{"id":"https://openalex.org/W2168750934","doi":"https://doi.org/10.1002/cne.903170108","title":"Morphological and neurochemical features of cultured primary skin fibroblasts of fischer 344 rats following striatal implantation","display_name":"Morphological and neurochemical features of cultured primary skin fibroblasts of fischer 344 rats following striatal implantation","publication_year":1992,"publication_date":"1992-03-01","ids":{"openalex":"https://openalex.org/W2168750934","doi":"https://doi.org/10.1002/cne.903170108","mag":"2168750934","pmid":"https://pubmed.ncbi.nlm.nih.gov/1573056"},"language":"en","primary_location":{"id":"doi:10.1002/cne.903170108","doi":"https://doi.org/10.1002/cne.903170108","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.903170108","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113459855","display_name":"Michael D. Kawaja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Kawaja","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla 92093-0624","Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla 92093-0624","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072968010","display_name":"Fred H. Gage","orcid":"https://orcid.org/0000-0002-0938-4106","observed_orcids":["https://orcid.org/0000-0002-0938-4106"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fred H. Gage","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072968010"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":1.9395,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.86541738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"317","issue":"1","first_page":"102","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.18520000576972961,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.18520000576972961,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.1485999971628189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.12150000035762787,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracerebral-grafting","display_name":"intracerebral grafting","score":0.7620000243186951},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.9340000152587891},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.6579999923706055},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9760000109672546},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.7559999823570251},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glucose-transporters","display_name":"glucose transporters","score":0.781000018119812},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8740000128746033},{"id":"https://openalex.org/keywords/capillary-permeability","display_name":"capillary permeability","score":0.6669999957084656},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6389999985694885},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.43700000643730164},{"id":"https://openalex.org/keywords/reactive-astrocytes","display_name":"reactive astrocytes","score":0.675000011920929},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.5950000286102295},{"id":"https://openalex.org/keywords/graft-morphology","display_name":"graft morphology","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.7328054904937744},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.7300559282302856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6587668061256409},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5466492772102356},{"id":"https://openalex.org/C2777831001","wikidata":"https://www.wikidata.org/wiki/Q1981429","display_name":"Neuropil","level":3,"score":0.44660478830337524},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.44182610511779785},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4257446527481079},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.41916540265083313},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.38566747307777405},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21937620639801025},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.20688262581825256},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14760830998420715},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10690784454345703},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006735","descriptor_name":"Horseradish Peroxidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D016038","descriptor_name":"Skin Transplantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cne.903170108","doi":"https://doi.org/10.1002/cne.903170108","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.903170108","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},{"id":"pmid:1573056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1573056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of comparative neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2835460839","display_name":"EXPERIMENTAL INTERVENTION IN MODELS OF CNS INJURY","funder_award_id":"P01NS028121","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G391286513","display_name":null,"funder_award_id":"AGO 8514","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W112437525","https://openalex.org/W1492954703","https://openalex.org/W1505588706","https://openalex.org/W1538012737","https://openalex.org/W1797273806","https://openalex.org/W1982131188","https://openalex.org/W1989036471","https://openalex.org/W1989197038","https://openalex.org/W1993897169","https://openalex.org/W1994458408","https://openalex.org/W2005447528","https://openalex.org/W2007748607","https://openalex.org/W2008508692","https://openalex.org/W2009115528","https://openalex.org/W2011066133","https://openalex.org/W2011406750","https://openalex.org/W2011856623","https://openalex.org/W2012540168","https://openalex.org/W2013554374","https://openalex.org/W2018168833","https://openalex.org/W2022196880","https://openalex.org/W2024072383","https://openalex.org/W2025652548","https://openalex.org/W2027762513","https://openalex.org/W2028477896","https://openalex.org/W2040807082","https://openalex.org/W2046346091","https://openalex.org/W2047945439","https://openalex.org/W2049958255","https://openalex.org/W2051187144","https://openalex.org/W2053963421","https://openalex.org/W2055087860","https://openalex.org/W2058028686","https://openalex.org/W2067118730","https://openalex.org/W2069660167","https://openalex.org/W2070709069","https://openalex.org/W2070898934","https://openalex.org/W2071971522","https://openalex.org/W2083837529","https://openalex.org/W2084595515","https://openalex.org/W2089683266","https://openalex.org/W2091084213","https://openalex.org/W2109135868","https://openalex.org/W2111840943","https://openalex.org/W2142835446","https://openalex.org/W2165097308","https://openalex.org/W2405903469","https://openalex.org/W4242913751"],"related_works":["https://openalex.org/W2008508692","https://openalex.org/W2028477896","https://openalex.org/W1996800446","https://openalex.org/W4300192813","https://openalex.org/W1964753456","https://openalex.org/W2046963526","https://openalex.org/W2018560111","https://openalex.org/W2163747867","https://openalex.org/W2094323259","https://openalex.org/W2004619199"],"abstract_inverted_index":{"In":[0,44],"order":[1],"to":[2,100,113,127,146,242,245,287],"assess":[3],"the":[4,22,26,68,75,82,109,123,128,152,171,175,185,216,249,253,278,293,316,339,348],"feasibility":[5],"of":[6,31,34,41,70,77,130,154,207,218,233,248,299,310,318,342],"using":[7],"primary":[8,36,46,72,131,234,300],"skin":[9,47,235,358],"fibroblasts":[10,37,48,236,259,301,344,359],"as":[11,197,199,363],"a":[12,39,51,238,289],"donor":[13,364],"population":[14],"for":[15,90,104,137,156,189,338,366],"genetic":[16],"modification":[17],"and":[18,28,95,168,177,224,260,282,295,335],"subsequent":[19],"intracerebral":[20,231,368],"grafting,":[21],"present":[23],"study":[24],"examines":[25],"structural":[27],"neurochemical":[29,336],"characteristics":[30],"intrastriatal":[32],"grafts":[33,87,110,176,186,212,232,256,294],"isogeneic":[35],"over":[38],"period":[40],"6":[42,101,119,169,225],"months.":[43,102,120,226],"culture,":[45],"obtained":[49],"from":[50,81,111,144],"female":[52],"Fischer":[53],"344":[54],"rat":[55,349],"display":[56],"robust":[57],"growth,":[58],"but":[59,116],"once":[60],"confluent":[61],"these":[62,352],"cells":[63,73],"exhibit":[64,237],"contact":[65],"inhibition.":[66],"Following":[67,204],"implantation":[69,129,346],"cultured":[71],"within":[74,108,122,184,210,230,347],"striatum":[76,124],"other":[78],"adult":[79],"rats":[80],"same":[83],"inbred":[84],"strain,":[85],"isologous":[86,343,357],"stain":[88,187],"immunohistochemically":[89,188],"fibronectin":[91],"at":[92,221],"1":[93,112,145],"week,":[94],"this":[96,219],"immunostaining":[97,155],"persists":[98],"up":[99],"Immunoreactivity":[103],"laminin":[105],"is":[106,308,328],"intense":[107],"8":[114,147,166,222],"weeks,":[115],"decreases":[117],"by":[118],"Astrocytes":[121],"respond":[125],"dramatically":[126],"fibroblasts,":[132],"such":[133],"that":[134,307,356],"immunohistochemical":[135],"staining":[136],"glial":[138,157],"fibrillary":[139,158],"acidic":[140,159],"protein":[141,160],"increases":[142],"markedly":[143],"weeks":[148,167,201,223],"after":[149,202,345],"implantation.":[150,203],"Although":[151],"intensity":[153],"diminishes":[161],"among":[162],"striatal":[163,178,296],"astrocytes":[164,281],"between":[165,174,292],"months,":[170],"astrocytic":[172,269,320],"border":[173,291],"neuropil":[179],"remains":[180],"intensely":[181],"immunoreactive.":[182],"Capillaries":[183],"glucose":[190,194],"transporter":[191],"(a":[192],"facilitated":[193],"uptake":[195],"carrier)":[196],"early":[198],"3":[200],"intravenous":[205],"infusions":[206],"peroxidase,":[208],"capillaries":[209,228,247,311,327],"fibroblast":[211],"do":[213],"not":[214],"permit":[215],"extravasation":[217],"macromolecule":[220],"Thus,":[227],"formed":[229],"functional":[239],"impermeable":[240],"barrier":[241],"macromolecules":[243],"similar":[244],"those":[246],"host":[250],"striatum.":[251,350],"At":[252],"ultrastructural":[254],"level,":[255],"possess":[257,303],"numerous":[258],"have":[261],"an":[262,304],"extracellular":[263],"matrix":[264],"filled":[265,271],"with":[266,272,312,324],"collagen.":[267],"Reactive":[268],"processes":[270,284,321],"intermediate":[273],"filaments":[274],"are":[275],"found":[276],"throughout":[277],"grafts.":[279],"Hypertrophied":[280],"their":[283],"also":[285,302],"appear":[286],"form":[288],"continuous":[290],"neuropil.":[297],"Grafts":[298],"extensive":[305],"vasculature":[306],"composed":[309],"nonfenestrated":[313],"endothelial":[314],"cells;":[315],"occurrence":[317],"reactive":[319],"closely":[322],"associated":[323],"or":[325],"enveloping":[326],"variable.":[329],"These":[330],"results":[331],"provide":[332],"direct":[333],"morphological":[334],"evidence":[337],"long-term":[340],"survival":[341],"From":[351],"data,":[353],"we":[354],"propose":[355],"can":[360],"be":[361],"considered":[362],"candidates":[365],"successful":[367],"grafting":[369],"following":[370],"gene":[371],"transfer.":[372]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
