{"id":"https://openalex.org/W2168595241","doi":"https://doi.org/10.1136/jcp.52.12.876","title":"Prognostic evaluation of metallothionein expression in human colorectal neoplasms.","display_name":"Prognostic evaluation of metallothionein expression in human colorectal neoplasms.","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2168595241","doi":"https://doi.org/10.1136/jcp.52.12.876","mag":"2168595241","pmid":"https://pubmed.ncbi.nlm.nih.gov/10711249","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/501652"},"language":"en","primary_location":{"id":"doi:10.1136/jcp.52.12.876","doi":"https://doi.org/10.1136/jcp.52.12.876","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jcp.52.12.876","pdf_url":"https://jcp.bmj.com/content/jclinpath/52/12/876.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jcp.bmj.com/content/jclinpath/52/12/876.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113702189","display_name":"Elli E. Ioachim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E E Ioachim","raw_affiliation_strings":["Department of Pathology, University of Ioannina Medical School, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Ioannina Medical School, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030767744","display_name":"Ann C. Goussia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A C Goussia","raw_affiliation_strings":["Department of Pathology, University of Ioannina Medical School, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Ioannina Medical School, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110181293","display_name":"Niki John Agnantis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"N J Agnantis","raw_affiliation_strings":["Department of Pathology, University of Ioannina Medical School, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Ioannina Medical School, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036023747","display_name":"Melpomeni Machera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"M Machera","raw_affiliation_strings":["Department of Pathology, University of Ioannina Medical School, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Ioannina Medical School, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063278439","display_name":"Epameinondas V. Tsianos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E V Tsianos","raw_affiliation_strings":["Department of Pathology, University of Ioannina Medical School, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Ioannina Medical School, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049855426","display_name":"Angelos M. Kappas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A M Kappas","raw_affiliation_strings":["Department of Pathology, University of Ioannina Medical School, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Ioannina Medical School, Greece","institution_ids":["https://openalex.org/I194019607"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I194019607"],"apc_list":null,"apc_paid":null,"fwci":1.8287,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.85751799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"52","issue":"12","first_page":"876","last_page":"879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.35569998621940613,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.35569998621940613,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.1624000072479248,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.07559999823570251,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":1.0},{"id":"https://openalex.org/keywords/colorectal-adenocarcinoma","display_name":"colorectal adenocarcinoma","score":0.8799999952316284},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7789999842643738},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.4449999928474426},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.7580000162124634},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8199999928474426},{"id":"https://openalex.org/keywords/c-erbb-2","display_name":"c-erbB-2","score":0.8289999961853027},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.7870000004768372},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.6819999814033508},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.9225907921791077},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6631874442100525},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5446065068244934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5376151204109192},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.48101478815078735},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4782363772392273},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4377216398715973},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3723587691783905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23574957251548767},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07256007194519043},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1136/jcp.52.12.876","doi":"https://doi.org/10.1136/jcp.52.12.876","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jcp.52.12.876","pdf_url":"https://jcp.bmj.com/content/jclinpath/52/12/876.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:501652","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/501652","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Pathol","raw_type":"Text"},{"id":"pmid:10711249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10711249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pathology","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jclinpath:52/12/876","doi":null,"is_oa":false,"landing_page_url":"http://jcp.bmj.com/cgi/content/short/52/12/876","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/jcp.52.12.876","doi":"https://doi.org/10.1136/jcp.52.12.876","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jcp.52.12.876","pdf_url":"https://jcp.bmj.com/content/jclinpath/52/12/876.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168595241.pdf","grobid_xml":"https://content.openalex.org/works/W2168595241.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W10202513","https://openalex.org/W62554519","https://openalex.org/W1529170481","https://openalex.org/W1554538771","https://openalex.org/W1561945723","https://openalex.org/W1927464414","https://openalex.org/W1970868538","https://openalex.org/W1972562299","https://openalex.org/W1984073255","https://openalex.org/W1988357599","https://openalex.org/W1988496770","https://openalex.org/W2000140656","https://openalex.org/W2000455314","https://openalex.org/W2002452703","https://openalex.org/W2023949965","https://openalex.org/W2024365580","https://openalex.org/W2026962138","https://openalex.org/W2039748712","https://openalex.org/W2040804282","https://openalex.org/W2059122543","https://openalex.org/W2061820966","https://openalex.org/W2064086130","https://openalex.org/W2074687520","https://openalex.org/W2087833146","https://openalex.org/W2092033253","https://openalex.org/W2092929271","https://openalex.org/W2095144806","https://openalex.org/W2096428903","https://openalex.org/W2121399201","https://openalex.org/W2399943279","https://openalex.org/W2411241259","https://openalex.org/W4250221563"],"related_works":["https://openalex.org/W2034797989","https://openalex.org/W1988357599","https://openalex.org/W2087933773","https://openalex.org/W2082787552","https://openalex.org/W2152925157","https://openalex.org/W1604130004","https://openalex.org/W2082868262","https://openalex.org/W2045761985","https://openalex.org/W2149536204","https://openalex.org/W2029963008"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"investigate":[2],"the":[3,11,70,76,132,159,184,197,204,208],"role":[4],"of":[5,22,52,59,93,100,104,108,120,124,134,155,187,207],"metallothionein":[6,53,89,115,129,136,156,199],"in":[7,56,98,143,178,181,212,226],"colorectal":[8,60,179,213,227],"tumours":[9],"and":[10,44,62,102,110,122,165],"possible":[12],"relation":[13],"with":[14,18,141,183,192],"other":[15,160,185],"factors":[16],"associated":[17],"tumour":[19],"progression:":[20],"expression":[21,51,66,90,137,169,200,216],"cathepsin":[23],"D":[24],"(CD),":[25],"CD44,":[26],"p53,":[27],"Rb,":[28],"bcl-2,":[29],"c-erbB-2,":[30],"epidermal":[31],"growth":[32],"factor":[33],"receptor":[34],"(EGFR),":[35],"proliferation":[36],"indices":[37],"(Ki-67,":[38],"proliferating":[39],"cell":[40],"nuclear":[41],"antigen":[42],"(PCNA)),":[43],"conventional":[45],"clinicopathological":[46],"variables.":[47],"METHODS:":[48],"The":[49,189],"immunohistochemical":[50],"was":[54,67,96,138,150],"investigated":[55],"23":[57],"cases":[58],"adenoma":[61],"94":[63],"adenocarcinomas.":[64],"Metallothionein":[65,168,215],"examined":[68],"by":[69],"avidinbiotin":[71],"peroxidase":[72],"immunoperoxidase":[73],"(ABC)":[74],"using":[75],"monoclonal":[77],"mouse":[78],"antibody":[79],"E9,":[80],"on":[81],"formalin":[82],"fixed,":[83],"paraffin":[84],"embedded":[85],"tissue.":[86],"RESULTS:":[87],"Positive":[88],"(>":[91],"5%":[92],"neoplastic":[94,144],"cells)":[95],"observed":[97],"30.4%":[99],"adenomas":[101,109,121],"25.5%":[103],"adenocarcinomas,":[105,135,180],"while":[106],"8.7%":[107],"14.9%":[111],"carcinomas":[112,125],"showed":[113],"focal":[114],"positivity.":[116],"In":[117,131],"contrast,":[118],"60.9%":[119],"59.6%":[123],"almost":[126],"completely":[127],"lacked":[128],"expression.":[130],"series":[133],"inversely":[139],"correlated":[140],"CD44":[142,193],"cells":[145],"(p":[146],"=":[147],"0.01).":[148],"There":[149],"no":[151],"statistically":[152],"significant":[153],"difference":[154],"expression,":[157],"or":[158],"variables":[161],"examined,":[162],"between":[163],"adenocarcinomas":[164],"adenomas.":[166],"CONCLUSIONS:":[167],"does":[170,217],"not":[171,218],"seem":[172,219],"to":[173,203,220],"indicate":[174],"aggressive":[175],"biological":[176],"behaviour":[177],"comparison":[182],"types":[186],"carcinoma.":[188],"inverse":[190],"correlation":[191],"could":[194],"suggest":[195],"that":[196],"decreased":[198],"may":[201],"contribute":[202],"metastatic":[205],"spread":[206],"lymph":[209],"node":[210],"involvement":[211],"cancer.":[214,228],"represent":[221],"an":[222],"independent":[223],"prognostic":[224],"marker":[225]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}