{"id":"https://openalex.org/W2169028362","doi":"https://doi.org/10.2215/cjn.02560314","title":"Nephron Hypertrophy and Glomerulosclerosis and Their Association with Kidney Function and Risk Factors among Living Kidney Donors","display_name":"Nephron Hypertrophy and Glomerulosclerosis and Their Association with Kidney Function and Risk Factors among Living Kidney Donors","publication_year":2014,"publication_date":"2014-10-16","ids":{"openalex":"https://openalex.org/W2169028362","doi":"https://doi.org/10.2215/cjn.02560314","mag":"2169028362","pmid":"https://pubmed.ncbi.nlm.nih.gov/25318758"},"language":"en","primary_location":{"id":"doi:10.2215/cjn.02560314","doi":"https://doi.org/10.2215/cjn.02560314","is_oa":false,"landing_page_url":"https://doi.org/10.2215/cjn.02560314","pdf_url":null,"source":{"id":"https://openalex.org/S184267533","display_name":"Clinical Journal of the American Society of Nephrology","issn_l":"1555-9041","issn":["1555-9041","1555-905X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4220756","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083638202","display_name":"Hisham E. Elsherbiny","orcid":"https://orcid.org/0000-0001-7238-9252","observed_orcids":["https://orcid.org/0000-0001-7238-9252"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hisham E. Elsherbiny","raw_affiliation_strings":["Division of Nephrology and Hypertension"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065376865","display_name":"Mariam P. Alexander","orcid":"https://orcid.org/0000-0001-9072-9871","observed_orcids":["https://orcid.org/0000-0001-9072-9871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariam P. Alexander","raw_affiliation_strings":["Division of Anatomic Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Anatomic Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055499310","display_name":"Walter K. Kremers","orcid":"https://orcid.org/0000-0001-5714-3473","observed_orcids":["https://orcid.org/0000-0001-5714-3473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter K. Kremers","raw_affiliation_strings":["Division of Biomedical Statistics and Informatics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Statistics and Informatics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057467074","display_name":"Walter D. Park","orcid":"https://orcid.org/0000-0002-0536-9515","observed_orcids":["https://orcid.org/0000-0002-0536-9515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter D. Park","raw_affiliation_strings":["Transplant Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043195515","display_name":"Emilio D. Poggio","orcid":"https://orcid.org/0000-0003-1492-5103","observed_orcids":["https://orcid.org/0000-0003-1492-5103"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emilio D. Poggio","raw_affiliation_strings":["Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland Ohio","Division of Nephrology and Hypertension"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland Ohio","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025369403","display_name":"Mikel Prieto","orcid":"https://orcid.org/0000-0001-6662-4252","observed_orcids":["https://orcid.org/0000-0001-6662-4252"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikel Prieto","raw_affiliation_strings":["Transplant Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048525391","display_name":"John Charles Lieske","orcid":"https://orcid.org/0000-0002-0202-5944","observed_orcids":["https://orcid.org/0000-0002-0202-5944"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John C. Lieske","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Laboratory Medicine and Pathology","Department of Laboratory Medicine and Pathology","Division of Nephrology and Hypertension"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Laboratory Medicine and Pathology","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology","institution_ids":[]},{"raw_affiliation_string":"Division of Nephrology and Hypertension","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031580643","display_name":"Andrew D. Rule","orcid":"https://orcid.org/0000-0003-0338-7784","observed_orcids":["https://orcid.org/0000-0003-0338-7784"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew D. Rule","raw_affiliation_strings":["Division of Nephrology and Hypertension, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota; and rule.andrew@mayo.edu","Division of Epidemiology, Mayo Clinic, Rochester, Minnesota","Division of Nephrology and Hypertension","Dr. Andrew D. Rule, Divisions of Nephrology and Hypertension and Epidemiology, Mayo Clinic 200 First Street SW, Rochester, MN 55905. Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota; and rule.andrew@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Epidemiology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension","institution_ids":[]},{"raw_affiliation_string":"Dr. Andrew D. Rule, Divisions of Nephrology and Hypertension and Epidemiology, Mayo Clinic 200 First Street SW, Rochester, MN 55905. Email: [email\u00a0protected]","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031580643","https://openalex.org/A5043195515","https://openalex.org/A5048525391","https://openalex.org/A5083638202"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":6.9142,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.97192376,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"9","issue":"11","first_page":"1892","last_page":"1902"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/living-kidney-donors","display_name":"living kidney donors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.8849999904632568},{"id":"https://openalex.org/keywords/glomerular-volume","display_name":"glomerular volume","score":0.828000009059906},{"id":"https://openalex.org/keywords/glomerular-density","display_name":"glomerular density","score":0.9039999842643738},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.6660000085830688},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.9190000295639038},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7129999995231628},{"id":"https://openalex.org/keywords/kidney-biopsy","display_name":"renal biopsy","score":0.5350000262260437},{"id":"https://openalex.org/keywords/chronic-kidney-disease-risk-factors","display_name":"chronic kidney disease risk factors","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7713404893875122},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7536205053329468},{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.7534675598144531},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6643959283828735},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6373026371002197},{"id":"https://openalex.org/C2911077047","wikidata":"https://www.wikidata.org/wiki/Q1434446","display_name":"Nephrosclerosis","level":3,"score":0.5893300175666809},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5539544820785522},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.5227180123329163},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.5099741220474243},{"id":"https://openalex.org/C2777390665","wikidata":"https://www.wikidata.org/wiki/Q5571239","display_name":"Glomerulosclerosis","level":4,"score":0.5040490031242371},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.4955333471298218},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.46620023250579834},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.44471266865730286},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3789314329624176}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005923","descriptor_name":"Glomerulosclerosis, Focal Segmental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005923","descriptor_name":"Glomerulosclerosis, Focal Segmental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005923","descriptor_name":"Glomerulosclerosis, Focal Segmental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005923","descriptor_name":"Glomerulosclerosis, Focal Segmental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005923","descriptor_name":"Glomerulosclerosis, Focal Segmental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005923","descriptor_name":"Glomerulosclerosis, Focal Segmental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019520","descriptor_name":"Living Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019520","descriptor_name":"Living Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019520","descriptor_name":"Living Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.2215/cjn.02560314","doi":"https://doi.org/10.2215/cjn.02560314","is_oa":false,"landing_page_url":"https://doi.org/10.2215/cjn.02560314","pdf_url":null,"source":{"id":"https://openalex.org/S184267533","display_name":"Clinical Journal of the American Society of Nephrology","issn_l":"1555-9041","issn":["1555-9041","1555-905X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmid:25318758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25318758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical journal of the American Society of Nephrology : CJASN","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3610005","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4220756","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4220756","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4220756","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin J Am Soc Nephrol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4220756","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4220756","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin J Am Soc Nephrol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G219020131","display_name":null,"funder_award_id":"UL1-TR000135","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G2396429442","display_name":null,"funder_award_id":"R01-DK090358","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3015807127","display_name":"Mayo Clinic Center for Clinical and Translational Science (CCaTS)","funder_award_id":"5ul1tr000135-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000902041","display_name":"Automated detection of microstructural features that have unique protein markers and are prognostic for chronic kidney disease","funder_award_id":"5r01dk090358-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1274402784","https://openalex.org/W1773804766","https://openalex.org/W1935902156","https://openalex.org/W1977107398","https://openalex.org/W1984191137","https://openalex.org/W1995011718","https://openalex.org/W2005030974","https://openalex.org/W2009473293","https://openalex.org/W2015336570","https://openalex.org/W2016366089","https://openalex.org/W2024526175","https://openalex.org/W2025691534","https://openalex.org/W2027171099","https://openalex.org/W2029535420","https://openalex.org/W2033910236","https://openalex.org/W2035471303","https://openalex.org/W2038479789","https://openalex.org/W2043172105","https://openalex.org/W2044991191","https://openalex.org/W2046383629","https://openalex.org/W2046918335","https://openalex.org/W2048447945","https://openalex.org/W2049684087","https://openalex.org/W2061285072","https://openalex.org/W2074650446","https://openalex.org/W2080760372","https://openalex.org/W2081523875","https://openalex.org/W2085343555","https://openalex.org/W2088726628","https://openalex.org/W2091142003","https://openalex.org/W2092855426","https://openalex.org/W2095406357","https://openalex.org/W2097655320","https://openalex.org/W2098175932","https://openalex.org/W2114155002","https://openalex.org/W2118913721","https://openalex.org/W2119885096","https://openalex.org/W2125259249","https://openalex.org/W2130717716","https://openalex.org/W2138466918","https://openalex.org/W2140070979","https://openalex.org/W2140950633","https://openalex.org/W2144235147","https://openalex.org/W2147043921","https://openalex.org/W2154254002","https://openalex.org/W2169458410","https://openalex.org/W2169831409","https://openalex.org/W2171056071","https://openalex.org/W2798643531","https://openalex.org/W4249815350"],"related_works":["https://openalex.org/W2405356478","https://openalex.org/W1507850986","https://openalex.org/W2085753441","https://openalex.org/W4390046851","https://openalex.org/W2943945349","https://openalex.org/W3025127235","https://openalex.org/W2034402884","https://openalex.org/W1982459564","https://openalex.org/W97213552","https://openalex.org/W789333984"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVES:":[2],"The":[3,68,132],"relationship":[4],"of":[5,19,61,96,193,218,230,233,250,253,263],"kidney":[6,38,54,64,300],"function":[7,39,301],"and":[8,30,40,73,78,85,117,168,187,202,220,241,268,283,297,302],"CKD":[9],"risk":[10,41,303],"factors":[11,304],"to":[12,50,98,294],"structural":[13,286],"changes":[14],"in":[15,93,288],"the":[16,83,178],"renal":[17],"parenchyma":[18],"normal":[20,289],"adults":[21,290],"is":[22],"unclear.":[23],"This":[24],"study":[25,179],"assessed":[26],"whether":[27],"nephron":[28,234,254,264],"hypertrophy":[29,106,282],"nephrosclerosis":[31,284],"had":[32,56,185,189],"similar":[33],"or":[34],"different":[35],"associations":[36],"with":[37,228,248,261,274],"factors.":[42],"DESIGN,":[43],"SETTING,":[44],"PARTICIPANTS,":[45],"&":[46],"MEASUREMENTS:":[47],"From":[48],"1999":[49],"2009,":[51],"1395":[52],"living":[53],"donors":[55],"a":[57,100,190],"core":[58],"needle":[59],"biopsy":[60],"their":[62],"donated":[63],"during":[65],"transplant":[66],"surgery.":[67],"mean":[69,101,133],"nonsclerotic":[70,119,204],"glomerular":[71,74,111,120,129,196,205,278],"volume":[72],"density":[75,206],"(globally":[76],"sclerotic":[77,128,277],"nonsclerotic)":[79],"were":[80,91,182,207,225,244,271],"estimated":[81],"using":[82],"Weibel":[84],"Gomez":[86],"stereologic":[87],"methods.":[88],"All":[89],"tubules":[90],"counted":[92],"1":[94],"cm(2)":[95],"cortex":[97],"determine":[99],"profile":[102,114,199],"tubular":[103,115,200],"area.":[104],"Nephron":[105,281],"was":[107,123,137,146,153,163,172,257],"identified":[108,124],"by":[109,125],"larger":[110,113,198],"volume,":[112,197],"area,":[116,201],"lower":[118,203],"density.":[121,130,279],"Nephrosclerosis":[122],"higher":[126,211,221,239,275],"globally":[127,276],"RESULTS:":[131],"(\u00b1":[134],"SD)":[135],"age":[136,243,270],"44":[138],"\u00b1":[139,148,155,165,174],"12":[140],"years,":[141],"24-hour":[142,212],"urine":[143,213],"albumin":[144,214],"excretion":[145],"5":[147,175],"7":[149],"mg,":[150],"measured":[151],"GFR":[152],"103":[154],"17":[156],"ml/min":[157],"per":[158],"1.73":[159],"m(2),":[160],"uric":[161,237],"acid":[162],"5.2":[164],"1.4":[166],"mg/dl,":[167],"body":[169,222],"mass":[170,223],"index":[171,224],"28":[173],"kg/m(2).":[176],"Of":[177],"participants,":[180],"43%":[181],"men,":[183],"11%":[184],"hypertension,":[186],"52%":[188],"family":[191,216],"history":[192,217],"ESRD.":[194],"Larger":[195],"correlated.":[208],"Male":[209],"sex,":[210],"excretion,":[215],"ESRD,":[219],"independently":[226,246,259,272],"associated":[227,247,260,273],"each":[229],"these":[231,251],"measures":[232,252,262],"hypertrophy.":[235,255,265],"Higher":[236],"acid,":[238],"GFR,":[240],"older":[242,269],"also":[245],"some":[249],"Hypertension":[256],"not":[258],"However,":[266],"hypertension":[267],"CONCLUSIONS:":[280],"are":[285],"characteristics":[287,296],"that":[291],"relate":[292],"differently":[293],"clinical":[295],"may":[298],"reflect":[299],"via":[305],"separate":[306],"but":[307],"inter-related":[308],"pathways.":[309]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}