{"id":"https://openalex.org/W2168565849","doi":"https://doi.org/10.1128/jvi.01130-10","title":"Transcriptomic Analysis Reveals a Mechanism for a Prefibrotic Phenotype in STAT1 Knockout Mice during Severe Acute Respiratory Syndrome Coronavirus Infection","display_name":"Transcriptomic Analysis Reveals a Mechanism for a Prefibrotic Phenotype in STAT1 Knockout Mice during Severe Acute Respiratory Syndrome Coronavirus Infection","publication_year":2010,"publication_date":"2010-08-12","ids":{"openalex":"https://openalex.org/W2168565849","doi":"https://doi.org/10.1128/jvi.01130-10","mag":"2168565849","pmid":"https://pubmed.ncbi.nlm.nih.gov/20702617","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2953159"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01130-10","doi":"https://doi.org/10.1128/jvi.01130-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01130-10","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2953159","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037784933","display_name":"Gregory A. Zornetzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory A. Zornetzer","raw_affiliation_strings":["Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034246875","display_name":"Matthew B. Frieman","orcid":"https://orcid.org/0000-0003-0107-0775","observed_orcids":["https://orcid.org/0000-0003-0107-0775"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew B. Frieman","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21202","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070569180","display_name":"Elizabeth Rosenzweig","orcid":"https://orcid.org/0000-0001-8464-8813","observed_orcids":["https://orcid.org/0000-0001-8464-8813"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Rosenzweig","raw_affiliation_strings":["Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064852161","display_name":"Marcus J. Korth","orcid":"https://orcid.org/0000-0002-8144-5831","observed_orcids":["https://orcid.org/0000-0002-8144-5831"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus J. Korth","raw_affiliation_strings":["Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060599444","display_name":"Carly Page","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carly Page","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21202","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017501496","display_name":"Ralph Steven Baric","orcid":"https://orcid.org/0000-0001-6827-8701","observed_orcids":["https://orcid.org/0000-0001-6827-8701"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph S. Baric","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111823790","display_name":"Michael G. Katze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael G. Katze","raw_affiliation_strings":["Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111823790"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":4.0317,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.93943556,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"84","issue":"21","first_page":"11297","last_page":"11309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.6718999743461609,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.6718999743461609,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.20739999413490295,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0706000030040741,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov","display_name":"SARS-CoV","score":0.8579999804496765},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.7229999899864197},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.8050000071525574},{"id":"https://openalex.org/keywords/type-i-interferon-receptor","display_name":"type I interferon receptor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ifnar1","display_name":"IFNAR1","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.8769999742507935},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.8420000076293945},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.781000018119812},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8790000081062317},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6029999852180481},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8423181176185608},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6578896641731262},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.6230714321136475},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.5952988862991333},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5860241055488586},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.5611783862113953},{"id":"https://openalex.org/C2778278966","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Interferon type I","level":3,"score":0.454670786857605},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.4388889968395233},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4353017807006836},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.432547390460968},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.4154411554336548},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4120827913284302},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.404025137424469},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3491772413253784},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3425672650337219},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3418963551521301},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24211499094963074},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1706734299659729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11236414313316345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07789137959480286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045169","descriptor_name":"Severe Acute Respiratory Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045169","descriptor_name":"Severe Acute Respiratory Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D045473","descriptor_name":"Severe acute respiratory syndrome-related coronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053633","descriptor_name":"Receptor, Interferon alpha-beta","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1128/jvi.01130-10","doi":"https://doi.org/10.1128/jvi.01130-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01130-10","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2953159","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2953159","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:20702617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20702617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:sb397d71p","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/mre8-gq66","pdf_url":"https://doi.org/10.17615/mre8-gq66","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, 84(21)","raw_type":"Article"},{"id":"pmh:cdr.lib.unc.edu:xs55mk76p","doi":null,"is_oa":false,"landing_page_url":"https://cdr.lib.unc.edu/concern/articles/xs55mk76p","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, 84(21)","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.896.4537","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.896.4537","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/84/21/11297.full.pdf","raw_type":"text"},{"id":"doi:10.17615/mre8-gq66","doi":"https://doi.org/10.17615/mre8-gq66","is_oa":true,"landing_page_url":"https://doi.org/10.17615/mre8-gq66","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2953159","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2953159","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1120873732","display_name":null,"funder_award_id":"R01-HL080621","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1895952441","display_name":"Pacific NorthWest Regional Center of Excellence (PNWRCE)","funder_award_id":"U54AI081680","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2097098677","display_name":null,"funder_award_id":"HHSN272200800060C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G233662523","display_name":"Immunity and Infection","funder_award_id":"T32AI007540","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5207772913","display_name":"Macaque Model and Gene Expression Profiling of SARS","funder_award_id":"5r01hl080621-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6055236974","display_name":"SARS-CoV Pathogenic Mechanisms in Senescent Mice","funder_award_id":"R01AI075297","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6611350873","display_name":null,"funder_award_id":"HHSN272200800060C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6922388935","display_name":null,"funder_award_id":"HL080621","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7402202298","display_name":"SARS-CoV Mediated Modulation of Innate Immunity","funder_award_id":"F32AI066542","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8194461225","display_name":"Developing Vaccine Candidates for the SARS Coronavirus","funder_award_id":"P01AI059443","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168565849.pdf","grobid_xml":"https://content.openalex.org/works/W2168565849.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W46766314","https://openalex.org/W71434449","https://openalex.org/W268300709","https://openalex.org/W317622466","https://openalex.org/W1511088713","https://openalex.org/W1547052876","https://openalex.org/W1766651653","https://openalex.org/W1959664751","https://openalex.org/W1961573346","https://openalex.org/W1963580683","https://openalex.org/W1966636646","https://openalex.org/W1967224833","https://openalex.org/W1967986697","https://openalex.org/W1977728069","https://openalex.org/W1978623713","https://openalex.org/W1985792696","https://openalex.org/W1985816756","https://openalex.org/W1987628377","https://openalex.org/W1993145638","https://openalex.org/W1997831206","https://openalex.org/W1998979892","https://openalex.org/W2001170176","https://openalex.org/W2006303725","https://openalex.org/W2008659442","https://openalex.org/W2011516984","https://openalex.org/W2020907530","https://openalex.org/W2026390886","https://openalex.org/W2029473819","https://openalex.org/W2035909252","https://openalex.org/W2047910378","https://openalex.org/W2048692951","https://openalex.org/W2049537492","https://openalex.org/W2049902839","https://openalex.org/W2053642612","https://openalex.org/W2059365438","https://openalex.org/W2059782047","https://openalex.org/W2060044866","https://openalex.org/W2070506007","https://openalex.org/W2070715537","https://openalex.org/W2073517332","https://openalex.org/W2083595834","https://openalex.org/W2083755620","https://openalex.org/W2088081374","https://openalex.org/W2093705034","https://openalex.org/W2093852073","https://openalex.org/W2100227317","https://openalex.org/W2100516702","https://openalex.org/W2107277218","https://openalex.org/W2108601142","https://openalex.org/W2108615089","https://openalex.org/W2108694342","https://openalex.org/W2113315901","https://openalex.org/W2114360920","https://openalex.org/W2116703025","https://openalex.org/W2118154607","https://openalex.org/W2118173129","https://openalex.org/W2120389623","https://openalex.org/W2121434292","https://openalex.org/W2122506044","https://openalex.org/W2124566107","https://openalex.org/W2126818469","https://openalex.org/W2130014663","https://openalex.org/W2135259291","https://openalex.org/W2136357996","https://openalex.org/W2136706532","https://openalex.org/W2139369020","https://openalex.org/W2140500533","https://openalex.org/W2140612509","https://openalex.org/W2141634694","https://openalex.org/W2145120842","https://openalex.org/W2145317632","https://openalex.org/W2146209521","https://openalex.org/W2148406410","https://openalex.org/W2154747690","https://openalex.org/W2158118659","https://openalex.org/W2160097418","https://openalex.org/W2160515346","https://openalex.org/W2164533762","https://openalex.org/W2167211373","https://openalex.org/W2168446943","https://openalex.org/W2258314763","https://openalex.org/W2334530874","https://openalex.org/W2427361530","https://openalex.org/W4245774281","https://openalex.org/W4294658238"],"related_works":["https://openalex.org/W7095697956","https://openalex.org/W2049537492","https://openalex.org/W2149784485","https://openalex.org/W2108358296","https://openalex.org/W2328323831","https://openalex.org/W4313385737","https://openalex.org/W3216618416","https://openalex.org/W145630246","https://openalex.org/W1992803487","https://openalex.org/W6962945442"],"abstract_inverted_index":{"Severe":[0],"acute":[1,18],"respiratory":[2,19],"syndrome":[3,21],"coronavirus":[4],"(SARS-CoV)":[5],"infection":[6,38],"can":[7],"cause":[8],"the":[9,48,75,89,102,111,121,131,154,166,181,187],"development":[10,155],"of":[11,51,77,88,96,104,110,123,142,156,173,183,189],"severe":[12],"end-stage":[13],"lung":[14],"disease":[15,83],"characterized":[16],"by":[17,28],"distress":[20],"(ARDS)":[22],"and":[23,32,60,126,144,153,177],"pulmonary":[24,30],"fibrosis.":[25],"The":[26],"mechanisms":[27],"which":[29],"lesions":[31,185],"fibrosis":[33],"are":[34,39],"generated":[35],"during":[36],"SARS-CoV":[37,70],"not":[40],"known.":[41],"Using":[42],"high-throughput":[43],"mRNA":[44],"profiling,":[45],"we":[46],"examined":[47],"transcriptional":[49],"response":[50,152],"wild-type":[52],"(WT),":[53],"type":[54,90],"I":[55,91],"interferon":[56,92],"receptor":[57],"knockout":[58,62],"(IFNAR1-/-),":[59],"STAT1":[61],"(STAT1-/-)":[63],"mice":[64,116,139],"infected":[65],"with":[66],"a":[67,86,118,135,149,162,171],"recombinant":[68],"mouse-adapted":[69],"(rMA15)":[71],"to":[72,82,108,129,148],"better":[73],"understand":[74],"contribution":[76],"specific":[78],"gene":[79],"expression":[80,95,122],"changes":[81],"progression.":[84],"Despite":[85],"deletion":[87],"receptor,":[93],"strong":[94],"interferon-stimulated":[97,124],"genes":[98,125],"was":[99],"observed":[100],"in":[101,120,134,186],"lungs":[103,188],"IFNAR1-/-":[105],"mice,":[106],"contributing":[107],"clearance":[109,176],"virus.":[112],"In":[113],"contrast,":[114],"STAT1-/-":[115,138,191],"exhibited":[117,140],"defect":[119],"were":[127],"unable":[128],"clear":[130],"infection,":[132],"resulting":[133],"lethal":[136],"outcome.":[137],"dysregulation":[141,179],"T-cell":[143],"macrophage":[145],"differentiation,":[146],"leading":[147],"TH2-biased":[150],"immune":[151],"alternatively":[157],"activated":[158],"macrophages":[159],"that":[160,170],"mediate":[161],"profibrotic":[163],"environment":[164],"within":[165],"lung.":[167],"We":[168],"propose":[169],"combination":[172],"impaired":[174],"viral":[175],"T-cell/macrophage":[178],"causes":[180],"formation":[182],"prefibrotic":[184],"rMA15-infected":[190],"mice.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
