{"id":"https://openalex.org/W2168737620","doi":"https://doi.org/10.1093/humupd/dmr047","title":"Assisted reproduction treatment and epigenetic inheritance","display_name":"Assisted reproduction treatment and epigenetic inheritance","publication_year":2012,"publication_date":"2012-01-19","ids":{"openalex":"https://openalex.org/W2168737620","doi":"https://doi.org/10.1093/humupd/dmr047","mag":"2168737620","pmid":"https://pubmed.ncbi.nlm.nih.gov/22267841","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3282574"},"language":"en","primary_location":{"id":"doi:10.1093/humupd/dmr047","doi":"https://doi.org/10.1093/humupd/dmr047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humupd/dmr047","pdf_url":"https://academic.oup.com/humupd/article-pdf/18/2/171/17055732/dmr047.pdf","source":{"id":"https://openalex.org/S19450991","display_name":"Human Reproduction Update","issn_l":"1355-4786","issn":["1355-4786","1362-4946","1460-2369"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction Update","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/humupd/article-pdf/18/2/171/17055732/dmr047.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084970322","display_name":"Aafke P.A. van Montfoort","orcid":"https://orcid.org/0000-0002-7318-3990","observed_orcids":["https://orcid.org/0000-0002-7318-3990"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"A.P.A. van Montfoort","raw_affiliation_strings":["Department of Obstetrics & Gynaecology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands. aafke.van.montfoort@mumc.nl","Department of Obstetrics & Gynaecology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynaecology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands. aafke.van.montfoort@mumc.nl","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]},{"raw_affiliation_string":"Department of Obstetrics & Gynaecology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L.L.P. Hanssen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L.L.P. Hanssen","raw_affiliation_strings":["Department of Obstetrics & Gynaecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynaecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015831817","display_name":"Petra De Sutter","orcid":"https://orcid.org/0000-0002-8792-3814","observed_orcids":["https://orcid.org/0000-0002-8792-3814"]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"P. de Sutter","raw_affiliation_strings":["Department of Reproductive Medicine, Ghent University Hospital, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reproductive Medicine, Ghent University Hospital, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044042417","display_name":"St\u00e9phane Viville","orcid":"https://orcid.org/0000-0002-5088-3003","observed_orcids":["https://orcid.org/0000-0002-5088-3003"]},"institutions":[{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210145324","display_name":"H\u00f4pitaux Universitaires de Strasbourg","ror":"https://ror.org/04bckew43","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210145324"]},{"id":"https://openalex.org/I4210158086","display_name":"Institut de Biologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05qpmg879","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210158086","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Viville","raw_affiliation_strings":["Institut de ge \u00b4ne \u00b4tique et de biologie mole \u00b4culaire et cellulaire , Centre Hospitalier Universitaire , Strasbourg , France","Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire, Centre Hospitalier Universitaire, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de ge \u00b4ne \u00b4tique et de biologie mole \u00b4culaire et cellulaire , Centre Hospitalier Universitaire , Strasbourg , France","institution_ids":["https://openalex.org/I4210145324"]},{"raw_affiliation_string":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire, Centre Hospitalier Universitaire, Strasbourg, France","institution_ids":["https://openalex.org/I4210086872","https://openalex.org/I4210145324","https://openalex.org/I4210158086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054409804","display_name":"Joep P.M. Geraedts","orcid":"https://orcid.org/0000-0002-0496-0039","observed_orcids":["https://orcid.org/0000-0002-0496-0039"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.P.M. Geraedts","raw_affiliation_strings":["Department of Clinical Genetics, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Genetics, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111652423","display_name":"P. de Boer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. de Boer","raw_affiliation_strings":["Department of Obstetrics & Gynaecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynaecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5084970322"],"corresponding_institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"],"apc_list":{"value":3973,"currency":"EUR","value_usd":4490},"apc_paid":{"value":3973,"currency":"EUR","value_usd":4490},"fwci":2.7696,"has_fulltext":true,"cited_by_count":177,"citation_normalized_percentile":{"value":0.93643512,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"18","issue":"2","first_page":"171","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.8029999732971191},{"id":"https://openalex.org/keywords/epigenetic-inheritance","display_name":"epigenetic inheritance","score":0.8899999856948853},{"id":"https://openalex.org/keywords/genomic-imprinting","display_name":"genomic imprinting","score":0.9850000143051147},{"id":"https://openalex.org/keywords/beckwith-wiedemann-syndrome","display_name":"Beckwith-Wiedemann syndrome","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/dna-hypomethylation","display_name":"DNA hypomethylation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/transgenerational-epigenetic-inheritance","display_name":"transgenerational epigenetic inheritance","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ovulation-induction","display_name":"ovulation induction","score":0.8460000157356262},{"id":"https://openalex.org/keywords/in-vitro-culture","display_name":"in vitro culture","score":0.7440000176429749},{"id":"https://openalex.org/keywords/sperm-dna-methylation","display_name":"sperm DNA methylation","score":0.843999981880188},{"id":"https://openalex.org/keywords/gamete-selection","display_name":"gamete selection","score":0.7229999899864197},{"id":"https://openalex.org/keywords/subfertility","display_name":"subfertility","score":0.8830000162124634},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.718999981880188},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7342987060546875},{"id":"https://openalex.org/C59659247","wikidata":"https://www.wikidata.org/wiki/Q11990","display_name":"Reproduction","level":2,"score":0.7209445834159851},{"id":"https://openalex.org/C2780902518","wikidata":"https://www.wikidata.org/wiki/Q6033780","display_name":"Inheritance (genetic algorithm)","level":3,"score":0.5239025354385376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5129058361053467},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46989938616752625},{"id":"https://openalex.org/C184151982","wikidata":"https://www.wikidata.org/wiki/Q7834236","display_name":"Transgenerational epigenetics","level":4,"score":0.4218834936618805},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3665775656700134},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13765475153923035}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001506","descriptor_name":"Beckwith-Wiedemann Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007246","descriptor_name":"Infertility","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018392","descriptor_name":"Genomic Imprinting","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025063","descriptor_name":"Chromosome Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027724","descriptor_name":"Reproductive Techniques, Assisted","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/humupd/dmr047","doi":"https://doi.org/10.1093/humupd/dmr047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humupd/dmr047","pdf_url":"https://academic.oup.com/humupd/article-pdf/18/2/171/17055732/dmr047.pdf","source":{"id":"https://openalex.org/S19450991","display_name":"Human Reproduction Update","issn_l":"1355-4786","issn":["1355-4786","1362-4946","1460-2369"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction Update","raw_type":"journal-article"},{"id":"pmid:22267841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22267841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction update","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/3672c0b0-bea3-40cf-8675-dfcad144b45b","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/3672c0b0-bea3-40cf-8675-dfcad144b45b","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"van Montfoort, A P A, Hanssen, L L P, de Sutter, P, Viville, S, Geraedts, J P M & de Boer, P 2012, 'Assisted reproduction treatment and epigenetic inheritance', Human Reproduction Update, vol. 18, no. 2, pp. 171-197. https://doi.org/10.1093/humupd/dmr047","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:3282574","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3282574/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Reprod Update","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-04963713v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04963713","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Reproduction Update, 2012, 18 (2), pp.171-197. &#x27E8;10.1093/humupd/dmr047&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:archive.ugent.be:2074959","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/2074959","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1355-4786","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/3672c0b0-bea3-40cf-8675-dfcad144b45b","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/3672c0b0-bea3-40cf-8675-dfcad144b45b","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Reproduction Update, 18(2), 171 - 197. Oxford University Press","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/humupd/dmr047","doi":"https://doi.org/10.1093/humupd/dmr047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humupd/dmr047","pdf_url":"https://academic.oup.com/humupd/article-pdf/18/2/171/17055732/dmr047.pdf","source":{"id":"https://openalex.org/S19450991","display_name":"Human Reproduction Update","issn_l":"1355-4786","issn":["1355-4786","1362-4946","1460-2369"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction Update","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168737620.pdf","grobid_xml":"https://content.openalex.org/works/W2168737620.grobid-xml"},"referenced_works_count":248,"referenced_works":["https://openalex.org/W201842558","https://openalex.org/W1502309883","https://openalex.org/W1507573193","https://openalex.org/W1511424866","https://openalex.org/W1528634627","https://openalex.org/W1533935872","https://openalex.org/W1534122645","https://openalex.org/W1550375751","https://openalex.org/W1608964217","https://openalex.org/W1712474450","https://openalex.org/W1821797507","https://openalex.org/W1892165070","https://openalex.org/W1964680210","https://openalex.org/W1966150502","https://openalex.org/W1967224500","https://openalex.org/W1968418248","https://openalex.org/W1968527508","https://openalex.org/W1970639728","https://openalex.org/W1971157495","https://openalex.org/W1971708895","https://openalex.org/W1972612324","https://openalex.org/W1973549360","https://openalex.org/W1973960846","https://openalex.org/W1975231696","https://openalex.org/W1976778637","https://openalex.org/W1978006592","https://openalex.org/W1979587818","https://openalex.org/W1979619694","https://openalex.org/W1979861092","https://openalex.org/W1980265918","https://openalex.org/W1980738706","https://openalex.org/W1981857936","https://openalex.org/W1983521494","https://openalex.org/W1983921161","https://openalex.org/W1985339446","https://openalex.org/W1985467296","https://openalex.org/W1987163411","https://openalex.org/W1987189614","https://openalex.org/W1987752798","https://openalex.org/W1988253444","https://openalex.org/W1990654003","https://openalex.org/W1990669455","https://openalex.org/W1992188147","https://openalex.org/W1992541066","https://openalex.org/W1993419284","https://openalex.org/W1993963545","https://openalex.org/W1994638303","https://openalex.org/W1996402791","https://openalex.org/W1997796525","https://openalex.org/W2000530953","https://openalex.org/W2001010162","https://openalex.org/W2004670643","https://openalex.org/W2006557744","https://openalex.org/W2007201884","https://openalex.org/W2008563981","https://openalex.org/W2008945055","https://openalex.org/W2009533183","https://openalex.org/W2010016618","https://openalex.org/W2011006143","https://openalex.org/W2012603112","https://openalex.org/W2016754212","https://openalex.org/W2018201532","https://openalex.org/W2018531315","https://openalex.org/W2020670236","https://openalex.org/W2022924863","https://openalex.org/W2023844789","https://openalex.org/W2026529460","https://openalex.org/W2027930414","https://openalex.org/W2031586320","https://openalex.org/W2034089747","https://openalex.org/W2035028401","https://openalex.org/W2035074912","https://openalex.org/W2035877973","https://openalex.org/W2036048970","https://openalex.org/W2036994672","https://openalex.org/W2037108634","https://openalex.org/W2037818631","https://openalex.org/W2038198462","https://openalex.org/W2039118690","https://openalex.org/W2040058302","https://openalex.org/W2041490610","https://openalex.org/W2043622843","https://openalex.org/W2044611683","https://openalex.org/W2044721366","https://openalex.org/W2045325185","https://openalex.org/W2047321973","https://openalex.org/W2047469234","https://openalex.org/W2050592293","https://openalex.org/W2050664489","https://openalex.org/W2053493807","https://openalex.org/W2053508758","https://openalex.org/W2053708734","https://openalex.org/W2054482637","https://openalex.org/W2055171335","https://openalex.org/W2055386916","https://openalex.org/W2055423494","https://openalex.org/W2056150996","https://openalex.org/W2057140399","https://openalex.org/W2058028299","https://openalex.org/W2059632047","https://openalex.org/W2061556094","https://openalex.org/W2061836227","https://openalex.org/W2062671393","https://openalex.org/W2066102450","https://openalex.org/W2066305483","https://openalex.org/W2070134425","https://openalex.org/W2071816185","https://openalex.org/W2072230758","https://openalex.org/W2075202597","https://openalex.org/W2076370469","https://openalex.org/W2077906468","https://openalex.org/W2079320702","https://openalex.org/W2079675533","https://openalex.org/W2080091452","https://openalex.org/W2080814457","https://openalex.org/W2081618368","https://openalex.org/W2084204422","https://openalex.org/W2084279635","https://openalex.org/W2085441698","https://openalex.org/W2085858842","https://openalex.org/W2086300068","https://openalex.org/W2086690715","https://openalex.org/W2087199631","https://openalex.org/W2088341189","https://openalex.org/W2089481117","https://openalex.org/W2090723511","https://openalex.org/W2091279754","https://openalex.org/W2092586481","https://openalex.org/W2094722357","https://openalex.org/W2094790659","https://openalex.org/W2095714216","https://openalex.org/W2096083625","https://openalex.org/W2096278403","https://openalex.org/W2096393244","https://openalex.org/W2097459238","https://openalex.org/W2097814975","https://openalex.org/W2098094952","https://openalex.org/W2098262110","https://openalex.org/W2099401496","https://openalex.org/W2100604823","https://openalex.org/W2101037833","https://openalex.org/W2103059889","https://openalex.org/W2103246764","https://openalex.org/W2103405053","https://openalex.org/W2103410123","https://openalex.org/W2103757755","https://openalex.org/W2104295028","https://openalex.org/W2104298184","https://openalex.org/W2105323880","https://openalex.org/W2105952005","https://openalex.org/W2108293531","https://openalex.org/W2108572636","https://openalex.org/W2110477266","https://openalex.org/W2110982631","https://openalex.org/W2111041757","https://openalex.org/W2111390374","https://openalex.org/W2111400671","https://openalex.org/W2112737916","https://openalex.org/W2113008059","https://openalex.org/W2113289576","https://openalex.org/W2113477073","https://openalex.org/W2114100575","https://openalex.org/W2114350943","https://openalex.org/W2115086062","https://openalex.org/W2115357728","https://openalex.org/W2115702140","https://openalex.org/W2116423396","https://openalex.org/W2118534883","https://openalex.org/W2118587761","https://openalex.org/W2119477130","https://openalex.org/W2120724095","https://openalex.org/W2120731490","https://openalex.org/W2123226237","https://openalex.org/W2123286470","https://openalex.org/W2123427245","https://openalex.org/W2123892768","https://openalex.org/W2123996197","https://openalex.org/W2126053533","https://openalex.org/W2127431151","https://openalex.org/W2127456840","https://openalex.org/W2127905342","https://openalex.org/W2130597092","https://openalex.org/W2130708302","https://openalex.org/W2130907138","https://openalex.org/W2131620064","https://openalex.org/W2133615187","https://openalex.org/W2133769516","https://openalex.org/W2133879173","https://openalex.org/W2134726260","https://openalex.org/W2134868253","https://openalex.org/W2135729860","https://openalex.org/W2137087363","https://openalex.org/W2137223619","https://openalex.org/W2138116401","https://openalex.org/W2139005435","https://openalex.org/W2140018835","https://openalex.org/W2141737525","https://openalex.org/W2141991853","https://openalex.org/W2142079477","https://openalex.org/W2142515731","https://openalex.org/W2143612227","https://openalex.org/W2143858605","https://openalex.org/W2144328273","https://openalex.org/W2144597014","https://openalex.org/W2145591214","https://openalex.org/W2147536097","https://openalex.org/W2147816015","https://openalex.org/W2148016791","https://openalex.org/W2148734614","https://openalex.org/W2149487210","https://openalex.org/W2149922901","https://openalex.org/W2150695051","https://openalex.org/W2150951264","https://openalex.org/W2152030944","https://openalex.org/W2152466864","https://openalex.org/W2152636479","https://openalex.org/W2153089127","https://openalex.org/W2153563181","https://openalex.org/W2155630480","https://openalex.org/W2156697437","https://openalex.org/W2157550195","https://openalex.org/W2157805276","https://openalex.org/W2158384762","https://openalex.org/W2162303623","https://openalex.org/W2163502722","https://openalex.org/W2163670586","https://openalex.org/W2164218159","https://openalex.org/W2166236051","https://openalex.org/W2167020978","https://openalex.org/W2167894711","https://openalex.org/W2169152523","https://openalex.org/W2170408710","https://openalex.org/W2171184117","https://openalex.org/W2171784287","https://openalex.org/W2172108532","https://openalex.org/W2172137263","https://openalex.org/W2175849508","https://openalex.org/W2220538814","https://openalex.org/W2323066994","https://openalex.org/W2325216703","https://openalex.org/W2914618148","https://openalex.org/W2952472435","https://openalex.org/W2978851794","https://openalex.org/W3030866711","https://openalex.org/W4290960820","https://openalex.org/W4300517032","https://openalex.org/W6685013661","https://openalex.org/W6999320546"],"related_works":["https://openalex.org/W2077952096","https://openalex.org/W2143558121","https://openalex.org/W2222727983","https://openalex.org/W1973858316","https://openalex.org/W5664765","https://openalex.org/W2330872738","https://openalex.org/W2040492608","https://openalex.org/W4312493717","https://openalex.org/W1983352262","https://openalex.org/W4251601073"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,224],"subject":[2],"of":[3,6,17,68,101,121,142,148,203,215,226,232,249],"epigenetic":[4,44,47,75,219,227,255],"risk":[5,160],"assisted":[7],"reproduction":[8],"treatment":[9],"(ART),":[10],"initiated":[11],"by":[12,50,140,246],"reports":[13],"on":[14,42,58,218],"an":[15,233],"increase":[16],"children":[18],"with":[19],"the":[20,66,99,134,149,177,198,230,247,262],"Beckwith-Wiedemann":[21],"imprinting":[22,70,163],"disorder,":[23],"is":[24,29,117,128,158,221,243],"very":[25],"topical.":[26],"Hence,":[27],"there":[28],"a":[30,95,159,181,200,212],"growing":[31],"literature,":[32],"including":[33],"mouse":[34],"studies.":[35],"METHODS:":[36],"In":[37,108,176,197],"order":[38],"to":[39,98,261],"gain":[40],"information":[41],"transgenerational":[43],"inheritance":[45,228],"and":[46,85,104,123,235,240],"effects":[48,169],"induced":[49],"ART,":[51],"literature":[52],"databases":[53],"were":[54],"searched":[55],"for":[56,83,144,162,180,184],"papers":[57],"this":[59],"topic":[60],"using":[61],"relevant":[62],"keywords.":[63],"RESULTS:":[64],"At":[65],"level":[67],"genomic":[69],"involving":[71],"CpG":[72,187,204],"methylation,":[73],"ART-induced":[74],"defects":[76,127],"are":[77,172],"convincingly":[78],"observed":[79,118,173],"in":[80,90,105,166,174,186],"mice,":[81],"especially":[82],"placenta,":[84],"seem":[86],"more":[87],"frequent":[88],"than":[89,189],"humans.":[91,175],"Data":[92],"generally":[93],"provide":[94],"warning":[96],"as":[97,131],"use":[100],"ovulation":[102],"induction":[103],"vitro":[106],"culture.":[107],"human":[109],"sperm":[110,122],"from":[111,133,170],"compromised":[112],"spermatogenesis,":[113],"sequence-specific":[114],"DNA":[115,125,191],"hypomethylation":[116],"repeatedly.":[119],"Transmittance":[120],"oocyte":[124],"methylation":[126,188],"possible":[129],"but,":[130],"deduced":[132],"limited":[135],"data":[136],"available,":[137],"largely":[138],"prevented":[139],"selection":[141],"gametes":[143],"ART":[145,171,217,252],"and/or":[146],"non-viability":[147],"resulting":[150],"embryos.":[151],"Some":[152],"evidence":[153],"indicates":[154],"that":[155,257],"subfertility":[156],"itself":[157],"factor":[161],"diseases.":[164],"As":[165],"mouse,":[167,199],"physiological":[168],"human,":[178],"indications":[179],"broader":[182,201],"target":[183],"changes":[185],"imprinted":[190],"sequences":[192,205],"alone":[193],"have":[194],"been":[195,209],"found.":[196],"range":[202],"has":[206],"not":[207],"yet":[208],"studied.":[210],"Also,":[211],"multigeneration":[213],"study":[214],"systematic":[216],"parameters":[220],"lacking.":[222],"CONCLUSIONS:":[223],"field":[225],"within":[229],"lifespan":[231],"individual":[234],"between":[236],"generations":[237],"(via":[238],"mitosis":[239],"meiosis,":[241],"respectively)":[242],"growing,":[244],"driven":[245],"expansion":[248],"chromatin":[250],"research.":[251],"can":[253],"induce":[254],"variation":[256],"might":[258],"be":[259],"transmitted":[260],"next":[263],"generation.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
