{"id":"https://openalex.org/W2168464765","doi":"https://doi.org/10.1152/ajpheart.1998.275.5.h1707","title":"Microtubules modulate cardiomyocyte \u03b2-adrenergic response in cardiac hypertrophy","display_name":"Microtubules modulate cardiomyocyte \u03b2-adrenergic response in cardiac hypertrophy","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W2168464765","doi":"https://doi.org/10.1152/ajpheart.1998.275.5.h1707","mag":"2168464765","pmid":"https://pubmed.ncbi.nlm.nih.gov/9815078"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1998.275.5.h1707","doi":"https://doi.org/10.1152/ajpheart.1998.275.5.h1707","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1998.275.5.h1707","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051231953","display_name":"Bradley M. Palmer","orcid":"https://orcid.org/0000-0002-4388-3160","observed_orcids":["https://orcid.org/0000-0002-4388-3160"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley M. Palmer","raw_affiliation_strings":["Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder 80309; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder 80309; and","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025190106","display_name":"Scott Valent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Valent","raw_affiliation_strings":["Cardiology Division, Health Sciences Center, University of Colorado at Denver, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Health Sciences Center, University of Colorado at Denver, Denver, Colorado 80262","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009189327","display_name":"Emma L. Holder","orcid":"https://orcid.org/0009-0009-6216-9032","observed_orcids":["https://orcid.org/0009-0009-6216-9032"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma L. Holder","raw_affiliation_strings":["Cardiology Division, Health Sciences Center, University of Colorado at Denver, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Health Sciences Center, University of Colorado at Denver, Denver, Colorado 80262","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109901049","display_name":"Howard D. Weinberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard D. Weinberger","raw_affiliation_strings":["Cardiology Division, Health Sciences Center, University of Colorado at Denver, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Health Sciences Center, University of Colorado at Denver, Denver, Colorado 80262","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085746691","display_name":"Roger D. Bies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger D. Bies","raw_affiliation_strings":["Cardiology Division, Health Sciences Center, University of Colorado at Denver, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Health Sciences Center, University of Colorado at Denver, Denver, Colorado 80262","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.019,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.87946198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"275","issue":"5","first_page":"H1707","last_page":"H1716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.6488999724388123,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.6488999724388123,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0778999999165535,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.06769999861717224,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9779999852180481},{"id":"https://openalex.org/keywords/beta-adrenergic-responsiveness","display_name":"beta-adrenergic responsiveness","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/microtubule-polymerization","display_name":"microtubule assembly","score":0.7870000004768372},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8659999966621399},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":1.0},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.8230000138282776},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9340000152587891},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.6150000095367432},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.45399999618530273},{"id":"https://openalex.org/keywords/abdominal-aortic-stenosis","display_name":"abdominal aortic stenosis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/pressure-overload","display_name":"pressure overload","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.8248002529144287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6971713900566101},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.689907431602478},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6033636927604675},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.5744868516921997},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.564534604549408},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.4309547245502472},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3618200421333313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34263768792152405},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.3188839852809906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3173661231994629},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19386953115463257},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06207031011581421}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016257","descriptor_name":"Fura-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1998.275.5.h1707","doi":"https://doi.org/10.1152/ajpheart.1998.275.5.h1707","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1998.275.5.h1707","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:9815078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6800000071525574,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1865723483","display_name":null,"funder_award_id":"HL44146","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3575739703","display_name":null,"funder_award_id":"HL40306","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5100659052","display_name":"HYPERTENSION--TRAINING-INDUCED INCREASE IN WORK CAPACITY","funder_award_id":"5r01hl044146-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G850005966","display_name":"Exercise Training &the Myocardium--Cellular Adaptations","funder_award_id":"R01HL040306","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W51843049","https://openalex.org/W158398419","https://openalex.org/W195223799","https://openalex.org/W1479814947","https://openalex.org/W1492780137","https://openalex.org/W1517947547","https://openalex.org/W1877889068","https://openalex.org/W1964227386","https://openalex.org/W1965700291","https://openalex.org/W1981717742","https://openalex.org/W1982429877","https://openalex.org/W1988692425","https://openalex.org/W1988792839","https://openalex.org/W1992127171","https://openalex.org/W1995049778","https://openalex.org/W1997473561","https://openalex.org/W1998343474","https://openalex.org/W2003318127","https://openalex.org/W2015129175","https://openalex.org/W2018378153","https://openalex.org/W2023394207","https://openalex.org/W2031753698","https://openalex.org/W2035857806","https://openalex.org/W2098238167","https://openalex.org/W2098953209","https://openalex.org/W2107989385","https://openalex.org/W2116424197","https://openalex.org/W2121586551","https://openalex.org/W2123513862","https://openalex.org/W2124307551","https://openalex.org/W2132079516","https://openalex.org/W2136210681","https://openalex.org/W2136297988","https://openalex.org/W2141260882","https://openalex.org/W2147794519","https://openalex.org/W2157869248","https://openalex.org/W2159830700","https://openalex.org/W2159876927","https://openalex.org/W2165317994","https://openalex.org/W2171087337","https://openalex.org/W2266017578","https://openalex.org/W2276591666","https://openalex.org/W2336125038","https://openalex.org/W2395367366","https://openalex.org/W2411034585","https://openalex.org/W2412099797","https://openalex.org/W2415063057","https://openalex.org/W2419639524","https://openalex.org/W2420684420","https://openalex.org/W2586340116"],"related_works":["https://openalex.org/W2106759566","https://openalex.org/W2104077860","https://openalex.org/W2073127574","https://openalex.org/W2148360707","https://openalex.org/W1973600844","https://openalex.org/W2133484634","https://openalex.org/W1965700291","https://openalex.org/W2269698742","https://openalex.org/W2009508503","https://openalex.org/W2115544657"],"abstract_inverted_index":{"The":[0,124],"role":[1,170],"of":[2,21,65,97],"microtubules":[3,67,105],"in":[4,11,42,106,130,171,176],"modulating":[5],"cardiomyocyte":[6,37,173],"beta-adrenergic":[7,125,149,174],"response":[8,126,150,175],"was":[9,52,76,134],"investigated":[10],"rats":[12,18,45],"with":[13,137],"cardiac":[14,40,178],"hypertrophy.":[15,179],"Male":[16],"Sprague-Dawley":[17],"underwent":[19],"stenosis":[20],"the":[22,43,131,147],"abdominal":[23],"aorta":[24],"(hypertensive,":[25],"HT)":[26],"or":[27,94],"sham":[28],"operation":[29],"(normotensive,":[30],"NT).":[31],"Echocardiography":[32],"and":[33,57,102,113,160],"isolated":[34],"left":[35],"ventricular":[36],"dimensions":[38],"demonstrated":[39],"hypertrophy":[41],"HT":[44,75,132],"after":[46,68],"30":[47],"wk.":[48],"Cardiomyocyte":[49,109],"microtubule":[50,72,141],"fraction":[51,73],"assayed":[53],"by":[54,143],"high-speed":[55],"centrifugation":[56],"Western":[58],"blot.":[59],"In":[60],"contrast":[61],"to":[62,86,120,153,157],"previous":[63],"reports":[64],"increased":[66,104,140],"acute":[69],"pressure":[70],"overload,":[71],"for":[74,81,127,151],"significantly":[77],"lower":[78],"than":[79],"that":[80],"NT.":[82,138],"Cardiomyocytes":[83],"were":[84,116],"exposed":[85],"either":[87],"1":[88],"microM":[89,92],"colchicine,":[90],"10":[91],"taxol,":[93],"equivalent":[95],"volume":[96],"vehicle.":[98],"Colchicine":[99],"decreased":[100],"microtubules,":[101],"taxol":[103,144],"both":[107],"groups.":[108],"cytosolic":[110],"calcium":[111],"([Ca2+]c)":[112],"shortening/relaxation":[114],"dynamics":[115],"assessed":[117],"during":[118],"exposure":[119],"increasing":[121],"isoproterenol":[122],"concentrations.":[123],"these":[128],"variables":[129],"group":[133],"blunted":[135],"compared":[136],"However,":[139],"assembly":[142,165],"partially":[145],"recovered":[146],"normal":[148],"time":[152,156],"peak":[154,158],"[Ca2+]c,":[155],"shortening,":[159],"mechanical":[161],"relaxation":[162],"variables.":[163],"Microtubule":[164],"may":[166],"play":[167],"a":[168],"significant":[169],"determining":[172],"chronic":[177]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
