogenic":[115,156],"presented":[117],"lower":[118,120,201],"21-hydroxylase,":[119],"11\u03b2-hydroxylase":[121,202],"0.0001),":[124],"statistically":[126],"significant":[127],"increases":[128],"3\u03b2-hydroxysteroid":[130],"dehydrogenase":[131],"II":[132],"(3\u03b2-HSDII)":[133],"<":[136,153],"0.0001).":[137,154],"Following":[138],"tetracosactrin":[139],"stimulation,":[140],"only":[141],"activity":[145,193],"remained":[146],"up-regulated":[147],"\u03944":[150],"pathway":[151],"CONCLUSION:":[155],"had":[158,200],"higher":[159],"activity,":[162],"Greater":[170],"conversion":[171,179],"of":[172,180,191],"dehydroepiandrosterone":[173],"(DHEA)":[174],"A":[176],"17-OHPE":[181],"17-OHP4":[183],"PCOS":[186],"indicated":[188],"different":[189],"levels":[190],"3\u03b2-HSDII":[192],"cells,":[196],"21-hydroxylase":[204],"activities.":[205]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}