{"id":"https://openalex.org/W2168798653","doi":"https://doi.org/10.1021/bi8019993","title":"The Crystal Structure of an Avian IgY-Fc Fragment Reveals Conservation with both Mammalian IgG and IgE","display_name":"The Crystal Structure of an Avian IgY-Fc Fragment Reveals Conservation with both Mammalian IgG and IgE","publication_year":2008,"publication_date":"2008-12-30","ids":{"openalex":"https://openalex.org/W2168798653","doi":"https://doi.org/10.1021/bi8019993","mag":"2168798653","pmid":"https://pubmed.ncbi.nlm.nih.gov/19115948"},"language":"en","primary_location":{"id":"doi:10.1021/bi8019993","doi":"https://doi.org/10.1021/bi8019993","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi8019993","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082302374","display_name":"Alexander I. Taylor","orcid":"https://orcid.org/0000-0003-3492-7667","observed_orcids":["https://orcid.org/0000-0003-3492-7667"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210141571","display_name":"Asthma UK","ror":"https://ror.org/03z7xev21","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801572420","https://openalex.org/I4210141571"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander I. Taylor","raw_affiliation_strings":["Randall Division of Cell and Molecular Biophysics, King\u2019s College London, and MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, New Hunt\u2019s House, Guy\u2019s Campus, London SE1 1UL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Division of Cell and Molecular Biophysics, King\u2019s College London, and MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, New Hunt\u2019s House, Guy\u2019s Campus, London SE1 1UL, United Kingdom","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210141571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089979026","display_name":"Stella M. Fabiane","orcid":"https://orcid.org/0000-0001-5957-7275","observed_orcids":["https://orcid.org/0000-0001-5957-7275"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210141571","display_name":"Asthma UK","ror":"https://ror.org/03z7xev21","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801572420","https://openalex.org/I4210141571"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stella M. Fabiane","raw_affiliation_strings":["Randall Division of Cell and Molecular Biophysics, King\u2019s College London, and MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, New Hunt\u2019s House, Guy\u2019s Campus, London SE1 1UL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Division of Cell and Molecular Biophysics, King\u2019s College London, and MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, New Hunt\u2019s House, Guy\u2019s Campus, London SE1 1UL, United Kingdom","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210141571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002370634","display_name":"Brian J. Sutton","orcid":"https://orcid.org/0000-0002-4363-7568","observed_orcids":["https://orcid.org/0000-0002-4363-7568"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210141571","display_name":"Asthma UK","ror":"https://ror.org/03z7xev21","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801572420","https://openalex.org/I4210141571"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian J. Sutton","raw_affiliation_strings":["Randall Division of Cell and Molecular Biophysics, King\u2019s College London, and MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, New Hunt\u2019s House, Guy\u2019s Campus, London SE1 1UL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Division of Cell and Molecular Biophysics, King\u2019s College London, and MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, New Hunt\u2019s House, Guy\u2019s Campus, London SE1 1UL, United Kingdom","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210141571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108230159","display_name":"Rosaleen A. Calvert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210141571","display_name":"Asthma UK","ror":"https://ror.org/03z7xev21","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801572420","https://openalex.org/I4210141571"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rosaleen A. Calvert","raw_affiliation_strings":["Randall Division of Cell and Molecular Biophysics, King\u2019s College London, and MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, New Hunt\u2019s House, Guy\u2019s Campus, London SE1 1UL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Division of Cell and Molecular Biophysics, King\u2019s College London, and MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, New Hunt\u2019s House, Guy\u2019s Campus, London SE1 1UL, United Kingdom","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210141571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108230159"],"corresponding_institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210141571"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.3449,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.79820196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"48","issue":"3","first_page":"558","last_page":"562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fc-region","display_name":"Fc fragment","score":0.7940000295639038},{"id":"https://openalex.org/keywords/antibody-evolution","display_name":"antibody evolution","score":0.6919999718666077},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.7860000133514404},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":1.0},{"id":"https://openalex.org/keywords/fc-receptor-binding","display_name":"Fc receptor binding","score":0.5009999871253967},{"id":"https://openalex.org/keywords/antibody-structure","display_name":"antibody structure","score":0.5839999914169312},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.5}],"concepts":[{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.7483600378036499},{"id":"https://openalex.org/C2776235265","wikidata":"https://www.wikidata.org/wiki/Q18392052","display_name":"Fragment (logic)","level":2,"score":0.7045583128929138},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4860697090625763},{"id":"https://openalex.org/C125823703","wikidata":"https://www.wikidata.org/wiki/Q1616930","display_name":"Fragment crystallizable region","level":3,"score":0.4697663486003876},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.42774122953414917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3364650011062622},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26705145835876465},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1315910518169403},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi8019993","doi":"https://doi.org/10.1021/bi8019993","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi8019993","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:19115948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19115948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/27acbf76-3def-4f30-b122-8c26d95e0510","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/27acbf76-3def-4f30-b122-8c26d95e0510","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Taylor, A I, Fabiane, S M, Sutton, B J & Calvert, R A 2009, 'The Crystal Structure of an Avian IgY-Fc Fragment Reveals Conservation with both Mammalian IgG and IgE', Biochemistry, vol. 48, no. 3, pp. 558 - 562. https://doi.org/10.1021/bi8019993","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G186237615","display_name":null,"funder_award_id":"BB/D011418/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8520187214","display_name":"Immunoglobulin Y: an IgG-like antibody with an IgE-like structure?","funder_award_id":"BB/D011418/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W113753478","https://openalex.org/W255996521","https://openalex.org/W1544611381","https://openalex.org/W1559766260","https://openalex.org/W1595328377","https://openalex.org/W1857685991","https://openalex.org/W1967194316","https://openalex.org/W1979004667","https://openalex.org/W1996607909","https://openalex.org/W1998659955","https://openalex.org/W1999003738","https://openalex.org/W2000634886","https://openalex.org/W2001641653","https://openalex.org/W2010919000","https://openalex.org/W2037257193","https://openalex.org/W2040640809","https://openalex.org/W2056576838","https://openalex.org/W2059222613","https://openalex.org/W2064719289","https://openalex.org/W2074986801","https://openalex.org/W2081836363","https://openalex.org/W2094445987","https://openalex.org/W2100518445","https://openalex.org/W2100837269","https://openalex.org/W2109184569","https://openalex.org/W2121107218","https://openalex.org/W2122844091","https://openalex.org/W2144081223","https://openalex.org/W2144998676","https://openalex.org/W2161464792","https://openalex.org/W2163341755","https://openalex.org/W4293253343","https://openalex.org/W4313307822"],"related_works":["https://openalex.org/W2067078004","https://openalex.org/W2597050443","https://openalex.org/W7163557808","https://openalex.org/W7160021983","https://openalex.org/W1999003738","https://openalex.org/W2037257193","https://openalex.org/W2790790650","https://openalex.org/W3177188572","https://openalex.org/W4414532439","https://openalex.org/W2077563990"],"abstract_inverted_index":{"Avian":[0],"IgY":[1,94],"is":[2,56],"closely":[3],"related":[4],"to":[5,51,64,85,96],"an":[6,73],"ancestor":[7],"of":[8,21,29,32,35,76],"both":[9,86],"mammalian":[10],"IgG":[11],"and":[12,14,24,38,44,46,66,88,90],"IgE":[13],"thus":[15],"provides":[16,67],"insights":[17],"into":[18],"the":[19,36,57,68,91],"evolution":[20],"antibody":[22,77],"structure":[23,49,62,81],"function.":[25],"A":[26,53],"recombinant":[27],"fragment":[28,61],"IgY-Fc":[30],"consisting":[31],"a":[33],"dimer":[34],"Cupsilon3":[37],"Cupsilon4":[39],"domains,":[40],"Fcupsilon3-4,":[41],"was":[42],"expressed":[43],"crystallized":[45],"its":[47,97],"X-ray":[48],"determined":[50,63],"1.75":[52],"resolution.":[54],"Fcupsilon3-4":[55,80],"only":[58],"nonmammalian":[59],"Fc":[60],"date":[65],"first":[69],"structural":[70],"evidence":[71],"for":[72,93],"ancient":[74],"origin":[75],"architecture.":[78],"The":[79],"reveals":[82],"features":[83],"common":[84],"IgE-Fc":[87],"IgG-Fc,":[89],"implications":[92],"binding":[95],"receptor":[98],"are":[99],"discussed.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}