{"id":"https://openalex.org/W2168523142","doi":"https://doi.org/10.1161/01.str.30.2.393","title":"Characterization of White Matter Damage in Ischemic Leukoaraiosis with Diffusion Tensor MRI","display_name":"Characterization of White Matter Damage in Ischemic Leukoaraiosis with Diffusion Tensor MRI","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W2168523142","doi":"https://doi.org/10.1161/01.str.30.2.393","mag":"2168523142","pmid":"https://pubmed.ncbi.nlm.nih.gov/9933277"},"language":"en","primary_location":{"id":"doi:10.1161/01.str.30.2.393","doi":"https://doi.org/10.1161/01.str.30.2.393","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.30.2.393","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2168523142"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008209004","display_name":"Derek Kenton Jones","orcid":"https://orcid.org/0000-0003-4409-8049","observed_orcids":["https://orcid.org/0000-0003-4409-8049","https://orcid.org/0000-0003-0592-6999"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]},{"id":"https://openalex.org/I4210115181","display_name":"Maudsley Hospital","ror":"https://ror.org/02788t795","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923","https://openalex.org/I4210115181"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Derek K. Jones","raw_affiliation_strings":["From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","Derek K. Jones From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)","Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I2800281165","https://openalex.org/I4210115181"]},{"raw_affiliation_string":"Derek K. Jones From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)","institution_ids":["https://openalex.org/I2800281165"]},{"raw_affiliation_string":"Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I4210115181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074415604","display_name":"David J. Lythgoe","orcid":"https://orcid.org/0000-0002-5078-9025","observed_orcids":["https://orcid.org/0000-0002-5078-9025"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]},{"id":"https://openalex.org/I4210115181","display_name":"Maudsley Hospital","ror":"https://ror.org/02788t795","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923","https://openalex.org/I4210115181"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Lythgoe","raw_affiliation_strings":["From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","David Lythgoe From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)","Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I2800281165","https://openalex.org/I4210115181"]},{"raw_affiliation_string":"David Lythgoe From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)","institution_ids":["https://openalex.org/I2800281165"]},{"raw_affiliation_string":"Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I4210115181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007366248","display_name":"Mark A. Horsfield","orcid":"https://orcid.org/0000-0002-0815-6697","observed_orcids":["https://orcid.org/0000-0002-0815-6697"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]},{"id":"https://openalex.org/I4210115181","display_name":"Maudsley Hospital","ror":"https://ror.org/02788t795","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923","https://openalex.org/I4210115181"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark A. Horsfield","raw_affiliation_strings":["From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","Mark A. Horsfield From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)","Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I2800281165","https://openalex.org/I4210115181"]},{"raw_affiliation_string":"Mark A. Horsfield From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)","institution_ids":["https://openalex.org/I2800281165"]},{"raw_affiliation_string":"Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I4210115181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067818010","display_name":"Andrew Simmons","orcid":"https://orcid.org/0000-0003-2306-5811","observed_orcids":["https://orcid.org/0000-0003-2306-5811","https://orcid.org/0000-0002-8855-3392"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]},{"id":"https://openalex.org/I4210115181","display_name":"Maudsley Hospital","ror":"https://ror.org/02788t795","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923","https://openalex.org/I4210115181"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Simmons","raw_affiliation_strings":["From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","Andrew Simmons From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)","Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I2800281165","https://openalex.org/I4210115181"]},{"raw_affiliation_string":"Andrew Simmons From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)","institution_ids":["https://openalex.org/I2800281165"]},{"raw_affiliation_string":"Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I4210115181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045174960","display_name":"Steven Williams","orcid":"https://orcid.org/0000-0003-4299-1941","observed_orcids":["https://orcid.org/0000-0003-4299-1941"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]},{"id":"https://openalex.org/I4210115181","display_name":"Maudsley Hospital","ror":"https://ror.org/02788t795","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923","https://openalex.org/I4210115181"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steve C. R. Williams","raw_affiliation_strings":["From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","Steve C. R. Williams From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I2800281165","https://openalex.org/I4210115181"]},{"raw_affiliation_string":"Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I4210115181"]},{"raw_affiliation_string":"Steve C. R. Williams From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)","institution_ids":["https://openalex.org/I2800281165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056940847","display_name":"Hugh Stephen Markus","orcid":"https://orcid.org/0000-0002-9794-5996","observed_orcids":["https://orcid.org/0000-0002-9794-5996","https://orcid.org/0000-0001-7100-623X"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]},{"id":"https://openalex.org/I4210115181","display_name":"Maudsley Hospital","ror":"https://ror.org/02788t795","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923","https://openalex.org/I4210115181"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hugh S. Markus","raw_affiliation_strings":["From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","Hugh S. Markus From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)","Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.); Department of Clinical Neuroscience, Kings College School of Medicine and Dentistry and Institute of Psychiatry, London (D.L., A.S., S.C.R.W., H.S.M.); and Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I2800281165","https://openalex.org/I4210115181"]},{"raw_affiliation_string":"Hugh S. Markus From the Division of Medical Physics, Leicester Royal Infirmary, Leicester (D.K.J., M.A.H.)","institution_ids":["https://openalex.org/I2800281165"]},{"raw_affiliation_string":"Neuroimaging Department, Maudsley Hospital, London (A.S., S.C.R.W.), UK","institution_ids":["https://openalex.org/I4210115181"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.8383,"has_fulltext":true,"cited_by_count":311,"citation_normalized_percentile":{"value":0.99314482,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"30","issue":"2","first_page":"393","last_page":"397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/white-matter-injury","display_name":"white matter injury","score":0.968999981880188},{"id":"https://openalex.org/keywords/diffusion-tensor-imaging","display_name":"diffusion tensor imaging","score":0.8090000152587891},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mean-diffusivity","display_name":"mean diffusivity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/axonal-loss","display_name":"axonal loss","score":0.8759999871253967},{"id":"https://openalex.org/keywords/gliosis","display_name":"gliosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lacunar-stroke","display_name":"lacunar stroke","score":0.9760000109672546},{"id":"https://openalex.org/keywords/white-matter-microstructure","display_name":"white matter microstructure","score":0.7639999985694885},{"id":"https://openalex.org/keywords/in-vivo-histology","display_name":"in vivo histology","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2776191500","wikidata":"https://www.wikidata.org/wiki/Q2123166","display_name":"Leukoaraiosis","level":4,"score":0.9309585690498352},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.886631190776825},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.8686379790306091},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.8041780591011047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7655668258666992},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3636358380317688},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.35632461309432983},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.32101938128471375},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.22071146965026855},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11695137619972229}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015161","descriptor_name":"Dementia, Multi-Infarct","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015161","descriptor_name":"Dementia, Multi-Infarct","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.str.30.2.393","doi":"https://doi.org/10.1161/01.str.30.2.393","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.30.2.393","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:9933277","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9933277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Comparative Study"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:35389","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/35389/1/Jones%201999.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/35389/1/Jones%201999.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/6ffd86ee-c81e-4ee2-b3be-e0e2c32284de","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/6ffd86ee-c81e-4ee2-b3be-e0e2c32284de","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jones, D K, Lythgoe, D, Horsfield, MA, Simmons, A, Williams, S & Markus, HS 1999, 'Characterisation of white matter damage in ischaemic leukoaraiosis with diffusion tensor MRI', Stroke, vol. 30, no. 2, pp. 393-397. https://doi.org/10.1161/\u200b01.STR.30.2.393","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320068","display_name":"Stroke Association","ror":"https://ror.org/05mgfq941"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W619187655","https://openalex.org/W1964802316","https://openalex.org/W1990634803","https://openalex.org/W1998450323","https://openalex.org/W2001672324","https://openalex.org/W2009039636","https://openalex.org/W2015365763","https://openalex.org/W2021556801","https://openalex.org/W2029510000","https://openalex.org/W2043618136","https://openalex.org/W2058986306","https://openalex.org/W2078103827","https://openalex.org/W2129841144","https://openalex.org/W2139158372","https://openalex.org/W2140099191","https://openalex.org/W2156267331","https://openalex.org/W4240347348"],"related_works":["https://openalex.org/W1965730864","https://openalex.org/W2786374852","https://openalex.org/W2385997555","https://openalex.org/W2037227288","https://openalex.org/W2044502542","https://openalex.org/W2133387193","https://openalex.org/W2317117466","https://openalex.org/W2131096301","https://openalex.org/W7095283704","https://openalex.org/W2350299109"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Information":[3],"on":[4,20,206],"the":[5,25,33,41,48,108,138,144,167,184,246,249],"neuropathological":[6],"changes":[7],"underlying":[8],"ischemic":[9,66,122],"leukoaraiosis":[10,67,69],"is":[11,38,214],"only":[12],"available":[13],"postmortem,":[14],"and":[15,70,74,85,90,99,110,134,160,177,197,219,225,243],"there":[16,188],"are":[17],"limited":[18],"data":[19],"histological":[21],"appearances":[22],"early":[23],"in":[24,40,60,104,114,137,143,158,163,175,180,210,239,244],"disease.":[26],"Diffusion":[27,80],"tensor":[28,81,208],"imaging":[29,82,209],"allows":[30],"determination":[31],"of":[32,35,43,56,87,97,107,132,227,248],"directionality":[34],"diffusion,":[36],"which":[37],"greater":[39],"direction":[42],"white":[44,112,139,147,185],"matter":[45,113,148,186],"bundles.":[46],"Therefore,":[47],"technique":[49],"might":[50],"be":[51,237,254],"expected":[52],"to":[53,222,224],"show":[54],"loss":[55,131,218,226],"anisotropy":[57,92,101,133,171,198],"(directional":[58],"diffusion)":[59],"leukoaraiosis.":[61],"METHODS:":[62],"Nine":[63],"patients":[64,120,159,176],"with":[65,121,130,216],"(radiological":[68],"clinical":[71],"lacunar":[72],"stroke)":[73],"10":[75],"age-matched":[76],"controls":[77,164,181],"were":[78,93,102],"studied.":[79],"was":[83,128,152,172,189],"performed,":[84],"maps":[86],"diffusion":[88,207],"trace":[89,98,136],"fractional":[91,100,170],"constructed.":[94],"Mean":[95],"values":[96],"determined":[103],"standard":[105],"regions":[106],"anterior":[109,146],"posterior":[111],"both":[115],"hemispheres.":[116],"RESULTS:":[117],"In":[118,166],"all":[119],"leukoaraiosis,":[123],"a":[124,190],"characteristic":[125,203],"abnormal":[126],"pattern":[127,204],"found,":[129],"increased":[135],"matter.":[140],"For":[141],"example,":[142],"right":[145],"mean":[149,195],"(SD)":[150],"trace/3":[151],"1.12":[153],"(0.33)":[154],"x10(-3)":[155],"mm2":[156],"s-1":[157],"0.75":[161],"(0.11)":[162,174],"(P=0.001).":[165],"same":[168],"region,":[169],"0.53":[173],"0.78":[178],"(0.09)":[179],"(P<0.001).":[182],"Within":[183],"regions,":[187],"strong":[191],"negative":[192],"correlation":[193],"between":[194],"diffusivity":[196],"(r=-0.92,":[199],"P<0.0001).":[200],"CONCLUSIONS:":[201],"The":[202,230],"found":[205],"this":[211],"patient":[212],"group":[213],"consistent":[215],"axonal":[217],"gliosis":[220],"leading":[221],"impairment":[223,251],"directional":[228],"diffusion.":[229],"\"in":[231],"vivo":[232],"histological\"":[233],"information":[234],"obtained":[235],"may":[236,253],"useful":[238],"monitoring":[240],"disease":[241],"progression":[242],"investigating":[245],"pathogenesis":[247],"cognitive":[250],"that":[252],"present.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}