{"id":"https://openalex.org/W2168535680","doi":"https://doi.org/10.1161/hypertensionaha.109.147843","title":"Direct Angiotensin II Type 2 Receptor Stimulation Acts Anti-Inflammatory Through Epoxyeicosatrienoic Acid and Inhibition of Nuclear Factor \u03baB","display_name":"Direct Angiotensin II Type 2 Receptor Stimulation Acts Anti-Inflammatory Through Epoxyeicosatrienoic Acid and Inhibition of Nuclear Factor \u03baB","publication_year":2010,"publication_date":"2010-02-15","ids":{"openalex":"https://openalex.org/W2168535680","doi":"https://doi.org/10.1161/hypertensionaha.109.147843","mag":"2168535680","pmid":"https://pubmed.ncbi.nlm.nih.gov/20157051"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.109.147843","doi":"https://doi.org/10.1161/hypertensionaha.109.147843","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.109.147843","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072535935","display_name":"Franziska Rompe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Franziska Rompe","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013934017","display_name":"Metin Artuc","orcid":"https://orcid.org/0000-0001-8851-5196","observed_orcids":["https://orcid.org/0000-0001-8851-5196"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Metin Artuc","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108389244","display_name":"Anders Hallberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Anders Hallberg","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110028978","display_name":"Mathias Alterman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Mathias Alterman","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003799334","display_name":"Katja Str\u00f6der","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Katja Stro\u0308der","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089238481","display_name":"Christa Th\u00f6ne\u2010Reineke","orcid":"https://orcid.org/0000-0003-0782-2755","observed_orcids":["https://orcid.org/0000-0003-0782-2755"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Christa Tho\u0308ne-Reineke","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020803172","display_name":"Anne Reichenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Anne Reichenbach","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081149018","display_name":"Jens Schacherl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Jens Schacherl","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016902658","display_name":"Bj\u00f6rn Dahl\u00f6f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Bjo\u0308rn Dahlo\u0308f","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039371456","display_name":"Michael B\u00e4der","orcid":"https://orcid.org/0000-0003-4780-4164","observed_orcids":["https://orcid.org/0000-0003-4780-4164"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Michael Bader","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059936166","display_name":"Natalia V. Alenina","orcid":"https://orcid.org/0000-0002-6071-5433","observed_orcids":["https://orcid.org/0000-0002-6071-5433"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Natalia Alenina","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009423317","display_name":"Markus Schwaninger","orcid":"https://orcid.org/0000-0002-4510-9718","observed_orcids":["https://orcid.org/0000-0002-4510-9718"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Markus Schwaninger","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004878337","display_name":"Torsten Zuberbier","orcid":"https://orcid.org/0000-0002-1466-8875","observed_orcids":["https://orcid.org/0000-0002-1466-8875"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Torsten Zuberbier","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052250280","display_name":"Heiko Funke\u2010Kaiser","orcid":"https://orcid.org/0009-0002-7947-9861","observed_orcids":["https://orcid.org/0009-0002-7947-9861"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Heiko Funke-Kaiser","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107145556","display_name":"Cosima Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Cosima Schmidt","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112759253","display_name":"Wolf\u2010Hagen Schunck","orcid":"https://orcid.org/0000-0001-7965-7731","observed_orcids":["https://orcid.org/0000-0001-7965-7731"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Wolf-Hagen Schunck","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052836637","display_name":"Thomas Unger","orcid":"https://orcid.org/0000-0002-0233-8705","observed_orcids":["https://orcid.org/0000-0002-0233-8705"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Thomas Unger","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070331776","display_name":"U. Muscha Steckelings","orcid":"https://orcid.org/0000-0002-5430-4275","observed_orcids":["https://orcid.org/0000-0002-5430-4275"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"U. Muscha Steckelings","raw_affiliation_strings":["From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Research (F.R., K.S., C.T.-R., A.R., J.S., H.F.-K., T.U., U.M.S.) and Department of Dermatology and Allergy (M.Ar., T.Z.), Charite\u0301-Universita\u0308tsmedizin Berlin, Berlin, Germany; Department of Medical Chemistry (A.H., M.Al.), University of Uppsala, Uppsala, Sweden; Sahlgrenska University Hospital/O\u0308stra (B.D.), Go\u0308teborg, Sweden; Max-Delbru\u0308ck-Center for Molecular Medicine (M.B., N.A., C.S., W.-H.S.), Berlin-Buch, Germany; Department of Pharmacology (M.S.),","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2801112325","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmacology (M.S.), University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.4868,"has_fulltext":false,"cited_by_count":215,"citation_normalized_percentile":{"value":0.99122186,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"55","issue":"4","first_page":"924","last_page":"931"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii-type-2-receptor","display_name":"angiotensin II type 2 receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/compound-21","display_name":"compound 21","score":0.9800000190734863},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/epoxyeicosatrienoic-acids","display_name":"epoxyeicosatrienoic acids","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nuclear-factor-kappab","display_name":"nuclear factor-kappaB","score":0.8709999918937683},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9259999990463257},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.570646345615387},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4942212402820587},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4908514618873596},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.47850146889686584},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4558084011077881},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.447243869304657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4445956349372864},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4227033853530884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42241156101226807},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38374483585357666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37718597054481506},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2517980635166168},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17669335007667542},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.08537286520004272}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015126","descriptor_name":"8,11,14-Eicosatrienoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/hypertensionaha.109.147843","doi":"https://doi.org/10.1161/hypertensionaha.109.147843","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.109.147843","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:20157051","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20157051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:10747","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/10747/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1913730804","https://openalex.org/W1965599418","https://openalex.org/W1965830002","https://openalex.org/W1971778857","https://openalex.org/W1974814786","https://openalex.org/W1992303064","https://openalex.org/W1994135647","https://openalex.org/W1995271823","https://openalex.org/W1997045912","https://openalex.org/W1998424002","https://openalex.org/W1999338190","https://openalex.org/W2007861988","https://openalex.org/W2014190096","https://openalex.org/W2025193872","https://openalex.org/W2035505806","https://openalex.org/W2062076920","https://openalex.org/W2071107627","https://openalex.org/W2072749612","https://openalex.org/W2082542825","https://openalex.org/W2092460415","https://openalex.org/W2101356983","https://openalex.org/W2112903359","https://openalex.org/W2118048953","https://openalex.org/W2121985419","https://openalex.org/W2129077714","https://openalex.org/W2131033837","https://openalex.org/W2134899427","https://openalex.org/W2137847782","https://openalex.org/W2142381016","https://openalex.org/W2148117025","https://openalex.org/W4255758041"],"related_works":["https://openalex.org/W1805092636","https://openalex.org/W2030221708","https://openalex.org/W7095369167","https://openalex.org/W2318123349","https://openalex.org/W2062829349","https://openalex.org/W1988502601","https://openalex.org/W2574496698","https://openalex.org/W2151851600","https://openalex.org/W2326207571","https://openalex.org/W2621319712"],"abstract_inverted_index":{"Angiotensin":[0],"II":[1,66],"type":[2,67],"2":[3],"(AT(2))":[4],"receptors":[5],"can":[6],"be":[7,241],"regarded":[8],"as":[9,80],"an":[10,242],"endogenous":[11],"repair":[12],"system,":[13],"because":[14],"the":[15,43,87,127,134,206,210,224,252],"AT(2)":[16,49,58,75,118,128,139,142,215,228,237],"receptor":[17,50,76,119,129,216,229,238],"is":[18,205],"upregulated":[19],"in":[20,111,138,176,193,196,201,218,221,248],"tissue":[21,25],"damage":[22],"and":[23,92,114,132,161,189,195,220],"mediates":[24],"protection.":[26],"A":[27],"potential":[28,82],"therapeutic":[29,84,246],"use":[30],"of":[31,42,89,93,136,153,158,163,167,213,254,259],"this":[32],"system":[33],"has":[34],"only":[35],"recently":[36],"come":[37],"within":[38],"reach":[39],"through":[40],"synthesis":[41,162],"first":[44,207],"selective,":[45],"orally":[46,225,243],"active,":[47,226],"nonpeptide":[48,227],"agonist,":[51],"compound":[52],"21":[53],"(C21;":[54],"dissociation":[55,62],"constant":[56,63],"for":[57,64,86,123],"receptor:":[59,69],"0.4":[60],"nM;":[61],"angiotensin":[65],"1":[68,102,188],">10,000":[70],"nM).":[71],"This":[72,203],"study":[73,204],"tested":[74],"stimulation":[77,217,239],"with":[78,126],"C21":[79,97,173,182],"a":[81],"future":[83,245],"approach":[85,247],"inhibition":[88,125,152,179,258],"proinflammatory":[90],"cytokines":[91],"nuclear":[94,154,260],"factor":[95,155,261],"kappaB.":[96,262],"dose-dependently":[98],"(1":[99],"nM":[100],"to":[101,146,178,208],"micromol/L)":[103],"reduced":[104,147,184],"tumor":[105,190],"necrosis":[106,191],"factor-alpha-induced":[107],"interleukin":[108,148,168,255],"6":[109,149,169,256],"levels":[110,150],"primary":[112],"human":[113],"murine":[115],"dermal":[116],"fibroblasts.":[117],"specificity":[120],"was":[121,174],"controlled":[122],"by":[124,133,172,180,223],"antagonist":[130],"PD123319":[131],"absence":[135],"effects":[137,212],"receptor-deficient":[140],"cells.":[141],"receptor-coupled":[143],"signaling":[144],"leading":[145],"involved":[151],"kappaB,":[156],"activation":[157],"protein":[159,187],"phosphatases,":[160],"epoxyeicosatrienoic":[164],"acid.":[165],"Inhibition":[166],"promoter":[170],"activity":[171],"comparable":[175],"strength":[177],"hydrocortisone.":[181],"also":[183],"monocyte":[185],"chemoattractant":[186],"factor-alpha":[192],"vitro":[194,219],"bleomycin-induced":[197],"toxic":[198],"cutaneous":[199],"inflammation":[200],"vivo.":[202],"show":[209],"anti-inflammatory":[211],"direct":[214],"vivo":[222],"agonist":[230],"C21.":[231],"These":[232],"data":[233],"suggest":[234],"that":[235],"pharmacological":[236],"may":[240],"applicable":[244],"pathological":[249],"settings":[250],"requiring":[251],"reduction":[253],"or":[257]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}