{"id":"https://openalex.org/W216849895","doi":null,"title":"Increased but imbalanced expression of VEGF and its receptors has no positive effect on angiogenesis in systemic sclerosis skin.","display_name":"Increased but imbalanced expression of VEGF and its receptors has no positive effect on angiogenesis in systemic sclerosis skin.","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W216849895","mag":"216849895","pmid":"https://pubmed.ncbi.nlm.nih.gov/12412194"},"language":"en","primary_location":{"id":"pmid:12412194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12412194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112136901","display_name":"Z Mackiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Z Mackiewicz","raw_affiliation_strings":["Institute of Experimental and Clinical Medicine, Vilnius, Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental and Clinical Medicine, Vilnius, Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012890854","display_name":"Antti Sukura","orcid":"https://orcid.org/0000-0002-8992-1695","observed_orcids":["https://orcid.org/0000-0002-8992-1695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Sukura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017248620","display_name":"D Povilenait\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Povilenait\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113886197","display_name":"Arnoldas \u010ceponis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Ceponis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113159885","display_name":"Ismo Virtanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Virtanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042103616","display_name":"Mika Hukkanen","orcid":"https://orcid.org/0000-0001-9687-9571","observed_orcids":["https://orcid.org/0000-0001-9687-9571"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Hukkanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111656412","display_name":"Yrj\u00f6 T. Konttinen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y T Konttinen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1325,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.77155617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"20","issue":"5","first_page":"641","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8690000176429749},{"id":"https://openalex.org/keywords/vegfr1","display_name":"VEGFR1","score":0.8230000138282776},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vegfr-3","display_name":"VEGFR-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/skin","display_name":"skin","score":0.765999972820282},{"id":"https://openalex.org/keywords/lymphatic-vessels","display_name":"lymphatic vessels","score":0.5699999928474426},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.8270000219345093},{"id":"https://openalex.org/keywords/raynaud-s-phenomenon","display_name":"Raynaud's phenomenon","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alpha-v-beta3-integrin","display_name":"alpha v beta 3 integrin","score":0.7269999980926514},{"id":"https://openalex.org/keywords/microvascular-dysfunction","display_name":"microvascular dysfunction","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7340878248214722},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6802856922149658},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5869839191436768},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5803871154785156},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5621546506881714},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5323370695114136},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.4891689121723175},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.43421411514282227},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.4248092472553253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24700433015823364},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.23562294244766235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20012927055358887},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011928","descriptor_name":"Raynaud Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12412194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12412194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Comparative Study"},{"id":"mag:216849895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12412194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W167443092","https://openalex.org/W1868937926","https://openalex.org/W1924639001","https://openalex.org/W1964774726","https://openalex.org/W1983573904","https://openalex.org/W2016998580","https://openalex.org/W2054760975","https://openalex.org/W2065923085","https://openalex.org/W2131393213","https://openalex.org/W2152089397","https://openalex.org/W2165090766","https://openalex.org/W2188739445","https://openalex.org/W2194405934","https://openalex.org/W2406267353","https://openalex.org/W2431188848","https://openalex.org/W2471626918"],"related_works":["https://openalex.org/W2143222045","https://openalex.org/W3103264823","https://openalex.org/W7135075420","https://openalex.org/W151787626","https://openalex.org/W1500972092","https://openalex.org/W1503948577","https://openalex.org/W2412165793","https://openalex.org/W1669522622","https://openalex.org/W2384535579","https://openalex.org/W2979278312"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,53,95,120,123,137,165,169,199,211],"expression":[4,76,128],"of":[5,69,122,129,152,171,213,217],"vascular":[6,13,70,84,133],"endothelial":[7],"growth":[8],"factor":[9],"(VEGF)":[10],"and":[11,14,32,60,88,106,115,131,191],"its":[12,83,132,214],"lymphatic":[15,96],"receptors":[16,85,134],"in":[17,19,45,63,67,72,103,110,143,145,180,210,220],"skin":[18,105],"systemic":[20,25],"sclerosis":[21],"(SSc)":[22],"compared":[23,157],"to":[24,140,148,158],"lupus":[26],"erythematosus":[27],"(SLE),":[28],"Raynaud's":[29],"phenomenon":[30],"(RP)":[31],"normal":[33,64],"healthy":[34],"control":[35],"skin.":[36,182],"METHODS:":[37],"Staining":[38],"was":[39,58,77,100,155],"performed":[40],"using":[41],"rabbit":[42],"anti-human":[43],"antibodies":[44],"DAKO":[46],"TechMate":[47],"Horizon":[48],"staining":[49,114],"robot":[50],"programmed":[51],"for":[52],"biotin-streptavidin":[54],"protocol.":[55],"RESULTS:":[56],"VEGF":[57,75,130,190],"sporadically":[59],"weakly":[61],"expressed":[62,108],"skin,":[65,74],"but":[66,205],"spite":[68],"damage":[71],"diseased":[73,104],"only":[78],"slightly":[79],"upregulated.":[80,93],"In":[81],"contrast,":[82],"VEGFR-1":[86],"(Flt-1)":[87],"VEGFR-2":[89],"(Flk-1),":[90],"were":[91],"clearly":[92],"Finally,":[94],"VEGFR-3":[97],"(Flt-4)":[98],"receptor":[99],"also":[101,109,196],"upregulated":[102],"ectopically":[107],"blood":[111,178],"vessels.":[112],"Negative":[113],"positive":[116],"sample":[117],"controls":[118],"confirmed":[119],"specificity":[121],"staining.":[124],"CONCLUSION:":[125],"The":[126],"imbalanced":[127],"suggest":[135,197],"that":[136,198],"compensatory":[138],"efforts":[139],"angiogenesis":[141],"fail":[142],"SSc,":[144],"part":[146],"due":[147],"insufficient":[149],"local":[150],"production":[151],"VEGF,":[153],"which":[154],"low":[156],"VEGFR":[159],"expression.":[160],"This":[161],"is":[162,202,207],"compatible":[163],"with":[164],"recent":[166],"observations":[167],"on":[168],"lack":[170],"alpha":[172],"V":[173],"beta":[174],"3+":[175],"newly":[176],"formed":[177],"vessels":[179],"SSc":[181,221],"Since":[183],"microvascular":[184],"angiogenic":[185,200,218],"stimuli":[186],"normally":[187],"induce":[188],"first":[189],"then":[192],"VEGFR,":[193],"these":[194],"findings":[195],"cascade":[201,219],"turned":[203],"on,":[204],"there":[206],"a":[208,224],"defect":[209],"finalization":[212],"effects.":[215],"Normalization":[216],"could":[222],"provide":[223],"future":[225],"therapeutic":[226],"target.":[227]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}