{"id":"https://openalex.org/W2168654583","doi":"https://doi.org/10.1093/nar/gkr458","title":"Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure","display_name":"Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure","publication_year":2011,"publication_date":"2011-07-15","ids":{"openalex":"https://openalex.org/W2168654583","doi":"https://doi.org/10.1093/nar/gkr458","mag":"2168654583","pmid":"https://pubmed.ncbi.nlm.nih.gov/21764778","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3201858"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkr458","doi":"https://doi.org/10.1093/nar/gkr458","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr458","pdf_url":"https://academic.oup.com/nar/article-pdf/39/19/8392/16777152/gkr458.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/39/19/8392/16777152/gkr458.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111947849","display_name":"Susumu Kodama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susumu Kodama","raw_affiliation_strings":["Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA","Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology and 2Human Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]},{"raw_affiliation_string":"Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology and 2Human Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091190110","display_name":"Fardin Hosseinpour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fardin Hosseinpour","raw_affiliation_strings":["Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology and 2 Human Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology and 2 Human Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103459153","display_name":"Joyce A. Goldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce A. Goldstein","raw_affiliation_strings":["Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology and 2 Human Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology and 2 Human Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089629096","display_name":"Masahiko Negishi","orcid":"https://orcid.org/0000-0002-2076-8928","observed_orcids":["https://orcid.org/0000-0002-2076-8928"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Masahiko Negishi","raw_affiliation_strings":["Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology and 2 Human Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology and 2 Human Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089629096"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":5.0568,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.94922521,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"39","issue":"19","first_page":"8392","last_page":"8403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6395999789237976,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6395999789237976,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.14329999685287476,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pregnane-x-receptor","display_name":"pregnane X receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sult1e1","display_name":"SULT1E1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/estrogen-sulfotransferase","display_name":"estrogen sulfotransferase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7770000100135803},{"id":"https://openalex.org/keywords/chromatin-looping","display_name":"chromatin looping","score":0.7160000205039978},{"id":"https://openalex.org/keywords/hnf4a","display_name":"HNF4\u03b1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.7760000228881836},{"id":"https://openalex.org/keywords/histone-h3-deacetylation","display_name":"histone H3 deacetylation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/enhancer-promoter-interactions","display_name":"enhancer-promoter interactions","score":0.8399999737739563},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.5450000166893005},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6200000047683716},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma-cells","display_name":"hepatocellular carcinoma cells","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C132040763","wikidata":"https://www.wikidata.org/wiki/Q409867","display_name":"Pregnane X receptor","level":5,"score":0.9331716895103455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7704681158065796},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.7610044479370117},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6241583824157715},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.5972989201545715},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5740140080451965},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5619649887084961},{"id":"https://openalex.org/C72699923","wikidata":"https://www.wikidata.org/wiki/Q3064192","display_name":"Hepatocyte nuclear factor 4","level":5,"score":0.5520775318145752},{"id":"https://openalex.org/C99535661","wikidata":"https://www.wikidata.org/wiki/Q5731779","display_name":"Hepatocyte nuclear factors","level":4,"score":0.5492182374000549},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4804489314556122},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.42285069823265076},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4187447428703308},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35687094926834106},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2316955327987671},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19898706674575806},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19004139304161072}],"mesh":[{"descriptor_ui":"D000077297","descriptor_name":"Pregnane X Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011987","descriptor_name":"Receptors, Steroid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015238","descriptor_name":"Sulfotransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051542","descriptor_name":"Hepatocyte Nuclear Factor 3-beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051557","descriptor_name":"Hepatocyte Nuclear Factor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkr458","doi":"https://doi.org/10.1093/nar/gkr458","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr458","pdf_url":"https://academic.oup.com/nar/article-pdf/39/19/8392/16777152/gkr458.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2202588","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3201858","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3201858","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3201858","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:21764778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21764778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkr458","doi":"https://doi.org/10.1093/nar/gkr458","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr458","pdf_url":"https://academic.oup.com/nar/article-pdf/39/19/8392/16777152/gkr458.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46000000834465027}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2724485247","display_name":null,"funder_award_id":"Z01ES1005-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2997049141","display_name":null,"funder_award_id":"Z01ES1005\u201001","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168654583.pdf","grobid_xml":"https://content.openalex.org/works/W2168654583.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1557387797","https://openalex.org/W1966140601","https://openalex.org/W1968946735","https://openalex.org/W1973238763","https://openalex.org/W1978213778","https://openalex.org/W1979543372","https://openalex.org/W1993736467","https://openalex.org/W1994242369","https://openalex.org/W1996593784","https://openalex.org/W2009838390","https://openalex.org/W2012740498","https://openalex.org/W2021173200","https://openalex.org/W2027038085","https://openalex.org/W2035000881","https://openalex.org/W2035835146","https://openalex.org/W2041485518","https://openalex.org/W2045416565","https://openalex.org/W2049557712","https://openalex.org/W2057743013","https://openalex.org/W2061783580","https://openalex.org/W2062301600","https://openalex.org/W2089894746","https://openalex.org/W2094806430","https://openalex.org/W2135248587","https://openalex.org/W2138989723","https://openalex.org/W2142749562","https://openalex.org/W2149038504","https://openalex.org/W2150009446","https://openalex.org/W2153392443","https://openalex.org/W2160142939"],"related_works":["https://openalex.org/W2756368853","https://openalex.org/W156668892","https://openalex.org/W1988825643","https://openalex.org/W2001318056","https://openalex.org/W2108498713","https://openalex.org/W2530139464","https://openalex.org/W2133113317","https://openalex.org/W1976488359","https://openalex.org/W2286046535","https://openalex.org/W2607039224"],"abstract_inverted_index":{"Pregnane":[0],"X":[1],"receptor":[2],"(PXR),":[3],"acting":[4],"as":[5,16,18,21],"a":[6,65],"xenobiotic-activated":[7],"transcription":[8],"factor,":[9],"regulates":[10],"the":[11,34,52,59,77,116,121,129,140,143,149,160,164,167,173,181,191],"hepatic":[12],"metabolism":[13],"of":[14,55,155,159,169,177,193],"therapeutics":[15],"well":[17],"endobiotics":[19],"such":[20],"steroid":[22],"hormones.":[23],"Given":[24],"our":[25],"finding":[26],"that":[27,75,108,176],"PXR":[28,136,178,185],"activation":[29,133],"by":[30,123,134],"rifampicin":[31],"(RIF)":[32],"represses":[33,186],"estrogen":[35],"sulfotransferase":[36],"(SULT1E1)":[37],"gene":[38],"in":[39],"human":[40,187],"primary":[41],"hepatocytes":[42],"and":[43,83,89,99,119,147,175],"hepatocellular":[44],"carcinoma":[45],"Huh7":[46],"cells,":[47],"here":[48],"we":[49],"have":[50],"investigated":[51],"molecular":[53],"mechanism":[54],"this":[56],"repression.":[57],"First":[58],"PXR-responsive":[60,117],"enhancer":[61,122,165],"was":[62],"delineated":[63],"to":[64,106,115,128,171,179],"100":[66],"bp":[67],"sequence":[68],"(-1000/-901),":[69],"which":[70],"contains":[71],"three":[72],"half":[73],"sites":[74,162],"constitute":[76],"overlapping":[78],"direct":[79,84],"repeat":[80,85],"1":[81],"(DR1)":[82],"2":[86],"(DR2)":[87],"motifs":[88],"two":[90],"forkhead":[91],"factor":[92,111],"binding":[93],"sites.":[94],"siRNA":[95],"knockdown,":[96],"chromatin":[97,100],"immunoprecipitation":[98],"conformation":[101],"capture":[102],"assays":[103],"were":[104],"employed":[105],"demonstrate":[107],"hepatocyte":[109],"nuclear":[110],"4\u03b1":[112],"(HNF4\u03b1)":[113],"bound":[114],"enhancer,":[118,141],"activated":[120],"looping":[124],"its":[125],"position":[126],"close":[127],"proximal":[130],"promoter.":[131],"Upon":[132],"RIF,":[135],"indirectly":[137],"interacted":[138],"with":[139,145,153],"decreasing":[142],"interaction":[144],"HNF4\u03b1":[146,170],"dissolving":[148],"looped":[150],"SULT1E1":[151],"promoter":[152,174,182],"deacetylation":[154],"histone":[156],"3.":[157],"Removal":[158],"DR":[161],"from":[163],"hampers":[166],"ability":[168],"loop":[172],"repress":[180],"activity.":[183],"Thus,":[184],"SULT1E1,":[188],"possibly":[189],"attenuating":[190],"inactivation":[192],"estrogen.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}