{"id":"https://openalex.org/W2168455259","doi":"https://doi.org/10.1093/molehr/gar062","title":"Dydrogesterone exerts endothelial anti-inflammatory actions decreasing expression of leukocyte adhesion molecules","display_name":"Dydrogesterone exerts endothelial anti-inflammatory actions decreasing expression of leukocyte adhesion molecules","publication_year":2011,"publication_date":"2011-10-04","ids":{"openalex":"https://openalex.org/W2168455259","doi":"https://doi.org/10.1093/molehr/gar062","mag":"2168455259","pmid":"https://pubmed.ncbi.nlm.nih.gov/21971309"},"language":"en","primary_location":{"id":"doi:10.1093/molehr/gar062","doi":"https://doi.org/10.1093/molehr/gar062","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molehr/gar062","pdf_url":"https://academic.oup.com/molehr/article-pdf/18/1/44/3775867/gar062.pdf","source":{"id":"https://openalex.org/S4210190516","display_name":"Molecular Human Reproduction","issn_l":"1360-9947","issn":["1360-9947","1460-2407"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/molehr/article-pdf/18/1/44/3775867/gar062.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027628707","display_name":"Xiaodong Fu","orcid":"https://orcid.org/0000-0003-2754-8976","observed_orcids":["https://orcid.org/0000-0003-2754-8976"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN","IT"],"is_corresponding":false,"raw_author_name":"X.-D. Fu","raw_affiliation_strings":["Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy","Department of Physiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Department of Physiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002461856","display_name":"Silvia Garibaldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Garibaldi","raw_affiliation_strings":["Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023775087","display_name":"Sandeep Gopal","orcid":"https://orcid.org/0000-0002-6706-6747","observed_orcids":["https://orcid.org/0000-0002-6706-6747"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Gopal","raw_affiliation_strings":["Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045793487","display_name":"Kinga Polak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"K. Polak","raw_affiliation_strings":["Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023999297","display_name":"Giulia Palla","orcid":"https://orcid.org/0000-0002-8661-1405","observed_orcids":["https://orcid.org/0000-0002-8661-1405"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Palla","raw_affiliation_strings":["Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082477296","display_name":"Stefania Spina","orcid":"https://orcid.org/0000-0002-7220-4016","observed_orcids":["https://orcid.org/0000-0002-7220-4016"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Spina","raw_affiliation_strings":["Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045884385","display_name":"Paolo Mannella","orcid":"https://orcid.org/0000-0001-8146-6731","observed_orcids":["https://orcid.org/0000-0001-8146-6731"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Mannella","raw_affiliation_strings":["Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038322094","display_name":"Andrea Ricardo Genazzani","orcid":"https://orcid.org/0000-0003-4260-3929","observed_orcids":["https://orcid.org/0000-0003-4260-3929"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. R. Genazzani","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Modena, Italy","Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052961246","display_name":"Alessandro David Genazzani","orcid":"https://orcid.org/0000-0002-2828-5840","observed_orcids":["https://orcid.org/0000-0002-2828-5840"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. D. Genazzani","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Modena, Italy","Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004083793","display_name":"Tommaso Simoncini","orcid":"https://orcid.org/0000-0002-2971-0079","observed_orcids":["https://orcid.org/0000-0002-2971-0079"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"T. Simoncini","raw_affiliation_strings":["Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, Pisa 56100, Italy","institution_ids":["https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004083793"],"corresponding_institution_ids":["https://openalex.org/I108290504"],"apc_list":{"value":3973,"currency":"EUR","value_usd":4490},"apc_paid":null,"fwci":0.608,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.59980383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"18","issue":"1","first_page":"44","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4713999927043915,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4713999927043915,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.125,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.12300000339746475,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dydrogesterone","display_name":"dydrogesterone","score":1.0},{"id":"https://openalex.org/keywords/progestins","display_name":"progestins","score":0.9539999961853027},{"id":"https://openalex.org/keywords/endothelial-inflammation","display_name":"endothelial inflammation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/leukocyte-adhesion-molecules","display_name":"leukocyte adhesion molecules","score":0.9879999756813049},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":1.0},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nuclear-factor-kappab","display_name":"nuclear factor-kappaB","score":0.8679999709129333},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/medroxyprogesterone-acetate","display_name":"medroxyprogesterone acetate","score":0.9419999718666077},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8560000061988831},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.7469582557678223},{"id":"https://openalex.org/C2776045411","wikidata":"https://www.wikidata.org/wiki/Q4161380","display_name":"Dydrogesterone","level":3,"score":0.5708269476890564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5682066679000854},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5362984538078308},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.49105143547058105},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47603562474250793},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4682166576385498},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3770146071910858},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34785550832748413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3435002267360687},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33604395389556885},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3006289005279541},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21279731392860413},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.2102797031402588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17593979835510254},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16602277755737305}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004394","descriptor_name":"Dydrogesterone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004394","descriptor_name":"Dydrogesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011372","descriptor_name":"Progestins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/molehr/gar062","doi":"https://doi.org/10.1093/molehr/gar062","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molehr/gar062","pdf_url":"https://academic.oup.com/molehr/article-pdf/18/1/44/3775867/gar062.pdf","source":{"id":"https://openalex.org/S4210190516","display_name":"Molecular Human Reproduction","issn_l":"1360-9947","issn":["1360-9947","1460-2407"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Human Reproduction","raw_type":"journal-article"},{"id":"pmid:21971309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21971309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular human reproduction","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.909.8222","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.909.8222","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://molehr.oxfordjournals.org/content/18/1/44.full.pdf","raw_type":"text"},{"id":"pmh:oai:arpi.unipi.it:11568/199619","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/199619","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unimore.it:11380/741553","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/741553","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/molehr/gar062","doi":"https://doi.org/10.1093/molehr/gar062","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molehr/gar062","pdf_url":"https://academic.oup.com/molehr/article-pdf/18/1/44/3775867/gar062.pdf","source":{"id":"https://openalex.org/S4210190516","display_name":"Molecular Human Reproduction","issn_l":"1360-9947","issn":["1360-9947","1460-2407"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Human Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168455259.pdf","grobid_xml":"https://content.openalex.org/works/W2168455259.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W38065259","https://openalex.org/W1586699954","https://openalex.org/W1593442063","https://openalex.org/W1971867327","https://openalex.org/W1981922048","https://openalex.org/W1986504582","https://openalex.org/W1993814898","https://openalex.org/W1993966022","https://openalex.org/W2001818002","https://openalex.org/W2006862162","https://openalex.org/W2018312028","https://openalex.org/W2032499409","https://openalex.org/W2043886678","https://openalex.org/W2049278249","https://openalex.org/W2058947545","https://openalex.org/W2061490724","https://openalex.org/W2096584099","https://openalex.org/W2098691880","https://openalex.org/W2104687197","https://openalex.org/W2106900101","https://openalex.org/W2110436785","https://openalex.org/W2117265317","https://openalex.org/W2118598944","https://openalex.org/W2118760305","https://openalex.org/W2125090750","https://openalex.org/W2128049273","https://openalex.org/W2129940081","https://openalex.org/W2130771020","https://openalex.org/W2130842658","https://openalex.org/W2143216610","https://openalex.org/W2149441446","https://openalex.org/W2154630561","https://openalex.org/W2161672871","https://openalex.org/W2615633554"],"related_works":["https://openalex.org/W7097025667","https://openalex.org/W1965699572","https://openalex.org/W2134071961","https://openalex.org/W1976883073","https://openalex.org/W2050947729","https://openalex.org/W2106900101","https://openalex.org/W4230832243","https://openalex.org/W2091836891","https://openalex.org/W2118646349","https://openalex.org/W2083329221"],"abstract_inverted_index":{"Clinical":[0],"observations":[1],"and":[2,8,42,89,104,112,136,149,167],"basic":[3],"studies":[4],"show":[5,75],"that":[6,76],"progesterone":[7,48,109],"progestins":[9,78],"have":[10,28],"a":[11,20],"variable":[12],"influence":[13],"on":[14,54],"endothelial":[15,26,63,70,81,152],"function.":[16],"Dydrogesterone":[17],"(DG)":[18],"is":[19],"widely":[21],"used":[22],"progestin,":[23],"but":[24],"its":[25,43],"actions":[27,170],"not":[29,139],"been":[30],"thoroughly":[31],"assessed.":[32],"In":[33,133,146],"this":[34],"study,":[35],"we":[36],"investigated":[37],"the":[38,55,127,141,162,175],"effects":[39,101,143,177],"of":[40,57,83,102,108,126,144,161,178],"DG":[41,103,111,135,148],"metabolite":[44],"20-\u03b1-dihydro-dydrogesterone":[45],"(DHD),":[46],"natural":[47],"as":[49,51],"well":[50],"medroxyprogesterone":[52],"acetate,":[53],"expression":[56,82,117,160],"leukocyte":[58],"adhesion":[59,86,91,115,164],"molecules":[60,165],"in":[61,67],"human":[62],"cells":[64],"using":[65],"an":[66],"vitro":[68],"experimental":[69],"inflammation":[71],"system.":[72],"Our":[73],"findings":[74],"all":[77],"significantly":[79],"suppress":[80],"vascular":[84,176],"cell":[85],"molecule-1":[87,92],"(VCAM-1)":[88],"inter-cellular":[90],"(ICAM-1)":[93],"induced":[94,155],"by":[95,122,156],"bacterial":[96],"lypopolysaccharide":[97],"(LPS).":[98],"These":[99,169],"inhibitory":[100],"DHD":[105,113,137,150],"require":[106],"activation":[107],"receptor.":[110],"decrease":[114,151],"molecule":[116],"associated":[118],"with":[119],"LPS":[120],"administration":[121],"preventing":[123],"nuclear":[124,131],"translocation":[125],"pro-inflammatory":[128],"transcription":[129],"factor":[130],"factor-\u03baB.":[132],"addition,":[134],"do":[138],"alter":[140],"anti-inflammatory":[142],"17\u03b2-estradiol.":[145],"conclusion,":[147],"inflammatory":[153],"responses":[154],"LPS,":[157],"via":[158],"reduced":[159],"pro-atherogenic":[163],"VCAM-1":[166],"ICAM-1.":[168],"may":[171],"be":[172],"relevant":[173],"for":[174],"DG.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
