{"id":"https://openalex.org/W2168735820","doi":"https://doi.org/10.1371/journal.pone.0005361","title":"Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol","display_name":"Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol","publication_year":2009,"publication_date":"2009-04-27","ids":{"openalex":"https://openalex.org/W2168735820","doi":"https://doi.org/10.1371/journal.pone.0005361","mag":"2168735820","pmid":"https://pubmed.ncbi.nlm.nih.gov/19399186","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2671171"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0005361","doi":"https://doi.org/10.1371/journal.pone.0005361","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005361","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005361&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005361&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072262068","display_name":"Franziska B. Mullauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Franziska B. Mullauer","raw_affiliation_strings":["Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine, Academic Medical Center (AMC), Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine, Academic Medical Center (AMC), Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110472656","display_name":"Jan H. Kessler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan H. Kessler","raw_affiliation_strings":["Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC), Leiden, The Netherlands","Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine, Academic Medical Center (AMC), Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC), Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine, Academic Medical Center (AMC), Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035211563","display_name":"Jan Paul Medema","orcid":"https://orcid.org/0000-0003-3045-2924","observed_orcids":["https://orcid.org/0000-0003-3045-2924"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Jan Paul Medema","raw_affiliation_strings":["Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine, Academic Medical Center (AMC), Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine, Academic Medical Center (AMC), Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035211563"],"corresponding_institution_ids":["https://openalex.org/I2802928900"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":30.4984,"has_fulltext":true,"cited_by_count":688,"citation_normalized_percentile":{"value":0.99950089,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"4","issue":"4","first_page":"e1","last_page":"e1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/betulin","display_name":"betulin","score":1.0},{"id":"https://openalex.org/keywords/betulinic-acid","display_name":"betulinic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.6740000247955322},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.843999981880188},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8043032884597778},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.7915831804275513},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7789434194564819},{"id":"https://openalex.org/C2778509883","wikidata":"https://www.wikidata.org/wiki/Q419726","display_name":"Betulin","level":2,"score":0.775510311126709},{"id":"https://openalex.org/C2777829905","wikidata":"https://www.wikidata.org/wiki/Q384111","display_name":"Betulinic acid","level":2,"score":0.7170675992965698},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5907012820243835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4581356346607208},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4235302209854126},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40802106261253357},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4013083279132843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3362976610660553},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13826465606689453},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000094062","descriptor_name":"Betulinic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019254","descriptor_name":"Genes, bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050998","descriptor_name":"bcl-2 Homologous Antagonist-Killer Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D050998","descriptor_name":"bcl-2 Homologous Antagonist-Killer Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053978","descriptor_name":"Pentacyclic Triterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0005361","doi":"https://doi.org/10.1371/journal.pone.0005361","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005361","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005361&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2671171","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2671171","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:19399186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19399186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.785.7667","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.785.7667","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ef/81/pone.0005361.PMC2671171.pdf","raw_type":"text"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/fdaf50eb-7428-48ee-ad64-db05c94d5178","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/betulin-is-a-potent-antitumor-agent-that-is-enhanced-by-cholesterol(fdaf50eb-7428-48ee-ad64-db05c94d5178).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 4(4). Public Library of Science","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.uva.nl:openaire/2328a37b-037c-4154-bd8d-33101104b81c","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/betulin-is-a-potent-antitumor-agent-that-is-enhanced-by-cholesterol(2328a37b-037c-4154-bd8d-33101104b81c).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mullauer, F B, Kessler, J H & Medema, J P 2009, 'Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol', PLoS ONE, vol. 4, no. 4, e5361. https://doi.org/10.1371/journal.pone.0005361","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:ffaed2f660ef45ada4c5615ad1e62d37","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ffaed2f660ef45ada4c5615ad1e62d37","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 4, p e1 (2009)","raw_type":"article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/a0539b64-6ae1-489f-acf1-6e77845c4182","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/a0539b64-6ae1-489f-acf1-6e77845c4182","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mullauer, F B, Kessler, J H & Medema, J P 2009, 'Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol', PLoS ONE, vol. 4, no. 4, pp. e1. https://doi.org/10.1371/journal.pone.0005361","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/2328a37b-037c-4154-bd8d-33101104b81c","doi":null,"is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/betulin-is-a-potent-antitumor-agent-that-is-enhanced-by-cholesterol(2328a37b-037c-4154-bd8d-33101104b81c).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 4(4):e5361. Public Library of Science","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0005361","doi":"https://doi.org/10.1371/journal.pone.0005361","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005361","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005361&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316280","display_name":"Nationaal Fonds tegen Kanker","ror":"https://ror.org/01gsd3t52"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168735820.pdf","grobid_xml":"https://content.openalex.org/works/W2168735820.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1533747850","https://openalex.org/W1566271574","https://openalex.org/W1928741718","https://openalex.org/W1969225559","https://openalex.org/W1976538401","https://openalex.org/W1981911388","https://openalex.org/W1984547206","https://openalex.org/W1987702938","https://openalex.org/W1989728946","https://openalex.org/W1990591488","https://openalex.org/W1996763573","https://openalex.org/W1998175560","https://openalex.org/W1998791620","https://openalex.org/W2013996412","https://openalex.org/W2015490751","https://openalex.org/W2022237652","https://openalex.org/W2028608807","https://openalex.org/W2034841810","https://openalex.org/W2037468156","https://openalex.org/W2041561160","https://openalex.org/W2042284982","https://openalex.org/W2043316693","https://openalex.org/W2043402957","https://openalex.org/W2048829161","https://openalex.org/W2049396254","https://openalex.org/W2049907515","https://openalex.org/W2060013956","https://openalex.org/W2060145133","https://openalex.org/W2060646951","https://openalex.org/W2070692423","https://openalex.org/W2072347882","https://openalex.org/W2087909543","https://openalex.org/W2096130774","https://openalex.org/W2099593329","https://openalex.org/W2127140763","https://openalex.org/W2135729408","https://openalex.org/W2136966358","https://openalex.org/W2137276707","https://openalex.org/W2169616232"],"related_works":["https://openalex.org/W7099676668","https://openalex.org/W2085270297","https://openalex.org/W2169616232","https://openalex.org/W2036686104","https://openalex.org/W117461297","https://openalex.org/W2168007808","https://openalex.org/W2000578504","https://openalex.org/W2084648807","https://openalex.org/W1970483536","https://openalex.org/W2057361927"],"abstract_inverted_index":{"Betulinic":[0],"Acid":[1],"(BetA)":[2],"and":[3,39],"its":[4,23],"derivatives":[5],"have":[6],"been":[7],"extensively":[8],"studied":[9],"in":[10,122],"the":[11,94,98],"past":[12],"for":[13],"their":[14],"anti-tumor":[15,119],"effects,":[16],"but":[17,56],"relatively":[18],"little":[19],"is":[20,40,70],"known":[21],"about":[22],"precursor":[24],"Betulin":[25],"(BE).":[26],"We":[27],"found":[28],"that":[29,75,115],"BE":[30,46,69,116],"induces":[31,47],"apoptosis":[32],"utilizing":[33],"a":[34,64],"similar":[35,59],"mechanism":[36],"as":[37,52,106],"BetA":[38],"prevented":[41],"by":[42],"cyclosporin":[43],"A":[44],"(CsA).":[45],"cell":[48,62,101,110],"death":[49,63,102],"more":[50],"rapidly":[51],"compared":[53],"to":[54,57,79],"BetA,":[55],"achieve":[58],"amounts":[60],"of":[61,68,87,100],"considerably":[65],"higher":[66],"concentration":[67],"needed.":[71],"Interestingly,":[72],"we":[73],"observed":[74],"cholesterol":[76,88],"sensitized":[77],"cells":[78],"BE-induced":[80],"apoptosis,":[81],"while":[82],"there":[83],"was":[84,103],"no":[85],"effect":[86],"when":[89],"combined":[90],"with":[91,124],"BetA.":[92],"Despite":[93],"significantly":[95],"enhanced":[96],"cytotoxicity,":[97],"mode":[99],"not":[104],"changed":[105],"CsA":[107],"completely":[108],"abrogated":[109],"death.":[111],"These":[112],"results":[113],"indicate":[114],"has":[117],"potent":[118],"activity":[120],"especially":[121],"combination":[123],"cholesterol.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":33},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":52},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":26},{"year":2018,"cited_by_count":36},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":45},{"year":2015,"cited_by_count":39},{"year":2014,"cited_by_count":43},{"year":2013,"cited_by_count":55},{"year":2012,"cited_by_count":56}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}