{"id":"https://openalex.org/W2168624927","doi":"https://doi.org/10.1192/bjp.bp.108.063156","title":"Dissecting the phenotype in genome-wide association studies of psychiatric illness","display_name":"Dissecting the phenotype in genome-wide association studies of psychiatric illness","publication_year":2009,"publication_date":"2009-08-01","ids":{"openalex":"https://openalex.org/W2168624927","doi":"https://doi.org/10.1192/bjp.bp.108.063156","mag":"2168624927","pmid":"https://pubmed.ncbi.nlm.nih.gov/19648536","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4739810"},"language":"en","primary_location":{"id":"doi:10.1192/bjp.bp.108.063156","doi":"https://doi.org/10.1192/bjp.bp.108.063156","is_oa":true,"landing_page_url":"https://doi.org/10.1192/bjp.bp.108.063156","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/DA9CA5940EA86C407870EAA1ABA1AACA/S0007125000007686a.pdf/div-class-title-dissecting-the-phenotype-in-genome-wide-association-studies-of-psychiatric-illness-div.pdf","source":{"id":"https://openalex.org/S127936299","display_name":"The British Journal of Psychiatry","issn_l":"0007-1250","issn":["0007-1250","1472-1465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Psychiatry","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/DA9CA5940EA86C407870EAA1ABA1AACA/S0007125000007686a.pdf/div-class-title-dissecting-the-phenotype-in-genome-wide-association-studies-of-psychiatric-illness-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"middle","author":{"id":"https://openalex.org/A5030438682","display_name":"Nick J. Craddock","orcid":"https://orcid.org/0000-0003-2171-0610","observed_orcids":["https://orcid.org/0000-0003-2171-0610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nick Craddock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011961838","display_name":"Kenneth S. Kendler","orcid":"https://orcid.org/0000-0001-8689-6570","observed_orcids":["https://orcid.org/0000-0001-8689-6570","https://orcid.org/0000-0003-0864-4380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth Kendler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027640245","display_name":"Michael Churton Neale","orcid":"https://orcid.org/0000-0003-4887-659X","observed_orcids":["https://orcid.org/0000-0003-4887-659X","https://orcid.org/0000-0002-8587-0974"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Neale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049429175","display_name":"John I. N\u00fcrnberger","orcid":"https://orcid.org/0000-0002-7674-1767","observed_orcids":["https://orcid.org/0000-0002-7674-1767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Nurnberger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051460895","display_name":"Shaun Purcell","orcid":"https://orcid.org/0000-0002-7402-5812","observed_orcids":["https://orcid.org/0000-0002-7402-5812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaun Purcell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031804624","display_name":"Marcella Rietschel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcella Rietschel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064278484","display_name":"Roy H. Perlis","orcid":"https://orcid.org/0000-0002-5862-6757","observed_orcids":["https://orcid.org/0000-0002-5862-6757"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roy Perlis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089665231","display_name":"Susan L. Santangelo","orcid":"https://orcid.org/0000-0001-5576-4495","observed_orcids":["https://orcid.org/0000-0001-5576-4495"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan L Santangelo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048877098","display_name":"Thomas G. Schulze","orcid":"https://orcid.org/0000-0001-6624-2975","observed_orcids":["https://orcid.org/0000-0001-6624-2975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas G Schulze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048877098","display_name":"Thomas G. Schulze","orcid":"https://orcid.org/0000-0001-6624-2975","observed_orcids":["https://orcid.org/0000-0001-6624-2975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Schulze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044998046","display_name":"Jordan W. Smoller","orcid":"https://orcid.org/0000-0002-0381-6334","observed_orcids":["https://orcid.org/0000-0002-0381-6334"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan W Smoller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025343580","display_name":"Anita Thapar","orcid":"https://orcid.org/0000-0002-3689-737X","observed_orcids":["https://orcid.org/0000-0002-3689-737X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anita Thapar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4920,"currency":"USD","value_usd":4920},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"195","issue":"2","first_page":"97","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.9539999961853027},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"genetic architecture","score":0.9449999928474426},{"id":"https://openalex.org/keywords/disease-classification","display_name":"disease classification","score":0.6169999837875366},{"id":"https://openalex.org/keywords/phenotypes","display_name":"phenotypes","score":0.4090000092983246},{"id":"https://openalex.org/keywords/susceptibility-loci","display_name":"genetic susceptibility loci","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.6254341006278992},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.613336980342865},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.5874552726745605},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5672030448913574},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5390244722366333},{"id":"https://openalex.org/C84201533","wikidata":"https://www.wikidata.org/wiki/Q7256235","display_name":"Psychiatric genetics","level":3,"score":0.48284226655960083},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35782259702682495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33230066299438477},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.31459665298461914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.286176472902298},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2741367220878601},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.23686444759368896},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.11625102162361145},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10381907224655151},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0959908664226532},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.07541093230247498}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1192/bjp.bp.108.063156","doi":"https://doi.org/10.1192/bjp.bp.108.063156","is_oa":true,"landing_page_url":"https://doi.org/10.1192/bjp.bp.108.063156","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/DA9CA5940EA86C407870EAA1ABA1AACA/S0007125000007686a.pdf/div-class-title-dissecting-the-phenotype-in-genome-wide-association-studies-of-psychiatric-illness-div.pdf","source":{"id":"https://openalex.org/S127936299","display_name":"The British Journal of Psychiatry","issn_l":"0007-1250","issn":["0007-1250","1472-1465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmid:19648536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19648536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of psychiatry : the journal of mental science","raw_type":"Editorial"},{"id":"pmh:oai:pubmedcentral.nih.gov:4739810","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4739810","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Br J Psychiatry","raw_type":"Text"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:28867","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/28867/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1192/bjp.bp.108.063156","doi":"https://doi.org/10.1192/bjp.bp.108.063156","is_oa":true,"landing_page_url":"https://doi.org/10.1192/bjp.bp.108.063156","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/DA9CA5940EA86C407870EAA1ABA1AACA/S0007125000007686a.pdf/div-class-title-dissecting-the-phenotype-in-genome-wide-association-studies-of-psychiatric-illness-div.pdf","source":{"id":"https://openalex.org/S127936299","display_name":"The British Journal of Psychiatry","issn_l":"0007-1250","issn":["0007-1250","1472-1465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3144576126","display_name":"1/5-The Psychiatric GWAS Consortium: Integrated & Coordinated GWAS Meta-Analyses","funder_award_id":"U01MH085520","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168624927.pdf","grobid_xml":"https://content.openalex.org/works/W2168624927.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W96109483","https://openalex.org/W1539996303","https://openalex.org/W1944558458","https://openalex.org/W2016205873","https://openalex.org/W2023171821","https://openalex.org/W2038648070","https://openalex.org/W2075492585","https://openalex.org/W2080714701","https://openalex.org/W2082832014","https://openalex.org/W2096296474","https://openalex.org/W2097660065","https://openalex.org/W2101983393","https://openalex.org/W2120388891","https://openalex.org/W2121626412","https://openalex.org/W2121926780","https://openalex.org/W2124794761","https://openalex.org/W2127442418","https://openalex.org/W2136078375"],"related_works":["https://openalex.org/W2602546956","https://openalex.org/W2084310124","https://openalex.org/W7100967021","https://openalex.org/W2901825704","https://openalex.org/W2096296474","https://openalex.org/W7016587550","https://openalex.org/W2020838969","https://openalex.org/W4396628491","https://openalex.org/W2131732489","https://openalex.org/W2565164890"],"abstract_inverted_index":{"Over":[0],"the":[1,14,25,34,40],"past":[2],"2":[3],"years":[4],"genome-wide":[5],"association":[6],"studies":[7,29],"have":[8],"made":[9],"major":[10],"contributions":[11],"to":[12],"understanding":[13,38],"genetic":[15],"architecture":[16],"of":[17,27,39,46],"many":[18],"common":[19],"human":[20],"diseases.":[21],"This":[22],"editorial":[23],"outlines":[24],"development":[26],"such":[28],"in":[30],"psychiatry":[31],"and":[32,43],"highlights":[33],"opportunities":[35],"for":[36],"advancing":[37],"biological":[41],"underpinnings":[42],"nosological":[44],"structure":[45],"psychiatric":[47],"disorders.":[48]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}