{"id":"https://openalex.org/W2168522320","doi":"https://doi.org/10.1152/ajpgi.1999.277.1.g127","title":"Molecular diversity of KV\u03b1- and \u03b2-subunit expression in canine gastrointestinal smooth muscles","display_name":"Molecular diversity of KV\u03b1- and \u03b2-subunit expression in canine gastrointestinal smooth muscles","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2168522320","doi":"https://doi.org/10.1152/ajpgi.1999.277.1.g127","mag":"2168522320","pmid":"https://pubmed.ncbi.nlm.nih.gov/10409159"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.1999.277.1.g127","doi":"https://doi.org/10.1152/ajpgi.1999.277.1.g127","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1999.277.1.g127","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042218858","display_name":"Anne Epperson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Epperson","raw_affiliation_strings":["Department of Physiology and Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091862175","display_name":"Helena P. Bonner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helena P. Bonner","raw_affiliation_strings":["Department of Physiology and Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055296224","display_name":"Sean M. Ward","orcid":"https://orcid.org/0000-0003-0217-1535","observed_orcids":["https://orcid.org/0000-0003-0217-1535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean M. Ward","raw_affiliation_strings":["Department of Physiology and Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038545067","display_name":"William J. Hatton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William J. Hatton","raw_affiliation_strings":["Department of Physiology and Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012648187","display_name":"Karri K. Bradley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karri K. Bradley","raw_affiliation_strings":["Department of Physiology and Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael E. Bradley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Bradley","raw_affiliation_strings":["Pharmacology, University of Nevada, School of Medicine, Reno, Nevada 89557; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology, University of Nevada, School of Medicine, Reno, Nevada 89557; and","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047555131","display_name":"James S. Trimmer","orcid":"https://orcid.org/0000-0002-6117-3912","observed_orcids":["https://orcid.org/0000-0002-6117-3912"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James S. Trimmer","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108583752","display_name":"Burton Horowitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Burton Horowitz","raw_affiliation_strings":["Department of Physiology and Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7228,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.84202705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"277","issue":"1","first_page":"G127","last_page":"G136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.8949999809265137},{"id":"https://openalex.org/keywords/gastrointestinal-smooth-muscle","display_name":"gastrointestinal smooth muscle","score":0.8970000147819519},{"id":"https://openalex.org/keywords/kv1-4","display_name":"Kv1.4","score":0.6990000009536743},{"id":"https://openalex.org/keywords/kv1-5","display_name":"Kv1.5","score":0.9769999980926514},{"id":"https://openalex.org/keywords/kv1-2","display_name":"Kv1.2","score":0.8309999704360962},{"id":"https://openalex.org/keywords/kv2-2","display_name":"Kv2.2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/kv4-3","display_name":"Kv4.3","score":0.8550000190734863},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7440000176429749},{"id":"https://openalex.org/keywords/spontaneous-electrical-activity","display_name":"spontaneous electrical activity","score":0.7080000042915344},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6499119997024536},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.617500901222229},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5289133787155151},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.5077744126319885},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.4788210988044739},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4711410403251648},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42877545952796936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39772823452949524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3498871326446533},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22969311475753784},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15223804116249084},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.129064679145813}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.1999.277.1.g127","doi":"https://doi.org/10.1152/ajpgi.1999.277.1.g127","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1999.277.1.g127","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:10409159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10409159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1447586319","display_name":"Regulatory mechanisms in intestinal motility","funder_award_id":"P01DK041315","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2614562143","display_name":null,"funder_award_id":"NS34383","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G606382658","display_name":null,"funder_award_id":"DK41315","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1487464667","https://openalex.org/W1542367756","https://openalex.org/W1600171386","https://openalex.org/W1677506667","https://openalex.org/W1945899623","https://openalex.org/W1967167619","https://openalex.org/W1970000366","https://openalex.org/W1978529028","https://openalex.org/W1979870127","https://openalex.org/W1982455660","https://openalex.org/W1983948790","https://openalex.org/W1987378376","https://openalex.org/W1997174350","https://openalex.org/W2009697737","https://openalex.org/W2015113067","https://openalex.org/W2017531990","https://openalex.org/W2035859002","https://openalex.org/W2040227221","https://openalex.org/W2050564667","https://openalex.org/W2053695860","https://openalex.org/W2059957319","https://openalex.org/W2064899443","https://openalex.org/W2068732182","https://openalex.org/W2072972683","https://openalex.org/W2078248237","https://openalex.org/W2083088703","https://openalex.org/W2086172025","https://openalex.org/W2087219553","https://openalex.org/W2089764275","https://openalex.org/W2125753558","https://openalex.org/W2127734534","https://openalex.org/W2129732144","https://openalex.org/W2136550767","https://openalex.org/W2150016059","https://openalex.org/W2171937944","https://openalex.org/W2181410479","https://openalex.org/W2182317314","https://openalex.org/W2187457442","https://openalex.org/W2284335314","https://openalex.org/W2308432522","https://openalex.org/W2398613706","https://openalex.org/W2409237734","https://openalex.org/W2410834977","https://openalex.org/W2417681579","https://openalex.org/W2418566513","https://openalex.org/W2465187776","https://openalex.org/W2469886659","https://openalex.org/W2471631336","https://openalex.org/W2474502530","https://openalex.org/W4247114810","https://openalex.org/W4293633566"],"related_works":["https://openalex.org/W2047341501","https://openalex.org/W1973731488","https://openalex.org/W2263424414","https://openalex.org/W2245874150","https://openalex.org/W1997554892","https://openalex.org/W2097354554","https://openalex.org/W2018505579","https://openalex.org/W2149782869","https://openalex.org/W2474502530","https://openalex.org/W2075345834"],"abstract_inverted_index":{"Voltage-activated":[0],"K(+)":[1],"(K(V))":[2],"channels":[3,22],"play":[4],"an":[5],"important":[6,25],"role":[7],"in":[8,13,26,51,71,97,129,173,184,203,214],"regulating":[9],"the":[10,39,47,52,62,78,87,101,139,170,188,196,207,217],"membrane":[11],"potential":[12],"excitable":[14],"cells.":[15,134,179],"In":[16,56],"gastrointestinal":[17],"(GI)":[18],"smooth":[19,74,132,177],"muscles,":[20],"these":[21,146],"are":[23,167],"particularly":[24],"modulating":[27],"spontaneous":[28],"electrical":[29,200],"activities.":[30],"The":[31],"purpose":[32],"of":[33,65,89,100,145,187,199,206,220],"this":[34,57],"study":[35],"was":[36,181],"to":[37,216],"identify":[38],"molecular":[40],"components":[41],"that":[42,161,195],"may":[43,211],"be":[44,212],"responsible":[45],"for":[46,142],"K(V)":[48,68,147,221],"currents":[49],"found":[50,202],"canine":[53,72,208],"GI":[54,73,102,131,174,189,209],"tract.":[55],"report,":[58],"we":[59],"have":[60,136],"examined":[61],"qualitative":[63],"expression":[64,88,141,219],"eighteen":[66],"different":[67,204],"channel":[69,148,222],"genes":[70],"muscle":[75,133,178],"cells":[76],"at":[77,169],"transcriptional":[79],"level":[80,172],"using":[81,150],"RT-PCR":[82],"analysis.":[83],"Our":[84],"results":[85,193],"demonstrate":[86],"K(V)1.4,":[90,163],"K(V)1.5,":[91,164],"K(V)1.6,":[92],"K(V)2.2,":[93],"and":[94,109,123,155,158,165,176],"K(V)4.3":[95],"transcripts":[96,125],"all":[98],"regions":[99,186,205],"tract":[103,190,210],"examined.":[104,191],"Transcripts":[105],"encoding":[106],"K(V)1.2,":[107,162],"K(V)beta1.1,":[108],"K(V)beta1.2":[110],"subunits":[111,149],"were":[112,126],"differentially":[113],"expressed.":[114],"K(V)1.1,":[115],"K(V)1.3,":[116],"K(V)2.1,":[117],"K(V)3.1,":[118],"K(V)3.2,":[119],"K(V)3.4,":[120],"K(V)4.1,":[121],"K(V)4.2,":[122],"K(V)beta2.1":[124],"not":[127,182],"detected":[128,183],"any":[130,185],"We":[135],"also":[137],"determined":[138],"protein":[140,171],"a":[143],"subset":[144],"specific":[151],"antibodies":[152],"by":[153],"immunoblotting":[154],"immunohistochemistry.":[156],"Immunoblotting":[157],"immunohistochemistry":[159],"demonstrated":[160],"K(V)2.2":[166],"expressed":[168],"tissues":[175],"K(V)2.1":[180],"These":[192],"suggest":[194],"wide":[197],"array":[198],"activity":[201],"due":[213],"part":[215],"differential":[218],"subunits.":[223]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
