{"id":"https://openalex.org/W2169027329","doi":"https://doi.org/10.1084/jem.168.5.1523","title":"A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.","display_name":"A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W2169027329","doi":"https://doi.org/10.1084/jem.168.5.1523","mag":"2169027329","pmid":"https://pubmed.ncbi.nlm.nih.gov/2972792","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2189122"},"language":"en","primary_location":{"id":"doi:10.1084/jem.168.5.1523","doi":"https://doi.org/10.1084/jem.168.5.1523","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.168.5.1523","pdf_url":"https://rupress.org/jem/article-pdf/168/5/1523/1098646/1523.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/168/5/1523/1098646/1523.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044564994","display_name":"Michel Streuli","orcid":"https://orcid.org/0000-0001-8566-4065","observed_orcids":["https://orcid.org/0000-0001-8566-4065"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Streuli","raw_affiliation_strings":["Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022184762","display_name":"Neil X. Krueger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N X Krueger","raw_affiliation_strings":["Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109100759","display_name":"Laura R. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L R Hall","raw_affiliation_strings":["Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109066087","display_name":"Stuart F. Schlossman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S F Schlossman","raw_affiliation_strings":["Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103399445","display_name":"Haruo Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Saito","raw_affiliation_strings":["Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":9.5657,"has_fulltext":true,"cited_by_count":264,"citation_normalized_percentile":{"value":0.97765363,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"168","issue":"5","first_page":"1523","last_page":"1530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03929999843239784,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd45","display_name":"CD45","score":0.7850000262260437},{"id":"https://openalex.org/keywords/immunoglobulin-superfamily","display_name":"immunoglobulin superfamily","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cd56","display_name":"CD56","score":0.7850000262260437},{"id":"https://openalex.org/keywords/ig-like-domains","display_name":"immunoglobulin-like domains","score":0.6880000233650208},{"id":"https://openalex.org/keywords/transmembrane-helices","display_name":"transmembrane helices","score":0.7459999918937683},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7630000114440918},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.5860000252723694},{"id":"https://openalex.org/keywords/protein-sequence-similarity","display_name":"protein sequence similarity","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.706836462020874},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6744503378868103},{"id":"https://openalex.org/C91682701","wikidata":"https://www.wikidata.org/wiki/Q41797304","display_name":"Immunoglobulin superfamily","level":3,"score":0.605388343334198},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.60401850938797},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5905903577804565},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.53168123960495},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5236056447029114},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4818233549594879},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.47477269172668457},{"id":"https://openalex.org/C149774189","wikidata":"https://www.wikidata.org/wiki/Q24770541","display_name":"Immunoglobulin domain","level":3,"score":0.46683183312416077},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4654425382614136},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.45586302876472473},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4453757107257843},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.4266805946826935},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22792565822601318},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006649","descriptor_name":"Histocompatibility Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1084/jem.168.5.1523","doi":"https://doi.org/10.1084/jem.168.5.1523","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.168.5.1523","pdf_url":"https://rupress.org/jem/article-pdf/168/5/1523/1098646/1523.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2189122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2189122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:2972792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2972792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.285.3262","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.285.3262","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d6/47/J_Exp_Med_1988_Nov_1_168(5)_1523-1530.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1084/jem.168.5.1523","doi":"https://doi.org/10.1084/jem.168.5.1523","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.168.5.1523","pdf_url":"https://rupress.org/jem/article-pdf/168/5/1523/1098646/1523.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4593750960","display_name":"STRUCTURE AND FUNCTION OF LEUKOCYTE COMMON ANTIGEN","funder_award_id":"R01AI026598","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2169027329.pdf","grobid_xml":"https://content.openalex.org/works/W2169027329.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W153292379","https://openalex.org/W1018379079","https://openalex.org/W1513717105","https://openalex.org/W1558516755","https://openalex.org/W1610209323","https://openalex.org/W1988130438","https://openalex.org/W2031209863","https://openalex.org/W2031808150","https://openalex.org/W2037508851","https://openalex.org/W2044697296","https://openalex.org/W2060630348","https://openalex.org/W2064803671","https://openalex.org/W2067495948","https://openalex.org/W2076899085","https://openalex.org/W2100210544","https://openalex.org/W2129625054","https://openalex.org/W2138879032","https://openalex.org/W2144634347","https://openalex.org/W6600419486"],"related_works":["https://openalex.org/W2115810916","https://openalex.org/W1598760962","https://openalex.org/W2037184282","https://openalex.org/W2012097971","https://openalex.org/W2011133292","https://openalex.org/W3016682575","https://openalex.org/W7096339070","https://openalex.org/W2071209219","https://openalex.org/W2163521672","https://openalex.org/W2121976226"],"abstract_inverted_index":{"A":[0],"human":[1],"gene":[2,20,45],"(LAR)":[3],"that":[4,91],"hybridizes":[5],"to":[6,96,139,153],"mouse":[7],"leukocyte":[8,102],"common":[9,103],"antigen":[10],"cDNA":[11],"under":[12],"relaxed":[13],"hybridization":[14],"conditions":[15],"was":[16,46],"isolated.":[17],"The":[18,36,58,84,105,143],"LAR":[19,44,56,60,114,131,148],"is":[21,62],"expressed":[22],"in":[23],"a":[24,54,65,71,78],"broad":[25],"range":[26],"of":[27,38,53,64,100,108,112,137,146,157],"cells,":[28],"including":[29],"T":[30],"lymphocytes,":[31],"kidney,":[32],"and":[33,77,121],"prostate":[34],"cells.":[35],"structure":[37],"the":[39,43,50,97,101,109,113,126,130,134,147,154],"protein":[40,61,115,132,149],"encoded":[41],"by":[42,48],"deduced":[47],"determining":[49],"nucleotide":[51],"sequences":[52],"7.7-kb":[55],"cDNA.":[57],"putative":[59],"composed":[63],"1,234":[66],"amino":[67,73,80],"acid":[68,74,81],"extracellular":[69,110],"region,":[70],"24":[72],"transmembrane":[75],"segment,":[76],"623":[79],"cytoplasmic":[82,85,98],"region.":[83],"region":[86,99,107],"contains":[87,116],"two":[88],"homologous":[89],"domains":[90,120,145,156],"have":[92],"extensive":[93],"sequence":[94],"similarity":[95,138],"antigens.":[104],"NH2-terminal":[106],"segment":[111],"three":[117],"tandem":[118],"Ig-like":[119,128],"nine":[122],"non-Ig-like":[123,144,155],"domains.":[124],"Among":[125],"known":[127],"proteins,":[129],"has":[133],"highest":[135],"degree":[136],"neural-cell":[140,158],"adhesion":[141,159],"molecule.":[142,160],"are":[150],"also":[151],"similar":[152]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}